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TAVI may have negative cognitive effects due to periprocedural micro-emboli inducing cerebral infarction. On the contrary, TAVI may also have positive cognitive effects due to increases in cardiac output and cerebral blood flow (CBF). However, studies that systematically assess these effects are scarce. Therefore, the main aim of this study is to assess cerebral and cognitive outcomes in patients with severe aortic valve stenosis undergoing TAVI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>\n                           <jats:italic>Study design<\/jats:italic>\n                        <\/jats:title>\n                <jats:p>In the prospective CAPITA (<jats:bold>CA<\/jats:bold>rdiac Out<jats:bold>P<\/jats:bold>ut, Cerebral Blood Flow and Cognition <jats:bold>I<\/jats:bold>n Patients With Severe Aortic Valve Stenosis Undergoing <jats:bold>T<\/jats:bold>ranscatheter <jats:bold>A<\/jats:bold>ortic Valve Implantation) study, cerebral and cognitive outcomes are assessed in patients undergoing TAVI. One day before and 3\u00a0months after TAVI, patients will undergo echocardiography (cardiac output, valve function), brain magnetic resonance imaging (CBF, structural lesions) and extensive neuropsychological assessment. To assess longer-term effects of TAVI, patients will again undergo echocardiography and neuropsychological assessment 1\u00a0year after the procedure. The co-primary outcome measures are change in CBF (in ml\/100\u202fg per min) and change in global cognitive functioning (Z-score) between baseline and 3\u2011month follow-up. Secondary objectives include change in cardiac output, white matter hyperintensities and other structural brain lesions. (ClinicalTrials.gov identifier NCT05481008)<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>\n                           <jats:italic>Conclusion<\/jats:italic>\n                        <\/jats:title>\n                <jats:p>The CAPITA study is the first study designed to systematically assess positive and negative cerebral and cognitive outcomes after TAVI. We hypothesise that TAVI improves cardiac output, CBF and cognitive functioning.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-023-01826-8","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T10:02:06Z","timestamp":1698832926000},"page":"461-470","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac output, cerebral blood flow and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation: design and rationale of the CAPITA study"],"prefix":"10.1007","volume":"31","author":[{"given":"Astrid C.","family":"van Nieuwkerk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley I.","family":"Hemelrijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther E.","family":"Bron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"Leeuwis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B. 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J.E.F.\u00a0Moonen has been appointed as a\u00a0postdoctoral researcher by the Netherlands Consortium of Dementia Cohorts, which is funded by the <i>Deltaplan Dementie<\/i> from the ZonMw Memorabel Programme (project no. 73305095005) and Alzheimer Netherlands. J.J.\u00a0Piek is Editor-in-Chief of the <i>Netherlands Heart Journal<\/i>. R.\u00a0Delewi has received educational fees from Boston Scientific and Edwards Lifesciences and is Editor of the Netherlands Heart Journal. A.C.\u00a0van Nieuwkerk, K.I.\u00a0Hemelrijk, E.E.\u00a0Bron, A.E.\u00a0Leeuwis, M.J.A.P.\u00a0Daemen, A.\u00a0de Sitter, B.J.\u00a0Bouma, W.M.\u00a0van der Flier, J.\u00a0Baan and G.J.\u00a0Biessels declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}