{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:03:44Z","timestamp":1778569424207,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>In refractory cardiogenic shock, temporary mechanical support (tMCS) may be crucial for maintaining tissue perfusion and oxygen delivery. tMCS can serve as a\u00a0bridge-to-decision to assess eligibility for left ventricular assist device (LVAD) implantation or heart transplantation, or as a\u00a0bridge-to-recovery. ECPELLA is a\u00a0novel tMCS configuration combining venoarterial extracorporeal membrane oxygenation with Impella. The present study presents the clinical parameters, outcomes, and complications of patients supported with ECPELLA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>All patients supported with ECPELLA at University Medical Centre Utrecht between December 2020 and August 2023 were included. The primary outcome was 30-day mortality, and secondary outcomes were LVAD implantation\/heart transplantation and safety outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty patients with an average age of 51\u00a0years, and of whom 70% were males, were included. Causes of cardiogenic shock were acute heart failure (due to acute coronary syndrome, myocarditis, or after cardiac surgery) or chronic heart failure, respectively 70\u00a0and 30% of cases. The median duration of ECPELLA support was 164\u202fh (interquartile range 98\u2013210). In 50% of cases, a\u00a0permanent LVAD was implanted. Cardiac recovery within 30\u00a0days was seen in 30% of cases and 30-day mortality rate was 20%. ECPELLA support was associated with major bleeding (40%), haemolysis (25%), vascular complications (30%), kidney failure requiring replacement therapy (50%), and Impella failure requiring extraction (15%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>ECPELLA can be successfully used as a\u00a0bridge to LVAD implantation or as a\u00a0bridge-to-recovery in patients with refractory cardiogenic shock. Despite a\u00a0significant number of complications, 30-day mortality was lower than observed in previous cohorts.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-024-01872-w","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T12:01:55Z","timestamp":1715083315000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["ECPELLA as a\u00a0bridge-to-decision in refractory cardiogenic shock: a\u00a0single-centre experience"],"prefix":"10.1007","volume":"32","author":[{"given":"Jan-Willem","family":"Balder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz K.","family":"Szymanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda W.","family":"van Laake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim","family":"van der Harst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiaan L.","family":"Meuwese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz Z.","family":"Ramjankhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon G.","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannine A. 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D.W.\u00a0Donker has received fees from Maquet Critical Care AB and HBOX GmbH, and reports research cooperation with Sonion BV. All financial compensation for these activities is paid to the University of Twente, Enschede, and no personal fees are received. M.I.F.J.\u00a0Oerlemans has received consultancy fees from Abbott, Medtronic, Vifor, Novartis, Pfizer and Alnylam, which were paid to the University Medical Centre Utrecht. A.O.\u00a0Kraaijeveld has received speaker fees from Abiomed. Outside the scope of this work, he has received speaker fees from Inari, consultancy fees from Boston Scientific and Pulsecath, and an institutional research grant from Xenios AG. These fees were paid to the University Medical Centre Utrecht. J.-W.\u00a0Balder, M.K.\u00a0Szymanski, P.\u00a0van der Harst, C.L.\u00a0Meuwese, F.Z.\u00a0Ramjankhan, M.G.\u00a0van der Meer, J.A.J.M.\u00a0Hermens, M.\u00a0Voskuil and E.E.C. de Waal declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}