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In recent years, several funding bodies, including the Dutch Heart Foundation, have launched numerous research initiatives and consortia in the Netherlands to address knowledge gaps in women. This article provides an overview of the current landscape of cardiovascular disease in women and emphasizes the critical need for continued investment in this field. One area with urgent knowledge gaps is the early detection, diagnosis, therapy, and prognosis of Angina with Non-Obstructive Coronary Arteries (ANOCA) in women with persistent signs and symptoms of ischemia. In the Netherlands, in recent years, we have established a\u00a0robust clinical infrastructure and a\u00a0translational framework that enables us to address these challenges. Additionally, we have performed implementation studies to fast-track knowledge on ANOCA in clinical practice, giving us a\u00a0unique opportunity to transform clinical care for women with signs and symptoms of ischemia. 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