{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:53:37Z","timestamp":1788173617198,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400576"],"award-info":[{"award-number":["81400576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s12519-018-0203-1","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T01:52:52Z","timestamp":1542765172000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Liver fibrosis in biliary atresia"],"prefix":"10.1007","volume":"15","author":[{"given":"Wen-Jun","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"203_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1055\/s-2007-1007164","volume":"18","author":"MD Bates","year":"1998","unstructured":"Bates MD, Bucuvalas JC, Alonso MH, Ryckman FC. Biliary atresia: pathogenesis and treatment. Semin Liver Dis. 1998;18:281\u201393.","journal-title":"Semin Liver Dis"},{"key":"203_CR2","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.jpeds.2015.08.041","volume":"167","author":"K Bessho","year":"2015","unstructured":"Bessho K. Complications and quality of life in long-term survivors of biliary atresia with their native livers. J Pediatr. 2015;167:1202\u20136.","journal-title":"J Pediatr"},{"key":"203_CR3","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1002\/lt.21303","volume":"13","author":"BL Shneider","year":"2007","unstructured":"Shneider BL, Mazariegos GV. Biliary atresia: a transplant perspective. Liver Transpl. 2007;13:1482\u201395.","journal-title":"Liver Transpl"},{"key":"203_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1399-3046.2008.00947.x","volume":"13","author":"NE Gibeli","year":"2009","unstructured":"Gibeli NE, Tanuri U, de Mello ES, Rodrigues CJ. Bile duct ligation in neonatal rats: is it a valid experimental model for biliary atresia studies? Pediatr Transplant. 2009;13:81\u20138.","journal-title":"Pediatr Transplant"},{"key":"203_CR5","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1002\/hep.21366","volume":"44","author":"CI Mack","year":"2006","unstructured":"Mack CI, Tuker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, et al. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 2006;44:1231\u20139.","journal-title":"Hepatology"},{"key":"203_CR6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.jpedsurg.2007.10.023","volume":"43","author":"S Shimadera","year":"2008","unstructured":"Shimadera S, Iwai N, Deguchi E, Kimura O, Ono S, Fumino S, et al. Significance of ductal plate malformation in the postoperative clinical course of biliary atresia. J Pediatr Surg. 2008;43:304\u20137.","journal-title":"J Pediatr Surg"},{"key":"203_CR7","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s00383-015-3728-6","volume":"31","author":"M Safwan","year":"2015","unstructured":"Safwan M, Ramachandran P, Vij M, Shanmugam N, Rela M. Impact of ductal plate malformation on survival with native liver in children with biliary atresia. Pediatr Surg Int. 2015;31:837\u201343.","journal-title":"Pediatr Surg Int"},{"key":"203_CR8","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1053\/jpsu.2000.8760","volume":"35","author":"V Vijayan","year":"2000","unstructured":"Vijayan V, El Tan C. Computer-generated three-dimensional morphology of the hepatic hilar bile ducts in biliary atresia. J Pediatr Surg. 2000;35:1230\u20135.","journal-title":"J Pediatr Surg"},{"key":"203_CR9","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/hep.510240318","volume":"24","author":"J Cocjin","year":"1996","unstructured":"Cocjin J, Rosenthal P, Buslon V, Luk L Jr, Barajas L, Geller SA, et al. Bile ductule formation in fetal, neonatal, and infant livers compared with extrahepatic biliary atresia. Hepatology. 1996;24:568\u201374.","journal-title":"Hepatology"},{"key":"203_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","volume":"115","author":"R Bataller","year":"2005","unstructured":"Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209\u201318.","journal-title":"J Clin Invest."},{"key":"203_CR11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00428-011-1048-3","volume":"458","author":"VJ Desmet","year":"2011","unstructured":"Desmet VJ. Ductal plates in hepatic ductular reactions. Hypothesis and implications. I. Types of ductular reaction reconsidered. Virchows Arch. 2011;458:251\u20139.","journal-title":"Virchows Arch"},{"key":"203_CR12","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1002\/stem.1167","volume":"30","author":"LA Stamp","year":"2012","unstructured":"Stamp LA, Braxton DR, Wu J, Akopian V, Hasegawa K, Chandrasoma PT, et al. The GCTM-5 epitope associated with the muciun-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stem Cells. 2012;30:1999\u20132009.","journal-title":"Stem Cells."},{"key":"203_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/hep.27203","volume":"60","author":"N Mavila","year":"2014","unstructured":"Mavila N, James D, Shivakumar P, Nguyen MV, Utley S, Mak K, et al. Expansion of promnin-1-expressing cells in association with fibrosis of biliary atresia. Hepatology. 2014;60:941\u201353.","journal-title":"Hepatology"},{"key":"203_CR14","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jpeds.2005.12.054","volume":"148","author":"BL Shneider","year":"2006","unstructured":"Shneider BL, Brown MB, Haber B, Whitington PF, Schwarz K, Squires R, et al. A multicenter study of the outcome of biliary atresia in the United States, 1997 to 2000. J Pediatr. 2006;148:467\u201374.","journal-title":"J Pediatr"},{"key":"203_CR15","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1002\/hep.26512","volume":"58","author":"KB Schwarz","year":"2013","unstructured":"Schwarz KB, Haber BH, Rosenthal P, Mack CL, Moore J, Bove K, et al. Extrahepatic anomalies in infants with biliary atresia: results of a large prospective North American multicenter study. Hepatology. 2013;58:1724\u201331.","journal-title":"Hepatology"},{"key":"203_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/01.mpg.0000304465.60788.f4","volume":"46","author":"A Davit-Spraul","year":"2008","unstructured":"Davit-Spraul A, Baussan C, Hermeziu B, Bernard O, Jacquemin E. CFC1 gene involvement in biliary atresia with polysplenia syndrome. J Pediatr Gastroenterol Nutr. 2008;46:111\u20132.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"203_CR17","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1111\/j.1478-3231.2011.02578.x","volume":"31","author":"OR Guttman","year":"2011","unstructured":"Guttman OR, Roberts EA, Schreiber RA, Barker CC, Ng VL. Canadian pediatric hepatology research group. Biliary atresia with associated structural malformations in Canadian infants. Liver Int. 2011;31:1485\u201393.","journal-title":"Liver Int."},{"key":"203_CR18","first-page":"1024","volume":"36","author":"ML Wells","year":"2016","unstructured":"Wells ML, Fenstad ER, Poterucha JT, Hough DM, Young PM, Araoz PA, et al. Imaging findings of congestive hepatopathy. Radioqraphics. 2016;36:1024\u201337.","journal-title":"Imaging findings of congestive hepatopathy. Radioqraphics."},{"key":"203_CR19","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jhep.2014.11.027","volume":"62","author":"Y Nakanuma","year":"2015","unstructured":"Nakanuma Y, Sasaki M, Harada K. Autophagy and senescence in fibrosing cholangiopathies. J Hepatol. 2015;62:934\u201345.","journal-title":"J Hepatol"},{"key":"203_CR20","doi-asserted-by":"publisher","first-page":"373878","DOI":"10.1155\/2010\/373878","volume":"2010","author":"K Harada","year":"2010","unstructured":"Harada K, Nakanuma Y. Biliary innate immunity: function and modulation. Mediators Inflamm. 2010;2010:373878.","journal-title":"Mediators Inflamm"},{"key":"203_CR21","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/j.jpedsurg.2015.03.001","volume":"50","author":"A Zani","year":"2015","unstructured":"Zani A, Quaglia A, Hadzi\u0107 N, Zuckerman M, Davenport M. Cytomegalovirus-associated biliary atresia: an aetiological and prognostic subgroup. J Pediatr Surg. 2015;50:1739\u201345.","journal-title":"J Pediatr Surg"},{"key":"203_CR22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1055\/s-2007-985068","volume":"27","author":"CL Mack","year":"2007","unstructured":"Mack CL. The pathogenesis of biliary atresia: evidence for a virus-induced autoimmune disease. Semin Liver Dis. 2007;27:233\u201342.","journal-title":"Semin Liver Dis"},{"key":"203_CR23","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00431-008-0774-2","volume":"168","author":"S Rauschenfels","year":"2009","unstructured":"Rauschenfels S, Krassmann M, Al-Masri AN, Verhagen W, Leonhardt J, Kuebler JF, et al. Incidence of hepatotropic viruses in biliary atresia. Eur J Pediatr. 2009;168:469\u201376.","journal-title":"Eur J Pediatr"},{"key":"203_CR24","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/ajcn\/48.5.1211","volume":"48","author":"A Kobayashi","year":"1988","unstructured":"Kobayashi A, Kawai S, Ohbe Y, Benno Y. Fecal flora of infants with biliary atresia: effects of the absence of bile on fecal flora. Am J Clin Nutr. 1988;48:1211\u20133.","journal-title":"Am J Clin Nutr"},{"key":"203_CR25","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/jpc.12463","volume":"50","author":"JY Lee","year":"2014","unstructured":"Lee JY, Lim LT, Quak SH, Prabhakaran K, Aw M. Cholangitis in children with biliary atresia: health-care resource utilisation. J Paediatr Child Health. 2014;50:196\u2013201.","journal-title":"J Paediatr Child Health"},{"key":"203_CR26","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1097\/MPG.0000000000000676","volume":"60","author":"TH Lien","year":"2015","unstructured":"Lien TH, Bu LN, Wu JF, Chen HL, Chen AC, Lai MW, et al. Use of Lactobacillus casei rhamnosus to prevent cholangitis in biliary atresia after Kasai pperation. J Pediatr Gastroenterol Nutr. 2015;60:654\u20138.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"203_CR27","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1053\/jpsu.2003.50128","volume":"38","author":"LN Bu","year":"2003","unstructured":"Bu LN, Chen HL, Chang CJ, Ni YH, Hsu HY, Lai HS, et al. Prophylactic oral antibiotics in prevention of recurrent cholangitis after the Kasai portoenterostomy. J Pediatr Surg. 2003;38:590\u20133.","journal-title":"J Pediatr Surg"},{"key":"203_CR28","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1016\/j.jpedsurg.2015.03.001","volume":"50","author":"A Zani","year":"2015","unstructured":"Zani A, Quaqlia A, Hadzi\u0107 N, Zuckerman M, Davenport M. Cytomegalovirus-associated biliary atresia: an aetiological and prognostic subgroup. J Pediatr Surg. 2015;50:1739\u201345.","journal-title":"J Pediatr Surg"},{"key":"203_CR29","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.jpedsurg.2005.05.007","volume":"40","author":"MA Kotb","year":"2005","unstructured":"Kotb MA, El Henawy A, Talaat S, Aziz M, El Tagy GH, El Barbary MM, et al. Immune-mediated liver injury: prognostic value of CD4\u2009+\u2009, CD8\u2009+\u2009, and CD68\u2009+\u2009in infants with extrahepatic biliary atresia. J Pediatr Surg. 2005;40:1252\u20137.","journal-title":"J Pediatr Surg"},{"key":"203_CR30","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1053\/j.sempedsurg.2012.05.003","volume":"21","author":"AG Feldman","year":"2012","unstructured":"Feldman AG, Mack CL. Biliary atresia: cellular dynamics and immune dysregulation. Semin Pediatr Surg. 2012;21:192\u2013200.","journal-title":"Semin Pediatr Surg"},{"key":"203_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1055\/s-0032-1306260","volume":"22","author":"P Vejchapipat","year":"2012","unstructured":"Vejchapipat P, Poomsawat S, Chongsrisawat V, Honsawek S, Poovorawan Y. Elevated serum IL-18 and interferon-gamma in medium-term survivors of biliary atresia. Eur J Pediatr Surg. 2012;22:29\u201333.","journal-title":"Eur J Pediatr Surg"},{"key":"203_CR32","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1053\/j.gastro.2010.07.042","volume":"139","author":"BR Lu","year":"2010","unstructured":"Lu BR, Brindley SM, Tucker RM, Lambert CL, Mack CL. \u03b1-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia. Gastroenterology. 2010;139:1753\u201361.","journal-title":"Gastroenterology"},{"key":"203_CR33","doi-asserted-by":"publisher","first-page":"5778","DOI":"10.1016\/j.vaccine.2013.07.023","volume":"31","author":"PM Hertel","year":"2013","unstructured":"Hertel PM, Crawford SE, Bessard BA, Estes MK. Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles. Vaccine. 2013;31:5778\u201384.","journal-title":"Vaccine."},{"key":"203_CR34","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1002\/hep.28947","volume":"65","author":"SK Mohanty","year":"2017","unstructured":"Mohanty SK, Donnelly B, Lobeck I, Walther A, Dupree P, Coots A, et al. The SRL peptide of rhesus rotavirus VP4 protein governs cholangiocyte infection and the murine model of biliary atresia. Hepatology. 2017;65:1278\u201392.","journal-title":"Hepatology"},{"key":"203_CR35","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/hep.24106","volume":"53","author":"RP Matthews","year":"2011","unstructured":"Matthews RP, Eauclaire SF, Mugnier M, Lorent K, Cui S, Ross MM, et al. DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia. Hepatology. 2011;53:905\u201314.","journal-title":"Hepatology"},{"issue":"8","key":"203_CR36","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/1479-5876-8-138","volume":"21","author":"MH Chou","year":"2010","unstructured":"Chou MH, Chuang JH, Eng HL, Chen CM, Wang CH, Chen CL, et al. Endotoxin and CD14 in the progression of biliary atresia. J Transl Med. 2010;21(8):138.","journal-title":"J Transl Med."},{"key":"203_CR37","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1053\/j.gastro.2007.04.031","volume":"133","author":"P Shivakumar","year":"2007","unstructured":"Shivakumar P, Sabla G, Mohanty S, McNeal M, Ward R, Stringer K, et al. Effector role of neonatal hepatic CD8\u2009+\u2009lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology. 2007;133:268\u201377.","journal-title":"Gastroenterology"},{"key":"203_CR38","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1172\/JCI73742","volume":"124","author":"J Li","year":"2014","unstructured":"Li J, Rzaumilava N, Gores GJ, Walters S, Mizuochi T, Mourya R, et al. Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest. 2014;124:3241\u201351.","journal-title":"J Clin Invest."},{"key":"203_CR39","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1111\/j.1582-4934.2009.00801.x","volume":"14","author":"P Marvie","year":"2010","unstructured":"Marvie P, Lisbonne M, L\u2019helgoualc\u2019h A, Rauch M, Turlin B, Preisser L, et al. Interlecukin-33 overexpression is associated with liver fibrosis in mice and humans. J Cell Mol Med. 2010;14:1726\u201339.","journal-title":"J Cell Mol Med."},{"key":"203_CR40","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jhep.2013.05.010","volume":"59","author":"RM Tucker","year":"2013","unstructured":"Tucker RM, Feldman AG, Fenner EK, Mack CL. Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol. 2013;59:790\u20136.","journal-title":"J Hepatol"},{"key":"203_CR41","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/hep.24807","volume":"55","author":"SM Brindley","year":"2012","unstructured":"Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012;55:1130\u20138.","journal-title":"Hepatology"},{"key":"203_CR42","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.jpedsurg.2015.02.005","volume":"50","author":"R Hill","year":"2015","unstructured":"Hill R, Quaqlia A, Hussain M, Hadzic N, Mieli-Vergani G, Vergani D, et al. Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome. J Pediatr Surg. 2015;50:1297\u2013303.","journal-title":"J Pediatr Surg"},{"key":"203_CR43","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s00383-013-3421-6","volume":"29","author":"Y Yang","year":"2013","unstructured":"Yang Y, Liu YJ, Tang ST, Yang L, Yang J, Cao GQ, et al. Elevated Th17 cells accompanied by decreased regulatory T cells and cytokine environment in infants with biliary atresia. Pediatr Surg Int. 2013;29:1249\u201360.","journal-title":"Pediatr Surg Int"},{"key":"203_CR44","first-page":"250","volume":"91","author":"F Schulze","year":"2007","unstructured":"Schulze F, Schardt K, Wedemeyer I, Konze E, Wendland K, Dirsch O, et al. Epithelial\u2013mesenchyal transition of biliary epithelial cells in advanced liver fibrosis. Verh Dtsch Ges Pathol. 2007;91:250\u20136 (in German).","journal-title":"Verh Dtsch Ges Pathol"},{"key":"203_CR45","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.bbrc.2009.11.056","volume":"39","author":"T Ogawa","year":"2010","unstructured":"Ogawa T, Lizuka M, Sekiya Y, Yoshizato K, Ikeda K, Kawada N. Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun. 2010;39:316\u201321.","journal-title":"Biochem Biophys Res Commun"},{"key":"203_CR46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.molimm.2014.10.021","volume":"64","author":"S Amara","year":"2015","unstructured":"Amara S, Lopez K, Banan B, Brown SK, Whalen M, Myles E, et al. Synergistic effect of pro-inflammatory TNF\u03b1 and IL-17 in periostin mediated collagen deposition: potential role in liver fibrosis. Mol Immunol. 2015;64:26\u201335.","journal-title":"Mol Immunol"},{"key":"203_CR47","doi-asserted-by":"publisher","first-page":"22089","DOI":"10.1074\/jbc.M700998200","volume":"282","author":"A Kaimori","year":"2007","unstructured":"Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A. Transforming growth factor-betal induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem. 2007;282:22089\u2013101.","journal-title":"J Biol Chem"},{"key":"203_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1055\/s-0034-1389906","volume":"227","author":"T Whitby","year":"2015","unstructured":"Whitby T, Schroeder D, Kim HS, Petersen C, Dirsch O, Baumann U, et al. Modifications in integrin expression and extracellular matrix composition in children with biliary atresia. Klin Padiatr. 2015;227:15\u201322.","journal-title":"Klin Padiatr"},{"key":"203_CR49","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/modpathol.3800374","volume":"18","author":"CC Huang","year":"2005","unstructured":"Huang CC, Chuang JH, Chou MH, Wu CL, Chen CM, Wang CC, et al. Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. Mod Pathol. 2005;18:941\u201350.","journal-title":"Mod Pathol"},{"key":"203_CR50","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cjp2.50","volume":"2","author":"A Kerola","year":"2016","unstructured":"Kerola A, Lampela H, Lohi J, Heikkil\u00e4 P, Mutanen A, Hagstr\u00f6m J, et al. Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia. J Pathol Clin Res. 2016;2:187\u201398.","journal-title":"J Pathol Clin Res."},{"key":"203_CR51","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s10620-010-1347-6","volume":"56","author":"YH Deng","year":"2011","unstructured":"Deng YH, Pu CL, Li YC, Zhu J, Xiang C, Zhang MM, et al. Analysis of biliary epithelial\u2013mesenchymal transition in portal tract fibrogenesis in biliary atresia. Dig Dis Sci. 2011;56:731\u201340.","journal-title":"Dig Dis Sci"},{"key":"203_CR52","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15017217","author":"FB Li","year":"2016","unstructured":"Li FB, Zhao H, Peng KR, Gao ZG, Huang SJ, Tou JF, et al. Expression of transforming growth factor-\u03b21 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue. Genet Mol Res. 2016. \n                    https:\/\/doi.org\/10.4238\/gmr.15017217\n                    \n                  .","journal-title":"Genet Mol Res."},{"key":"203_CR53","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/pr.2014.181","volume":"77","author":"Y Xiao","year":"2015","unstructured":"Xiao Y, Zhou Y, Chen Y, Zhou K, Wen J, Wang Y, et al. The expression of epithelial\u2013mesenchymal transition-related proteins in biliary epithelial cells is associated with liver fibrosis in biliary atresia. Pediatr Res. 2015;77:310\u20135.","journal-title":"Pediatr Res."},{"key":"203_CR54","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","volume":"95","author":"CG Miao","year":"2013","unstructured":"Miao CG, Yang YY, He X, Huang C, Huang Y, Zhang L, et al. Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie. 2013;95:2326\u201335.","journal-title":"Biochimie"},{"key":"203_CR55","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00795-016-0149-0","volume":"50","author":"K Kurioka","year":"2017","unstructured":"Kurioka K, Wato M, Iseki T, Tanaka A, Morita S. Differential expression of the epithelial mesenchymal transition factors Snail, Slug, Twist, TGF-\u03b2, and E-cadherin in ameloblastoma. Med Mol Morphol. 2017;50:68\u201375.","journal-title":"Med Mol Morphol."},{"key":"203_CR56","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3748\/wjg.v16.i3.281","volume":"16","author":"C Paternostro","year":"2010","unstructured":"Paternostro C, David E, Novo E, Parola M. Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases. World J Gastroenterol. 2010;16:281\u20138.","journal-title":"World J Gastroenterol"},{"key":"203_CR57","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1053\/jhep.2002.32524","volume":"35","author":"C Corpechot","year":"2002","unstructured":"Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology. 2002;35:1010\u201321.","journal-title":"Hepatology"},{"key":"203_CR58","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/MCG.0b013e3181b152c2","volume":"44","author":"HC Lee","year":"2010","unstructured":"Lee HC, Chang TY, Yeung CY, Chan WT, Jiang CB, Chen WF, et al. Genetic variation in the vascular endothelial growth factor gene is associated with biliary atresia. J Clin Gastroenterol. 2010;44:135\u20139.","journal-title":"J Clin Gastroenterol"},{"key":"203_CR59","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","volume":"146","author":"L Yang","year":"2014","unstructured":"Yang L, Kwon J, Popv Y, Gajdos GB, Ordog T, Brekken RA, et al. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014;146:1339\u201350.","journal-title":"Gastroenterology"},{"key":"203_CR60","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1002\/hep.27376","volume":"61","author":"LD DeLeve","year":"2015","unstructured":"DeLeve LD. Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015;61:1740\u20136.","journal-title":"Hepatology"},{"key":"203_CR61","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/liv.12034","volume":"33","author":"Y Liu","year":"2013","unstructured":"Liu Y, Wang Z, Wang J, Lam W, Kwong S, Li F, et al. A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-\u03b2 and vascular endothelial growth factor signaling. Liver Int. 2013;33:504\u201315.","journal-title":"Liver Int."},{"key":"203_CR62","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3892\/mmr.2013.1493","volume":"8","author":"ZY Yu","year":"2013","unstructured":"Yu ZY, Bai YN, Luo LX, Wu H, Zeng Y. Expression of microRNA-150 targeting vascular endothelial growth factor-A is downregulated under hypoxia during liver regeneration. Mol Med Rep. 2013;8:287\u201393.","journal-title":"Mol Med Rep."},{"key":"203_CR63","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.jhep.2010.07.004","volume":"53","author":"D Thabut","year":"2010","unstructured":"Thabut D, Shah V. Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension? J Hepatol. 2010;53:976\u201380.","journal-title":"J Hepatol"},{"key":"203_CR64","doi-asserted-by":"publisher","first-page":"e92273","DOI":"10.1371\/journal.pone.0092273","volume":"9","author":"l Nakamura","year":"2014","unstructured":"Nakamura l, Zakharia K, Banini BA, Mikhail DS, Kim TH, Yang JD, et al. Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling. PLoS One. 2014;9:e92273.","journal-title":"PLoS One"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-018-0203-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12519-018-0203-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-018-0203-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T19:44:00Z","timestamp":1574279040000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12519-018-0203-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,21]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["203"],"URL":"https:\/\/doi.org\/10.1007\/s12519-018-0203-1","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,21]]},"assertion":[{"value":"18 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work had the permit from IRB of the Children\u2019s Hospital of Fudan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors have no conflicts of interest or ties to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}