{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:31:41Z","timestamp":1761863501858},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Gender and complete revascularisation are known to affect mortality. The objective of this study was to analyse a gender difference in mortality with respect to complete revascularisation for multivessel disease after primary percutaneous coronary intervention (PPCI) in ST-elevation myocardial infarction (STEMI) patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>In a prospective consecutive cohort of 1472 patients presenting with STEMI for PPCI, between January 2006 and January 2010, 832 patients with multivessel disease were analysed. The primary outcome was long-term mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Median follow-up was 3.3\u2009\u00b1\u20091.2 years. Complete revascularisation was performed less in females than in males (30 vs. 38\u2009%; <jats:italic>p<\/jats:italic>\u2009=\u20090.04). At PPCI, women (27\u2009%, <jats:italic>n<\/jats:italic>\u2009=\u2009221) were \u00b1\u200910 years older (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), had more hypertension, renal failure and symptoms of heart failure (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Cumulative long-term mortality with incomplete revascularisation was higher in females (F: 30 vs. M: 15\u2009%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01). After adjustment for baseline characteristics, complete revascularisation (0.84; 95\u2009% CI 0.54\u20131.32) and gender (1.11; 95\u2009% CI 0.73\u20131.69) lost significance. Also the gender-by-complete revascularisation interaction was not significant at long term. In women, age under 60 years independently predicted higher mortality (HR 10.09; 95\u2009% CI 3.08\u201333.08; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In STEMI patients with multivessel disease at PPCI, women under the age of 60 years had higher mortality, but in women older than 60 years comorbidity impacted the outcome of revascularisation strategy in the long term.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12471-015-0754-x","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T09:46:55Z","timestamp":1444297615000},"page":"592-599","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of gender on long-term mortality in patients with multivessel disease after primary percutaneous coronary intervention"],"prefix":"10.1007","volume":"23","author":[{"given":"S.","family":"Ghauharali-Imami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Haasdijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schotborgh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Oemrawsingh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"van Domburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zijlstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"754_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ahj.2010.09.030","volume":"161","author":"EA Jackson","year":"2011","unstructured":"Jackson EA, Moscucci M, Smith DE, et al. The association of sex with outcomes among patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction in the contemporary era: insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2). Am Heart J. 2011;161:106\u201312.","journal-title":"Am Heart J"},{"key":"754_CR2","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.amjcard.2010.10.038","volume":"107","author":"F D\u2019Ascenzo","year":"2011","unstructured":"D\u2019Ascenzo F, Gonella A, Quadri G, et al. Comparison of mortality rates in women versus men presenting with ST-segment elevation myocardial infarction. Am J Cardiol. 2011;107:651\u20134.","journal-title":"Am J Cardiol"},{"key":"754_CR3","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1056\/NEJMoa1305520","volume":"369","author":"DS Wald","year":"2013","unstructured":"Wald DS, Morris JK, Wald NJ, et al. Randomized trial of preventive angioplasty in myocardial infarction. N Engl J Med. 2013;369:1115\u201323.","journal-title":"N Engl J Med"},{"key":"754_CR4","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1001\/jama.1996.03530340041027","volume":"275","author":"WD Weaver","year":"1996","unstructured":"Weaver WD, White HD, Wilcox RG, et al. Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. GUSTO-I investigators. JAMA. 1996;275:777\u201382.","journal-title":"JAMA"},{"key":"754_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1056\/NEJM199907223410402","volume":"341","author":"JS Hochman","year":"1999","unstructured":"Hochman JS, Tamis JE, Thompson TD, et al. Sex, clinical presentation, and outcome in patients with acute coronary syndromes. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes IIb Investigators. N Engl J Med. 1999;341:226\u201332.","journal-title":"N Engl J Med"},{"key":"754_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0140-6736(03)12113-7","volume":"361","author":"EC Keeley","year":"2003","unstructured":"Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003;361:13\u201320.","journal-title":"Lancet"},{"key":"754_CR7","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.ahj.2004.05.018","volume":"148","author":"G De Luca","year":"2004","unstructured":"De Luca G, Suryapranata H, Dambrink JH, et al. Sex-related differences in outcome after ST-segment elevation myocardial infarction treated by primary angioplasty: data from the Zwolle Myocardial Infarction study. Am Heart J. 2004;148:852\u20136.","journal-title":"Am Heart J"},{"key":"754_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.pcad.2004.05.001","volume":"47","author":"S Mallik","year":"2004","unstructured":"Mallik S, Vaccarino V. Outcomes of thrombolytic therapy for acute myocardial infarction in women. Prog Cardiovasc Dis. 2004;47:58\u201371.","journal-title":"Prog Cardiovasc Dis"},{"key":"754_CR9","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1136\/hrt.2006.110866","volume":"94","author":"Z Motovska","year":"2008","unstructured":"Motovska Z, Widimsky P, Aschermann M. The impact of gender on outcomes of patients with ST elevation myocardial infarction transported for percutaneous coronary intervention: analysis of the PRAGUE-1 and 2 studies. Heart. 2008;94:e5.","journal-title":"Heart"},{"key":"754_CR10","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ccd.24800","volume":"82","author":"I Wijnbergen","year":"2013","unstructured":"Wijnbergen I, Tijssen J, \u2019t Veer M van, et al. Gender differences in long-term outcome after primary percutaneous intervention for ST-segment elevation myocardial infarction. Catheter Cardiovasc Interv. 2013;82:379\u201384.","journal-title":"Catheter Cardiovasc Interv"},{"key":"754_CR11","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.4244\/EIJV6I9A187","volume":"6","author":"H Benamer","year":"2011","unstructured":"Benamer H, Tafflet M, Bataille S, et al. Female gender is an independent predictor of in-hospital mortality after STEMI in the era of primary PCI: insights from the greater Paris area PCI Registry. EuroIntervention. 2011;6:1073\u20139.","journal-title":"EuroIntervention"},{"key":"754_CR12","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1161\/CIRCOUTCOMES.114.001194","volume":"7","author":"MB Iqbal","year":"2014","unstructured":"Iqbal MB, Ilsley C, Kabir T, et al. Culprit vessel versus multivessel intervention at the time of primary percutaneous coronary intervention in patients with ST-segment-elevation myocardial infarction and multivessel disease: real-world analysis of 3984 patients in London. Circ Cardiovasc Qual Outcomes. 2014;7:936\u201343.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"754_CR13","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","volume":"60","author":"K Thygesen","year":"2012","unstructured":"Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol. 2012;60:1581\u201398.","journal-title":"J Am Coll Cardiol"},{"key":"754_CR14","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1016\/j.jacc.2012.11.019","volume":"61","author":"PT O\u2019Gara","year":"2013","unstructured":"O\u2019Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;61:e78\u2013140.","journal-title":"J Am Coll Cardiol"},{"key":"754_CR15","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.jacc.2014.12.038","volume":"65","author":"AH Gershlick","year":"2015","unstructured":"Gershlick AH, Khan JN, Kelly DJ, et al. Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial. J Am Coll Cardiol. 2015;65:963\u201372.","journal-title":"J Am Coll Cardiol"},{"key":"754_CR16","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.ahj.2007.11.036","volume":"155","author":"JT Nguyen","year":"2008","unstructured":"Nguyen JT, Berger AK, Duval S, et al. Gender disparity in cardiac procedures and medication use for acute myocardial infarction. Am Heart J. 2008;155:862\u20138.","journal-title":"Am Heart J"},{"key":"754_CR17","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1161\/CIRCULATIONAHA.108.789800","volume":"118","author":"H Jneid","year":"2008","unstructured":"Jneid H, Fonarow GC, Cannon CP, et al. Sex differences in medical care and early death after acute myocardial infarction. Circulation. 2008;118:2803\u201310.","journal-title":"Circulation"},{"key":"754_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1471-2369-14-62","volume":"14","author":"SA Gevaert","year":"2013","unstructured":"Gevaert SA, De Bacquer D, Evrard P, et al. Renal dysfunction in STEMI-patients undergoing primary angioplasty: higher prevalence but equal prognostic impact in female patients; an observational cohort study from the Belgian STEMI registry. BMC Nephrol. 2013;14:62.","journal-title":"BMC Nephrol"},{"key":"754_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1001\/jama.287.2.210","volume":"287","author":"J Mehilli","year":"2002","unstructured":"Mehilli J, Kastrati A, Dirschinger J, et al. Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. JAMA. 2002;287:210\u20135.","journal-title":"JAMA"},{"key":"754_CR20","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1089\/jwh.2009.1371","volume":"19","author":"A Bufe","year":"2010","unstructured":"Bufe A, Wolfertz J, Dinh W, et al. Gender-based differences in long-term outcome after ST-elevation myocardial infarction in patients treated with percutaneous coronary intervention. J Womens Health (Larchmt). 2010;19:471\u20135.","journal-title":"J Womens Health (Larchmt)"},{"key":"754_CR21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s12471-014-0613-1","volume":"23","author":"H den Ruijter","year":"2015","unstructured":"den Ruijter H, Pasterkamp G, Rutten FH, et al. Heart failure with preserved ejection fraction in women: the Dutch Queen of Hearts program. Neth Heart J. 2015;23:89\u201393.","journal-title":"Neth Heart J"},{"key":"754_CR22","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1001\/jamainternmed.2014.4762","volume":"174","author":"SB Pancholy","year":"2014","unstructured":"Pancholy SB, Shantha GP, Patel T, et al. Sex differences in short-term and long-term all-cause mortality among patients with ST-segment elevation myocardial infarction treated by primary percutaneous intervention: a meta-analysis. JAMA Intern Med. 2014;174:1822\u201330.","journal-title":"JAMA Intern Med"},{"key":"754_CR23","doi-asserted-by":"publisher","first-page":"780","DOI":"10.4244\/EIJV5I7A131","volume":"5","author":"KD Sjauw","year":"2010","unstructured":"Sjauw KD, Stegenga NK, Engstrom AE, et al. The influence of gender on short- and long-term outcome after primary PCI and delivered medical care for ST-segment elevation myocardial infarction. EuroIntervention. 2010;5:780\u20137.","journal-title":"EuroIntervention"},{"key":"754_CR24","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1016\/j.jacc.2005.12.072","volume":"47","author":"RL McNamara","year":"2006","unstructured":"McNamara RL, Wang Y, Herrin J, et al. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2006;47:2180\u20136.","journal-title":"J Am Coll Cardiol"},{"key":"754_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.amjcard.2012.10.007","volume":"111","author":"MA Velders","year":"2013","unstructured":"Velders MA, Boden H, Boven AJ van, et al. Influence of gender on ischemic times and outcomes after ST-elevation myocardial infarction. Am J Cardiol. 2013;111:312\u20138.","journal-title":"Am J Cardiol"},{"key":"754_CR26","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12471-012-0323-5","volume":"21","author":"M Dong","year":"2013","unstructured":"Dong M, Guo F, Yang J, et al. Detrimental effects of endogenous oestrogens on primary acute myocardial infarction among postmenopausal women. Neth Heart J. 2013;21:175\u201380.","journal-title":"Neth Heart J"},{"key":"754_CR27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1056\/NEJM199907223410401","volume":"341","author":"V Vaccarino","year":"1999","unstructured":"Vaccarino V, Parsons L, Every NR, et al. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med. 1999;341:217\u201325.","journal-title":"N Engl J Med"},{"key":"754_CR28","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1001\/jama.287.2.210","volume":"287","author":"J Mehilli","year":"2002","unstructured":"Mehilli J, Kastrati A, Dirschinger J, et al. Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. JAMA. 2002;287:210\u20135.","journal-title":"JAMA"},{"key":"754_CR29","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1136\/hrt.2008.155804","volume":"95","author":"KP Champney","year":"2009","unstructured":"Champney KP, Frederick PD, Bueno H, et al. The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction. Heart. 2009;95:895\u20139.","journal-title":"Heart"}],"container-title":["Netherlands Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-015-0754-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12471-015-0754-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-015-0754-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-015-0754-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:05:44Z","timestamp":1630609544000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12471-015-0754-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["754"],"URL":"https:\/\/doi.org\/10.1007\/s12471-015-0754-x","relation":{},"ISSN":["1568-5888","1876-6250"],"issn-type":[{"value":"1568-5888","type":"print"},{"value":"1876-6250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]},"assertion":[{"value":"8 October 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}