{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:27:05Z","timestamp":1769844425002,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1007\/s12350-023-03281-9","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T15:01:35Z","timestamp":1684940495000},"page":"2379-2388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy"],"prefix":"10.1016","volume":"30","author":[{"given":"Adriana Soares Xavier","family":"de Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Junqueira","family":"Moll-Bernardes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha Val\u00e9ria Tavares","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Cordeiro","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Paiva Rossini","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee Sarmento","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Pereira","family":"Glavam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Altino","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Teixeira","family":"de Holanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Henrique Conde","family":"Sangenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda de Souza Nogueira Sardinha","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique","family":"Rosado-de-Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Silvestre","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-023-03281-9_bib1","first-page":"33","article-title":"Chagas disease in Latin America: An epidemiological update based on 2010 estimates","volume":"90","year":"2015","journal-title":"Releve Epidemiol Hebd"},{"key":"10.1007\/s12350-023-03281-9_bib2","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet Lond Engl"},{"key":"10.1007\/s12350-023-03281-9_bib3","first-page":"7","article-title":"[Brazilian Consensus on Chagas Disease, 2015]","volume":"25","author":"Dias","year":"2016","journal-title":"Epidemiol E Serv Saude Rev Sist Unico Saude Bras"},{"key":"10.1007\/s12350-023-03281-9_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10741-010-9211-5","article-title":"Chronic Chagas\u2019 heart disease: A disease on its way to becoming a worldwide health problem: Epidemiology, etiopathology, treatment, pathogenesis and laboratory medicine","volume":"17","author":"Mu\u00f1oz-Saravia","year":"2012","journal-title":"Heart Fail Rev"},{"key":"10.1007\/s12350-023-03281-9_bib5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejim.2017.05.001","article-title":"Chagas disease in Europe: A review for the internist in the globalized world","volume":"43","author":"Antinori","year":"2017","journal-title":"Eur J Intern Med"},{"key":"10.1007\/s12350-023-03281-9_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1590\/S0066-782X2001000100008","article-title":"Sudden death in Chagas\u2019 disease","volume":"76","author":"Rassi","year":"2001","journal-title":"Arq Bras Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib7","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.ijcard.2015.03.372","article-title":"Development of a risk score to predict sudden death in patients with Chaga\u2019s heart disease","volume":"187","author":"de Souza","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0167-5273(96)02878-1","article-title":"Sudden and unexpected death in clinically \u201csilent\u201d Chagas\u2019 disease. A hypothesis","volume":"58","author":"Baroldi","year":"1997","journal-title":"Int J Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1540-8167.2005.00315.x","article-title":"Sudden cardiac death in patients with chagas heart disease and preserved left ventricular function","volume":"17","author":"Sternick","year":"2006","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1007\/s12350-023-03281-9_bib10","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1016\/j.jacc.2018.08.2195","article-title":"Long-term prognostic value of myocardial fibrosis in patients with Chagas cardiomyopathy","volume":"72","author":"Senra","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib11","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.jacc.2018.09.035","article-title":"Left ventricular scar and prognosis in chronic Chagas cardiomyopathy","volume":"72","author":"Volpe","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/RLU.0b013e31821772a9","article-title":"Iodine-123 metaiodobenzylguanidine cardiac imaging as a method to detect early sympathetic neuronal dysfunction in chagasic patients with normal or borderline electrocardiogram and preserved ventricular function","volume":"36","author":"Landesmann","year":"2011","journal-title":"Clin Nucl Med"},{"key":"10.1007\/s12350-023-03281-9_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12350-016-0556-6","article-title":"The severity of ventricular arrhythmia correlates with the extent of myocardial sympathetic denervation, but not with myocardial fibrosis extent in chronic Chagas cardiomyopathy: Chagas disease, denervation and arrhythmia","volume":"25","author":"Gadioli","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s12350-018-1290-z","article-title":"Relationship between microvascular changes, autonomic denervation, and myocardial fibrosis in Chagas cardiomyopathy: Evaluation by MRI and SPECT imaging","volume":"27","author":"Barizon","year":"2020","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib15","doi-asserted-by":"crossref","first-page":"E74","DOI":"10.3390\/tropicalmed5020074","article-title":"New imaging parameters to predict sudden cardiac death in Chagas disease","volume":"5","author":"Moll-Bernardes","year":"2020","journal-title":"Trop Med Infect Dis"},{"key":"10.1007\/s12350-023-03281-9_bib16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0002-9149(91)90404-9","article-title":"Prevalence, characteristics and significance of ventricular premature complexes and ventricular tachycardia detected by 24-hour continuous electrocardiographic recording in the Cardiac Arrhythmia Suppression Trial CAST Investigators","volume":"68","author":"Denes","year":"1991","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib17","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/jmri.24116","article-title":"Validation of sub-segmental visual scoring for the quantification of ischemic and nonischemic myocardial fibrosis using late gadolinium enhancement MRI","volume":"38","author":"Fine","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib18","first-page":"539","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"18","author":"Cerqueira","year":"2002","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib19","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00259-010-1491-4","article-title":"Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology","volume":"37","author":"Flotats","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib20","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic Chagas heart disease","volume":"115","author":"Marin-Neto","year":"2007","journal-title":"Circulation"},{"key":"10.1007\/s12350-023-03281-9_bib21","first-page":"333","article-title":"Chagas disease: A disease of the peripheral autonomic nervous system","volume":"68","author":"Koberle","year":"1956","journal-title":"Wien Klin Wochenschr"},{"key":"10.1007\/s12350-023-03281-9_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.CIR.31.2.273","article-title":"The pathologic lesions of the cardiac autonomic nervous system in chronic Chagas\u2019 myocarditis","volume":"31","author":"Mott","year":"1965","journal-title":"Circulation"},{"key":"10.1007\/s12350-023-03281-9_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0167-5273(98)00132-6","article-title":"Cardiac autonomic impairment and early myocardial damage involving the right ventricle are independent phenomena in Chagas\u2019 disease","volume":"65","author":"Marin-Neto","year":"1998","journal-title":"Int J Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib24","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1067\/mhj.2001.111406","article-title":"Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease","volume":"141","author":"Ribeiro","year":"2001","journal-title":"Am Heart J"},{"key":"10.1007\/s12350-023-03281-9_bib25","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2967\/jnumed.110.082032","article-title":"Sustained ventricular tachycardia is associated with regional myocardial sympathetic denervation assessed with 123I-metaiodobenzylguanidine in chronic Chagas cardiomyopathy","volume":"52","author":"Miranda","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-023-03281-9_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ehjci\/jex154","article-title":"Multimodality imaging evaluation of Chagas disease: An expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI)","volume":"19","author":"Nunes","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jcmg.2008.09.012","article-title":"Changes in myocardial perfusion correlate with deterioration of left ventricular systolic function in chronic Chagas\u2019 cardiomyopathy","volume":"2","author":"Hiss","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000674","article-title":"Coronary microvascular disease in chronic Chagas cardiomyopathy including an overview on history, pathology, and other proposed pathogenic mechanisms","volume":"4","author":"Rossi","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1007\/s12350-023-03281-9_bib29","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1590\/0037-8682-0028-2013","article-title":"Pathogenesis of chronic Chagas cardiomyopathy: The role of coronary microvascular derangements","volume":"46","author":"Marin-Neto","year":"2013","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1007\/s12350-023-03281-9_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s12350-021-02869-3","article-title":"Regional myocardial sympathetic denervation precedes the development of left ventricular systolic dysfunction in chronic Chagas\u2019 cardiomyopathy","author":"Gadioli","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0008-6363(95)00039-9","article-title":"Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content","volume":"30","author":"Dae","year":"1995","journal-title":"Cardiovasc Res"},{"key":"10.1007\/s12350-023-03281-9_bib32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.mric.2007.08.009","article-title":"The role of cardiovascular MRI in heart failure and the cardiomyopathies","volume":"15","author":"White","year":"2007","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"10.1007\/s12350-023-03281-9_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12968-015-0200-7","article-title":"Myocardial tissue characterization in Chagas\u2019 heart disease by cardiovascular magnetic resonance","volume":"17","author":"Torre\u00e3o","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1007\/s12350-023-03281-9_bib34","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jacc.2005.06.067","article-title":"Myocardial delayed enhancement by magnetic resonance imaging in patients with Chagas\u2019 disease: A marker of disease severity","volume":"46","author":"Rochitte","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib35","first-page":"287","article-title":"Patterns of myocardial fibrosis in idiopathic cardiomyopathies and chronic Chagasic cardiopathy","volume":"7","author":"Rossi","year":"1991","journal-title":"Can J Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib36","doi-asserted-by":"crossref","first-page":"745","DOI":"10.4269\/ajtmh.20-0122","article-title":"Associations between cardiac magnetic resonance T1 mapping parameters and ventricular arrhythmia in patients with Chagas disease","volume":"103","author":"Pinheiro","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"10.1007\/s12350-023-03281-9_bib37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jcmg.2017.11.017","article-title":"Assessment of left ventricular function by echocardiography: The case for routinely adding global longitudinal strain to ejection fraction","volume":"11","author":"Potter","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib38","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jacc.2009.04.061","article-title":"Global 2-dimensional strain as a new prognosticator in patients with heart failure","volume":"54","author":"Cho","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-023-03281-9_bib39","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1007\/s10554-021-02246-8","article-title":"Association between myocardial mechanical dispersion and ventricular arrhythmogenicity in chagas cardiomyopathy","volume":"37","author":"Azevedo","year":"2021","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1007\/s12350-023-03281-9_bib40","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.echo.2015.12.008","article-title":"Mechanical dispersion assessed by strain echocardiography is associated with malignant arrhythmias in Chagas cardiomyopathy","volume":"29","author":"Barros","year":"2016","journal-title":"J Am Soc Echocardiogr"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-023-03281-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12350-023-03281-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107135812400179X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107135812400179X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-023-03281-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:15:00Z","timestamp":1761027300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107135812400179X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S107135812400179X"],"URL":"https:\/\/doi.org\/10.1007\/s12350-023-03281-9","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-023-03281-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}