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A\u00a0substantial amount of data is reported by relatively few, highly experienced centres. This study describes the first experience of LBB pacing in a\u00a0high-volume device centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Success rates (i.e. the ability to achieve LBB pacing), electrophysiological parameters and complications at implant and up to 6\u00a0months of follow-up were prospectively assessed in 100\u00a0consecutive patients referred for various pacing indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 71\u202f\u00b1\u200911\u00a0years and 65% were male. Primary pacing indication was atrioventricular (AV) block in 40%, CRT in 42%, and sinus node dysfunction or refractory atrial fibrillation prior to AV node ablation in 9% each. Baseline left ventricular ejection fraction was &lt;\u202f50% in 57% of patients, mean baseline QRS duration 145\u202f\u00b1\u200934\u202fms. Overall LBB pacing was successful in 83\u00a0of 100 (83%) patients but tended to be lower in patients with CRT pacing indication (69%,<jats:italic>p<\/jats:italic>\u202f=\u2009ns). Mean left ventricular activation time (LVAT) during LBB pacing was 81\u202fms and paced QRS duration was 120\u202f\u00b1\u200919\u202fms. LBB capture threshold and R\u2011wave sense at implant was 0.74\u202f\u00b1\u20090.4\u202fmV at 0.4\u202fms and 11.9\u202f\u00b1\u20095.9\u202fV and remained stable at 6\u2011month follow-up. No complications occurred during implant or follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LBB pacing for bradycardia pacing and resynchronisation therapy can be easily adopted by experienced implanters, with favourable success rates and safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12471-021-01648-6","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T17:02:41Z","timestamp":1637946161000},"page":"258-266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Initial experience, feasibility and safety of permanent left bundle branch pacing: results from a\u00a0prospective single-centre study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-7354","authenticated-orcid":false,"given":"L. 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