{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:49:53Z","timestamp":1792684193729,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Acute myocarditis (AMC) can cause poor outcomes or even death in children. We aimed to identify AMC risk factors and create a mortality prediction model for AMC in children at hospital admission.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a single-center retrospective cohort study of AMC children hospitalized between January 2016 and January 2020. The demographics, clinical examinations, types of AMC, and laboratory results were collected at hospital admission. In-hospital survival or death was documented. Clinical characteristics associated with death were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 67 children, 51 survived, and 16 died. The most common symptom was digestive disorder (67.2%). Based on the Bayesian model averaging and Hosmer\u2013Lemeshow test, we created a final best mortality prediction model (acute myocarditis death risk score, AMCDRS) that included ten variables (male sex, fever, congestive heart failure, left-ventricular ejection fraction\u2009&lt;\u200950%, pulmonary edema, ventricular tachycardia, lactic acid value\u2009&gt;\u20094, fulminant myocarditis, abnormal creatine\u00a0kinase-MB, and hypotension). Despite differences in the characteristics of the validation cohort, the model discrimination was only marginally lower, with an AUC of 0.781 (95% confidence interval\u2009=\u20090.675\u20130.852) compared with the derivation cohort. Model calibration likewise indicated acceptable fit (Hosmer\u2012Lemeshow goodness-of-fit, <jats:italic>P<\/jats:italic>\u00bc\u2009=\u20090.10).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Multiple factors were associated with increased mortality in children with AMC. The prediction model AMCDRS might be used at hospital admission to accurately identify AMC in children who are at an increased risk of death.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12519-022-00637-y","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T11:06:54Z","timestamp":1668510414000},"page":"180-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical characteristics and mortality risk prediction model in children with acute myocarditis"],"prefix":"10.1007","volume":"19","author":[{"given":"Shi-Xin","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Nan","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"637_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.gheart.2014.01.007","volume":"9","author":"LT Cooper Jr","year":"2014","unstructured":"Cooper LT Jr, Keren A, Sliwa K, Matsumori A, Mensah GA. The global burden of myocarditis: part 1: a systematic literature review for the global burden of diseases, injuries, and risk factors 2010 study. Glob Heart. 2014;9:121\u20139.","journal-title":"Glob Heart"},{"key":"637_CR2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1017\/S1047951116000706","volume":"27","author":"G Kim","year":"2017","unstructured":"Kim G, Ban GH, Lee HD, Sung SC, Kim H, Choi KH. Left ventricular end-diastolic dimension as a predictive factor of outcomes in children with acute myocarditis. Cardiol Young. 2017;27:443\u201351.","journal-title":"Cardiol Young"},{"key":"637_CR3","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1253\/circj.CJ-16-0234","volume":"80","author":"H Matsuura","year":"2016","unstructured":"Matsuura H, Ichida F, Saji T, Ogawa S, Waki K, Kaneko M, et al. Clinical features of acute and fulminant myocarditis in children-2nd nationwide survey by Japanese society of pediatric cardiology and cardiac surgery. 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The paper was handled by the other Editor and has undergone rigorous peer review process. Author Guo-Ying Huang was not involved in the journal\u2019s review of, or decisions related to this manuscript. No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. The authors have no conflict of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}