{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:21:24Z","timestamp":1778001684297,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The HEART score is a\u00a0validated risk stratification tool for chest pain patients presenting to the emergency department and was recently investigated for implementation in a\u00a0pre-hospital setting. Fingerstick (capillary blood) point-of-care (POC) troponin testing enables quick measurements outside the hospital and seems easier to implement than the current venous blood sampling techniques. This study investigates the diagnostic accuracy of the modified HEART score, integrating fingerstick POC troponin testing, in ruling out acute coronary syndrome (ACS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The data of 96\u00a0patients with chest pain, included in a\u00a0study investigating a\u00a0novel POC troponin device under development at the cardiac emergency department, were analysed retrospectively. Based on the patients\u2019 admission data and capillary POC high-sensitivity troponin\u00a0I (hs-cTnI) results, the modified HEART score was determined. The outcome measure, for evaluating the diagnostic accuracy of the modified HEART score, was the occurrence of ACS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the total study population, 33\u00a0patients (34%) were diagnosed with ACS. Seventeen patients (18%) were classified as low risk (0\u20133\u00a0points) and one patient (6%) in this group was diagnosed with ACS. The sensitivity and negative predictive value of the modified HEART score was 97.0 and 97.6%, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The modified HEART score, integrating capillary POC hs-cTnI results, is a\u00a0promising tool for ruling out ACS in patients with chest pain presenting to the cardiac emergency department. These results encourage prospective investigation into the integration of fingerstick POC troponin testing in the modified HEART score in a\u00a0pre-hospital setting.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-021-01646-8","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T07:02:30Z","timestamp":1637737350000},"page":"360-369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["URGENT\u00a01.5: diagnostic accuracy of the modified HEART score, with fingerstick point-of-care troponin testing, in ruling out acute coronary syndrome"],"prefix":"10.1007","volume":"30","author":[{"given":"L. H.","family":"Koper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. D. S.","family":"Frenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Meeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. H. M.","family":"van Osch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Bruinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J. W.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W. J.","family":"van \u2019t Hof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Rahel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"1646_CR1","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1016\/j.ijcard.2013.01.255","volume":"168","author":"BE Backus","year":"2013","unstructured":"Backus\u00a0BE, Six\u00a0AJ, Kelder\u00a0JC, et\u00a0al. A\u00a0prospective validation of the HEART score for chest pain patients at the emergency department. Int J Cardiol. 2013;168:2153\u20138.","journal-title":"Int J Cardiol"},{"key":"1646_CR2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1177\/2048872616687116","volume":"7","author":"M Ishak","year":"2018","unstructured":"Ishak\u00a0M, Ali\u00a0D, Fokkert\u00a0MJ, et\u00a0al. Fast assessment and management of chest pain patients without ST-elevation in the pre-hospital gateway (FamouS Triage): ruling out a\u00a0myocardial infarction at home with the modified HEART score. Eur Heart J Acute Cardiovasc Care. 2018;7:102\u201310.","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"1646_CR3","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1136\/heartjnl-2018-314306","volume":"105","author":"AR Chapman","year":"2019","unstructured":"Chapman\u00a0AR, Stewart\u00a0S, Mills\u00a0NL. Contemporary point of care cardiac troponin testing in suspected acute coronary syndrome. Heart. 2019;105:740\u20131.","journal-title":"Heart"},{"key":"1646_CR4","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/HPC.0b013e3181ec36d8","volume":"9","author":"BE Backus","year":"2010","unstructured":"Backus\u00a0BE, Six\u00a0AJ, Kelder\u00a0JC, et\u00a0al. Chest pain in the emergency room. A\u00a0multicenter validation of the HEART score. Crit Pathw Cardiol. 2010;9:164\u20139.","journal-title":"Crit Pathw Cardiol"},{"key":"1646_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/BF03086144","volume":"16","author":"AJ Six","year":"2008","unstructured":"Six\u00a0AJ, Backus\u00a0BE, Kelder\u00a0JC. Chest pain in the emergency room: value of the HEART score. Neth Heart\u00a0J. 2008;16:191\u20136.","journal-title":"Neth Heart J"},{"key":"1646_CR6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/clc.23325","volume":"43","author":"G Wang","year":"2020","unstructured":"Wang\u00a0G, Zheng\u00a0W, Wu\u00a0S, et al. Comparison of usual care and the HEART score for effectively and safely discharging patients with low-risk chest pain in the emergency department: would the score always help? Clin Cardiol. 2020;43:371\u20138.","journal-title":"Clin Cardiol"},{"key":"1646_CR7","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/j.ajem.2019.158448","volume":"38","author":"DN van Dongen","year":"2020","unstructured":"van Dongen\u00a0DN, Fokker\u00a0MJ, Tolsma\u00a0RT, et al. Accuracy of pre-hospital HEART score risk classification using point of care versus high sensitive troponin in suspected NSTE-ACS. Am J Emerg Med. 2020;38:1616\u201320.","journal-title":"Am J Emerg Med"},{"key":"1646_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ijcard.2014.09.026","volume":"177","author":"S Aldous","year":"2014","unstructured":"Aldous\u00a0S, Richards\u00a0AM, George\u00a0PM, et al. Comparison of new point-of-care troponin assay with HS sensitivity troponin in diagnosing myocardial infarction. Int J Cardiol. 2014;177:182\u20136.","journal-title":"Int J Cardiol"},{"key":"1646_CR9","unstructured":"Mol K. Improvements in acute coronary syndrome diagnosis: focus on pre-hospital management. University of Utrecht, doctoral thesis, chapter 8. 2018. https:\/\/dspace.library.uu.nl\/bitstream\/handle\/1874\/372279\/Mol.pdf?sequence=1&isAllowed=y. Accessed 9 Apr 2021."}],"container-title":["Netherlands Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-021-01646-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12471-021-01646-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-021-01646-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T15:24:52Z","timestamp":1657293892000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12471-021-01646-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":9,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1646"],"URL":"https:\/\/doi.org\/10.1007\/s12471-021-01646-8","relation":{},"ISSN":["1568-5888","1876-6250"],"issn-type":[{"value":"1568-5888","type":"print"},{"value":"1876-6250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"12 October 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"L.H.\u00a0Koper, L.D.S.\u00a0Frenk, J.G.\u00a0Meeder, F.H.M.\u00a0van Osch, A.L.\u00a0Bruinen, M.J.W.\u00a0Janssen, A.W.J.\u00a0van \u2019t Hof and B.M.\u00a0Rahel declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}