{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T09:18:06Z","timestamp":1788081486732,"version":"build-2784847793"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Despite considerable advances in the last decade, major adverse events remain a\u00a0concern after transcatheter aortic valve implantation (TAVI). The aim of this study was to provide a\u00a0detailed overview of their underlying causes and contributing factors in order to identify key domains for quality improvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This observational, prospective registry included all patients undergoing TAVI between 31\u00a0December 2015 and 1\u00a0January 2020\u202fat the St. Antonius Hospital in Nieuwegein and the University Medical Centre in Utrecht. Outcomes of interest were all-cause mortality, stroke, major bleeding, life-threatening or disabling bleeding, major vascular complications, myocardial infarction, severe acute kidney injury and conduction disturbances requiring permanent pacemaker implantation within 30\u00a0days after TAVI, according to the Valve Academic Research Consortium\u20112 criteria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 1250\u00a0patients who underwent TAVI in the evaluated period, 146 (11.7%) developed a\u00a0major complication. In 54\u00a0(4.3%) patients a\u00a0thromboembolic event occurred, leading to stroke in 36\u00a0(2.9%), myocardial infarction in 13\u00a0(1.0%) and lower limb ischaemia in 11\u00a0(0.9%). Major bleeding occurred in 65\u00a0(5.2%) patients, most frequently consisting of acute cardiac tamponade (<jats:italic>n<\/jats:italic>\u202f=\u200925; 2.0%) and major access-site bleeding (<jats:italic>n<\/jats:italic>\u202f=\u200921; 1.7%). Most complications occurred within 1\u00a0day of the procedure. Within 30\u00a0days a\u00a0total of 54\u00a0(4.3%) patients died, the cause being directly TAVI-related in 30\u00a0(2.4%). Of the patients who died from causes that were not directly TAVI-related, 14\u00a0(1.1%) had multiple hospital-acquired complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A\u00a0variety of underlying mechanisms and causes form a\u00a0wide spectrum of major threats affecting early safety in 11.7% of patients undergoing TAVI in a\u00a0contemporary cohort of real-world patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-021-01638-8","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T13:02:46Z","timestamp":1635771766000},"page":"632-642","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Major threats to early safety after transcatheter aortic valve implantation in a\u00a0contemporary cohort of real-world patients"],"prefix":"10.1007","volume":"29","author":[{"given":"D. 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