{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:14:44Z","timestamp":1792293284807,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s12350-021-02733-4","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T12:20:41Z","timestamp":1626438041000},"page":"2325-2335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of mineralocorticoid receptor antagonist eplerenone on cardiac sympathetic nerve activity and left ventricular remodeling after reperfusion therapy in patients with first ST-segment elevation myocardial infarction"],"prefix":"10.1016","volume":"29","author":[{"given":"Kazuyoshi","family":"Toda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Kasama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kurabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-021-02733-4_bib1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-021-02733-4_bib2","doi-asserted-by":"crossref","first-page":"e466","DOI":"10.1161\/CIRCULATIONAHA.111.067918","article-title":"Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling","volume":"124","author":"Leopold","year":"2011","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib3","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system","volume":"83","author":"Weber","year":"1991","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib4","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1210\/en.2005-1167","article-title":"Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats","volume":"147","author":"Buss","year":"2006","journal-title":"Endocrinology"},{"key":"10.1007\/s12350-021-02733-4_bib5","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1161\/CIRCULATIONAHA.108.809194","volume":"119","author":"Iraqi","year":"2009","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib6","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s002590000311","article-title":"Cardiac sympathetic dysfunction contributes to left ventricular remodeling after acute myocardial infarction","volume":"27","author":"Sakata","year":"2000","journal-title":"Eur J Nucl Med"},{"key":"10.1007\/s12350-021-02733-4_bib7","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1161\/01.CIR.101.22.2579","article-title":"Extent of cardiac sympathetic neuronal damage is determined by the area of ischemia in patients with acute coronary syndromes","volume":"101","author":"Matsunari","year":"2000","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/hrt.2010.204149","article-title":"Prognostic value of cardiac sympathetic nerve activity evaluated by [123I]m-iodobenzylguanidine imaging in patients with ST-segment elevation myocardial infarction","volume":"97","author":"Kasama","year":"2011","journal-title":"Heart"},{"key":"10.1007\/s12350-021-02733-4_bib9","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/S0735-1097(01)01243-8","article-title":"Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure","volume":"37","author":"Yee","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib10","doi-asserted-by":"crossref","first-page":"R994","DOI":"10.1152\/ajpregu.90903.2008","article-title":"Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats","volume":"296","author":"Huang","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1007\/s12350-021-02733-4_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MNM.0000000000000619","article-title":"Impact of concomitant medication use on myocardial 123I-mIBG imaging results in patients with heart failure","volume":"38","author":"Jacobson","year":"2017","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-021-02733-4_bib12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jacc.2004.11.038","article-title":"Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction","volume":"45","author":"Kasama","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib13","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jacc.2006.09.048","article-title":"Effects of intravenous atrial natriuretic peptide on cardiac sympathetic nerve activity and left ventricular remodeling in patients with first anterior acute myocardial infarction","volume":"49","author":"Kasama","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib14","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/eurheartj\/ehm048","article-title":"Evaluation of cardiac sympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy on the treatment containing carvedilol","volume":"28","author":"Kasama","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-021-02733-4_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib16","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1007\/s12350-021-02733-4_bib17","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.2967\/jnumed.107.043075","article-title":"Long-term nicorandil therapy improves cardiac sympathetic nerve activity after reperfusion therapy in patients with first acute myocardial infarction","volume":"48","author":"Kasama","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-021-02733-4_bib18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/hrt.2010.215459","article-title":"Effects of spironolactone on cardiac sympathetic nerve activity and left ventricular remodelling after reperfusion therapy in patients with first ST-segment elevation myocardial infarction","volume":"97","author":"Kasama","year":"2011","journal-title":"Heart"},{"key":"10.1007\/s12350-021-02733-4_bib19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/0193841X05275596","article-title":"Propensity scores: An introduction and experimental test","volume":"29","author":"Luellen","year":"2005","journal-title":"Eval Rev"},{"key":"10.1007\/s12350-021-02733-4_bib20","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/01.HYP.24.5.571","article-title":"Chronic administration of aldosterone depresses baroreceptor reflex function in the dog","volume":"24","author":"Wang","year":"1994","journal-title":"Hypertension"},{"key":"10.1007\/s12350-021-02733-4_bib21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/01.HYP.31.1.451","article-title":"Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats","volume":"31","author":"Rocha","year":"1998","journal-title":"Hypertension"},{"key":"10.1007\/s12350-021-02733-4_bib22","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1210\/jcem.87.8.8731","article-title":"Expression of aldosterone synthase gene in failing human heart: Quantitative analysis using modified real-time polymerase chain reaction","volume":"87","author":"Yoshimura","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1007\/s12350-021-02733-4_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1161\/01.CIR.103.1.72","article-title":"Aldosterone production is activated in failing ventricle in humans","volume":"103","author":"Mizuno","year":"2001","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/01.CIR.104.2.137","article-title":"Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes","volume":"104","author":"Harada","year":"2001","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib25","first-page":"349","article-title":"Radiolabeled adrenergic neuron-blocking agents: Adrenomedullary imaging with [131I]iodobenzylguanidine","volume":"21","author":"Wieland","year":"1980","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-021-02733-4_bib26","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/0735-1097(88)92608-3","article-title":"Iodine-123 meta-iodobenzylguanidine scintigraphy: A noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy","volume":"12","author":"Schofer","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib27","first-page":"1085","article-title":"ACE inhibition reduces cardiac iodine-123-MIBG release in heart failure","volume":"38","author":"Takeishi","year":"1997","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-021-02733-4_bib28","first-page":"217","article-title":"Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy","volume":"40","author":"Toyama","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-021-02733-4_bib29","first-page":"884","article-title":"Addition of valsartan to an angiotensin-converting enzyme inhibitor improves cardiac sympathetic nerve activity and left ventricular function in patients with congestive heart failure","volume":"44","author":"Kasama","year":"2003","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-021-02733-4_bib30","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0735-1097(02)02855-3","article-title":"Effect of spironolactone on cardiac sympathetic nerve activity and left ventricular 12remodeling in patients with dilated cardiomyopathy","volume":"41","author":"Kasama","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijcard.2011.12.080","article-title":"Effects of mineralocorticoid receptor antagonist spironolactone on cardiac sympathetic nerve activity and prognosis in patients with chronic heart failure","volume":"167","author":"Kasama","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib32","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00259-017-3760-y","article-title":"Regional interaction between myocardial sympathetic denervation, contractile dysfunction, and fibrosis in heart failure with preserved ejection fraction: 11C-hydroxyephedrine PET study","volume":"44","author":"Aikawa","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-021-02733-4_bib33","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0735-1097(97)00244-1","article-title":"Reduced sympathetic innervation underlies adjacent noninfarcted region dysfunction during left ventricular remodeling","volume":"30","author":"Kramer","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib34","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0002-9149(99)80686-9","article-title":"Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis","volume":"75","author":"Klappacher","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib35","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0002-9149(99)80251-3","article-title":"The aminoterminal propeptide of type III procollagen provides new information on prognosis after acute myocardial infarction","volume":"76","author":"Host","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-021-02733-4_bib36","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.CIR.0000036014.90197.FA","article-title":"Left ventricular remodeling after primary coronary angioplasty: Patterns of left ventricular dilation and long-term prognostic implications","volume":"106","author":"Bolognese","year":"2002","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib37","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/01.CIR.0000068340.96506.0F","volume":"107","author":"Hayashi","year":"2003","journal-title":"Circulation"},{"key":"10.1007\/s12350-021-02733-4_bib38","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","article-title":"Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study","volume":"55","author":"Jacobson","year":"2010","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-021-02733-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12350-021-02733-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123005421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123005421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-021-02733-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:11:43Z","timestamp":1761027103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123005421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1071358123005421"],"URL":"https:\/\/doi.org\/10.1007\/s12350-021-02733-4","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of mineralocorticoid receptor antagonist eplerenone on cardiac sympathetic nerve activity and left ventricular remodeling after reperfusion therapy in patients with first ST-segment elevation myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-021-02733-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}