{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:27:52Z","timestamp":1780432072450,"version":"3.54.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve replacement (TAVR) is increasingly being used as an alternative to conventional surgical valve replacement. Prosthetic valve endocarditis (PVE) is a\u00a0rare but feared complication after TAVR, with reported first-year incidences varying from 0.57 to 3.1%. This study was performed to gain insight into the incidence and outcome of PVE after TAVR in the Netherlands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A\u00a0multicentre retrospective registry study was performed. All patients who underwent TAVR in the period 2010\u20132017 were screened for the diagnosis of infective endocarditis in the insurance database and checked for the presence of PVE before analysis of general characteristics, PVE parameters and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A\u00a0total of 3968 patients who underwent TAVR were screened for PVE. During a\u00a0median follow-up of 33.5\u00a0months (interquartile range (IQR) 22.8\u201345.8), 16\u00a0patients suffered from PVE (0.4%), with a\u00a0median time to onset of 177 days (IQR 67.8\u2013721.3). First-year incidence was 0.24%, and the overall incidence rate was 0.14 events per 1000 person-years. Overall mortality during follow-up in our study was 31%, of which 25% occurred in hospital. All patients were treated conservatively with intravenous antibiotics alone, and none underwent a\u00a0re-intervention. Other complications of PVE occurred in 5\u00a0patients (31%) and included aortic abscess\u00a0(2), decompensated heart failure\u00a0(2) and cerebral embolisation\u00a0(1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PVE in patients receiving TAVR is a\u00a0relatively rare complication and has a\u00a0high mortality rate.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12471-020-01420-2","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T13:03:38Z","timestamp":1587733418000},"page":"520-525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Incidence and outcome of prosthetic valve endocarditis after transcatheter aortic valve replacement in the Netherlands"],"prefix":"10.1007","volume":"28","author":[{"given":"J.","family":"Brouwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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