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To date, this is still one of the largest and best described <jats:italic>SCN5A <\/jats:italic>founder families worldwide. It was the first time that a\u00a0single pathogenic variant in <jats:italic>SCN5A<\/jats:italic> proved to be sufficient to cause a\u00a0sodium channel overlap syndrome. Affected family members displayed features of Brugada syndrome, cardiac conduction disease and long QT syndrome type\u00a03, thus encompassing features of both loss and gain of sodium channel function. This brief summary takes us past 70\u00a0years of clinical experience and over 2\u00a0decades of research. It is remarkable to what extent researchers and clinicians have managed to gain understanding of this complex phenotype in a\u00a0relatively short time. Extensive clinical, genetic, electrophysiological and molecular studies have provided fundamental insights into <jats:italic>SCN5A<\/jats:italic> and the cardiac sodium channel Nav1.5.<\/jats:p>","DOI":"10.1007\/s12471-023-01799-8","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:02:10Z","timestamp":1689872530000},"page":"263-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["SCN5A-1795insD founder variant: a\u00a0unique Dutch experience spanning 7\u00a0decades"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2658-3385","authenticated-orcid":false,"given":"Virginnio M.","family":"Proost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten P.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Ann","family":"Remme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A. 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