{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:48:05Z","timestamp":1770911285641,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014476","name":"Pfizer Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Untreated atrial fibrillation (AF) often results in increased morbidity and mortality. Opportunistic AF screening in persons aged \u2265\u202f65\u00a0years is recommended to identify patients with AF in order to prevent AF-related complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The aim of this study was to assess the feasibility of screening persons for AF with the Kardia mobile electrocardiogram device (MED) and to determine the percentage of newly detected AF cases by selective population screening in the Netherlands.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Persons aged \u2265\u202f65\u00a0years, without a\u00a0medical history of AF, in nursing homes, at public events or visiting the general practitioner (GP) were approached to participate. A\u00a0Kardia MED smartphone ECG (sECG) was recorded and the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score was calculated. An automated AF algorithm classified the sECGs as \u2018sinus rhythm\u2019, \u2018AF\u2019 or \u2018unclassified\u2019. In the case of AF, participants were referred to their GP. All sECGs were assessed by blinded experts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A\u00a0total of 2168 participants were screened for AF. According to the expert\u2019s interpretation, 2.5% had newly detected AF, of whom 76.4% never experienced palpitations and 89.1% had a\u00a0CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc score\u202f\u2265\u20092. The algorithm result was unclassified in 12.2% of cases, of which 95.5% were interpretable by experts. With expert opinion as the gold standard and excluding unclassified sECGs, the Kardia MED\u2019s negative and positive predictive value for detecting AF was 99.8% and 60.0%, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Screening for AF using the Kardia MED is feasible and results in 2.5% newly detected AF cases. Expert interpretation of algorithm outcomes AF and unclassified is recommended.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-023-01828-6","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T16:02:35Z","timestamp":1701187355000},"page":"160-166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Detection of atrial fibrillation in persons aged 65\u00a0years and above using a\u00a0mobile electrocardiogram device"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-3161","authenticated-orcid":false,"given":"Fenna","family":"Dani\u00ebls","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanwier T. T. K.","family":"Ramdjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"M\u00e1nfai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Adiyaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap Jan J.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Paul H. M.","family":"Delnoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Elvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"issue":"7","key":"1828_CR1","doi-asserted-by":"publisher","first-page":"e006350","DOI":"10.1161\/CIRCEP.118.006350","volume":"11","author":"L Mou","year":"2018","unstructured":"Mou\u00a0L, Norby\u00a0FL, Chen\u00a0LY, et\u00a0al. Lifetime risk of atrial fibrillation by race and socioeconomic status: ARIC study (Atherosclerosis Risk in Communities). Circ Arrhythm Electrophysiol. 2018;11:e6350.","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"1828_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1378\/chest.09-1584","volume":"137(2","author":"GYH Lip","year":"2010","unstructured":"Lip\u00a0GYH, Nieuwlaat\u00a0R, Pisters\u00a0R, et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a\u00a0novel risk factor-based approach: the Euro Heart Survey on atrial fibrillation. Chest. 2010;137:263\u201372.","journal-title":"Chest"},{"issue":"5","key":"1828_CR3","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.amjmed.2014.11.026","volume":"128","author":"G Boriani","year":"2015","unstructured":"Boriani\u00a0G, Laroche\u00a0C, Diemberger\u00a0I, et al. Asymptomatic atrial fibrillation: clinical correlates, management, and outcomes in the EORP-AF pilot general registry. Am J Med. 2015;128:509\u2013518.e2.","journal-title":"Am J Med"},{"issue":"6","key":"1828_CR4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/europace\/euq080","volume":"12","author":"R Pisters","year":"2010","unstructured":"Pisters\u00a0R, Van Oostenbrugge\u00a0RJ, Knottnerus\u00a0ILH, et\u00a0al. The likelihood of decreasing strokes in atrial fibrillation patients by strict application of guidelines. Europace. 2010;12:779\u201384.","journal-title":"Europace"},{"issue":"9","key":"1828_CR5","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1161\/STROKEAHA.114.006070","volume":"45","author":"L Friberg","year":"2014","unstructured":"Friberg\u00a0L, Rosenqvist\u00a0M, Lindgren\u00a0A, Ter\u00e9nt\u00a0A, Norrving\u00a0B, Asplund\u00a0K. High prevalence of atrial fibrillation among patients with ischemic stroke. Stroke. 2014;45:2599\u2013605.","journal-title":"Stroke"},{"issue":"1","key":"1828_CR6","first-page":"12","volume":"20","author":"MS Jacobs","year":"2018","unstructured":"Jacobs\u00a0MS, Kaasenbrood\u00a0F, Postma\u00a0MJ, van Hulst\u00a0M, Tieleman\u00a0RG. Cost-effectiveness of screening for atrial fibrillation in primary care with a\u00a0handheld, single-lead electrocardiogram device in the Netherlands. Europace. 2018;20:12\u20138.","journal-title":"Europace"},{"issue":"10","key":"1828_CR7","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1093\/europace\/euv426","volume":"18","author":"F Kaasenbrood","year":"2016","unstructured":"Kaasenbrood\u00a0F, Hollander\u00a0M, Rutten\u00a0FH, Gerhards\u00a0LJ, Hoes\u00a0AW, Tieleman\u00a0RG. Yield of screening for atrial fibrillation in primary care with a\u00a0hand-held, single-lead electrocardiogram device during influenza vaccination. Europace. 2016;18:1514\u201320.","journal-title":"Europace"},{"key":"1828_CR8","first-page":"CD009586","volume":"6","author":"PS Moran","year":"2016","unstructured":"Moran\u00a0PS, Teljeur\u00a0C, Ryan\u00a0M, Smith\u00a0SM. Systematic screening for the detection of atrial fibrillation. Cochrane Database Syst Rev. 2016;6:CD9586.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"1828_CR9","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","volume":"42","author":"G Hindricks","year":"2021","unstructured":"Hindricks\u00a0G, Potpara\u00a0T, Dagres\u00a0N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart\u00a0J. 2021;42:373\u2013498.","journal-title":"Eur Heart J"},{"issue":"1","key":"1828_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ijcard.2013.01.220","volume":"165","author":"JK Lau","year":"2013","unstructured":"Lau\u00a0JK, Lowres\u00a0N, Neubeck\u00a0L, et\u00a0al. IPhone ECG application for community screening to detect silent atrial fibrillation: a\u00a0novel technology to prevent stroke. Int J Cardiol. 2013;165:193\u20134.","journal-title":"Int J Cardiol"},{"issue":"5","key":"1828_CR11","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/jce.12634","volume":"26","author":"ZC Haberman","year":"2015","unstructured":"Haberman\u00a0ZC, Jahn\u00a0RT, Bose\u00a0R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J\u00a0Cardiovasc Electrophysiol. 2015;26:520\u20136.","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"1","key":"1828_CR12","first-page":"29","volume":"19","author":"L Desteghe","year":"2017","unstructured":"Desteghe\u00a0L, Raymaekers\u00a0Z, Lutin\u00a0M, et\u00a0al. Performance of handheld electrocardiogram devices to detect atrial fibrillation in a\u00a0cardiology and geriatric ward setting. Europace. 2017;19:29\u201339.","journal-title":"Europace"},{"issue":"6","key":"1828_CR13","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1161\/STROKEAHA.110.609297","volume":"42","author":"G Boriani","year":"2011","unstructured":"Boriani\u00a0G, Botto\u00a0GL, Padeletti\u00a0L, et al. Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring. Stroke. 2011;42:1768\u201370.","journal-title":"Stroke"},{"issue":"5","key":"1828_CR14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1370\/afm.2438","volume":"17","author":"JCL Himmelreich","year":"2019","unstructured":"Himmelreich\u00a0JCL, Karregat\u00a0EPM, Lucassen\u00a0WAM, et al. Diagnostic accuracy of a\u00a0smartphone-operated, single-lead electrocardiography device for detection of rhythm and conduction abnormalities in primary care. Ann Fam Med. 2019;17:403\u201311.","journal-title":"Ann Fam Med"},{"issue":"9","key":"1828_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1136\/heartjnl-2019-316004","volume":"106","author":"K Rajakariar","year":"2020","unstructured":"Rajakariar\u00a0K, Koshy\u00a0AN, Sajeev\u00a0JK, Nair\u00a0S, Roberts\u00a0L, Teh\u00a0AW. Accuracy of a\u00a0smartwatch based single-lead electrocardiogram device in detection of atrial fibrillation. Heart. 2020;106:665\u201370.","journal-title":"Heart"},{"key":"1828_CR16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s12471-018-1203-4","volume":"27(1","author":"JL Selder","year":"2019","unstructured":"Selder\u00a0JL, Breukel\u00a0L, Blok\u00a0S, van Rossum\u00a0AC. Tulevski II, Allaart CP. A\u00a0mobile one-lead ECG device incorporated in a\u00a0symptom-driven remote arrhythmia monitoring program. The first 5,982 Hartwacht ECGs. Neth Heart\u00a0J. 2019;27:38\u201345.","journal-title":"Neth Heart J"},{"issue":"10","key":"1828_CR17","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.hrthm.2018.06.037","volume":"15","author":"AD William","year":"2018","unstructured":"William\u00a0AD, Kanbour\u00a0M, Callahan\u00a0T, et\u00a0al. Assessing the accuracy of an automated atrial fibrillation detection algorithm using smartphone technology: the iREAD Study. Heart Rhythm. 2018;15:1561\u20135.","journal-title":"Heart Rhythm"},{"issue":"7616","key":"1828_CR18","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/bmj.39280.660567.55","volume":"335","author":"DA Fitzmaurice","year":"2007","unstructured":"Fitzmaurice\u00a0DA, Hobbs\u00a0FDR, Jowett\u00a0S, et\u00a0al. Screening versus routine practice in detection of atrial fibrillation in patients aged 65 or over: cluster randomised controlled trial. Br Med\u00a0J. 2007;335:383\u20136.","journal-title":"Br Med J"},{"key":"1828_CR19","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1161\/CIRCULATIONAHA.114.014343","volume":"131(25","author":"E Svennberg","year":"2015","unstructured":"Svennberg\u00a0E, Engdahl\u00a0J, Al-Khalili\u00a0F, Friberg\u00a0L, Frykman\u00a0V, Rosenqvist\u00a0M. Mass screening for untreated atrial fibrillation the STROKESTOP study. Circulation. 2015;131:2176\u201384.","journal-title":"Circulation"},{"key":"1828_CR20","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.117.030583","volume":"136(19","author":"JPJ Halcox","year":"2017","unstructured":"Halcox\u00a0JPJ, Wareham\u00a0K, Cardew\u00a0A, et al. Assessment of remote heart rhythm sampling using the AliveCor heart monitor to screen for atrial fibrillation the REHEARSE-AF study. Circulation. 2017;136:1784\u201394.","journal-title":"Circulation"},{"issue":"3","key":"1828_CR21","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.chest.2018.09.011","volume":"155","author":"YG Li","year":"2019","unstructured":"Li\u00a0YG, Pastori\u00a0D, Farcomeni\u00a0A, et\u00a0al. A\u00a0simple clinical risk score (C2HEST) for predicting incident atrial fibrillation in Asian subjects: derivation in 471,446 Chinese subjects, with internal validation and external application in 451,199 Korean subjects. Chest. 2019;155:510\u20138.","journal-title":"Chest"},{"issue":"11","key":"1828_CR22","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.3390\/jcm10112321","volume":"10","author":"K Mitrega","year":"2021","unstructured":"Mitrega\u00a0K, Lip\u00a0GYH, Sredniawa\u00a0B, et al. Predicting silent atrial fibrillation in the elderly: a\u00a0report from the NOMED-AF cross-sectional study. J\u00a0Clin Med. 2021;10:2321.","journal-title":"J Clin Med"},{"issue":"1","key":"1828_CR23","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/europace\/euac144","volume":"25","author":"Z Kalarus","year":"2023","unstructured":"Kalarus\u00a0Z, Mairesse\u00a0GH, Sokal\u00a0A, et\u00a0al. Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper. Europace. 2023;25:185\u201398.","journal-title":"Europace"}],"container-title":["Netherlands Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-023-01828-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12471-023-01828-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-023-01828-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T14:31:40Z","timestamp":1710858700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12471-023-01828-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["1828"],"URL":"https:\/\/doi.org\/10.1007\/s12471-023-01828-6","relation":{},"ISSN":["1568-5888","1876-6250"],"issn-type":[{"value":"1568-5888","type":"print"},{"value":"1876-6250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"27 September 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"F.\u00a0Dani\u00ebls, T.T.T.K.\u00a0Ramdjan, B.\u00a0M\u00e1nfai, A.\u00a0Adiyaman, J.J.J.\u00a0Smit, P.P.H.M.\u00a0Delnoy and A.\u00a0Elvan declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the principles of the Declaration of Helsinki and a\u00a0non-WMO (Dutch Act on Research Involving Human Subjects) declaration was received from the local ethics committee of the Isala Hospital in Zwolle, the Netherlands.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}