{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:07:06Z","timestamp":1769126826322,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Impella percutaneous mechanical circulatory support device is designed to augment cardiac output and reduce left ventricular wall stress and aims to improve survival in cases of cardiogenic shock. In this meta-analysis we investigated the haemodynamic effects of the Impella device in a\u00a0clinical setting. We systematically searched all articles in PubMed\/Medline and Embase up to July 2019. The primary outcomes were cardiac power (CP) and cardiac power index (CPI). Survival rates and other haemodynamic data were included as secondary outcomes. For the critical appraisal, we used a\u00a0modified version of the U.S.\u00a0Department of Health and Human Services quality assessment form. The systematic review included 12\u00a0studies with a\u00a0total of 596 patients. In 258 patients the CP and\/or CPI could be extracted. Our meta-analysis showed an increase of 0.39\u202fW [95% confidence interval (CI): 0.24, 0.54], (<jats:italic>p<\/jats:italic>\u202f=\u20090.01) and 0.22\u202fW\/m<jats:sup>2<\/jats:sup> (95% CI: 0.18, 0.26), (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.01) for the CP and CPI, respectively. The overall survival rate was 56% (95% CI: 0.50, 0.62), (<jats:italic>p<\/jats:italic>\u202f=\u20090.09). The quality of the studies was moderate, mostly due to the presence of confounders. Our study suggests that in patients with cardiogenic shock, Impella support seems effective in augmenting CP(I). This study merely investigates the haemodynamic effectiveness of the Impella device and does not reflect the complete clinical impact for the patient.<\/jats:p>","DOI":"10.1007\/s12471-019-01351-7","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T18:02:34Z","timestamp":1575655354000},"page":"179-189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Haemodynamic efficacy of microaxial left ventricular assist device in cardiogenic shock: a\u00a0systematic review and meta-analysis"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-7491","authenticated-orcid":false,"given":"D. I. M.","family":"van Dort","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. R. A. H.","family":"Peij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. C.","family":"Manintveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Hoeks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. J.","family":"Morshuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"van Royen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ten Cate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S. C","family":"Geuzebroek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"1351_CR1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jcin.2012.12.122","volume":"6","author":"X Wei","year":"2013","unstructured":"Wei\u00a0X, Li\u00a0T, Hagen\u00a0B, et al. Short-term mechanical unloading with left ventricular assist devices after acute myocardial infarction conserves calcium cycling and improves heart function. JACC Cardiovasc Interv. 2013;6:406\u201315.","journal-title":"JACC Cardiovasc Interv"},{"key":"1351_CR2","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.ijcard.2015.07.065","volume":"201","author":"F Burzotta","year":"2015","unstructured":"Burzotta\u00a0F, Trani\u00a0C, Doshi\u00a0SN, et\u00a0al. Impella ventricular support in clinical practice: collaborative viewpoint from a\u00a0European expert user group. Int J Cardiol. 2015;201:684\u201391.","journal-title":"Int J Cardiol"},{"issue":"21","key":"1351_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cardfail.2015.03.002","volume":"2015","author":"CS Rihal","year":"2015","unstructured":"Rihal\u00a0CS, Naidu\u00a0SS, Givertz\u00a0MM, et al. SCAI\/ACC\/HFSA\/STS clinical expert consensus statement on the use of percutaneous mechanical circulatory support devices in cardiovascular care (endorsed by the American Heart Association, the Cardiological Society of India, and Sociedad Latino Americana de Cardiologia Intervencion; affirmation of value by the Canadian Association of Interventional Cardiology-Association Canadienne de Cardiologie d\u2019intervention). J\u00a0Card Fail. 2015;2015(21):499\u2013518.","journal-title":"J Card Fail"},{"key":"1351_CR4","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/j.jacc.2014.07.958","volume":"64","author":"R Stretch","year":"2014","unstructured":"Stretch\u00a0R, Sauer\u00a0CM, Yuh\u00a0DD, Bonde\u00a0P. National trends in the utilization of short-term mechanical circulatory support: incidence, outcomes, and cost analysis. J\u00a0Am Coll Cardiol. 2014;64:1407\u201315.","journal-title":"J Am Coll Cardiol"},{"key":"1351_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/joic.12080","volume":"27","author":"WW O\u2019Neill","year":"2014","unstructured":"O\u2019Neill\u00a0WW, Schreiber\u00a0T, Wohns\u00a0DH, et\u00a0al. The current use of Impella 2.5 in acute myocardial infarction complicated by cardiogenic shock: results from the USpella Registry. J\u00a0Interv Cardiol. 2014;27:1\u201311.","journal-title":"J Interv Cardiol"},{"key":"1351_CR6","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1161\/01.CIR.0000075927.67673.F2","volume":"107","author":"JS Hochman","year":"2003","unstructured":"Hochman\u00a0JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation. 2003;107:2998\u20133002.","journal-title":"Circulation"},{"key":"1351_CR7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jacc.2004.03.060","volume":"44","author":"R Fincke","year":"2004","unstructured":"Fincke\u00a0R, Hochman\u00a0JS, Lowe\u00a0AM, et\u00a0al. Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a\u00a0report from the SHOCK trial registry. J\u00a0Am Coll Cardiol. 2004;44:340\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"1351_CR8","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619828959","author":"A Sionis","year":"2019","unstructured":"Sionis\u00a0A, Rivas-Lasarte\u00a0M, Mebazaa\u00a0A, et al. Current use and impact on 30-day mortality of pulmonary artery catheter in cardiogenic shock patients: results from the CardShock study. J\u00a0Intensive Care Med. 2019; https:\/\/doi.org\/10.1177\/0885066619828959.","journal-title":"J Intensive Care Med"},{"key":"1351_CR9","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","volume":"62","author":"D Moher","year":"2009","unstructured":"Moher\u00a0D, Liberati\u00a0A, Tetzlaff\u00a0J, Altman\u00a0DG, Group\u00a0P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J\u00a0Clin Epidemiol. 2009;62:1006\u201312.","journal-title":"J Clin Epidemiol"},{"key":"1351_CR10","unstructured":"Quality assessment tool for before-after (pre-post) studies with no control group [available from: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools]. Accessed 12 January 2018."},{"key":"1351_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo\u00a0SP, Djulbegovic\u00a0B, Hozo\u00a0I. Estimating the mean and variance from the median, range, and the size of a\u00a0sample. BMC Med Res Methodol. 2005;5:13.","journal-title":"BMC Med Res Methodol"},{"key":"1351_CR12","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1055\/s-2003-45422","volume":"51","author":"B Meyns","year":"2003","unstructured":"Meyns\u00a0B, Dens\u00a0J, Sergeant\u00a0P, et\u00a0al. Initial experiences with the Impella device in patients with cardiogenic shock\u2014Impella support for cardiogenic shock. Thorac cardiovasc Surg. 2003;51:312\u20137.","journal-title":"Thorac cardiovasc Surg"},{"key":"1351_CR13","first-page":"84","volume":"2","author":"J Dens","year":"2006","unstructured":"Dens\u00a0J, Meyns\u00a0B, Hilgers\u00a0R\u2011D, et al. First experience with the Impella Recover\u00ae LP 2.5 micro axial pump in patients with cardiogenic shock or undergoing high-risk revascularisation. EuroIntervention. 2006;2:84\u201390.","journal-title":"EuroIntervention"},{"key":"1351_CR14","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.jacc.2008.05.065","volume":"52","author":"M Seyfarth","year":"2008","unstructured":"Seyfarth\u00a0M, Sibbing\u00a0D, Bauer\u00a0I, et al. A randomized clinical trial to evaluate the safety and efficacy of a\u00a0percutaneous left ventricular assist device versus intra-aortic balloon pumping for treatment of cardiogenic shock caused by myocardial infarction. J\u00a0Am Coll Cardiol. 2008;52:1584\u20138.","journal-title":"J Am Coll Cardiol"},{"key":"1351_CR15","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.acvd.2011.04.005","volume":"104","author":"D Bresson","year":"2011","unstructured":"Bresson\u00a0D, Sibellas\u00a0F, Farhat\u00a0F, et\u00a0al. Preliminary experience with Impella Recover \u00ae LP5.0 in nine patients with cardiogenic shock: a\u00a0new circulatory support system in the intensive cardiac care unit. Arch Cardiovasc Dis. 2011;104:458\u201364.","journal-title":"Arch Cardiovasc Dis"},{"key":"1351_CR16","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.jtcvs.2012.01.067","volume":"145","author":"BP Griffith","year":"2013","unstructured":"Griffith\u00a0BP, Anderson\u00a0MB, Samuels\u00a0LE, et\u00a0al. The RECOVER I: a\u00a0multicenter prospective study of Impella 5.0\/LD for postcardiotomy circulatory support. J\u00a0Thorac Cardiov Sur. 2013;145:548\u201354.","journal-title":"J Thorac Cardiov Sur"},{"key":"1351_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/joic.12172","volume":"28","author":"F Casassus","year":"2015","unstructured":"Casassus\u00a0F, Corre\u00a0J, Leroux\u00a0L, et\u00a0al. The use of Impella 2.5 in severe refractory cardiogenic shock complicating an acute myocardial infarction. J\u00a0Interv Cardiol. 2015;28:41\u201350.","journal-title":"J Interv Cardiol"},{"key":"1351_CR18","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1016\/j.amjcard.2016.02.038","volume":"117","author":"B Lima","year":"2016","unstructured":"Lima\u00a0B, Kale\u00a0P, Gonzalez-Stawinski\u00a0GV, et al. Effectiveness and safety of the Impella 5.0 as a\u00a0bridge to cardiac transplantation or durable left ventricular assist device. Am J Cardiol. 2016;117:1622\u20138.","journal-title":"Am J Cardiol"},{"key":"1351_CR19","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/icvts\/ivv305","volume":"22","author":"P Schiller","year":"2016","unstructured":"Schiller\u00a0P, Vikholm\u00a0P, The Impella\u00a0HL. R) Recover mechanical assist device in acute cardiogenic shock: a\u00a0single-centre experience of 66 patients. Interact CardioVasc Thorac Surg. 2016;22:452\u20138.","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"1351_CR20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/joic.12298","volume":"29","author":"SM Joseph","year":"2016","unstructured":"Joseph\u00a0SM, Brisco\u00a0MA, Colvin\u00a0M, et\u00a0al. Women with cardiogenic shock derive greater benefit from early mechanical circulatory support: an update from the cVAD registry. J\u00a0Interv Cardiol. 2016;29:248\u201356.","journal-title":"J Interv Cardiol"},{"key":"1351_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1177\/2048872616633877","volume":"6","author":"C Mastroianni","year":"2017","unstructured":"Mastroianni\u00a0C, Bouabdallaoui\u00a0N, Leprince\u00a0P, Lebreton\u00a0G. Short-term mechanical circulatory support with the Impella 5.0 device for cardiogenic shock at La Pitie-Salpetriere. Eur Heart J Acute Cardiovasc Care. 2017;6:87\u201392.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"1351_CR22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.healun.2017.09.020","volume":"37","author":"SA Hall","year":"2018","unstructured":"Hall\u00a0SA, Uriel\u00a0N, Carey\u00a0SA, et\u00a0al. Use of a\u00a0percutaneous temporary circulatory support device as a\u00a0bridge to decision during acute decompensation of advanced heart failure. J\u00a0Heart Lung Transplant. 2018;37:100\u20136.","journal-title":"J Heart Lung Transplant"},{"key":"1351_CR23","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jacc.2016.10.022","volume":"69","author":"DM Ouweneel","year":"2017","unstructured":"Ouweneel\u00a0DM, Eriksen\u00a0E, Sjauw\u00a0KD, et al. Percutaneous mechanical circulatory support versus intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction. J\u00a0Am Coll Cardiol. 2017;69:278\u201387.","journal-title":"J Am Coll Cardiol"},{"key":"1351_CR24","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.118.036614","volume":"139","author":"B Schrage","year":"2019","unstructured":"Schrage\u00a0B, Ibrahim\u00a0K, Loehn\u00a0T, et\u00a0al. Impella support for acute myocardial infarction complicated by cardiogenic shock. Circulation. 2019;139:1249\u201358.","journal-title":"Circulation"},{"key":"1351_CR25","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.cardfail.2018.09.007","volume":"24","author":"SK Annamalai","year":"2018","unstructured":"Annamalai\u00a0SK, Esposito\u00a0ML, Jorde\u00a0L, et\u00a0al. The Impella microaxial flow catheter is safe and effective for treatment of myocarditis complicated by cardiogenic shock: an analysis from the global cVAD registry. J\u00a0Card Fail. 2018;24:706\u201310.","journal-title":"J Card Fail"},{"key":"1351_CR26","first-page":"539","volume":"61","author":"AE Engstrom","year":"2013","unstructured":"Engstrom\u00a0AE, Granfeldt\u00a0H, Seybold-Epting\u00a0W, et al. Mechanical circulatory support with the Impella 5.0 device for postcardiotomy cardiogenic shock: a\u00a0three-center experience. Minerva Cardioangiol. 2013;61:539\u201346.","journal-title":"Minerva Cardioangiol"},{"key":"1351_CR27","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.jtcvs.2003.09.055","volume":"127","author":"MP Siegenthaler","year":"2004","unstructured":"Siegenthaler\u00a0MP, Brehm\u00a0K, Strecker\u00a0T, et al. The Impella Recover microaxial left ventricular assist device reduces mortality for postcardiotomy failure: a\u00a0three-center experience. J\u00a0Thorac Cardiovasc Surg. 2004;127:812\u201322.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1351_CR28","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/HCO.0000000000000057","volume":"29","author":"J Nativi-Nicolau","year":"2014","unstructured":"Nativi-Nicolau\u00a0J, Selzman\u00a0CH, Fang\u00a0JC, Stehlik\u00a0J. Pharmacologic therapies for acute cardiogenic shock. Curr Opin Cardiol. 2014;29:250\u20137.","journal-title":"Curr Opin Cardiol"},{"key":"1351_CR29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10047-012-0640-x","volume":"15","author":"I Yoshitake","year":"2012","unstructured":"Yoshitake\u00a0I, Hata\u00a0M, Sezai\u00a0A, et\u00a0al. The effect of combined treatment with Impella((R)) and landiolol in a\u00a0swine model of acute myocardial infarction. J\u00a0Artif Organs. 2012;15:231\u20139.","journal-title":"J Artif Organs"},{"key":"1351_CR30","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.amjcard.2016.11.037","volume":"119","author":"MB Basir","year":"2017","unstructured":"Basir\u00a0MB, Schreiber\u00a0TL, Grines\u00a0CL, et\u00a0al. Effect of early initiation of mechanical circulatory support on survival in cardiogenic shock. Am J Cardiol. 2017;119:845\u201351.","journal-title":"Am J Cardiol"},{"key":"1351_CR31","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/joic.12409","volume":"30","author":"M Lazkani","year":"2017","unstructured":"Lazkani\u00a0M, Murarka\u00a0S, Kobayashi\u00a0A, et al. A retrospective analysis of Impella use in all-comers: 1\u2011year outcomes. J\u00a0Interv Cardiol. 2017;30:577\u201383.","journal-title":"J Interv Cardiol"},{"key":"1351_CR32","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/joic.12434","volume":"30","author":"PM Meraj","year":"2017","unstructured":"Meraj\u00a0PM, Editorial\u00a0DR. Stop thinking and start acting: Early Impella placement associated with improved outcomes, again! J\u00a0Interv Cardiol. 2017;30:584\u20135.","journal-title":"J Interv Cardiol"},{"key":"1351_CR33","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jacc.2018.05.034","volume":"72","author":"ML Esposito","year":"2018","unstructured":"Esposito\u00a0ML, Zhang\u00a0Y, Qiao\u00a0X, et\u00a0al. Left ventricular unloading before reperfusion promotes functional recovery after acute myocardial infarction. J\u00a0Am Coll Cardiol. 2018;72:501\u201314.","journal-title":"J Am Coll Cardiol"},{"key":"1351_CR34","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/ccd.27427","volume":"91","author":"MB Basir","year":"2018","unstructured":"Basir\u00a0MB, Schreiber\u00a0T, Dixon\u00a0S, et\u00a0al. Feasibility of early mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock: the Detroit cardiogenic shock initiative. Catheter Cardiovasc Interv. 2018;91:454\u201361.","journal-title":"Catheter Cardiovasc Interv"},{"key":"1351_CR35","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/2048872618805486","volume":"8","author":"DM Ouweneel","year":"2019","unstructured":"Ouweneel\u00a0DM, de Brabander\u00a0J, Karami\u00a0M, et al. Real-life use of left ventricular circulatory support with Impella in cardiogenic shock after acute myocardial infarction: 12 years AMC experience. Eur Heart J Acute Cardiovasc Care. 2019;8:338\u201349.","journal-title":"Eur Heart J Acute Cardiovasc Care"}],"container-title":["Netherlands Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-019-01351-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12471-019-01351-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-019-01351-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T01:00:58Z","timestamp":1607130058000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12471-019-01351-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1351"],"URL":"https:\/\/doi.org\/10.1007\/s12471-019-01351-7","relation":{},"ISSN":["1568-5888","1876-6250"],"issn-type":[{"value":"1568-5888","type":"print"},{"value":"1876-6250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,6]]},"assertion":[{"value":"6 December 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.I.M.\u00a0van Dort is a\u00a0shareholder of and consultant to CardiacBooster B.V. and K.R.A.H.\u00a0Peij Peij is an employee of CardiacBooster B.V. O.C.\u00a0Manintveld, S.E.\u00a0Hoeks, W.J.\u00a0Morshuis, N.\u00a0van Royen, T.\u00a0Ten Cate and G.S.C.\u00a0Geuzebroek declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}