{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:17:21Z","timestamp":1793740641228,"version":"4.6.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["843001792"],"award-info":[{"award-number":["843001792"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity is a\u00a0known and commonly encountered risk factor for the development of cardiac diseases. Patients with cardiac diseases who also have obesity do not benefit optimally from standard cardiac rehabilitation (CR) programs. Exercises performed during CR are not the best fit for patients with obesity and counselling sessions often do not address their specific needs. OPTICARE XL is the first large multicentre randomised controlled trial to investigate the added value of a\u00a0dedicated one-year CR program specifically designed for patients with obesity and integrated in daily practice. The short-term effects on body weight and physical activity were promising and patients with obesity experienced the program as highly desirable. However, the OPTICARE XL CR program did not show long-term added value compared with standard CR on health-related quality of life, psychosocial well-being, body weight, physical activity and physical fitness, nor on costs. The current article offers an overview of the background of this trial and discusses the most important results of the OPTICARE XL trial and the reasons behind the unanticipated long-term outcomes. Furthermore, it offers recommendations for future research and how to redesign the OPTICARE XL CR program to expand the short-term results.<\/jats:p>","DOI":"10.1007\/s12471-023-01832-w","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T14:01:45Z","timestamp":1700488905000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiac rehabilitation for patients with obesity: lessons learned from the OPTICARE XL trial"],"prefix":"10.1007","volume":"32","author":[{"given":"Iris","family":"den Uijl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madoka","family":"Sunamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger M. W.","family":"Brouwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk J.","family":"Stam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita J. G.","family":"van den Berg-Emons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"ter Hoeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"1832_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1614362","volume":"377","author":"GBD Obesity Collaborators","year":"2017","unstructured":"Obesity Collaborators\u00a0GBD. Health effects of overweight and obesity in 195 countries over 25\u00a0years. New Engl J Med. 2017;377:13\u201327.","journal-title":"New Engl J Med"},{"key":"1832_CR2","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1177\/2047487318825350","volume":"26","author":"K Kotseva","year":"2019","unstructured":"Kotseva\u00a0K, De Backer\u00a0G, De Bacquer\u00a0D, et al. Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27\u00a0countries: results from the European society of cardiology ESC-EORP EUROASPIRE V registry. Eur J Prev Cardiol. 2019;26:824\u201335.","journal-title":"Eur J Prev Cardiol"},{"key":"1832_CR3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ahj.2007.10.004","volume":"155","author":"N Wanahita","year":"2008","unstructured":"Wanahita\u00a0N, Messerli\u00a0FH, Bangalore\u00a0S, et al. Atrial fibrillation and obesity\u2014results of a\u00a0meta-analysis. Am Heart\u00a0J. 2008;155:310\u20135.","journal-title":"Am Heart J"},{"key":"1832_CR4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/clc.22108","volume":"36","author":"J Zhuang","year":"2013","unstructured":"Zhuang\u00a0J, Lu\u00a0Y, Tang\u00a0K, Peng\u00a0W, Xu\u00a0Y. Influence of body mass index on recurrence and quality of life in atrial fibrillation patients after catheter ablation: a\u00a0meta-analysis and systematic review. Clin Cardiol. 2013;36:269\u201375.","journal-title":"Clin Cardiol"},{"key":"1832_CR5","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","volume":"2016","author":"MF Piepoli","year":"2016","unstructured":"Piepoli\u00a0MF, Hoes\u00a0AW, Agewall\u00a0S, et\u00a0al. European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart\u00a0J. 2016;2016:2315.","journal-title":"Eur Heart J"},{"key":"1832_CR6","unstructured":"Revalidatiecommissie NVVC\/ NHS en projectgroep PAAHR. Multidisciplinary guidelines cardiac rehabilitation on 2011. Multidisciplinaire Richtlijn Hartrevalidatie, Vol. 2011. Utrecht: Nederlandse Vereniging voor Cardiologie; 2011."},{"key":"1832_CR7","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1080\/09638288.2022.2050428","volume":"45","author":"I Den Uijl","year":"2023","unstructured":"Den Uijl\u00a0I, Ter Hoeve\u00a0N, Sunamura\u00a0M, et al. Cardiac rehabilitation designed for patients with obesity: OPTICARE XL RCT results on health-related quality of life and psychosocial well-being. Disabil Rehabil. 2023;45:1046\u201355.","journal-title":"Disabil Rehabil"},{"key":"1832_CR8","doi-asserted-by":"publisher","first-page":"pzad055","DOI":"10.1093\/ptj\/pzad055","volume":"103","author":"I Den Uijl","year":"2023","unstructured":"Den Uijl\u00a0I, Van den Berg-Emons\u00a0RJ, Sunamura\u00a0M, et al. Effects of a\u00a0dedicated cardiac rehabilitation program for patients with obesity on body weight, physical activity, sedentary behaviour and physical fitness: the OPTICARE XL randomized controlled trial. Phys Ther\u00a0J. 2023;103:pzad55.","journal-title":"Phys Ther J"},{"key":"1832_CR9","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.apmr.2023.02.005","volume":"104","author":"L Visser","year":"2023","unstructured":"Visser\u00a0L, den Uijl\u00a0I, Redekop\u00a0W, et al. Cost-effectiveness of a\u00a0cardiac rehabilitation program specifically designed for patients with obesity within the OPTICARE XL randomized controlled trial. Arch Phys Med Rehabil. 2023;104:855\u201362.","journal-title":"Arch Phys Med Rehabil"},{"key":"1832_CR10","doi-asserted-by":"crossref","unstructured":"Balady GJ, Williams MA, Ades PA, et\u00a0al. Core components of cardiac rehabilitation\/secondary prevention programs: 2007 update: A\u00a0scientific statement from the American Heart Association Exercise, Cardiac rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circ. 2007;115:2675\u201382.","DOI":"10.1161\/CIRCULATIONAHA.106.180945"},{"key":"1832_CR11","first-page":"CD001800","volume":"1","author":"L Anderson","year":"2016","unstructured":"Anderson\u00a0L, Thompson\u00a0DR, Oldridge\u00a0N, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2016;1:CD1800.","journal-title":"Cochrane Database Syst Rev"},{"key":"1832_CR12","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1093\/eurheartj\/ehv111","volume":"36","author":"H De Vries","year":"2015","unstructured":"De Vries\u00a0H, Kemps\u00a0HM, van Engen-Verheul\u00a0MM, Kraaijenhagen\u00a0RA, Peek\u00a0N. Cardiac rehabilitation and survival in a\u00a0large representative community cohort of Dutch patients. Eur Heart\u00a0J. 2015;36:1519\u201328.","journal-title":"Eur Heart J"},{"key":"1832_CR13","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.cjca.2018.11.013","volume":"35","author":"T Francis","year":"2019","unstructured":"Francis\u00a0T, Kabboul\u00a0N, Rac\u00a0V, et al. The effect of cardiac rehabilitation on health-related quality of life in patients with coronary artery disease: a\u00a0meta-analysis. Can J Cardiol. 2019;35:352\u201364.","journal-title":"Can J Cardiol"},{"key":"1832_CR14","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.pcad.2011.02.008","volume":"53","author":"CJ Lavie","year":"2011","unstructured":"Lavie\u00a0CJ, Milani\u00a0RV. Cardiac rehabilitation and exercise training in secondary coronary heart disease prevention. Prog Cardiovasc Dis. 2011;53:397\u2013403.","journal-title":"Prog Cardiovasc Dis"},{"key":"1832_CR15","doi-asserted-by":"crossref","unstructured":"Takura T, Ebata-Kogure N, Goto Y, et al. Cost-effectiveness of cardiac rehabilitation in patients with coronary artery disease: A meta-analysis. Cardiol Res Pract. 2019;4:2019:1840894.","DOI":"10.1155\/2019\/1840894"},{"key":"1832_CR16","doi-asserted-by":"crossref","unstructured":"NCD Risk Factor Collaboration. Trends in adult body-mass index in 200 countries from 1975to 2014: a\u00a0pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387:1377\u201396.","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"1832_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.1520-037X.2007.05860.x","volume":"10","author":"J Gunstad","year":"2007","unstructured":"Gunstad\u00a0J, Luyster\u00a0F, Hughes\u00a0J, et\u00a0al. The effects of obesity on functional work capacity and quality of life in phase\u00a0II cardiac rehabilitation. Prev Cardiol. 2007;10:64\u20137.","journal-title":"Prev Cardiol"},{"key":"1832_CR18","series-title":"zab","first-page":"101","volume-title":"Physical Activity and Sedentary Behavior in Cardiac Rehabilitation: Does Body","author":"I Den Uijl","year":"2021","unstructured":"Den Uijl\u00a0I, Ter Hoeve\u00a0N, Sunamura\u00a0M, et\u00a0al. Physical Activity and Sedentary Behavior in Cardiac Rehabilitation: Does Body. zab, Vol. 142. Mass: Index Matter? Phys Ther; 2021. p.\u00a0101."},{"key":"1832_CR19","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.jacc.2017.09.002","volume":"70","author":"CJ Lavie","year":"2017","unstructured":"Lavie\u00a0CJ, Pandey\u00a0A, Lau\u00a0DH, Alpert\u00a0MA, Sanders\u00a0P. Obesity and atrial fibrillation prevalence, pathogenesis, and prognosis: effects of weight loss and exercise. J\u00a0Am Coll Cardiol. 2017;70:2022\u201335.","journal-title":"J Am Coll Cardiol"},{"key":"1832_CR20","doi-asserted-by":"publisher","first-page":"4570","DOI":"10.1136\/bmj.l4570","volume":"366","author":"U Ekelund","year":"2019","unstructured":"Ekelund\u00a0U, Tarp\u00a0J, Steene-Johannessen\u00a0J, et al. Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis. Br Med\u00a0J. 2019;366:4570.","journal-title":"Br Med J"},{"key":"1832_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/HCR.0b013e3181d6f9a8","volume":"30","author":"PA Ades","year":"2010","unstructured":"Ades\u00a0PA, Savage\u00a0PD, Harvey-Berino\u00a0J. The treatment of obesity in cardiac rehabilitation. J\u00a0Cardiopulm Rehabil Prev. 2010;30:289.","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"1832_CR22","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1080\/13548506.2010.542167","volume":"16","author":"GM Manzoni","year":"2011","unstructured":"Manzoni\u00a0GM, Villa\u00a0V, Compare\u00a0A, et al. Short-term effects of a\u00a0multi-disciplinary cardiac rehabilitation program on psychological well-being, exercise capacity and weight in a\u00a0sample of obese in-patients with coronary heart disease: a\u00a0practice-level study. Psychol Health Med. 2011;16:178\u201389.","journal-title":"Psychol Health Med"},{"key":"1832_CR23","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.2337\/dc10-2415","volume":"34","author":"RR Wing","year":"2011","unstructured":"Wing\u00a0RR, Lang\u00a0W, Wadden\u00a0TA, et\u00a0al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type\u00a02 diabetes. Diabetes Care. 2011;34:1481\u20136.","journal-title":"Diabetes Care"},{"key":"1832_CR24","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/ehjqcco\/qcab043","volume":"8","author":"D De Bacquer","year":"2022","unstructured":"De Bacquer\u00a0D, Jennings\u00a0CS, Mirrakhimov\u00a0E, et\u00a0al. Potential for optimizing management of obesity in the secondary prevention of coronary heart disease. Eur Heart J Qual Care Clin Outcomes. 2022;8:568\u201376.","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"1832_CR25","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/HCR.0000000000000637","volume":"41","author":"PA Ades","year":"2021","unstructured":"Ades\u00a0PA, Savage\u00a0PD. The Treatment of Obesity in Cardiac Rehabilitation: a\u00a0review and practical recommendations. J\u00a0Cardiopulm Rehabil Prev. 2021;41:295\u2013301.","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"1832_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1253\/circj.72.299","volume":"72","author":"M Ayabe","year":"2008","unstructured":"Ayabe\u00a0M, Brubaker\u00a0PH, Dobrosielski\u00a0D, et\u00a0al. Target step count for the secondary prevention of cardiovascular disease. Circ\u00a0J. 2008;72:299\u2013303.","journal-title":"Circ J"},{"key":"1832_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2458-12-704","volume":"12","author":"SS Ho","year":"2012","unstructured":"Ho\u00a0SS, Dhaliwal\u00a0SS, Hills\u00a0AP, Pal\u00a0S. The effect of 12\u00a0weeks of aerobic, resistance or combination exercise training on cardiovascular risk factors in the overweight and obese in a\u00a0randomized trial. Bmc Public Health. 2012;12:1\u201310.","journal-title":"Bmc Public Health"},{"key":"1832_CR28","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1042\/CS20070332","volume":"115","author":"IE Schjerve","year":"2008","unstructured":"Schjerve\u00a0IE, Tyldum\u00a0GA, Tj\u00f8nna\u00a0AE, et\u00a0al. Both aerobic endurance and strength training programs improve cardiovascular health in obese adults. Clin Sci. 2008;115:283\u201393.","journal-title":"Clin Sci"},{"key":"1832_CR29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1097\/HJR.0b013e328336a05f","volume":"17","author":"B De Dirk","year":"2010","unstructured":"De Dirk\u00a0B, Dallongeville\u00a0J, Heidrich\u00a0J, et\u00a0al. Management of overweight and obese patients with coronary heart disease across Europe. Eur J Prev Cardiol. 2010;17:447\u201354.","journal-title":"Eur J Prev Cardiol"},{"key":"1832_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ijcard.2017.12.015","volume":"255","author":"N Ter Hoeve","year":"2018","unstructured":"Ter Hoeve\u00a0N, Sunamura\u00a0M, Stam\u00a0HJ, et\u00a0al. Effects of two behavioral cardiac rehabilitation interventions on physical activity: a\u00a0randomized controlled trial. Int J Cardiol. 2018;255:221\u20138.","journal-title":"Int J Cardiol"},{"key":"1832_CR31","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1097\/HCR.0b013e318220a7c9","volume":"31","author":"SA Aldcroft","year":"2011","unstructured":"Aldcroft\u00a0SA, Taylor\u00a0NF, Blackstock\u00a0FC, O\u2019Halloran\u00a0PD. Psychoeducational rehabilitation for health behavior change in coronary artery disease: a\u00a0systematic review of controlled trials. J\u00a0Cardiopulm Rehabil Prev. 2011;31:273\u201381.","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"1832_CR32","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/JCN.0b013e3182049f00","volume":"26","author":"J-AD Chase","year":"2011","unstructured":"Chase J\u2011AD. Systematic review of physical activity intervention studies after cardiac rehabilitation. J\u00a0Cardiovasc Nurs. 2011;26:351\u20138.","journal-title":"J Cardiovasc Nurs"},{"key":"1832_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/HJR.0b013e32833ace0e","volume":"18","author":"S Ferrier","year":"2011","unstructured":"Ferrier\u00a0S, Blanchard\u00a0CM, Vallis\u00a0M, Giacomantonio\u00a0N. Behavioural interventions to increase the physical activity of cardiac patients: a\u00a0review. Eur J Prev Cardiol. 2011;18:15\u201332.","journal-title":"Eur J Prev Cardiol"},{"key":"1832_CR34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2340\/16501977-2522","volume":"51","author":"HE Braakhuis","year":"2019","unstructured":"Braakhuis\u00a0HE, Berger\u00a0MA, Bussmann\u00a0JB. Effectiveness of healthcare interventions using objective feedback on physical activity: A\u00a0systematic review and meta-analysis. J\u00a0Rehabil Med. 2019;51:151\u20139.","journal-title":"J Rehabil Med"},{"key":"1832_CR35","doi-asserted-by":"crossref","unstructured":"Jensen MD, Ryan DH, Apovian CM, et\u00a0al. 2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: a\u00a0report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J\u00a0Am Coll Cardiol. 2014;63(25 Part B):2985\u20133023.","DOI":"10.1161\/01.cir.0000437739.71477.ee"},{"key":"1832_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1159\/000442721","volume":"8","author":"V Yumuk","year":"2015","unstructured":"Yumuk\u00a0V, Tsigos\u00a0C, Fried\u00a0M, et\u00a0al. European guidelines for obesity management in adults. Obes Facts. 2015;8:402\u201324.","journal-title":"Obes Facts"},{"key":"1832_CR37","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.apmr.2010.11.023","volume":"92","author":"V Gremeaux","year":"2011","unstructured":"Gremeaux\u00a0V, Troisgros\u00a0O, Bena\u00efm\u00a0S, et al. Determining the minimal clinically important difference for the six-minute walk test and the 200-meter fast-walk test during cardiac rehabilitation program in coronary artery disease patients after acute coronary syndrome. Arch Phys Med Rehabil. 2011;92:611\u20139.","journal-title":"Arch Phys Med Rehabil"},{"key":"1832_CR38","first-page":"64","volume":"2","author":"M Stiggelbout","year":"2023","unstructured":"Stiggelbout\u00a0M, De Gecombineerde Leefstijlinterventie\u00a0RH. Goed Op Weg!? Ned Tijdschr Leefstijlgeneesk. 2023;2:64\u20139.","journal-title":"Goed Op Weg!? Ned Tijdschr Leefstijlgeneesk"},{"key":"1832_CR39","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s12471-020-01432-y","volume":"28","author":"RWM Brouwers","year":"2020","unstructured":"Brouwers\u00a0RWM, van Exel\u00a0HJ, van Hal\u00a0JMC, et al. Cardiac telerehabilitation as an alternative to centre-based cardiac rehabilitation. Neth Heart\u00a0J. 2020;28:443\u201351.","journal-title":"Neth Heart J"}],"container-title":["Netherlands Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-023-01832-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12471-023-01832-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12471-023-01832-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T11:19:28Z","timestamp":1704885568000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12471-023-01832-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["1832"],"URL":"https:\/\/doi.org\/10.1007\/s12471-023-01832-w","relation":{},"ISSN":["1568-5888","1876-6250"],"issn-type":[{"value":"1568-5888","type":"print"},{"value":"1876-6250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"19 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"I.\u00a0den Uijl, M.\u00a0Sunamura, R.M.W.\u00a0Brouwers, H.J.\u00a0Stam, E.\u00a0Boersma, R.J.G.\u00a0van den Berg-Emons and N.\u00a0ter Hoeve declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}