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The integration of computational fluid dynamics and quantitative anatomic and physiologic modeling now enables simulation of patient-specific hemodynamic parameters including blood velocity, pressure, pressure gradients, and FFR from standard acquired coronary computed tomography (CT) datasets. In this review article, we describe the potential impact on clinical practice and the science behind noninvasive coronary computed tomography (CT) angiography derived fractional flow reserve (FFR<jats:sub>CT<\/jats:sub>) as well as future applications of this technology in treatment planning and quantifying forces on atherosclerotic plaques.<\/jats:p>","DOI":"10.1007\/s12410-015-9366-5","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T08:31:31Z","timestamp":1451982691000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Coronary Computed Tomography Angiography Derived Fractional Flow Reserve and Plaque Stress"],"prefix":"10.1007","volume":"9","author":[{"given":"Bjarne Linde","family":"N\u00f8rgaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon","family":"Leipsic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon-Kwon","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Zarins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper M\u00f8ller","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Peter","family":"Sand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"key":"9366_CR1","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1093\/eurheartj\/ehm466","volume":"28","author":"J Abdulla","year":"2007","unstructured":"Abdulla J, Abildstrom SZ, Gotzsche O, Christensen E, Kober L, Torp-Pedersen C. 64-multislice detector computed tomography coronary angiography as potential alternative to conventional coronary angiography: a systematic review and meta-analysis. 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