{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:00:06Z","timestamp":1786982406666,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Innovative research team of high-level local universities in Shanghai","award":["SHSMU-ZDCX20212800"],"award-info":[{"award-number":["SHSMU-ZDCX20212800"]}]},{"DOI":"10.13039\/501100020089","name":"Science and Technology Commission of Fengxian District, Shanghai Municipality","doi-asserted-by":"publisher","award":["20JC1410200"],"award-info":[{"award-number":["20JC1410200"]}],"id":[{"id":"10.13039\/501100020089","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Commission Shanghai Municipality","award":["20JC1410204"],"award-info":[{"award-number":["20JC1410204"]}]},{"name":"2021 Shanghai University teacher training plan-industry university research practice plan project","award":["EYJ26.RL017"],"award-info":[{"award-number":["EYJ26.RL017"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2019SY049"],"award-info":[{"award-number":["2019SY049"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Medical Leading Talents Program","award":["2019LJ22"],"award-info":[{"award-number":["2019LJ22"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s12519-022-00621-6","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:03:47Z","timestamp":1665983027000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical characteristics of pediatric cases infected with the SARS-CoV-2 Omicron variant in a tertiary children\u2019s medical center in Shanghai, China"],"prefix":"10.1007","volume":"19","author":[{"given":"Nan","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-2068","authenticated-orcid":false,"given":"Qing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"621_CR1","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/S0140-6736(22)00838-8","volume":"399","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhang W, Chen S. Shanghai\u2019s life-saving efforts against the current omicron wave of the COVID-19 pandemic. Lancet. 2022;399:2011\u20132.","journal-title":"Lancet"},{"key":"621_CR2","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.chom.2022.05.001","volume":"30","author":"J Ai","year":"2022","unstructured":"Ai J, Wang X, He X, Zhao X, Zhang Y, Jiang Y, et al. Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages. Cell Host Microbe. 2022;30:1077\u201383.","journal-title":"Cell Host Microbe"},{"key":"621_CR3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3201\/eid2802.212422","volume":"28","author":"H Gu","year":"2022","unstructured":"Gu H, Krishnan P, Ng DYM, Chang LDJ, Liu GYZ, Cheng SSM, et al. Probable transmission of SARS-CoV-2 Omicron variant in quarantine hotel, Hong Kong, China, November 2021. Emerg Infect Dis. 2022;28:460\u20132.","journal-title":"Emerg Infect Dis"},{"key":"621_CR4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac275","author":"AA Butt","year":"2022","unstructured":"Butt AA, Dargham SR, Loka S, Shaik RM, Chemaitelly H, Tang P, et al. COVID-19 disease severity in children infected with the Omicron variant. Clin Infect Dis. 2022. https:\/\/doi.org\/10.1093\/cid\/ciac275.","journal-title":"Clin Infect Dis"},{"key":"621_CR5","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/s41422-022-00674-2","volume":"32","author":"H Zheng","year":"2022","unstructured":"Zheng H, Cao Y, Chen X, Wang F, Hu Y, Song W, et al. Disease profile and plasma neutralizing activity of post-vaccination Omicron BA1 infection in Tianjin, China: a retrospective study. Cell Res. 2022;32:781\u20134.","journal-title":"Cell Res"},{"key":"621_CR6","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1001\/jama.2022.8025","volume":"327","author":"N Levy","year":"2022","unstructured":"Levy N, Koppel JH, Kaplan O, Yechiam H, Shahar-Nissan K, Cohen NK, et al. Severity and incidence of multisystem inflammatory syndrome in children during 3 SARS-CoV-2 pandemic waves in Israel. JAMA. 2022;327:2452\u20134.","journal-title":"JAMA"},{"key":"621_CR7","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s12519-021-00466-5","volume":"17","author":"FX Xue","year":"2021","unstructured":"Xue FX, Shen KL. COVID-19 in children and the importance of COVID-19 vaccination. World J Pediatr. 2021;17:462\u20136.","journal-title":"World J Pediatr"},{"key":"621_CR8","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1056\/NEJMoa2108891","volume":"385","author":"J Lopez Bernal","year":"2021","unstructured":"Lopez Bernal J, Andrews N, Gower C, Gallagher E, Simmons R, Thelwall S, et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N Engl J Med. 2021;385:585\u201394.","journal-title":"N Engl J Med"},{"key":"621_CR9","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1056\/NEJMoa2115481","volume":"386","author":"N Andrews","year":"2022","unstructured":"Andrews N, Tessier E, Stowe J, Gower C, Kirsebom F, Simmons R, et al. Duration of protection against mild and severe disease by Covid-19 vaccines. N Engl J Med. 2022;386:340\u201350.","journal-title":"N Engl J Med"},{"key":"621_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1056\/NEJMc2104974","volume":"385","author":"LJ Abu-Raddad","year":"2021","unstructured":"Abu-Raddad LJ, Chemaitelly H, Butt AA, National Study Group for COVID-19 Vaccination. Effectiveness of the BNT162b2 Covid-19 vaccine against the B.1.1.7 and B.1.351 variants. N Engl J Med. 2021;385:187\u20139.","journal-title":"N Engl J Med"},{"key":"621_CR11","doi-asserted-by":"publisher","first-page":"e20200702","DOI":"10.1542\/peds.2020-0702","volume":"145","author":"Y Dong","year":"2020","unstructured":"Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145:e20200702.","journal-title":"Pediatrics."},{"key":"621_CR12","doi-asserted-by":"publisher","first-page":"e2020037812","DOI":"10.1542\/peds.2020-037812","volume":"147","author":"SG Pinninti","year":"2021","unstructured":"Pinninti SG, Pati S, Poole C, Latting M, Seleme MC, Yarbrough A, et al. Virological characteristics of hospitalized children with SARS-CoV-2 infection. Pediatrics. 2021;147:e2020037812.","journal-title":"Pediatrics."},{"key":"621_CR13","doi-asserted-by":"publisher","first-page":"4678","DOI":"10.1038\/s41467-021-24938-4","volume":"12","author":"CA Cohen","year":"2021","unstructured":"Cohen CA, Li APY, Hachim A, Hui DSC, Kwan MYW, Tsang OTY, et al. SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection. Nat Commun. 2021;12:4678.","journal-title":"Nat Commun"},{"key":"621_CR14","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1080\/22221751.2022.2060137","volume":"11","author":"PH Cheung","year":"2022","unstructured":"Cheung PH, Chan CP, Jin DY. Lessons learned from the fifth wave of COVID-19 in Hong Kong in early 2022. Emerg Microbes Infect. 2022;11:1072\u20138.","journal-title":"Emerg Microbes Infect"},{"key":"621_CR15","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.4110\/in.2021.21.e38","volume":"21","author":"S Kim","year":"2021","unstructured":"Kim S, Nguyen TT, Taitt AS, Jhun H, Park HY, Kim SH, et al. SARS-CoV-2 Omicron mutation is faster than the chase: multiple mutations on spike\/ACE2 interaction residues. Immune Netw. 2021;21:e38.","journal-title":"Immune Netw."},{"key":"621_CR16","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41586-022-04411-y","volume":"603","author":"R Viana","year":"2022","unstructured":"Viana R, Moyo S, Amoako DG, Tegally H, Scheepers C, Althaus CL, et al. Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa. Nature. 2022;603:679\u201386.","journal-title":"Nature"},{"key":"621_CR17","doi-asserted-by":"publisher","DOI":"10.1101\/2021.12.31.474653","author":"TP Peacock","year":"2022","unstructured":"Peacock TP, Brown JC, Zhou J, Thakur N, Newman J, Kugathasan R, et al. The SARS-CoV-2 variant, Omicron, shows rapid replication in human primary nasal epithelial cultures and efficiently uses the endosomal route of entry. BioRxiv. 2022. https:\/\/doi.org\/10.1101\/2021.12.31.474653 (Preprint).","journal-title":"BioRxiv"},{"key":"621_CR18","doi-asserted-by":"publisher","first-page":"146","DOI":"10.15585\/mmwr.mm7104e4","volume":"71","author":"AD Iuliano","year":"2022","unstructured":"Iuliano AD, Brunkard JM, Boehmer TK, Peterson E, Adjei S, Binder AM, et al. Trends in disease severity and health care utilization during the early Omicron variant period compared with previous SARS-CoV-2 high transmission periods-United States, December 2020-January 2022. MMWR Morb Mortal Wkly Rep. 2022;71:146\u201352.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"621_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41586-022-04856-1","volume":"607","author":"R Uraki","year":"2022","unstructured":"Uraki R, Kiso M, Iida S, Imai M, Takashita E, Kuroda M, et al. Characterization and antiviral susceptibility of SARS-CoV-2 Omicron\/BA.2. Nature. 2022;607:119\u201327.","journal-title":"Nature"},{"key":"621_CR20","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1093\/infdis\/jiab509","volume":"224","author":"LM Yonker","year":"2021","unstructured":"Yonker LM, Boucau J, Regan J, Choudhary MC, Burns MD, Young N, et al. Virologic features of severe acute respiratory syndrome coronavirus 2 infection in children. J Infect Dis. 2021;224:1821\u20139.","journal-title":"J Infect Dis"},{"key":"621_CR21","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1056\/NEJMoa2119451","volume":"386","author":"N Andrews","year":"2022","unstructured":"Andrews N, Stowe J, Kirsebom F, Toffa S, Rickeard T, Gallagher E, et al. Covid-19 vaccine effectiveness against the Omicron (B.1.1.529) variant. N Engl J Med. 2022;386:1532\u201346.","journal-title":"N Engl J Med"},{"key":"621_CR22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/22221751.2021.2022440","volume":"11","author":"J Ai","year":"2022","unstructured":"Ai J, Zhang H, Zhang Y, Lin K, Zhang Y, Wu J, et al. Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost. Emerg Microbes Infect. 2022;11:337\u201343.","journal-title":"Emerg Microbes Infect"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-022-00621-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-022-00621-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-022-00621-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T12:03:20Z","timestamp":1673352200000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-022-00621-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["621"],"URL":"https:\/\/doi.org\/10.1007\/s12519-022-00621-6","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"31 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Review Board and the Ethics Committee of Shanghai Children\u2019s Medical Center (SCMCIRB-K2022053-3).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Nan Shen is a member of the Editorial Board for <i>World Journal of Pediatrics<\/i>. The paper was handled by the other Editor and has undergone a rigorous peer review process. Nan Shen was not involved in the journal's review of, or decisions related to, this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}