{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:59:54Z","timestamp":1769576394469,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s12350-021-02610-0","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T11:04:29Z","timestamp":1625569469000},"page":"2274-2291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["MIBG cardiac imaging compared to ejection fraction in evaluation of cardiotoxicity: a systematic review"],"prefix":"10.1016","volume":"29","author":[{"given":"Tha\u00eds Rossato","family":"Arrais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano Dallegrave","family":"Cavalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Tietbohl","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Bartzen","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina Borges","family":"Migliavaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Blacher","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9ia","family":"Biolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejcsup.2014.03.001","article-title":"Cancer survivorship: a positive side-effect of more successful cancer treatment","volume":"12","author":"Moser","year":"2014","journal-title":"Eur J Cancer Suppl"},{"issue":"24","key":"10.1007\/s12350-021-02610-0_bib2","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2009.02.050","article-title":"Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management","volume":"53","author":"Yeh","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1007\/s12350-021-02610-0_bib3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12350-012-9512-2","article-title":"Non-invasive imaging and monitoring cardiotoxicity of cancer therapeutic drugs","volume":"19","author":"Jiji","year":"2012","journal-title":"J Nucl Cardiol."},{"issue":"3","key":"10.1007\/s12350-021-02610-0_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.nuclcard.2006.03.002","article-title":"Monitoring chemotherapy-induced cardiotoxicity: role of cardiac nuclear imaging","volume":"13","author":"Panjrath","year":"2006","journal-title":"J Nucl Cardiol."},{"issue":"11","key":"10.1007\/s12350-021-02610-0_bib5","first-page":"2869","article-title":"Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials","volume":"97","author":"Swain","year":"2003","journal-title":"Cancer Interdisciplinary Int J Am Cancer Soc."},{"issue":"6","key":"10.1007\/s12350-021-02610-0_bib6","first-page":"533","article-title":"The use of cardiac 123I-mIBG scintigraphy in clinical practice: the necessity to standardize!","volume":"30","author":"Rocha","year":"2017","journal-title":"Int J Cardiovas Sci."},{"issue":"6","key":"10.1007\/s12350-021-02610-0_bib7","first-page":"857","article-title":"Invasive and noninvasive methods of assessing adriamycin cardiotoxic effects in man: superiority of histopathologic assessment using endomyocardial biopsy","volume":"62","author":"Mason","year":"1978","journal-title":"Cancer Treat Rep"},{"issue":"22","key":"10.1007\/s12350-021-02610-0_bib8","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1161\/01.CIR.0000130926.51766.CC","article-title":"Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy","volume":"109","author":"Cardinale","year":"2004","journal-title":"Circulation"},{"issue":"25","key":"10.1007\/s12350-021-02610-0_bib9","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1200\/JCO.2009.27.3615","article-title":"Trastuzumab-induced cardiotoxicity: clinical and prognostic implications of troponin I evaluation","volume":"28","author":"Cardinale","year":"2010","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1007\/s12350-021-02610-0_bib10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jacc.2013.10.061","article-title":"Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab","volume":"63","author":"Ky","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1007\/s12350-021-02610-0_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/heartjnl-2015-307894","article-title":"Roadmap for biomarkers of cancer therapy cardiotoxicity","volume":"102","author":"Anthony","year":"2016","journal-title":"Heart"},{"issue":"2 Suppl 1","key":"10.1007\/s12350-021-02610-0_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0066-782X2011000700001","article-title":"I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia [I Brazilian Guideline for Cardio-Oncology from Sociedade Brasileira de Cardiologia]","volume":"96","author":"Filho","year":"2011","journal-title":"Arq Bras Cardiol"},{"issue":"36","key":"10.1007\/s12350-021-02610-0_bib13","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1007\/s12350-021-02610-0_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1200\/JCO.2016.70.5400","article-title":"Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American society of clinical oncology clinical practice guideline","volume":"35","author":"Armenian","year":"2016","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1007\/s12350-021-02610-0_bib15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1200\/JCO.1984.2.2.112","article-title":"A comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving Adriamycin","volume":"2","author":"Ewer","year":"1984","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejcsup.2014.03.002","article-title":"Cardiovascular disease after cancer therapy","volume":"12","author":"Aleman","year":"2014","journal-title":"Eur J Cancer Suppl"},{"issue":"25 Part A","key":"10.1007\/s12350-021-02610-0_bib17","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1016\/j.jacc.2014.01.073","article-title":"Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: A systematic review","volume":"63","author":"Thavendiranathan","year":"2014","journal-title":"Journal of the American College of Cardiology."},{"issue":"10","key":"10.1007\/s12350-021-02610-0_bib18","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1001\/jamacardio.2019.2952","article-title":"Assessment of prognostic value of left ventricular global longitudinal strain for early prediction of chemotherapy-induced cardiotoxicity: a systematic review and meta-analysis","volume":"4","author":"Oikonomou","year":"2019","journal-title":"JAMA cardiology."},{"issue":"11","key":"10.1007\/s12350-021-02610-0_bib19","first-page":"2044","article-title":"Indium-111-antimyosin and iodine-123-MIBG studies in early assessment of doxorubicin cardiotoxicity","volume":"36","author":"Carri\u00f3","year":"1995","journal-title":"J Nucl Med"},{"issue":"9","key":"10.1007\/s12350-021-02610-0_bib20","first-page":"1503","article-title":"Detection of doxorubicin cardiotoxicity in patients with sarcomas by indium-111-antimyosin monoclonal antibody studies","volume":"34","author":"Carri\u00f3","year":"1993","journal-title":"J Nucl Med"},{"issue":"12","key":"10.1007\/s12350-021-02610-0_bib21","first-page":"1965","article-title":"Indium-111-antimyosin scintigraphy after doxorubicin therapy in patients with advanced breast cancer","volume":"31","author":"Estorch","year":"1990","journal-title":"J Nucl Med"},{"issue":"3","key":"10.1007\/s12350-021-02610-0_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03164994","article-title":"Noninvasive identification of anthracycline cardiotoxicity: Comparison of 123 I-MIBG and 123 I-BMIPP imaging","volume":"8","author":"Takeishi","year":"1994","journal-title":"Ann Nucl Med"},{"issue":"7","key":"10.1007\/s12350-021-02610-0_bib23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4329\/wjr.v6.i7.486","article-title":"Nuclear imaging in detection and monitoring of cardiotoxicity","volume":"6","author":"D\u2019Amore","year":"2014","journal-title":"World J Radiol."},{"issue":"7","key":"10.1007\/s12350-021-02610-0_bib24","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jcmg.2013.02.007","article-title":"A pooled analysis of multicenter cohort studies of 123I-m IBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure","volume":"6","author":"Nakata","year":"2013","journal-title":"JACC Cardiovasc Imaging."},{"issue":"2","key":"10.1007\/s12350-021-02610-0_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.pcad.2010.06.007","article-title":"Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?","volume":"53","author":"Sawyer","year":"2010","journal-title":"Prog Cardiovasc Dis"},{"issue":"4","key":"10.1007\/s12350-021-02610-0_bib26","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2967\/jnumed.110.082784","article-title":"Scintigraphic techniques for early detection of cancer treatment\u2013induced cardiotoxicity","volume":"52","author":"de Geus-Oei","year":"2011","journal-title":"J Nucl Med"},{"issue":"8","key":"10.1007\/s12350-021-02610-0_bib27","first-page":"1283","article-title":"Metaiodobenzylguanidine: Evaluation of its potential as a tracer for monitoring doxorubicin cardiomyopathy","volume":"34","author":"Wakasugi","year":"1993","journal-title":"J Nucl Med"},{"issue":"2","key":"10.1007\/s12350-021-02610-0_bib28","first-page":"208","article-title":"Detection of abnormal cardiac adrenergic neuron activity in adriamycin-induced cardiomyopathy with iodine-125-metaiodobenzylguanidine","volume":"33","author":"Wakasugi","year":"1992","journal-title":"J Nucl Med"},{"issue":"4","key":"10.1007\/s12350-021-02610-0_bib29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1007\/s12350-021-02610-0_bib30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s12350-018-01566-y","article-title":"123 I-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma","volume":"27","author":"Laursen","year":"2018","journal-title":"J Nucl Cardiol."},{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1071-3581(96)90022-7","article-title":"Doxorubicin-induced cardiac neurotoxicity: study with iodine 123-labeled metaiodobenzylguanidine scintigraphy","volume":"3","author":"Lekakis","year":"1996","journal-title":"J Nucl Cardiol."},{"issue":"4","key":"10.1007\/s12350-021-02610-0_bib32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF01247376","article-title":"Iodine-123 metaiodobenzylguanidine in the assessment of late cardiac effects from cancer therapy","volume":"23","author":"Olmos","year":"1996","journal-title":"Eur J Nucl Med"},{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12350-015-0309-y","article-title":"Assessment of late anthracycline-induced cardiotoxicity by 123 I-mIBG cardiac scintigraphy in patients treated during childhood and adolescence","volume":"24","author":"dos Santos","year":"2017","journal-title":"J Nucl Cardiol."},{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MNM.0b013e32835ae523","article-title":"I-123-MIBG myocardial imaging in trastuzumab-based cardiotoxicity: the first experience","volume":"34","author":"Stokkel","year":"2013","journal-title":"Nucl Med Commun"},{"issue":"3","key":"10.1007\/s12350-021-02610-0_bib35","first-page":"228","article-title":"Hiperatividade Simp\u00e1tica Card\u00edaca Ap\u00f3s Quimioterapia: Sinal Precoce de Cardiotoxicidade?","volume":"105","author":"Guimar\u00e3es","year":"2015","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2281.2001.00292.x","article-title":"Anthracycline-induced cardiomyopathy: long-term effects on myocardial cell integrity, cardiac adrenergic innervation and fatty acid uptake","volume":"21","author":"Nousiainen","year":"2001","journal-title":"Clin Physiol"},{"issue":"1","key":"10.1007\/s12350-021-02610-0_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0959-8049(94)00357-B","article-title":"Assessment of anthracycline-related myocardial adrenergic derangement by [123I] metaiodobenzylguanidine scintigraphy","volume":"31","author":"Olmos","year":"1995","journal-title":"Eur J Cancer"},{"issue":"5","key":"10.1007\/s12350-021-02610-0_bib38","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00280-015-2874-9","article-title":"Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients","volume":"76","author":"Bulten","year":"2015","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3","key":"10.1007\/s12350-021-02610-0_bib39","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00003072-199203000-00001","article-title":"I-123 MIBG and serial radionuclide angiocardiography in doxorubicin-related cardiotoxicity","volume":"17","author":"Vald\u00e9s","year":"1992","journal-title":"Clin Nucl Med"},{"issue":"14","key":"10.1007\/s12350-021-02610-0_bib40","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/archinternmed.2010.233","article-title":"Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study","volume":"170","author":"van der Pal","year":"2010","journal-title":"Arch Intern Med"},{"issue":"5","key":"10.1007\/s12350-021-02610-0_bib41","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/CIRCIMAGING.112.973321","article-title":"Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab","volume":"5","author":"Sawaya","year":"2012","journal-title":"Circ Cardiovasc Imaging."},{"issue":"5","key":"10.1007\/s12350-021-02610-0_bib42","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.echo.2013.02.008","article-title":"Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity","volume":"26","author":"Negishi","year":"2013","journal-title":"J Am Soc Echocardiogr"},{"issue":"20","key":"10.1007\/s12350-021-02610-0_bib43","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","article-title":"Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure: results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study","volume":"55","author":"Jacobson","year":"2010","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-021-02610-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12350-021-02610-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123005214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123005214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-021-02610-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:11:24Z","timestamp":1761027084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123005214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1071358123005214"],"URL":"https:\/\/doi.org\/10.1007\/s12350-021-02610-0","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MIBG cardiac imaging compared to ejection fraction in evaluation of cardiotoxicity: a systematic review","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-021-02610-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}