{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:08:01Z","timestamp":1774843681976,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s12519-021-00499-w","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T15:02:48Z","timestamp":1641308568000},"page":"83-90","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Clinical practice guidelines in multisystem inflammatory syndrome (MIS-C) related to COVID-19: a critical review and recommendations"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-8731","authenticated-orcid":false,"given":"Alanood S.","family":"Algarni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Njoud M.","family":"Alamri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Z.","family":"Khayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghad A.","family":"Alabdali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawabi S.","family":"Alsubhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahad H.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"499_CR1","unstructured":"American Academy of Pediatrics. Multisystem inflammatory syndrome in children (MIS-C) interim guidance. Retrieved 2 Oct 2020. https:\/\/services.aap.org\/en\/pages\/2019-novel-coronavirus-covid-19-infections\/clinical-guidance\/multisystem-inflammatory-syndrome-in-children-mis-c-interim-guidance\/. Accessed 7 Feb 2021."},{"key":"499_CR2","first-page":"e13","volume":"73","author":"LA Henderson","year":"2021","unstructured":"Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, et al. American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 2. Arthritis Rheumatol. 2021;73:e13-29.","journal-title":"Arthritis Rheumatol"},{"key":"499_CR3","unstructured":"HDVCH guidelines for management of pediatric patient with multisystem inflammatory syndrome. Spectrum health. https:\/\/www.spectrumhealth.org\/for-health-professionals\/clinical-pathways\/management-of-multisystem-inflammatory-syndrome-in-children-guideline. Accessed 7 Feb 2021."},{"key":"499_CR4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jped.2020.08.004","volume":"97","author":"H Simon Junior","year":"2021","unstructured":"Simon Junior H, Sakano TMS, Rodrigues RM, Eisencraft AP, Carvalho VEL, Schvartsman C, et al. Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician\u2019s point of view. J Pediatr (Rio J). 2021;97:140\u201359.","journal-title":"J Pediatr (Rio J)"},{"key":"499_CR5","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","volume":"395","author":"S Riphagen","year":"2020","unstructured":"Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395:1607\u20138.","journal-title":"Lancet"},{"key":"499_CR6","unstructured":"Parsons S, Sass L. Children\u2019s Hospital of The King\u2019s Daughters Health System (CHKDHS). Evaluation and management of COVID-19 multisystem inflammatory syndrome in children (MIS-C). https:\/\/www.chkd.org\/uploadedFiles\/Documents\/COVID-19\/CHKD%20MIS-C%20Guideline%20D2.pdf. Accessed 3 Feb 2021."},{"key":"499_CR7","first-page":"e10589","volume":"12","author":"HH Al Ameer","year":"2020","unstructured":"Al Ameer HH, AlKadhem SM, Busaleh F, AlKhwaitm S, Llaguno MB. Multisystem inflammatory syndrome in children temporally related to COVID-19: a case report from Saudi Arabia. Cureus. 2020;12:e10589.","journal-title":"Cureus."},{"key":"499_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jpeds.2020.08.003","volume":"226","author":"JY Abrams","year":"2020","unstructured":"Abrams JY, Godfred-Cato SE, Oster ME, Chow EJ, Koumans EH, Bryant B, et al. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review. J Pediatr. 2020;226:45-54.e1.","journal-title":"J Pediatr"},{"key":"499_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa478","author":"A Bhimraj","year":"2020","unstructured":"Bhimraj A, Morgan RL, Shumaker AH, Lavergne V, Baden L, Cheng VC, et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. Clin Infect Dis. 2020. https:\/\/doi.org\/10.1093\/cid\/ciaa478.","journal-title":"Clin Infect Dis"},{"key":"499_CR10","unstructured":"World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19. www.who.int\/publications-detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19. Accessed 5 Feb 2020."},{"key":"499_CR11","doi-asserted-by":"publisher","first-page":"fmab01","DOI":"10.1093\/tropej\/fmab071","volume":"67","author":"L Takia","year":"2021","unstructured":"Takia L, Angurana SK, Nallasamy K, Bansal A, Muralidharan J. Updated management protocol for multisystem inflammatory syndrome in children (MIS-C). J Trop Pediatr. 2021;67:fmab01.","journal-title":"J Trop Pediatr"},{"key":"499_CR12","doi-asserted-by":"publisher","first-page":"e276","DOI":"10.1016\/S1473-3099(20)30651-4","volume":"20","author":"L Jiang","year":"2020","unstructured":"Jiang L, Tang K, Levin M, Irfan O, Morris SK, Wilson K, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020;20:e276\u201388.","journal-title":"Lancet Infect Dis"},{"key":"499_CR13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1719173","author":"V Williams","year":"2020","unstructured":"Williams V, Dash N, Suthar R, Mohandoss V, Jaiswal N, Kavitha TK, et al. Clinicolaboratory profile, treatment, intensive care needs, and outcome of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2: a systematic review and meta-analysis. J Pediatr Intensive. 2020. https:\/\/doi.org\/10.1055\/s-0040-1719173.","journal-title":"J Pediatr Intensive."},{"key":"499_CR14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.15585\/mmwr.mm6914e4","volume":"69","author":"CDC COVID-19 Response Team","year":"2020","unstructured":"CDC COVID-19 Response Team. Coronavirus disease 2019 in children\u2014United States, February 12\u2013April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:422\u20136.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"499_CR15","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.tim.2020.10.004","volume":"28","author":"NN Brodsky","year":"2020","unstructured":"Brodsky NN, Ramaswamy A, Lucas CL. The mystery of MIS-C post-SARS-CoV-2 infection. Trends Microbiol. 2020;28:956\u20138.","journal-title":"Trends Microbiol"},{"key":"499_CR16","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.15585\/mmwr.mm6940e1","volume":"69","author":"SB Morris","year":"2020","unstructured":"Morris SB, Schwartz NG, Patel P, Abbo L, Beauchamps L, Balan S, et al. Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection\u2014United Kingdom and United States, March\u2013August 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1450\u20136.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"499_CR17","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","volume":"395","author":"L Verdoni","year":"2020","unstructured":"Verdoni L, Mazza A, Gervasoni A, Martelli L, Ruggeri M, Ciuffreda M, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771\u20138.","journal-title":"Lancet"},{"key":"499_CR18","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1056\/NEJMoa2021680","volume":"383","author":"LR Feldstein","year":"2020","unstructured":"Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MB, et al. Multisystem inflammatory syndrome in US children and adolescents. N Engl J Med. 2020;383:334\u201346.","journal-title":"N Engl J Med"},{"key":"499_CR19","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.15585\/mmwr.mm6932e2","volume":"69","author":"S Godfred-Cato","year":"2020","unstructured":"Godfred-Cato S, Bryant B, Leung J, Oster ME, Conklin L, Abrams J, et al. COVID-19\u2013associated multisystem inflammatory syndrome in children\u2014United States, March\u2013July 2020. MMWR Morb Mortal Wkly Rep. 2020;69:1074\u201380.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"499_CR20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa2102968","volume":"385","author":"AJ McArdle","year":"2021","unstructured":"McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, et al. Treatment of multisystem inflammatory syndrome in children. N Engl J Med. 2021;385:11\u201322.","journal-title":"N Engl J Med"},{"key":"499_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1056\/NEJMoa2102605","volume":"385","author":"MB Son","year":"2021","unstructured":"Son MB, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, et al. Multisystem inflammatory syndrome in children\u2014initial therapy and outcomes. N Engl J Med. 2021;385:23\u201334.","journal-title":"N Engl J Med"},{"key":"499_CR22","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3389\/fphar.2020.01333","volume":"11","author":"TS Schoot","year":"2020","unstructured":"Schoot TS, Kerckhoffs AP, Hilbrands LB, Van Marum RJ. Immunosuppressive drugs and COVID-19: a review. Front Pharmacol. 2020;11:1333.","journal-title":"Front Pharmacol"},{"key":"499_CR23","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1111\/jth.15340","volume":"19","author":"M Al-Ghafry","year":"2021","unstructured":"Al-Ghafry M, Vagrecha A, Malik M, Levine C, Uster E, Aygun B, et al. Multisystem inflammatory syndrome in children (MIS-C) and the prothrombotic state: coagulation profiles and rotational thromboelastometry in a MIS-C cohort. J Thromb Haemost. 2021;19:1764\u201370.","journal-title":"J Thromb Haemost"},{"key":"499_CR24","unstructured":"Panteli D, Legido-Quigley H, Reichebner C, Ollenschl\u00e4ger G, Sch\u00e4fer C, Busse R. Clinical practice guidelines as a quality strategy. Copenhagen, Denmark: European Observatory on Health Systems and Policies; 2019."},{"key":"499_CR25","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1080\/13543784.2021.1950687","volume":"30","author":"JG Rizk","year":"2021","unstructured":"Rizk JG, Lavie CJ, Gupta A. Low-dose aspirin for early COVID-19: does the early bird catch the worm? Expert Opin Investig Drugs. 2021;30:785\u20138.","journal-title":"Expert Opin Investig Drugs"},{"key":"499_CR26","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1111\/febs.15784","volume":"288","author":"E Merzon","year":"2021","unstructured":"Merzon E, Green I, Vinker S, Golan-Cohen A, Gorohovski A, Avramovich E, et al. The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection. FEBS J. 2021;288:5179\u201389.","journal-title":"FEBS J"},{"key":"499_CR27","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/NMD.0b013e3182125d4c","volume":"199","author":"L Samalin","year":"2011","unstructured":"Samalin L, Guillaume S, Auclair C, Llorca PM. Adherence to guidelines by French psychiatrists in their real world of clinical practice. J Nerv Ment Dis. 2011;199:239\u201343.","journal-title":"J Nerv Ment Dis"},{"key":"499_CR28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.5455\/aim.2008.16.219-225","volume":"16","author":"I Masic","year":"2008","unstructured":"Masic I, Miokovic M, Muhamedagic B. Evidence based medicine\u2013new approaches and challenges. Acta Inform Med. 2008;16:219\u201325.","journal-title":"Acta Inform Med"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-021-00499-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-021-00499-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-021-00499-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T14:10:57Z","timestamp":1644847857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-021-00499-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["499"],"URL":"https:\/\/doi.org\/10.1007\/s12519-021-00499-w","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]},"assertion":[{"value":"21 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not need.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. The authors have no conflict of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}