{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T17:54:46Z","timestamp":1762106086475,"version":"build-2065373602"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Mortality rates in patients with cardiogenic shock complicating acute myocardial infarction (AMICS) remain high despite advancements in AMI care. Our study aimed to investigate the impact of prehospital symptom duration on the prognosis of AMICS patients and those receiving mechanical circulatory support (MCS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>We conducted a\u00a0retrospective cohort study with data registered in the Netherlands Heart Registration. A\u00a0total of 1,363 patients with AMICS who underwent percutaneous coronary intervention between 2017 and 2021 were included. Patients presenting after out-of-hospital cardiac arrest were excluded. Most patients were male (68%), with a\u00a0median age of 69\u00a0years (IQR 61\u201377), predominantly presenting with ST-elevation myocardial infarction (86%). The overall 30-day mortality was 32%. Longer prehospital symptom duration was associated with a\u00a0higher 30-day mortality with the following rates: &lt;\u202f3\u202fh, 26%; 3\u20136\u202fh, 29%; 6\u201324\u202fh, 36%; \u2265\u202f24\u202fh, 46%; <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001. In a\u00a0subpopulation of AMICS patients with MCS (<jats:italic>n<\/jats:italic>\u202f=\u2009332, 24%), symptom duration of &gt;\u202f24\u202fh was associated with significantly higher mortality compared to symptom duration of &lt;\u202f24\u202fh (59% vs 45%, <jats:italic>p<\/jats:italic>\u202f=\u20090.029). Multivariate analysis identified &gt;\u202f24\u202fh symptom duration, age and in-hospital cardiac arrest as predictors of 30-day mortality in MCS patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Prolonged prehospital symptom duration was associated with significantly increased 30-day mortality in patients presenting with AMICS. In AMICS patients treated with MCS, a\u00a0symptom duration of &gt;\u202f24\u202fh was an independent predictor of poor survival. These results emphasise the critical role of early recognition and intervention in the prognosis of AMICS patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12471-024-01881-9","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T19:01:42Z","timestamp":1719946902000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of symptom duration and mechanical circulatory support on prognosis in cardiogenic shock complicating acute myocardial infarction"],"prefix":"10.1007","volume":"32","author":[{"given":"Florien","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ca\u00efa","family":"Crooijmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"van \u2019t Veer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke J. 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A.O.\u00a0Kraaijeveld has received an institutional research grant from Xenios A.G. J.P.S.\u00a0Henriques is an Editor of the <i>Netherlands Heart Journal<\/i>.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}