{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:40:22Z","timestamp":1781286022251,"version":"3.54.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Key Program of the Independent Design Project of National Clinical Research Center for Child Health","award":["S20C0004"],"award-info":[{"award-number":["S20C0004"]}]},{"name":"Shanghai Pujiang Program","award":["21PJ1423100"],"award-info":[{"award-number":["21PJ1423100"]}]},{"name":"Ministry of Industry and Information Technology Artificial Intelligence Medical Devices Innovation Program"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Biliary atresia (BA) is a rare fatal liver disease in children, and the aim of this study was to develop a method to diagnose BA early.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We determined serum levels of matrix metalloproteinase-7 (MMP-7), the results of 13 liver tests, and the levels of 20 bile acids, and integrated computational models were constructed to diagnose BA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our findings demonstrated that MMP-7 expression levels, as well as the results of four liver tests and levels of ten bile acids, were significantly different between 86 BA and 59 non-BA patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy [area under the receiver operating characteristic curve (AUC)\u2009=\u20090.966, 95% confidence interval (CI): 0.942, 0.989] than liver test results and bile acid levels. The AUC was 0.890 (95% CI 0.837, 0.943) for liver test results and 0.825 (95% CI 0.758, 0.892) for bile acid levels. Furthermore, bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels (AUC\u2009=\u20090.976, 95% CI 0.953, 1.000) than liver test results. The AUC was 0.983 (95% CI 0.962, 1.000) for MMP-7 levels combined with liver test results and bile acid levels. In addition, we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis score.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s12519-023-00779-7","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T08:02:16Z","timestamp":1703318536000},"page":"822-833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-136X","authenticated-orcid":false,"given":"Yi-Jiang","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Qi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-Ming","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Hai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Le","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fa","family":"Tou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"779_CR1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1002\/hep.29905","volume":"68","author":"JA Bezerra","year":"2018","unstructured":"Bezerra JA, Wells RG, Mack CL, Karpen SJ, Hoofnagle JH, Doo E, et al. Biliary atresia: clinical and research challenges for the twenty-first century. Hepatology. 2018;68:1163\u201373.","journal-title":"Hepatology"},{"key":"779_CR2","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1002\/hep.31745","volume":"74","author":"SK Mohanty","year":"2021","unstructured":"Mohanty SK, Donnelly B, Temple H, Ortiz-Perez A, Mowery S, Lobeck I, et al, Tiao G. High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants. Hepatology. 2021;74:864\u201378.","journal-title":"Hepatology"},{"key":"779_CR3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013837","volume":"98","author":"X Liu","year":"2019","unstructured":"Liu X, Peng X, Huang Y, Shu C, Liu P, Xie W, et al. Design and validation of a noninvasive diagnostic criteria for biliary atresia in infants based on the STROBE compliant. Medicine (Baltimore). 2019;98:e13837.","journal-title":"Medicine (Baltimore)"},{"key":"779_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pedneo.2022.12.002","volume":"64","author":"MW Lai","year":"2023","unstructured":"Lai MW. Challenges in the diagnosis of biliary atresia in cholestatic neonates. Pediatr Neonatol. 2023;64:3\u20134.","journal-title":"Pediatr Neonatol"},{"key":"779_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103689","volume":"74","author":"U Lendahl","year":"2021","unstructured":"Lendahl U, Lui VCH, Chung PHY, Tam PKH. Biliary atresia - emerging diagnostic and therapy opportunities. EBioMedicine. 2021;74:103689.","journal-title":"EBioMedicine"},{"key":"779_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.931637","volume":"9","author":"H Lyu","year":"2022","unstructured":"Lyu H, Ye Y, Lui VCH, Wu W, Chung PHY, Wong KKY, et al. Plasma amyloid-beta levels correlated with impaired hepatic functions: an adjuvant biomarker for the diagnosis of biliary atresia. Front Surg. 2022;9:931637.","journal-title":"Front Surg"},{"key":"779_CR7","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1001\/jama.2020.2727","volume":"323","author":"RA Schreiber","year":"2020","unstructured":"Schreiber RA. Newborn screening for biliary atresia. JAMA. 2020;323:1137\u20138.","journal-title":"JAMA"},{"key":"779_CR8","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1002\/hep.30234","volume":"68","author":"L Yang","year":"2018","unstructured":"Yang L, Zhou Y, Xu PP, Mourya R, Lei HY, Cao GQ, et al. Diagnostic accuracy of serum matrix metalloproteinase-7 for biliary atresia. Hepatology. 2018;68:2069\u201377.","journal-title":"Hepatology"},{"key":"779_CR9","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1007\/s12072-022-10322-x","volume":"16","author":"S Chi","year":"2022","unstructured":"Chi S, Xu P, Yu P, Cao G, Wang H, Ye Y, et al. Dynamic analysis of serum MMP-7 and its relationship with disease progression in biliary atresia: a multicenter prospective study. Hepatol Int. 2022;16:954\u201363.","journal-title":"Hepatol Int"},{"key":"779_CR10","first-page":"1676","volume":"9","author":"ST Gunda","year":"2022","unstructured":"Gunda ST, Chambara N, Chen XF, Pang MYC, Ying MT. Diagnostic efficacy of advanced ultrasonography imaging techniques in infants with biliary atresia (BA): a systematic review and meta-analysis. Children (Basel). 2022;9:1676.","journal-title":"Children (Basel)"},{"key":"779_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.103241","volume":"41","author":"J Zhao","year":"2023","unstructured":"Zhao J, Zhao Y, Zhang Y, Liao J, Li S, Wang D, et al. Preliminary exploration of the efficacy of laparoscopic fluorescence cholangiography (LFC) in the diagnosis of biliary atresia compared with intraoperative cholangiography (IOC). Photodiagn Photodyn Ther. 2023;41:103241.","journal-title":"Photodiagn Photodyn Ther"},{"key":"779_CR12","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jpeds.2018.12.006","volume":"208","author":"JF Wu","year":"2019","unstructured":"Wu JF, Jeng YM, Chen HL, Ni YH, Hsu HY, Chang MH. Quantification of serum matrix metallopeptide 7 levels may assist in the diagnosis and predict the outcome for patients with biliary atresia. J Pediatr. 2019;208:30-7e1.","journal-title":"J Pediatr"},{"key":"779_CR13","doi-asserted-by":"publisher","first-page":"eaan8462","DOI":"10.1126\/scitranslmed.aan8462","volume":"9","author":"C Lertudomphonwanit","year":"2017","unstructured":"Lertudomphonwanit C, Mourya R, Fei L, Zhang Y, Gutta S, Yang L, et al. Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia. Sci Transl Med. 2017;9:eaan8462.","journal-title":"Sci Transl Med."},{"key":"779_CR14","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jpeds.2019.01.026","volume":"208","author":"S Harpavat","year":"2019","unstructured":"Harpavat S. MMP-7: the next best serum biomarker for biliary atresia? J Pediatr. 2019;208:8\u20139.","journal-title":"J Pediatr"},{"key":"779_CR15","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/joim.13028","volume":"287","author":"H Johansson","year":"2020","unstructured":"Johansson H, Svensson JF, Almstrom M, Van Hul N, Rudling M, Angelin B, et al. Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome. J Intern Med. 2020;287:534\u201345.","journal-title":"J Intern Med"},{"key":"779_CR16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jceh.2021.08.017","volume":"12","author":"N Farooqui","year":"2022","unstructured":"Farooqui N, Elhence A, Shalimar E. A current understanding of bile acids in chronic liver disease. J Clin Exp Hepatol. 2022;12:155\u201373.","journal-title":"J Clin Exp Hepatol"},{"key":"779_CR17","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1021\/acs.jproteome.5b00676","volume":"14","author":"K Zhou","year":"2015","unstructured":"Zhou K, Wang J, Xie G, Zhou Y, Yan W, Pan W, et al. Distinct plasma bile acid profiles of biliary atresia and neonatal hepatitis syndrome. J Proteome Res. 2015;14:4844\u201350.","journal-title":"J Proteome Res"},{"key":"779_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s11894-021-00825-2","volume":"23","author":"T Rabbani","year":"2021","unstructured":"Rabbani T, Guthery SL, Himes R, Shneider BL, Harpavat S. Newborn screening for biliary atresia: a review of current methods. Curr Gastroenterol Rep. 2021;23:28.","journal-title":"Curr Gastroenterol Rep"},{"key":"779_CR19","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ebiom.2018.07.025","volume":"34","author":"R Dong","year":"2018","unstructured":"Dong R, Jiang J, Zhang S, Shen Z, Chen G, Huang Y, et al. Development and validation of novel diagnostic models for biliary atresia in a large cohort of Chinese patients. EBioMedicine. 2018;34:223\u201330.","journal-title":"EBioMedicine"},{"key":"779_CR20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.21037\/qims-22-324","volume":"13","author":"H Yan","year":"2023","unstructured":"Yan H, Liu J, Jin S, Du L, Wang Q, Luo Y. A novel prediction tool based on shear wave elastography, gallbladder ultrasound, and serum biomarkers for the early diagnosis of biliary atresia in infants younger than 60 days old. Quant Imaging Med Surg. 2023;13:259\u201370.","journal-title":"Quant Imaging Med Surg"},{"key":"779_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s12887-020-02169-8","volume":"20","author":"D Zhao","year":"2020","unstructured":"Zhao D, Zhou K, Chen Y, Xie W, Zhang Y. Development and validation of bile acid profile-based scoring system for identification of biliary atresia: a prospective study. BMC Pediatr. 2020;20:255.","journal-title":"BMC Pediatr"},{"key":"779_CR22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.dld.2021.09.011","volume":"54","author":"G Ranucci","year":"2022","unstructured":"Ranucci G, Della Corte C, Alberti D, Bondioni MP, Boroni G, Calvo PL, et al. Diagnostic approach to neonatal and infantile cholestasis: a position paper by the SIGENP liver disease working group. Dig Liver Dis. 2022;54:40\u201353.","journal-title":"Dig Liver Dis"},{"key":"779_CR23","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00383-013-3368-7","volume":"29","author":"S Fumino","year":"2013","unstructured":"Fumino S, Higuchi K, Aoi S, Furukawa T, Kimura O, Tajiri T. Clinical analysis of liver fibrosis in choledochal cyst. Pediatr Surg Int. 2013;29:1097\u2013102.","journal-title":"Pediatr Surg Int"},{"key":"779_CR24","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.3748\/wjg.v26.i21.2821","volume":"26","author":"MH Lee","year":"2020","unstructured":"Lee MH, Shin HJ, Yoon H, Han SJ, Koh H, Lee MJ. Periportal thickening on magnetic resonance imaging for hepatic fibrosis in infantile cholestasis. World J Gastroenterol. 2020;26:2821\u201330.","journal-title":"World J Gastroenterol"},{"key":"779_CR25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s12519-022-00619-0","volume":"19","author":"JJ Zhu","year":"2023","unstructured":"Zhu JJ, Yang YF, Dong R, Zheng S. Biliatresone: progress in biliary atresia study. World J Pediatr. 2023;19:417\u201324.","journal-title":"World J Pediatr"},{"key":"779_CR26","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s00383-017-4159-3","volume":"33","author":"C Goodhue","year":"2017","unstructured":"Goodhue C, Fenlon M, Wang KS. Newborn screening for biliary atresia in the United States. Pediatr Surg Int. 2017;33:1315\u20138.","journal-title":"Pediatr Surg Int"},{"key":"779_CR27","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/hepr.13753","volume":"52","author":"H Sakaguchi","year":"2022","unstructured":"Sakaguchi H, Konishi KI, Yasuda R, Sasaki H, Yoshimaru K, Tainaka T, et al. Serum matrix metalloproteinase-7 in biliary atresia: a Japanese multicenter study. Hepatol Res. 2022;52:479\u201387.","journal-title":"Hepatol Res"},{"key":"779_CR28","doi-asserted-by":"publisher","first-page":"11692","DOI":"10.1038\/s41598-021-91072-y","volume":"11","author":"L He","year":"2021","unstructured":"He L, Ip DKM, Tam G, Lui VCH, Tam PKH, Chung PHY. Biomarkers for the diagnosis and post-Kasai portoenterostomy prognosis of biliary atresia: a systematic review and meta-analysis. Sci Rep. 2021;11:11692.","journal-title":"Sci Rep"},{"key":"779_CR29","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-0902","volume":"144","author":"J Jiang","year":"2019","unstructured":"Jiang J, Wang J, Shen Z, Lu X, Chen G, Huang Y, et al. Serum MMP-7 in the diagnosis of biliary atresia. Pediatrics. 2019;144:e20190902.","journal-title":"Pediatrics"},{"key":"779_CR30","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s12887-022-03409-9","volume":"22","author":"P Rohani","year":"2022","unstructured":"Rohani P, Mirrahimi SB, Bashirirad H, Rahmani P, Kamran N, Alimadadi H, et al. Serum matrix metalloproteinase-7 levels in infants with cholestasis and biliary atresia. BMC Pediatr. 2022;22:351.","journal-title":"BMC Pediatr"},{"key":"779_CR31","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1001\/jama.2020.0837","volume":"323","author":"S Harpavat","year":"2020","unstructured":"Harpavat S, Garcia-Prats JA, Anaya C, Brandt ML, Lupo PJ, Finegold MJ, et al. Diagnostic yield of newborn screening for biliary atresia using direct or conjugated bilirubin measurements. JAMA. 2020;323:1141\u201350.","journal-title":"JAMA"},{"key":"779_CR32","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jpedsurg.2017.10.001","volume":"53","author":"K Ihn","year":"2018","unstructured":"Ihn K, Ho IG, Chang EY, Han SJ. Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia. J Pediatr Surg. 2018;53:461\u20137.","journal-title":"J Pediatr Surg"},{"key":"779_CR33","first-page":"270","volume":"24","author":"SL Siu","year":"2018","unstructured":"Siu SL, Chan LW, Kwong AN. Clinical and biochemical characteristics of infants with prolonged neonatal jaundice. Hong Kong Med J. 2018;24:270\u20136.","journal-title":"Hong Kong Med J"},{"key":"779_CR34","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1097\/MPG.0000000000003701","volume":"76","author":"CS Lee","year":"2023","unstructured":"Lee CS, Ni YH, Chen HL, Wu JF, Hsu HY, Chien YH, et al. A pilot study of biliary atresia newborn screening using dried blood spot matrix metalloproteinase-7. J Pediatr Gastroenterol Nutr. 2023;76:418\u201323.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"779_CR35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/cld.1165","volume":"19","author":"MM Corrado","year":"2022","unstructured":"Corrado MM, Mack CL. Diagnostic tools for early detection of biliary atresia: is a newborn screen attainable? Clin Liver Dis (Hoboken). 2022;19:25\u20138.","journal-title":"Clin Liver Dis (Hoboken)"},{"key":"779_CR36","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-052328","volume":"11","author":"J Jiang","year":"2021","unstructured":"Jiang J, Deng J, Chen G, Dong R, Sun S, Du M, et al. Protocol for a diagnostic accuracy study to develop diagnosis algorithm for biliary atresia using MMP-7 (DIABA-7 study): a study recruiting from Chinese Biliary Atresia Collaborative Network. BMJ Open. 2021;11:e052328.","journal-title":"BMJ Open"},{"key":"779_CR37","doi-asserted-by":"publisher","first-page":"227","DOI":"10.4103\/jiaps.JIAPS_389_20","volume":"27","author":"TR Singh","year":"2022","unstructured":"Singh TR, Goel P, Bajpai M, Kandasamy D, Malik R, Yadav R, et al. Serum matrix metalloproteinase 7 as a diagnostic and prognostic biomarker for extrahepatic biliary atresia. J Indian Assoc Pediatr Surg. 2022;27:227\u201335.","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"779_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21037\/dmr-21-52","volume":"4","author":"B Sun","year":"2021","unstructured":"Sun B, Kelleher S, Short C, Valencia PA, Zagory JA. Recent advancements in laboratory screening, diagnosis, and prognosis of biliary atresia: a literature review. Dig Med Res. 2021;4:1\u201310.","journal-title":"Dig Med Res"},{"key":"779_CR39","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1007\/s00431-022-04612-7","volume":"181","author":"B Wu","year":"2022","unstructured":"Wu B, Zhou Y, Tian X, Cai W, Xiao Y. Diagnostic values of plasma matrix metalloproteinase-7, interleukin-8, and gamma-glutamyl transferase in biliary atresia. Eur J Pediatr. 2022;181:3945\u201353.","journal-title":"Eur J Pediatr"},{"key":"779_CR40","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1007\/s12262-021-03107-3","volume":"84","author":"X Tang","year":"2021","unstructured":"Tang X, Lv Y, Pu L, Ma J, Jin S, Xiang B. Matrix metalloproteinase-7 as a diagnostic marker for biliary atresia: a systematic review and meta-analysis. Indian J Surg. 2021;84:682\u20139.","journal-title":"Indian J Surg"},{"key":"779_CR41","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3390\/s16122106","volume":"16","author":"N Jeon","year":"2016","unstructured":"Jeon N, Lee H. Integrated fault diagnosis algorithm for motor sensors of in-wheel independent drive electric vehicles. Sensors (Basel). 2016;16:2106.","journal-title":"Sensors (Basel)"},{"key":"779_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s43856-023-00295-9","volume":"3","author":"F Pan","year":"2023","unstructured":"Pan F, Huang Y, Cai X, Wang Y, Guan Y, Deng J, et al. Integrated algorithm combining plasma biomarkers and cognitive assessments accurately predicts brain beta-amyloid pathology. Commun Med (Lond). 2023;3:65.","journal-title":"Commun Med (Lond)"},{"key":"779_CR43","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3390\/cells9051212","volume":"9","author":"E Geervliet","year":"2020","unstructured":"Geervliet E, Bansal R. Matrix metalloproteinases as potential biomarkers and therapeutic targets in liver diseases. Cells. 2020;9:1212.","journal-title":"Cells"},{"key":"779_CR44","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cjp2.50","volume":"2","author":"A Kerola","year":"2016","unstructured":"Kerola A, Lampela H, Lohi J, Heikkila P, Mutanen A, Hagstrom J, et al. Increased MMP-7 expression in biliary epithelium and serum underpins native liver fibrosis after successful portoenterostomy in biliary atresia. J Pathol Clin Res. 2016;2:187\u201398.","journal-title":"J Pathol Clin Res"},{"key":"779_CR45","doi-asserted-by":"publisher","first-page":"218","DOI":"10.12688\/f1000research.16732.1","volume":"8","author":"A Wehrman","year":"2019","unstructured":"Wehrman A, Waisbourd-Zinman O, Wells RG. Recent advances in understanding biliary atresia. F1000Res. 2019;8:218.","journal-title":"F1000Res"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-023-00779-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-023-00779-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-023-00779-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T12:03:10Z","timestamp":1726401790000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-023-00779-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,23]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["779"],"URL":"https:\/\/doi.org\/10.1007\/s12519-023-00779-7","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,23]]},"assertion":[{"value":"15 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Author Li-Zhong Du is a member of the Editorial Board for <i>World Journal of Pediatrics<\/i>. The paper was handled by the other Editor and has undergone rigorous peer review process. Author Li-Zhong Du was not involved in the journal\u2019s review of, or decisions related to, this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Written informed consents were obtained from all the children\u2019s caregivers. This study was approved by the Ethics Committee of Children\u2019s Hospital, Zhejiang University School of Medicine (2023-IRB-0066-P-01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}