{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:26:23Z","timestamp":1777047983175,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Aim<\/jats:title>\n            <jats:p>To evaluate the impact of the 2023 Dutch national guidelines for primary prevention implantable cardioverter-defibrillator (ICD) implantation on outcomes in non-ischaemic cardiomyopathy (NICM) patients and to assess the role of late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR) in predicting ICD therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective, single-centre observational exploratory cohort study included patients with NICM who received a\u00a0primary prevention single-chamber, dual-chamber or subcutaneous ICD between January 2008 and April 2022 and underwent LGE-CMR prior to implantation. Patients were classified into LGE+ and LGE\u2212 groups based on the presence of late enhancement detected by CMR. The primary endpoint was time to first appropriate ICD therapy. The secondary endpoint was all-cause mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of the 258 NICM patients in the database, a\u00a0total of 85\u00a0patients were included, of whom 41\u00a0had LGE on CMR. After a\u00a05-year follow-up period, appropriate ICD therapy occurred in 20% of the patients in the LGE+ group and 14% of patients in the LGE\u2212 group (<jats:italic>p<\/jats:italic>\u202f=\u20090.37). All-cause mortality was 7% in the LGE+ group and 14% in the LGE\u2212 group (<jats:italic>p<\/jats:italic>\u202f=\u20090.46). Multivariable analysis showed no parameters significantly associated with appropriate ICD therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Applying the 2023 national guidelines retrospectively on a\u00a0population of NICM patients with a\u00a0primary prevention ICD indication demonstrated no significant association between LGE on CMR and appropriate ICD therapy over a\u00a0follow-up period of 5\u00a0years. These findings underscore the need for further research and randomised trials to refine risk stratification and ICD implantation guidelines in NICM, ideally leveraging a\u00a0multicentre approach to address current limitations in sample size and enhance the generalisability of the results.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s12471-025-01946-3","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:32:39Z","timestamp":1743121959000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic value of late gadolinium enhancement cardiac MRI for ICD therapy in non-ischaemic cardiomyopathy"],"prefix":"10.1007","volume":"33","author":[{"given":"Luuk H. G. A.","family":"Hopman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marthe A. 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