{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:05:40Z","timestamp":1791039940332,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Guangdong Science and Technology Committee of China","award":["2015A020220005"],"award-info":[{"award-number":["2015A020220005"]}]},{"DOI":"10.13039\/501100012241","name":"Guangzhou Research Collaborative Innovation Projects","doi-asserted-by":"publisher","award":["201704030081"],"award-info":[{"award-number":["201704030081"]}],"id":[{"id":"10.13039\/501100012241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s12519-019-00325-4","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T18:02:21Z","timestamp":1578420141000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Etiology of newborn hearing impairment in Guangdong province: 10-year experience with screening, diagnosis, and follow-up"],"prefix":"10.1007","volume":"16","author":[{"given":"Bi-Xing","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tian","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen-Di","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Fei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-5965","authenticated-orcid":false,"given":"Xiang-Li","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"325_CR1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ijporl.2008.01.012","volume":"72","author":"N Verhaert","year":"2008","unstructured":"Verhaert N, Willems M, Van Kerschaver E, Desloovere C. Impact of early hearing screening and treatment on language development and education level: evaluation of 6\u00a0years of universal newborn hearing screening (ALGO) in Flanders, Belgium. Int J Pediatr Otorhinolaryngol. 2008;72:599\u2013608.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"325_CR2","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/j.1469-8749.2010.03621.x","volume":"52","author":"AM Chilosi","year":"2010","unstructured":"Chilosi AM, Comparini A, Scusa MF, Berrettini S, Forli F, Battini R, et al. Neurodevelopmental disorders in children with severe to profound sensorineural hearing loss: a clinical study. Dev Med Child Neurol. 2010;52:856\u201362.","journal-title":"Dev Med Child Neurol"},{"key":"325_CR3","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1136\/bmj.323.7312.536","volume":"323","author":"HM Fortnum","year":"2001","unstructured":"Fortnum HM, Summerfield AQ, Marshall DH, Davis AC, Bamford JM. Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment study. BMJ. 2001;323:536\u201340.","journal-title":"BMJ"},{"key":"325_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1044\/1059-0889(2000\/005)","volume":"9","author":"Joint Committee on Infant Hearing","year":"2000","unstructured":"Joint Committee on Infant Hearing. Year 2000 position statement: principles and guidelines for early hearing detection and intervention programs. Am J Audiol. 2000;9:9\u201329.","journal-title":"Am J Audiol"},{"key":"325_CR5","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.jcomdis.2004.04.008","volume":"37","author":"C Yoshinaga-Itano","year":"2004","unstructured":"Yoshinaga-Itano C. Levels of evidence: universal newborn hearing screening (UNHS) and early hearing detection and intervention systems (EHDI). J Commun Disord. 2004;37:451\u201365.","journal-title":"J Commun Disord"},{"key":"325_CR6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/pr.2016.250","volume":"81","author":"KE Wroblewska-Seniuk","year":"2017","unstructured":"Wroblewska-Seniuk KE, Dabrowski P, Szyfter W, Mazela J. Universal newborn hearing screening: methods and results, obstacles, and benefits. Pediatr Res. 2017;81:415\u201322.","journal-title":"Pediatr Res"},{"key":"325_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ijporl.2019.02.045","volume":"120","author":"LX Ngui","year":"2019","unstructured":"Ngui LX, Tang IP, Prepageran N, Lai ZW. Comparison of distortion product otoacoustic emission (DPOAE) and automated auditory brainstem response (AABR) for neonatal hearing screening in a hospital with high delivery rate. Int J Pediatr Otorhinolaryngol. 2019;120:184\u20138.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"325_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ijporl.2017.09.027","volume":"103","author":"Y Schwarz","year":"2017","unstructured":"Schwarz Y, Kaufman GN, Daniel SJ. Newborn hearing screening failure and maternal factors during pregnancy. Int J Pediatr Otorhinolaryngol. 2017;103:65\u201370.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"325_CR9","doi-asserted-by":"publisher","first-page":"i\u2013iv, 1\u2013176","DOI":"10.3310\/hta1100","volume":"1","author":"A Davis","year":"1997","unstructured":"Davis A, Bamford J, Wilson I, Ramkalawan T, Forshaw M, Wright S. A critical review of the role of neonatal hearing screening in the detection of congenital hearing impairment. Health Technol Assess. 1997;1:i\u2013iv, 1\u2013176.","journal-title":"Health Technol Assess"},{"key":"325_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1651-2227.1999.tb01164.x","volume":"88","author":"CR Kennedy","year":"1999","unstructured":"Kennedy CR. Controlled trial of universal neonatal screening for early identification of permanent childhood hearing impairment: coverage, positive predictive value, effect on mothers and incremental yield. Wessex Universal Neonatal Screening Trial Group. Acta Paediatr Suppl. 1999;88:73\u20135.","journal-title":"Acta Paediatr Suppl"},{"key":"325_CR11","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1542\/peds.2007-2333","volume":"120","author":"J Year","year":"2007","unstructured":"Year J. Position statement: principles and guidelines for early hearing detection and intervention programs. Pediatrics. 2007;120:898\u2013921.","journal-title":"Pediatrics"},{"key":"325_CR12","first-page":"319","volume":"19","author":"X Zeng","year":"2011","unstructured":"Zeng X, Li Z, Cen J, Wang S, Li P, Zhang G, et al. The audiological characteristics of the infants with delayed auditory development. J Audiol Speech Pathol. 2011;19:319\u201322.","journal-title":"J Audiol Speech Pathol"},{"key":"325_CR13","doi-asserted-by":"publisher","first-page":"16094","DOI":"10.1038\/nrdp.2016.94","volume":"3","author":"AM Korver","year":"2017","unstructured":"Korver AM, Smith RJ, Van Camp G, Schleiss MR, Bitner-Glindzicz MA, Lustig LR, et al. Congenital hearing loss. Nat Rev Dis Primers. 2017;3:16094.","journal-title":"Nat Rev Dis Primers"},{"key":"325_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1136\/adc.74.1.8","volume":"74","author":"VK Das","year":"1996","unstructured":"Das VK. Aetiology of bilateral sensorineural hearing impairment in children: a 10\u00a0year study. Arch Dis Child. 1996;74:8\u201312.","journal-title":"Arch Dis Child"},{"key":"325_CR15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/MLG.0b013e31802e3726","volume":"117","author":"JE Saunders","year":"2007","unstructured":"Saunders JE, Vaz S, Greinwald JH, Lai J, Morin L, Mojica K. Prevalence and etiology of hearing loss in rural Nicaraguan children. Laryngoscope. 2007;117:387\u201398.","journal-title":"Laryngoscope."},{"key":"325_CR16","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17:405\u201324.","journal-title":"Genet Med"},{"key":"325_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/cge.12856","volume":"91","author":"S Naz","year":"2017","unstructured":"Naz S, Imtiaz A, Mujtaba G, Maqsood A, Bashir R, Bukhari I, et al. Genetic causes of moderate to severe hearing loss point to modifiers. Clin Genet. 2017;91:589\u201398.","journal-title":"Clin Genet"},{"key":"325_CR18","doi-asserted-by":"publisher","first-page":"e357","DOI":"10.1111\/j.1651-2227.2012.02711.x","volume":"101","author":"E Karltorp","year":"2012","unstructured":"Karltorp E, Hellstr\u00f6m S, Lewensohn-Fuchs I, Carlsson-Hans\u00e9n E, Carlsson P, Engman M. Congenital cytomegalovirus infection\u2014a common cause of hearing loss of unknown aetiology. Acta Paediatr. 2012;101:e357\u201362.","journal-title":"Acta Paediatr"},{"key":"325_CR19","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/1469-7610.00430","volume":"40","author":"C Roberts","year":"1999","unstructured":"Roberts C, Hindley P. The assessment and treatment of deaf children with psychiatric disorders. J Child Psychol Psychiatry. 1999;40:151\u201367.","journal-title":"J Child Psychol Psychiatry"},{"key":"325_CR20","doi-asserted-by":"publisher","first-page":"21104","DOI":"10.1073\/pnas.1012989107","volume":"107","author":"AE Shearer","year":"2010","unstructured":"Shearer AE, DeLuca AP, Hildebrand MS, Taylor KR, Gurrola J 2nd, Scherer S, et al. Comprehensive genetic testing for hereditary hearing loss using massively parallel sequencing. Proc Natl Acad Sci U S A. 2010;107:21104\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"325_CR21","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1044\/2019_AJA-19-0007","volume":"28","author":"LA Krishnan","year":"2019","unstructured":"Krishnan LA, Van Hyfte S, Richards KAR. Newborn hearing screening: early education\u2009=\u2009more satisfied mothers. Am J Audiol. 2019;28:617\u201327.","journal-title":"Am J Audiol"},{"key":"325_CR22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.pcl.2018.12.010","volume":"66","author":"JE Stewart","year":"2019","unstructured":"Stewart JE, Bentley JE. Hearing loss in pediatrics: what the medical home needs to know. Pediatr Clin N Am. 2019;66:425\u201336.","journal-title":"Pediatr Clin N Am"},{"key":"325_CR23","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1056\/NEJMoa1006561","volume":"364","author":"SB Boppana","year":"2011","unstructured":"Boppana SB, Ross SA, Shimamura M, Palmer AL, Ahmed A, Michaels MG, et al. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med. 2011;364:2111\u20138.","journal-title":"N Engl J Med"},{"key":"325_CR24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ijporl.2019.05.024","volume":"124","author":"A Feresin","year":"2019","unstructured":"Feresin A, Ghiselli S, Marchi R, Staffa P, Monasta L, Orzan E. Who misses the newborn hearing screening? Five years\u2019 experience in Friuli-Venezia Giulia Region (Italy). Int J Pediatr Otorhinolaryngol. 2019;124:193\u20139.","journal-title":"Int J Pediatr Otorhinolaryngol"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-019-00325-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12519-019-00325-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-019-00325-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T01:43:08Z","timestamp":1609897388000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12519-019-00325-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["325"],"URL":"https:\/\/doi.org\/10.1007\/s12519-019-00325-4","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"5 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The present experimental protocol was reviewed and approved by the Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors report no conflicts of interest or commercial associations in association with this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}