{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:10:45Z","timestamp":1784196645163,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neth Heart J"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinician-assessed symptoms are expected to agree with patient-perceived symptoms. However, patients may value the impact of symptoms on their health-related quality of life (HRQoL) differently from clinicians. This study aimed to evaluate the relationship between patient-perceived HRQoL and clinician-assessed symptom severity in patients with Heart Failure (HF) and Atrial Fibrillation (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Newly diagnosed HF and AF patients were prospectively included. Information on symptoms and HRQoL was collected at diagnosis and after 12\u00a0months during routine HF- and AF-outpatient clinic visits. Symptom severity was assessed by clinicians using the NYHA classification for HF and EHRA score for AF. HRQoL was assessed using the CaReQol-CHF (HF) and AFEQT (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Complete baseline and 12-month follow-up information was available for 254 HF patients and 765 AF patients. Moderate correlations were observed between NYHA classification and CaReQoL-CHF at diagnosis and follow-up (Spearman\u2019s \u03c1: HF\n                      <jats:sub>social<\/jats:sub>\n                      : 0.202 and 0.426, HF\n                      <jats:sub>physical<\/jats:sub>\n                      : 0.317 and 0.421, respectively), and between EHRA score and AFEQT (Spearman\u2019s \u03c1: \u22120.363 and \u22120.305). Clinician-assessed improvement in HF or AF symptoms from diagnosis to 12\u00a0months was associated with patient-reported improvement in HRQoL (HF\n                      <jats:sub>social<\/jats:sub>\n                      : F(250.2)\u202f=\u20093.11,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.046; HF\n                      <jats:sub>physical<\/jats:sub>\n                      : F(251.2)\u202f=\u200911.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001; and AF: F(762.2)\u202f=\u200925.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001). When clinicians reported unchanged or worsening symptoms, no significant HRQoL changes were reported by patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinician-assessed symptoms correlate moderately with patient-reported HRQoL, with large inter-individual variation in HRQoL. NYHA and EHRA classifications may not accurately reflect patient-perceived burden of disease over time. Incorporating patient-reported outcomes into routine care may better guide treatment, improve the identification of patients\u2019 needs, and support informed clinical and shared decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12471-026-02051-9","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:05:21Z","timestamp":1783350321000},"page":"274-282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinician-assessed NYHA and EHRA symptom classifications only moderately reflect patient-reported quality of life in heart failure and atrial fibrillation"],"prefix":"10.1007","volume":"34","author":[{"given":"Jeroen A. 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J.A.A.\u00a0van de Pol, F.J.\u00a0Hafkamp, P.H.\u00a0van der Voort, J.C.\u00a0Post, S.F.A.M.S.\u00a0de Jong, M.\u00a0Monroy, S.C.M.\u00a0Eijsbouts, A.R.T.\u00a0van de Ven and B.\u00a0Klop declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted according to the principles of the Declaration of Helsinki (version\u00a08, 2013), and was approved by the local Medical Ethical Review Board (Medical Research Ethics Committees United (MEC-U), Nieuwegein, The Netherlands, reference number: W17.156).","order":2,"name":"Ethics","label":"Ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}}]}}