{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:24:45Z","timestamp":1780323885165,"version":"3.54.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:00:00Z","timestamp":1485302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s12519-017-0002-0","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T00:02:03Z","timestamp":1485302523000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Identifying key genes associated with Hirschsprung\u2019s disease based on bioinformatics analysis of RNA-sequencing data"],"prefix":"10.1007","volume":"13","author":[{"given":"Wei-Kang","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Fei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Jun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"key":"2_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1053\/j.sempedsurg.2003.09.004","volume":"13","author":"P Puri","year":"2004","unstructured":"Puri P, Shinkai T. Pathogenesis of Hirschsprung\u2019s disease and its variants: recent progress. Semin Pediatr Surg 2004;13:18\u201324.","journal-title":"Semin Pediatr Surg"},{"key":"2_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11894-007-0026-z","volume":"9","author":"LF De","year":"2007","unstructured":"De LF, Boeckxstaens GE, Benninga MA. Symptomatology, pathophysiology, diagnostic work-up, and treatment of Hirschsprung disease in infancy and childhood. Curr Gastroenterol Rep 2007;9:245\u2013253.","journal-title":"Curr Gastroenterol Rep"},{"key":"2_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2013.03.001","volume":"162","author":"NE Butler Tjaden","year":"2013","unstructured":"Butler Tjaden NE, Trainor PA. The developmental etiology and pathogenesis of Hirschsprung disease. Transl Res 2013;162:1\u201315.","journal-title":"Transl Res"},{"key":"2_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jpedsurg.2004.09.052","volume":"40","author":"S Suita","year":"2005","unstructured":"Suita S, Taguchi T, Ieiri S, Nakatsuji T. Hirschsprung\u2019s disease in Japan: analysis of 3852 patients based on a nationwide survey in 30 years. J Pediatr Surg 2005;40:197\u2013202.","journal-title":"J Pediatr Surg"},{"key":"2_CR5","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1242\/dev.022319","volume":"135","author":"Y Okamura","year":"2008","unstructured":"Okamura Y, Saga Y. Notch signaling is required for the maintenance of enteric neural crest progenitors. Development 2008;135:3555\u20133565.","journal-title":"Development"},{"key":"2_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1136\/jmg.2005.040113","volume":"43","author":"L de Pontual","year":"2006","unstructured":"de Pontual L, Pelet A, Trochet D, Jaubert F, Espinosa-Parrilla Y, Munnich A, et al. Mutations of the RET gene in isolated and syndromic Hirschsprung\u2019s disease in human disclose major and modifier alleles at a single locus. J Med Genet 2006;43:419\u2013423.","journal-title":"J Med Genet"},{"key":"2_CR7","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1073\/pnas.0809630105","volume":"106","author":"MM Garcia-Barcelo","year":"2009","unstructured":"Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, et al. Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung\u2019s disease. Proc Natl Acad Sci U S A 2009;106:2694\u20132699.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2_CR8","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/jhg.2012.18","volume":"57","author":"T Phusantisampan","year":"2012","unstructured":"Phusantisampan T, Sangkhathat S, Phongdara A, Chiengkriwate P, Patrapinyokul S, Mahasirimongkol S. Association of genetic polymorphisms in the RET-protooncogene and NRG1 with Hirschsprung disease in Thai patients. J Hum Genet 2012;57:286\u2013293.","journal-title":"J Hum Genet"},{"key":"2_CR9","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1242\/dev.001388","volume":"134","author":"T Uesaka","year":"2007","unstructured":"Uesaka T, Jain S, Yonemura S, Uchiyama Y, Milbrandt J, Enomoto H. Conditional ablation of GFRa1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung\u2019s disease phenotype. Development 2007;134:2171\u20132181.","journal-title":"Development"},{"key":"2_CR10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1469-1809.2008.00479.x","volume":"73","author":"RM Fern\u00e1ndez","year":"2009","unstructured":"Fern\u00e1ndez RM, S\u00e1nchez-Mej\u00edas A, Mena M, Ruiz-Ferrer M, L\u00f3pez-Alonso M, Anti\u00f1olo G, et al. A novel point variant in NTRK3, R645C, suggests a role of this gene in the pathogenesis of Hirschsprung disease. Ann Hum Genet 2009;73:19\u201325.","journal-title":"Ann Hum Genet"},{"key":"2_CR11","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.jpedsurg.2008.02.076","volume":"43","author":"M Ruiz-Ferrer","year":"2008","unstructured":"Ruiz-Ferrer M, Fernandez RM, Anti\u00f1olo G, Lopez-Alonso M, Borrego S. NTF-3, a gene involved in the enteric nervous system development, as a candidate gene for Hirschsprung disease. J Pediatr Surg 2008;43:1308\u20131311.","journal-title":"J Pediatr Surg"},{"key":"2_CR12","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.3748\/wjg.v9.i12.2839","volume":"9","author":"X-L Duan","year":"2003","unstructured":"Duan X-L, Zhang X-S, Li G-W. Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung\u2019s disease. World J Gastroenterol 2003;9:2839.","journal-title":"World J Gastroenterol"},{"key":"2_CR13","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1093\/hmg\/ddh243","volume":"13","author":"VA Cantrell","year":"2004","unstructured":"Cantrell VA, Owens SE, Chandler RL, Airey DC, Bradley KM, Smith JR, et al. Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. Hum Mol Genet 2004;13:2289\u20132301.","journal-title":"Hum Mol Genet"},{"key":"2_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nrg2934","volume":"12","author":"F Ozsolak","year":"2011","unstructured":"Ozsolak F, Milos PM. RNA sequencing: advances, challenges and opportunities. Nat Rev Genet 2011;12:87\u201398.","journal-title":"Nat Rev Genet"},{"key":"2_CR15","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.jpedsurg.2011.11.017","volume":"47","author":"A Saeed","year":"2012","unstructured":"Saeed A, Barreto L, Neogii SG, Loos A, Mcfarlane I, Aslam A. Identification of novel genes in Hirschsprung disease pathway using whole genome expression study. J Pediatr Surg 2012;47:303\u2013307.","journal-title":"J Pediatr Surg"},{"key":"2_CR16","first-page":"61","volume-title":"Cancer Inform","author":"B Afsari","year":"2014","unstructured":"Afsari B, Geman D, Fertig EJ. Learning dysregulated pathways in cancers from differential variability analysis. Cancer Inform 2014:61."},{"key":"2_CR17","doi-asserted-by":"publisher","first-page":"e30619","DOI":"10.1371\/journal.pone.0030619","volume":"7","author":"RK Patel","year":"2012","unstructured":"Patel RK, Jain M. NGS QC Toolkit: a toolkit for quality control of next generation sequencing data. PLoS One 2012;7:e30619.","journal-title":"PLoS One"},{"key":"2_CR18","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome biol 2013;14:R36.","journal-title":"Genome biol"},{"key":"2_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/nar\/gkg129","volume":"31","author":"D Karolchik","year":"2003","unstructured":"Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu Y, et al. The UCSC genome browser database. Nucleic Acids Res 2003;31:51\u201354.","journal-title":"Nucleic Acids Res"},{"key":"2_CR20","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nprot.2012.016","volume":"7","author":"C Trapnell","year":"2012","unstructured":"Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 2012;7:562\u2013578.","journal-title":"Nat Protoc"},{"key":"2_CR21","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","volume-title":"Bioinformatics and computational biology solutions using R and Bioconductor","author":"GK Smyth","year":"2005","unstructured":"Smyth GK. Limma: linear models for microarray data. In: Gentleman R, Carey VJ, Huber W, Irizarry RA, Dudoit S, eds. Bioinformatics and computational biology solutions using R and Bioconductor. New York: Springer, 2005: 397\u2013420."},{"key":"2_CR22","doi-asserted-by":"publisher","first-page":"D331","DOI":"10.1093\/nar\/gkp1018","volume":"38","author":"GO Consortium","year":"2010","unstructured":"Consortium GO. The Gene Ontology in 2010: extensions and refinements. Nucleic acids research 2010;38:D331\u2013D335.","journal-title":"Nucleic acids research"},{"key":"2_CR23","doi-asserted-by":"publisher","first-page":"D480","DOI":"10.1093\/nar\/gkm882","volume":"36","author":"M Kanehisa","year":"2008","unstructured":"Kanehisa M, Araki M, Goto S, Hattori M, Hirakawa M, Itoh M, et al. KEGG for linking genomes to life and the environment. Nucleic Acids Res 2008;36:D480\u2013D484.","journal-title":"Nucleic Acids Res"},{"key":"2_CR24","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43:D447\u2013D52.","journal-title":"Nucleic Acids Res."},{"key":"2_CR25","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nmeth.2212","volume":"9","author":"R Saito","year":"2012","unstructured":"Saito R, Smoot ME, Ono K, Ruscheinski J, Wang P-L, Lotia S, et al. A travel guide to Cytoscape plugins. Nat Methods 2012;9:1069\u20131076.","journal-title":"Nat Methods"},{"key":"2_CR26","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2105-4-2","volume":"4","author":"GD Bader","year":"2003","unstructured":"Bader GD, Hogue CW. An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics 2003;4:2.","journal-title":"BMC Bioinformatics"},{"key":"2_CR27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1365-2982.2008.01094.x","volume":"20","author":"JB Furness","year":"2008","unstructured":"Furness JB. The enteric nervous system: normal functions and enteric neuropathies. Neurogastroenterol Motil 2008;20 Suppl 1:32\u201338.","journal-title":"Neurogastroenterol Motil"},{"key":"2_CR28","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.tins.2010.06.002","volume":"33","author":"MD Gershon","year":"2010","unstructured":"Gershon MD. Developmental determinants of the independence and complexity of the enteric nervous system. Trends Neurosci 2010;33:446\u2013456.","journal-title":"Trends Neurosci"},{"key":"2_CR29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/wdev.57","volume":"2","author":"SJ McKeown","year":"2013","unstructured":"McKeown SJ, Stamp L, Hao MM, Young HM. Hirschsprung disease: a developmental disorder of the enteric nervous system. Wiley Interdiscip Rev Dev Biol 2013;2:113\u2013129.","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"2_CR30","first-page":"2442","volume":"43","author":"T Oshitari","year":"2002","unstructured":"Oshitari T, Dezawa M, Okada S, Takano M, Negishi H, Horie H, et al. The role of c-fos in cell death and regeneration of retinal ganglion cells. Invest Ophthalmol Vis Sci 2002;43:2442\u20132449.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2_CR31","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.expneurol.2004.01.020","volume":"187","author":"BM Howe","year":"2004","unstructured":"Howe BM, Bruno SB, Higgs KA, Stigers RL, Cunningham JT. FosB expression in the central nervous system following isotonic volume expansion in unanesthetized rats. Exp Neurol 2004;187:190\u2013198.","journal-title":"Exp Neurol"},{"key":"2_CR32","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/cne.22370","volume":"518","author":"H Horita","year":"2010","unstructured":"Horita H, Wada K, Rivas MV, Hara E, Jarvis ED. The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons. J Comp Neurol 2010;518:2873\u20132901.","journal-title":"J Comp Neurol"},{"key":"2_CR33","doi-asserted-by":"publisher","first-page":"4018","DOI":"10.4049\/jimmunol.172.7.4018","volume":"172","author":"WG Glass","year":"2004","unstructured":"Glass WG, Hickey MJ, Hardison JL, Liu MT, Manning JE, Lane TE. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol 2004;172:4018\u20134025.","journal-title":"J Immunol"},{"key":"2_CR34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1006\/viro.2001.1050","volume":"288","author":"WG Glass","year":"2001","unstructured":"Glass WG, Liu MT, Kuziel WA, Lane TE. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology 2001;288:8\u201317.","journal-title":"Virology"},{"key":"2_CR35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1128\/JVI.77.1.191-198.2003","volume":"77","author":"WG Glass","year":"2003","unstructured":"Glass WG, Lane TE. Functional expression of chemokine receptor CCR5 on CD4+ T cells during virus-induced central nervous system disease. J Virol 2003;77:191\u2013198.","journal-title":"J Virol"},{"key":"2_CR36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0042-6822(03)00237-X","volume":"312","author":"WG Glass","year":"2003","unstructured":"Glass WG, Lane TE. Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system. Virology 2003;312:407\u2013414.","journal-title":"Virology"},{"key":"2_CR37","doi-asserted-by":"publisher","first-page":"15547","DOI":"10.1523\/JNEUROSCI.0412-12.2012","volume":"32","author":"S Farioli-Vecchioli","year":"2012","unstructured":"Farioli-Vecchioli S, Cin\u00e0 I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, et al. Tis 21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons. J Neurosci 2012;32:15547\u201315564.","journal-title":"J Neurosci"},{"key":"2_CR38","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1006\/mcne.1999.0814","volume":"15","author":"H Tsujino","year":"2000","unstructured":"Tsujino H, Kondo E, Fukuoka T, Dai Y, Tokunaga A, Miki K, et al. Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury. Mol Cell Neurosci 2000;15:170\u2013182.","journal-title":"Mol Cell Neurosci"},{"key":"2_CR39","doi-asserted-by":"publisher","first-page":"7911","DOI":"10.1523\/JNEUROSCI.5313-06.2007","volume":"27","author":"R Seijffers","year":"2007","unstructured":"Seijffers R, Mills CD, Woolf CJ. ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration. J Neurosci 2007;27:7911\u20137920.","journal-title":"J Neurosci"},{"key":"2_CR40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fnmol.2012.00007","volume":"5","author":"D Hunt","year":"2012","unstructured":"Hunt D, Raivich G, Anderson PN. Activating transcription factor 3 and the nervous system. Front Mol Neurosci 2012;5:7.","journal-title":"Front Mol Neurosci"},{"key":"2_CR41","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.mcn.2006.03.005","volume":"32","author":"R Seijffers","year":"2006","unstructured":"Seijffers R, Allchorne AJ, Woolf CJ. The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci 2006;32:143\u2013154.","journal-title":"Mol Cell Neurosci"},{"key":"2_CR42","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.molbrainres.2003.09.014","volume":"120","author":"AG Pearson","year":"2003","unstructured":"Pearson AG, Gray CW, Pearson JF, Greenwood JM, During MJ, Dragunow M. ATF3 enhances c-Jun-mediated neurite sprouting. Mol Brain Res 2003;120:38\u201345.","journal-title":"Mol Brain Res"},{"key":"2_CR43","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0016-5085(19)32133-X","volume":"73","author":"D Waldman","year":"1977","unstructured":"Waldman D, Gardner J, Zfass A, Makhlouf G. Effects of vasoactive intestinal peptide, secretin, and related peptides on rat colonic transport and adenylate cyclase activity. Gastroenterology 1977;73:518\u2013523.","journal-title":"Gastroenterology"},{"key":"2_CR44","doi-asserted-by":"publisher","first-page":"G262","DOI":"10.1152\/ajpcell.00070.2005","volume":"290","author":"FH Mourad","year":"2006","unstructured":"Mourad FH, Barada KA, Rached NAB, Khoury CI, Saad\u00e9 NE, Nassar CF. Inhibitory effect of experimental colitis on fluid absorption in rat jejunum: role of the enteric nervous system, VIP, and nitric oxide. Am J Physiol-Gastrl 2006;290:G262\u2013G268.","journal-title":"Am J Physiol-Gastrl"},{"key":"2_CR45","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0008-6363(99)00115-7","volume":"43","author":"PJ Andrew","year":"1999","unstructured":"Andrew PJ, Mayer B. Enzymatic function of nitric oxide synthases. Cardiovasc Res 1999;43:521\u2013531.","journal-title":"Cardiovasc Res"},{"key":"2_CR46","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.coph.2014.07.009","volume":"19","author":"TC Savidge","year":"2014","unstructured":"Savidge TC. Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility. Curr Opin Pharmacol 2014;19:54\u201360.","journal-title":"Curr Opin Pharmacol"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-017-0002-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-017-0002-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-017-0002-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:02:04Z","timestamp":1744164124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-017-0002-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,25]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["2"],"URL":"https:\/\/doi.org\/10.1007\/s12519-017-0002-0","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,25]]},"assertion":[{"value":"23 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}