{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:13:03Z","timestamp":1777655583255,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12350-020-02262-6","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T22:02:36Z","timestamp":1594936956000},"page":"2965-2975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel 68Ga-mCXCL12 PET tracer"],"prefix":"10.1016","volume":"28","author":[{"given":"Mathias Johannes","family":"Zacherl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Todica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"W\u00e4ngler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Schirrmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Ali","family":"Hajebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Pircher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Massberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Lehner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno C.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-020-02262-6_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s12410-017-9400-x","article-title":"Novel noninvasive nuclear medicine imaging techniques for cardiac inflammation","volume":"10","author":"Kircher","year":"2017","journal-title":"Curr Cardiovasc Imaging Rep"},{"key":"10.1007\/s12350-020-02262-6_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrcardio.2018.6","article-title":"Inflammation: New insights from PET imaging","volume":"15","author":"Fern\u00e1ndez-Ruiz","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1007\/s12350-020-02262-6_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jacc.2011.08.066","article-title":"PET\/MRI of inflammation in myocardial infarction","volume":"59","author":"Lee","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-020-02262-6_bib4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00259-014-2956-7","article-title":"Clinically relevant strategies for lowering cardiomyocyte glucose uptake for 18F-FDG imaging of myocardial inflammation in mice","volume":"42","author":"Thackeray","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-020-02262-6_bib5","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.2967\/jnumed.111.098798","article-title":"PET of CXCR4 expression by a 68Ga-labeled highly specific targeted contrast agent","volume":"52","author":"Gourni","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-020-02262-6_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/smim.1998.0126","article-title":"Introduction: HIV co-receptors solve old questions and raise many new ones","volume":"10","author":"Berger","year":"1998","journal-title":"Semin Immunol"},{"key":"10.1007\/s12350-020-02262-6_bib7","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/ijc.22024","article-title":"Chemokines and cancer","volume":"119","author":"Zlotnik","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1007\/s12350-020-02262-6_bib8","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1182\/blood-2005-08-3182","article-title":"CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment","volume":"107","author":"Burger","year":"2006","journal-title":"Blood"},{"key":"10.1007\/s12350-020-02262-6_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","article-title":"Chemokines-chemotactic cytokines that mediate inflammation","volume":"338","author":"Luster","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-020-02262-6_bib10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-020-02262-6_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1007\/s12350-020-02262-6_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1517\/14712590903460286","article-title":"Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy","volume":"10","author":"Zaruba","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"10.1007\/s12350-020-02262-6_bib13","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1096\/fj.06-6558com","article-title":"SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction","volume":"21","author":"Zhang","year":"2007","journal-title":"FASEB J"},{"key":"10.1007\/s12350-020-02262-6_bib14","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2353\/ajpath.2010.090451","article-title":"Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury","volume":"176","author":"Chen","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1007\/s12350-020-02262-6_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.yjmcc.2010.07.010","article-title":"Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction","volume":"49","author":"Dai","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1007\/s12350-020-02262-6_bib16","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0914248107","article-title":"CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction","volume":"107","author":"Jujo","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1007\/s12350-020-02262-6_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/CIRCULATIONAHA.112.099242","article-title":"CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia\/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism","volume":"127","author":"Jujo","year":"2013","journal-title":"Circulation"},{"key":"10.1007\/s12350-020-02262-6_bib18","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2967\/jnumed.110.082198","article-title":"A universally applicable 68Ga-labeling technique for proteins","volume":"52","author":"W\u00e4ngler","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-020-02262-6_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvr014","article-title":"Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart","volume":"90","author":"Huber","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1007\/s12350-020-02262-6_bib20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2967\/jnumed.112.114660","article-title":"Longitudinal assessment of cerebral \u03b2-amyloid deposition in mice overexpressing Swedish mutant \u03b2-amyloid precursor protein using 18F-florbetaben PET","volume":"54","author":"Rominger","year":"2013","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-020-02262-6_bib21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2310\/7290.2012.00010","article-title":"Temporal changes in phosphatidylserine expression and glucose metabolism after myocardial infarction: An in vivo imaging study in mice","volume":"11","author":"Lehner","year":"2012","journal-title":"Mol Imaging"},{"key":"10.1007\/s12350-020-02262-6_bib22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.7150\/thno.11251","article-title":"Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging","volume":"5","author":"Wester","year":"2015","journal-title":"Theranostics"},{"key":"10.1007\/s12350-020-02262-6_bib23","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.jcmg.2015.09.008","article-title":"Molecular imaging of the chemokine receptor CXCR4 after acute myocardial infarction","volume":"8","author":"Thackeray","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-020-02262-6_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12350-015-0347-5","article-title":"Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET\/MRI","volume":"23","author":"Rischpler","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02262-6_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmg.2018.01.001","article-title":"Imaging of C-X-C motif chemokine receptor CXCR4 expression after myocardial infarction with [68Ga]Pentixafor-PET\/CT in correlation with cardiac MRI","author":"Reiter","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-020-02262-6_bib26","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jcmg.2015.09.007","article-title":"[68Ga]Pentixafor-PET\/CT for imaging of chemokine receptor 4 expression after myocardial infarction","volume":"8","author":"Lapa","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-020-02262-6_bib27","doi-asserted-by":"crossref","first-page":"9614","DOI":"10.1021\/acs.analchem.8b02553","article-title":"Radioiodinated pentixather for SPECT imaging of expression of the chemokine receptor CXCR4 in rat myocardial-infarction-reperfusion models","volume":"90","author":"Li","year":"2018","journal-title":"Anal Chem"},{"key":"10.1007\/s12350-020-02262-6_bib28","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.jacc.2016.01.073","article-title":"Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction","volume":"67","author":"Westman","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-020-02262-6_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00011-013-0605-4","article-title":"Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus","volume":"62","author":"Ruparelia","year":"2013","journal-title":"Inflamm Res"},{"key":"10.1007\/s12350-020-02262-6_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ehjci\/jev237","article-title":"FDG-PET reveals improved cardiac regeneration and attenuated adverse remodelling following Sitagliptin + G-CSF therapy after acute myocardial infarction","volume":"17","author":"Gross","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1007\/s12350-020-02262-6_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/2191-219X-2-43","article-title":"Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using [18 F]FDG-PET: Comparison with cardiac MRI and monitoring erythropoietin therapy","volume":"2","author":"Brunner","year":"2012","journal-title":"EJNMMI Res"},{"key":"10.1007\/s12350-020-02262-6_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s11307-017-1114-6","article-title":"Monitoring of cardiac remodeling in a mouse model of pressure-overload left ventricular hypertrophy with [18F]FDG MicroPET","volume":"20","author":"Todica","year":"2018","journal-title":"Mol Imaging Biol"},{"key":"10.1007\/s12350-020-02262-6_bib33","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1073\/pnas.95.12.6941","article-title":"Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 \u201cfusin\u201d coreceptor","volume":"95","author":"Dealwis","year":"1998","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-020-02262-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12350-020-02262-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123017099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123017099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-020-02262-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T15:52:51Z","timestamp":1735573971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123017099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1071358123017099"],"URL":"https:\/\/doi.org\/10.1007\/s12350-020-02262-6","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel 68Ga-mCXCL12 PET tracer","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-020-02262-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 THE AUTHORS. Published by ELSEVIER INC. on behalf of American Society of Nuclear Cardiology. Published by Mosby, Inc.","name":"copyright","label":"Copyright"}]}}