{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:30:15Z","timestamp":1773711015879,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NWO-Vidi","award":["91717339"],"award-info":[{"award-number":["91717339"]}]},{"DOI":"10.13039\/501100022216","name":"Medical Delta","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022216","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CIRCULAR NWO","award":["NWA.1389.20.157"],"award-info":[{"award-number":["NWA.1389.20.157"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is increasing evidence that presentation, progression, and management of atrial arrhythmias, such as atrial fibrillation (AF), differ between women and men. Bachmann\u2019s bundle (BB) is the main route for interatrial conduction, and sex-related differences in structural and electrical remodeling of BB may contribute to differences in AF development between women and men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Investigate whether sex differences in the electrophysiological properties of BB assessed by high-resolution and density maps exist in patients with AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sinus rhythm at BB was recorded for 5\u202fs during cardiac surgery. Potential voltage, low-voltage area (LVA), conduction heterogeneity, unipolar potential morphology, and conduction velocity were assessed for both men and women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study population consisted of 108 patients (73\u00a0men, 35\u00a0women). Women had significantly lower potential voltages (5th\u00a0percentile: 0.7\u202fmV [0.6\u20131.0] vs 1.1\u202fmV [0.6\u20131.4],\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.028), more LVAs (10.8% [4.6\u201319.7] vs 4.3% [2.2\u201311.7],\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.012) and more long double potentials (11.1% [3.6\u201313.5] vs 5.0% [1.0\u201310.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.015) compared to men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed sex-related differences in the electrical remodeling of BB in AF patients. Women have a\u00a0higher proportion of low voltage potentials, and more abnormal potential morphologies compared to men. These findings may reflect sex-specific differences in the underlying substrate of AF at BB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12471-025-02001-x","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:22:57Z","timestamp":1762874577000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Men and women\u2019s hearts don\u2019t beat the same: Epicardial mapping of Bachmann\u2019s bundle"],"prefix":"10.1007","volume":"33","author":[{"given":"Anouk I.","family":"Freriks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole L. 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A.I.\u00a0Freriks, N.L.M.\u00a0de Kruijf, M.S.\u00a0van Schie, V.\u00a0Yildirim, P.\u00a0Knops, L.M.\u00a0Vos, Y.J.H.J.\u00a0Taverne and N.M.S.\u00a0de Groot declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}