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Individuals with the pathogenic c.40_42del; p.(Arg14del) variant in the <jats:italic>PLN<\/jats:italic> gene are frequently diagnosed with ARVC or dilated cardiomyopathy (DCM). The aim of this study was to evaluate the effect of exercise in <jats:italic>PLN<\/jats:italic> p.(Arg14del) carriers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In total, 207 adult <jats:italic>PLN<\/jats:italic> p.(Arg14del) carriers (39.1% male; mean age 53\u202f\u00b1\u200915\u00a0years) were interviewed on their regular physical activity since the age of 10\u00a0years. The association of exercise with diagnosis of ARVC, DCM, sustained VA and hospitalisation for heart failure (HF) was studied.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Individuals participated in regular physical activities with a\u00a0median of 1661 metabolic equivalent of task (MET) hours per year (31.9\u00a0MET-hours per week) until clinical presentation. The 50% most and least active individuals had a\u00a0similar frequency of sustained VA (18.3% vs 18.4%; <jats:italic>p<\/jats:italic>\u202f=\u20090.974) and hospitalisation for HF (9.6% vs 8.7%; <jats:italic>p<\/jats:italic>\u202f=\u20090.827). There was no relationship between exercise and survival free from (incident) sustained VA (<jats:italic>p<\/jats:italic>\u202f=\u20090.65), hospitalisation for HF (<jats:italic>p<\/jats:italic>\u202f=\u20090.81), diagnosis of ARVC (<jats:italic>p<\/jats:italic>\u202f=\u20090.67) or DCM (<jats:italic>p<\/jats:italic>\u202f=\u20090.39) during follow-up. In multivariate analyses, exercise was not associated with sustained VA or HF hospitalisation during follow-up in this relatively not-active cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>There was no association between the amount of exercise and the susceptibility to develop ARVC, DCM, VA or HF in <jats:italic>PLN<\/jats:italic> p.(Arg14del) carriers. This suggested unaffected <jats:italic>PLN<\/jats:italic> p.(Arg14del) carriers can safely perform mild-moderate exercise, in contrast to desmosomal variant carriers and ARVC patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-023-01800-4","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T17:02:10Z","timestamp":1689872530000},"page":"291-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Exercise does not influence development of phenotype in PLN p.(Arg14del) cardiomyopathy"],"prefix":"10.1007","volume":"31","author":[{"given":"Freyja H. 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F.H.\u00a0M.\u00a0van Lint, F.\u00a0Hassanzada,T.E.\u00a0Verstraelen, W.\u00a0Wang, L.P.\u00a0Bosman, P.A.\u00a0van der Zwaag, T.\u00a0Oomen, H.\u00a0Calkins, B.\u00a0Murray, C.\u00a0Tichnell, T.M.A.\u00a0Beuren, F.W.\u00a0Asselbergs, A.\u00a0Houweling, M.P.\u00a0van den Berg, A.A.M.\u00a0Wilde and J.\u00a0P.\u00a0van Tintelen declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}