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We assessed the association between various patient characteristics, intervention, and outcome variables, and HRQoL both prior to and one year after PVI, with specific attention to groups that did not improve or were still impaired in HRQoL post PVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational, retrospective multicenter cohort study within 8\u00a0hospitals participating in the Netherlands Heart Registration (NHR). Patients who underwent PVI between 2016 and 2019 and completed the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both prior to and one year after were included. Accepted cut-off values for impaired HRQoL and clinically important difference (CID) were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean AFEQT score (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u20092,534) was 55.6\u202f\u00b1\u200919.7 prior to intervention and 79.8\u202f\u00b1\u200920.2 after. Post-PVI, 39.5% of the population was still impaired in HRQoL (&lt;\u202f80\u00a0points), and 19.2% failed to achieve CID (delta \u2265\u202f5\u00a0points). Lower baseline AFEQT-score (odds ratio [OR], 0.96 [per 1\u2011point increase]; 95% CI, 0.96\u20130.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001) and female sex (odds ratio [OR], 1.42; 95% CI, 1.16\u20131.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001) were the most prominent related factors with impaired HRQoL post-PVI. Higher baseline AFEQT-score (odds ratio [OR], 1.04 [per 1\u2011point increase]; 95% CI, 1.04\u20131.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001) was strongly associated with failure to achieve CID.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite a\u00a0major increase in HRQoL across the population, over one-third of patients were still impaired in HRQoL post-PVI. Multiple factors were identified that may guide counselling of AF patients about treatment choice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12471-025-02014-6","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:51:21Z","timestamp":1768819881000},"page":"72-79","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality of life before and after catheter ablation (pulmonary vein isolation) for atrial fibrillation: Results from the Netherlands Heart Registration"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1994-1920","authenticated-orcid":false,"given":"Tom","family":"Oirbans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas S. S. 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T.\u00a0Oirbans, J.S.S.G.\u00a0de Jong, G.J.\u00a0van Steenbergen, A.\u00a0Adiyaman, B.A.\u00a0Schoonderwoerd, H.G.\u00a0Rijnhart-de Jong, P.H.\u00a0van der Voort, J.G.L.M.\u00a0Luermans, S.\u00a0Westra, W.\u00a0Kuijt, M.D.\u00a0van der Stoel, J.C.\u00a0Kelder and J.C.\u00a0Balt declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}