{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:58:15Z","timestamp":1791197895442,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s12519-022-00605-6","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T16:02:47Z","timestamp":1663084967000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vitamin D therapy in pediatric patients with inflammatory bowel disease: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"19","author":[{"given":"Mohammad Hassan","family":"Sohouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Farahmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosein","family":"Alimadadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Motamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma Izze","family":"da Silva Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Rohani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"605_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.yapd.2021.05.005","volume":"68","author":"NS Rubalcava","year":"2021","unstructured":"Rubalcava NS, Gadepalli SK. Inflammatory bowel disease in children and adolescents. Adv Pediatr. 2021;68:121\u201342.","journal-title":"Adv Pediatr"},{"key":"605_CR2","first-page":"619","volume":"26","author":"Y Ye","year":"2020","unstructured":"Ye Y, Manne S, Treem WR, Bennett D. Prevalence of inflammatory bowel disease in pediatric and adult populations: recent estimates from large national databases in the United States, 2007\u20132016. Inflamm Bowel Dis. 2020;26:619\u201325.","journal-title":"Inflamm Bowel Dis"},{"key":"605_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","volume":"15","author":"AN Ananthakrishnan","year":"2018","unstructured":"Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, et al. Environmental triggers in IBD: a review of progress and evidence. Nat Rev Gastroenterol Hepatol. 2018;15:39\u201349.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"605_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","volume":"13","author":"HS De Souza","year":"2016","unstructured":"De Souza HS, Fiocchi C. Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol. 2016;13:13\u201327.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"605_CR5","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3390\/nu11050947","volume":"11","author":"N Green","year":"2019","unstructured":"Green N, Miller T, Suskind D, Lee D. A review of dietary therapy for IBD and a vision for the future. Nutrients. 2019;11:947.","journal-title":"Nutrients"},{"key":"605_CR6","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3390\/nu14051029","volume":"14","author":"K \u015aledzi\u0144ska","year":"2022","unstructured":"\u015aledzi\u0144ska K, Landowski P, \u017bmijewski M, Kami\u0144ska B, Kowalski K, Liberek A. Diet, sun, physical activity and vitamin D status in children with inflammatory bowel disease. Nutrients. 2022;14:1029.","journal-title":"Nutrients"},{"key":"605_CR7","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1093\/ibd\/izaa087","volume":"26","author":"Y Guzman-Prado","year":"2020","unstructured":"Guzman-Prado Y, Samson O, Segal JP, Limdi JK, Hayee BH. Vitamin D therapy in adults with inflammatory bowel disease: a systematic review and meta-analysis. Inflamm Bowel Dis. 2020;26:1819\u201330.","journal-title":"Inflamm Bowel Dis"},{"key":"605_CR8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.tem.2019.04.005","volume":"30","author":"MT Cantorna","year":"2019","unstructured":"Cantorna MT, Rogers CJ, Arora J. Aligning the paradoxical role of vitamin D in gastrointestinal immunity. Trends Endocrinol Metab. 2019;30:459\u201366.","journal-title":"Trends Endocrinol Metab"},{"key":"605_CR9","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390:2769\u201378.","journal-title":"Lancet"},{"key":"605_CR10","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3389\/fimmu.2016.00697","volume":"7","author":"W Dankers","year":"2017","unstructured":"Dankers W, Colin EM, Van Hamburg JP, Lubberts E. Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential. Front Immunol. 2017;7:697.","journal-title":"Front Immunol"},{"key":"605_CR11","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/ncpendmet0716","volume":"4","author":"JS Adams","year":"2008","unstructured":"Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008;4:80\u201390.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"605_CR12","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/MIB.0000000000001047","volume":"23","author":"O Hradsky","year":"2017","unstructured":"Hradsky O, Soucek O, Maratova K, Matyskova J, Copova I, Zarubova K, et al. Supplementation with 2000 IU of cholecalciferol is associated with improvement of trabecular bone mineral density and muscle power in pediatric patients with IBD. Inflamm Bowel Dis. 2017;23:514\u201323.","journal-title":"Inflamm Bowel Dis"},{"key":"605_CR13","doi-asserted-by":"publisher","first-page":"S432","DOI":"10.1016\/S1873-9946(14)50130-4","volume":"8","author":"P Jantchou","year":"2014","unstructured":"Jantchou P, Mailhot G, Ezri J, Le Deist F, Deslandres C, Delvin E. P-102: Bioavailability and tolerance of high doses vitamin D in children with newly diagnosed Crohn\u2019s disease. J Crohns Colitis. 2014;8:S432.","journal-title":"J Crohns Colitis"},{"key":"605_CR14","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1097\/MPG.0000000000002590","volume":"70","author":"R Lee","year":"2020","unstructured":"Lee R, Maltz RM, Crandall WV, Plogsted SW, Shaikhkhalil AK, Bowden SA, et al. Single high-dose vitamin D3 supplementation in pediatric patients With inflammatory bowel disease and hypovitaminosis D. J Pediatr Gastroenterol Nutr. 2020;70:e77\u201380.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"605_CR15","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.jpeds.2013.11.071","volume":"164","author":"KE Wingate","year":"2014","unstructured":"Wingate KE, Jacobson K, Issenman R, Carroll M, Barker C, Israel D, et al. 25-Hydroxyvitamin D concentrations in children with Crohn\u2019s disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study. J Pediatr. 2014;164:860\u20135.","journal-title":"J Pediatr"},{"key":"605_CR16","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1093\/ecco-jcc\/jjz056","volume":"13","author":"H Moran-Lev","year":"2019","unstructured":"Moran-Lev H, Galai T, Yerushalmy-Feler A, Weisman Y, Anafy A, Deutsch V, et al. Vitamin D decreases hepcidin and inflammatory markers in newly diagnosed inflammatory bowel disease paediatric patients: a prospective study. J Crohns Colitis. 2019;13:1287\u201391.","journal-title":"J Crohns Colitis"},{"key":"605_CR17","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1210\/jc.2013-4218","volume":"99","author":"HM Pappa","year":"2014","unstructured":"Pappa HM, Mitchell PD, Jiang H, Kassiff S, Filip-Dhima R, DiFabio D, et al. Maintenance of optimal vitamin D status in children and adolescents with inflammatory bowel disease: a randomized clinical trial comparing two regimens. J Clin Endocrinol Metab. 2014;99:3408\u201317.","journal-title":"J Clin Endocrinol Metab"},{"key":"605_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906","volume":"88","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg. 2021;88:105906.","journal-title":"Int J Surg"},{"key":"605_CR19","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603\u20135.","journal-title":"Eur J Epidemiol"},{"key":"605_CR20","unstructured":"Higgins J. Cochrane handbook for systematic reviews of interventions. Version 5.1. 0. The Cochrane Collaboration. 2011. https:\/\/training.cochrane.org\/handbook\/current."},{"key":"605_CR21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5:13.","journal-title":"BMC Med Res Methodol"},{"key":"605_CR22","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557\u201360.","journal-title":"BMJ"},{"key":"605_CR23","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629\u201334.","journal-title":"BMJ"},{"key":"605_CR24","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3390\/nu11051019","volume":"11","author":"J Fletcher","year":"2019","unstructured":"Fletcher J, Cooper SC, Ghosh S, Hewison M. The role of vitamin D in inflammatory bowel disease: mechanism to management. Nutrients. 2019;11:1019.","journal-title":"Nutrients"},{"key":"605_CR25","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1210\/jc.2011-3182","volume":"97","author":"HM Pappa","year":"2012","unstructured":"Pappa HM, Mitchell PD, Jiang H, Kassiff S, Filip-Dhima R, DiFabio D, et al. Treatment of vitamin D insufficiency in children and adolescents with inflammatory bowel disease: a randomized clinical trial comparing three regimens. J Clin Endocrinol Metab. 2012;97:2134\u201342.","journal-title":"J Clin Endocrinol Metab"},{"key":"605_CR26","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/MPG.0000000000000823","volume":"61","author":"D Shepherd","year":"2015","unstructured":"Shepherd D, Day AS, Leach ST, Lopez R, Messenger R, Woodhead HJ, et al. Single high-dose oral vitamin D3 therapy (stoss): a solution to vitamin D deficiency in children with inflammatory bowel disease? J Pediatr Gastroenterol Nutr. 2015;61:411\u20134.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"605_CR27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1097\/MPG.0b013e3180dca0cc","volume":"45","author":"EI Benchimol","year":"2007","unstructured":"Benchimol EI, Ward LM, Gallagher J, Rauch F, Barrowman N, Warren J, et al. Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2007;45:538\u201345.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"605_CR28","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/MCG.0000000000001443","volume":"55","author":"D El Amrousy","year":"2021","unstructured":"El Amrousy D, El Ashry H, Hodeib H, Hassan S. Vitamin D in children with inflammatory bowel disease: a randomized controlled clinical trial. J Clin Gastroenterol. 2021;55:815\u201320.","journal-title":"J Clin Gastroenterol"},{"key":"605_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012662","volume":"97","author":"J Li","year":"2018","unstructured":"Li J, Chen N, Wang D, Zhang J, Gong X. Efficacy of vitamin D in treatment of inflammatory bowel disease: a meta-analysis. Medicine. 2018;97:e12662.","journal-title":"Medicine"},{"key":"605_CR30","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1111\/apt.15506","volume":"50","author":"J Gubatan","year":"2019","unstructured":"Gubatan J, Chou ND, Nielsen OH, Moss AC. Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2019;50:1146\u201358.","journal-title":"Aliment Pharmacol Ther"},{"key":"605_CR31","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1744-6155.2011.00280.x","volume":"16","author":"T O'Malley","year":"2011","unstructured":"O\u2019Malley T, Heuberger R. Vitamin D status and supplementation in pediatric gastrointestinal disease. J Spec Pediatr Nurs. 2011;16:140\u201350.","journal-title":"J Spec Pediatr Nurs"},{"key":"605_CR32","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1542\/peds.2006-0841","volume":"118","author":"HM Pappa","year":"2006","unstructured":"Pappa HM, Gordon CM, Saslowsky TM, Zholudev A, Horr B, Shih MC, et al. Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics. 2006;118:1950\u201361.","journal-title":"Pediatrics"},{"key":"605_CR33","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1096\/fj.04-3284com","volume":"19","author":"AF Gombart","year":"2005","unstructured":"Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. FASEB J. 2005;19:1067\u201377.","journal-title":"FASEB J"},{"key":"605_CR34","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1074\/jbc.C109.071225","volume":"285","author":"T-T Wang","year":"2010","unstructured":"Wang TT, Dabbas B, Laperriere D, Bitton AJ, Soualhine H, Tavera-Mendoza LE, et al. Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2\/CARD15-defensin \u03b22 innate immune pathway defective in Crohn disease. J Biol Chem. 2010;285:2227\u201331.","journal-title":"J Biol Chem"},{"key":"605_CR35","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nri2378","volume":"8","author":"JR Mora","year":"2008","unstructured":"Mora JR, Iwata M, Von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008;8:685\u201398.","journal-title":"Nat Rev Immunol"},{"key":"605_CR36","doi-asserted-by":"publisher","first-page":"4974","DOI":"10.4049\/jimmunol.167.9.4974","volume":"167","author":"A Boonstra","year":"2001","unstructured":"Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O\u2019Garra A. 1\u03b1, 25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells. J Immunol. 2001;167:4974\u201380.","journal-title":"J Immunol"},{"key":"605_CR37","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.4049\/jimmunol.1102412","volume":"188","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, et al. Vitamin D inhibits monocyte\/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012;188:2127\u201335.","journal-title":"J Immunol"},{"key":"605_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-230X-12-1","volume":"12","author":"H Zhao","year":"2012","unstructured":"Zhao H, Zhang H, Wu H, Li H, Liu L, Guo J, et al. Protective role of 1, 25 (OH) 2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol. 2012;12:1\u201314.","journal-title":"BMC Gastroenterol"},{"key":"605_CR39","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/ecco-jcc\/jju004","volume":"9","author":"T Hlavaty","year":"2015","unstructured":"Hlavaty T, Krajcovicova A, Payer J. Vitamin D therapy in inflammatory bowel diseases: who, in what form, and how much? J Crohns Colitis. 2015;9:198\u2013209.","journal-title":"J Crohns Colitis"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-022-00605-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-022-00605-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-022-00605-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T22:24:25Z","timestamp":1701037465000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-022-00605-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["605"],"URL":"https:\/\/doi.org\/10.1007\/s12519-022-00605-6","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,13]]},"assertion":[{"value":"8 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was ethically approved by the Regional Bioethics Committee of Tehran University of Medical Sciences (No: IR.TUMS.CHMC.REC.1401.060).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}