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Despite the lack of randomised controlled trials comparing different revascularisation strategies, guidelines currently recommend percutaneous coronary intervention (PCI) in patients with significant proximal CAD undergoing TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this systematic review and meta-analysis, a\u00a0systematic search was conducted to identify studies comparing TAVI with and without PCI in patients with significant CAD on pre-TAVI coronary angiography. Endpoints were all-cause mortality, cardiac death, stroke, myocardial infarction and major bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 14\u00a0studies were included, involving 3838 patients, of whom 1806 (47%) underwent PCI before TAVI. All-cause mortality did not differ significantly between TAVI with and without preceding PCI at 30\u00a0days, 1\u00a0year and &gt;\u202f1\u00a0year. There were no significant differences in risk of cardiac death, stroke or myocardial infarction between the groups. However, TAVI performed with PCI resulted in a\u00a0higher risk of major bleeding within 30\u00a0days after TAVI (odds ratio: 0.66; 95% confidence interval: 0.46\u20130.94).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis showed no significant differences in clinical outcomes between patients with concomitant significant CAD who were treated with TAVI with and without preceding PCI at both short- and long-term follow-up. However, there was a\u00a0higher risk of major bleeding at 30\u00a0days in patients undergoing TAVI with preceding PCI. In the context of serious risk of bias in the included studies, results of randomised controlled trials are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12471-023-01824-w","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T09:05:48Z","timestamp":1698829548000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: a\u00a0systematic review and meta-analysis"],"prefix":"10.1007","volume":"31","author":[{"given":"Hugo M.","family":"Aarts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole D.","family":"van Hemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timion A.","family":"Meijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid C.","family":"van Nieuwkerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurri\u00ebn M. ten","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna J.","family":"Wykrzykowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"van Royen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Schotborgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A. 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H.M.\u00a0Aarts, N.D.\u00a0van Hemert, T.A.\u00a0Meijs, A.C.\u00a0van Nieuwkerk, J.M.\u00a0t.\u00a0Berg, J.J.\u00a0Wykrzykowska, N.\u00a0van Royen, C.E.\u00a0Schotborgh, P.A.\u00a0L.\u00a0Tonino, A.\u00a0IJsselmuiden, T.N.\u00a0Vossenberg, G.K.\u00a0van Houwelingen, T.\u00a0Slagboom, M.\u00a0Voskuil and R.\u00a0Delewi report no financial relationships or conflicts of interest regarding the content herein.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}