{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:30:56Z","timestamp":1780471856645,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Zhejiang Medical and Health Science and Technology Project","award":["No. 2017KY440"],"award-info":[{"award-number":["No. 2017KY440"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s12519-019-00314-7","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T14:03:26Z","timestamp":1569247406000},"page":"205-209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of Epstein\u2013Barr virus infection and characteristics of lymphocyte subsets in newly onset juvenile dermatomyositis"],"prefix":"10.1007","volume":"17","author":[{"given":"Qi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Na","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-9493","authenticated-orcid":false,"given":"Mei-Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"314_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/art.11122","volume":"49","author":"EP Mendez","year":"2003","unstructured":"Mendez EP, Lipton R, Ramsey-Goldman R, Roettcher P, Bowyer S, Dyer A, et al. US incidence of juvenile dermatomyositis, 1995\u20131998: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Registry. Arthritis Rheum. 2003;49:300\u20135.","journal-title":"Arthritis Rheum"},{"key":"314_CR2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/joim.12444","volume":"280","author":"LG Rider","year":"2016","unstructured":"Rider LG, Nistala K. The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes. J Intern Med. 2016;280:24\u201338.","journal-title":"J Intern Med"},{"key":"314_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2165\/11310550-000000000-00000","volume":"11","author":"AM Huber","year":"2009","unstructured":"Huber AM. Juvenile dermatomyositis advances in pathogenesis, evaluation, and treatment. Pediatr Drugs. 2009;11:361\u201374.","journal-title":"Pediatr Drugs"},{"key":"314_CR4","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1002\/art.22216","volume":"54","author":"G Mamyrova","year":"2006","unstructured":"Mamyrova G, O'Hanlon TP, Monroe JB, Carrick DM, Malley JD, Adams S, et al. Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis Rheum. 2006;54:3979\u201387.","journal-title":"Arthritis Rheum."},{"key":"314_CR5","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1093\/rheumatology\/kem265","volume":"46","author":"LR Wedderburn","year":"2007","unstructured":"Wedderburn LR, McHugh N, Chinoy H, Cooper RG, Salway F, Ollier WE, et al. HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. Rheumatology (Oxford). 2007;46:1786\u20139.","journal-title":"Rheumatology (Oxford)"},{"key":"314_CR6","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/acr.22358","volume":"66","author":"MA Orione","year":"2014","unstructured":"Orione MA, Silva CA, Sallum AM, Campos LM, Omori CH, Braga AL, et al. Risk factors for juvenile dermatomyositis: exposure to tobacco and air pollutants during pregnancy. Arthritis Care Res (Hoboken). 2014;66:1571\u20135.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"314_CR7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1196\/annals.1422.059","volume":"1108","author":"O Barzilai","year":"2007","unstructured":"Barzilai O, Sherer Y, Ram M, Izhaky D, Anaya JM, Shoenfeld Y. Epstein\u2013Barr virus and cytomegalovirus in autoimmune diseases: are they truly notorious? A preliminary report. Ann N Y Acad Sci. 2007;1108:567\u201377.","journal-title":"Ann N Y Acad Sci"},{"key":"314_CR8","first-page":"255","volume":"57","author":"DE Dietzman","year":"1976","unstructured":"Dietzman DE, Schaller JG, Ray CG, Reed ME. Acute myositis associated with influenza B infection. Pediatrics. 1976;57:255\u20138.","journal-title":"Pediatrics"},{"key":"314_CR9","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1002\/jmv.23670","volume":"85","author":"F Broccolo","year":"2013","unstructured":"Broccolo F, Drago F, Cassina G, Fava A, Fusetti L, Matteoli B, et al. Selective reactivation of human herpesvirus 6 in patients with autoimmune connective tissue diseases. J Med Virol. 2013;85:1925\u201334.","journal-title":"J Med Virol"},{"key":"314_CR10","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1046\/j.1365-2133.2002.05037.x","volume":"147","author":"F Shirasaki","year":"2002","unstructured":"Shirasaki F, Taniuchi K, Matsushita T, Hamaguhi Y, Takata M, Takehara K. Epstein\u2013Barr virus-associated T-cell lymphoma: a case of eyelid swelling and intramuscular infiltration mimicking dermatomyositis. Br J Dermatol. 2002;147:1244\u20138.","journal-title":"Br J Dermatol"},{"key":"314_CR11","first-page":"189096","volume":"2012","author":"MP Pender","year":"2012","unstructured":"Pender MP. CD8+ T-cell deficiency, Epstein\u2013Barr virus infection, vitamin D deficiency, and steps to autoimmunity: a unifying hypothesis. Autoimmune Dis. 2012;2012:189096.","journal-title":"Autoimmune Dis"},{"key":"314_CR12","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1128\/JVI.52.2.722-725.1984","volume":"52","author":"C Garzelli","year":"1984","unstructured":"Garzelli C, Taub FE, Schaff JE, Prabhakar BS, Ginsberg-Fellner F, et al. Epstein\u2013Barr virus transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs. J Virol. 1984;52:722\u20135.","journal-title":"J Virol"},{"key":"314_CR13","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3899\/jrheum.121031","volume":"40","author":"FC Ernste","year":"2013","unstructured":"Ernste FC, Crowson CS, de Padilla CL, Hein MS, Reed AM. Longitudinal peripheral blood lymphocyte subsets correlate with decreased disease activity in juvenile dermatomyositis. J Rheumatol. 2013;40:1200\u201311.","journal-title":"J Rheumatol"},{"key":"314_CR14","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.3389\/fimmu.2018.01372","volume":"6","author":"CJM Piper","year":"2018","unstructured":"Piper CJM, Wilkinson MGL, Deakin CT,\u00a0Otto GW,\u00a0Dowle S,\u00a0Duurland CL, et al. CD19+CD24hiCD38hi B cells are expanded in juvenile dermatomyositis and exhibit a pro-inflammatory phenotype after activation through Toll-like receptor 7 and interferon-\u03b1. Front Immunol. 2018;6:1372.","journal-title":"Front Immunol"},{"key":"314_CR15","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1056\/NEJM197502202920807","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975;292:403\u20137.","journal-title":"N Engl J Med"},{"key":"314_CR16","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1006\/clin.1995.1156","volume":"77","author":"Y Hashimoto","year":"1995","unstructured":"Hashimoto Y, Nawata Y, Kurasawa K, Takabayashi K, Oda K, Mikata A, et al. Investigation of EB virus and cytomegalovirus in rapidly progressive interstitial pneumonitis in polymyositis\/dermatomyositis by in situ hybridization and polymerase chain reaction. Clin Immunol Immunopathol. 1995;77:298\u2013306.","journal-title":"Clin Immunol Immunopathol"},{"key":"314_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1136\/mp.54.2.98","volume":"54","author":"AA Brink","year":"2001","unstructured":"Brink AA, Meijer CJ, Nicholls JM, Middeldorp JM, van den Brule AJ. Activity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein\u2013Barr virus associated disorders. Mol Pathol. 2001;54:98\u2013102.","journal-title":"Mol Pathol"},{"key":"314_CR18","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1099\/0022-1317-70-7-1755","volume":"70","author":"MJ Allday","year":"1989","unstructured":"Allday MJ, Crawford DH, Griffin BE. Epstein\u2013Barr virus latent gene expression during the initiation of B cell immortalization. J Gen Virol. 1989;70:1755\u201364.","journal-title":"J Gen Virol"},{"key":"314_CR19","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1084\/jem.20072397","volume":"205","author":"JD L\u00fcnemann","year":"2008","unstructured":"L\u00fcnemann JD, Jelci\u0107 I, Roberts S, Lutterotti A, Tackenberg B, Martin R, et al. EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2. J Exp Med. 2008;205:1763\u201373.","journal-title":"J Exp Med"},{"key":"314_CR20","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1556\/EuJMI.1.2011.4.2","volume":"1","author":"G F\u00fcst","year":"2013","unstructured":"F\u00fcst G. The role of the Epstein\u2013Barr virus in the pathogenesis of some autoimmune disorders\u2014similarities and differences. Eur J Microbiol Immunol (Bp). 2013;1:267\u201378.","journal-title":"Eur J Microbiol Immunol (Bp)"},{"key":"314_CR21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.imlet.2014.11.001","volume":"163","author":"C Cornaby","year":"2014","unstructured":"Cornaby C, Gibbons L, Mayhew V, Taylor-Albert E, Lehman TJ, Harley JB. B cell epitope spreading: mechanisms and contribution to autoimmune diseases. Immunol Lett. 2014;163:56\u201368.","journal-title":"Immunol Lett"},{"issue":"100","key":"314_CR22","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1172\/JCI119856","volume":"15","author":"JA James","year":"1997","unstructured":"James JA, Kaufman KM, Farris AD, Taylor-Albert E,\u00a0Lehman TJ,\u00a0Harley JB. An increased prevalence of Epstein\u2013Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J Clin Invest. 1997;15:3019\u201326.","journal-title":"J Clin Invest"},{"key":"314_CR23","first-page":"640","volume":"10","author":"ML Miller","year":"1983","unstructured":"Miller ML, Lantner R, Pachman LM. Natural and antibody-dependent cellular cytotoxicity in children with systemic lupus erythematosus and juvenile dermatomyositis. J Rheumatol. 1983;10:640\u20132.","journal-title":"J Rheumatol"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-019-00314-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-019-00314-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-019-00314-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T12:49:32Z","timestamp":1659098972000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-019-00314-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["314"],"URL":"https:\/\/doi.org\/10.1007\/s12519-019-00314-7","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,23]]},"assertion":[{"value":"24 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The study was approved by the pediatric review board committee (approval number: 2019-IRB-099), and informed consent from patients and healthy individuals was acquired before the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}