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The clinical characteristics and phenotypes of pediatric BS as a highly heterogeneous variable vessel vasculitis were investigated in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted to compare clinical variables and descriptive characteristics of BS by age of onset and gender. Cluster analysis was then performed to identify the phenotypes of pediatric BS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2082 BS patients were included in this study, 1834 adults and 248 children. Compared with adult-onset BS, pediatric BS had a higher incidence of folliculitis [relative risks (RR) and 95% confidence interval (CI) 1.3 (1.0\u20131.5)], uveitis of the left eye [RR and 95% CI 2.3 (1.0\u20135.0)], intestinal ulcer complications [RR and 95% CI 2.1 (1.1\u20134.2)], pericarditis [RR and 95% CI 2.5 (1.0\u20136.2)], and psychiatric disorders [RR and 95% CI 2.8(1.0\u20137.9)], while the incidence of thrombocytopenia was lower [RR 0.2 (0.1\u20131.0)]. Among pediatric BS, females had more genital ulcers, while males were more likely to have skin lesions, panuveitis, vascular involvement, venous lesions, cardiac involvement, and aortic aneurysms. Cluster analysis classified pediatric BS into five clusters (C1\u2013C5): C1 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961, 24.6%) showed gastrointestinal (GI) involvement; C2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944, 17.7%) was the central nervous system (CNS) type where 23 cases overlapped joint involvement; in C3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935, 14.1%), all patients presented with arthritis or arthralgia; all patients in C4 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929, 11.7%) manifested ocular involvement, with a few patients overlapping with GI involvement or joint damage; C5 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200979, 31.9%) was the mucocutaneous type, presenting both oral ulcers, genital ulcers, and skin lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The clinical features of pediatric and adult BS differ significantly. Male and female pediatric BS also have a distinct demography. Five phenotypes including GI, CNS, joint, ocular, and mucocutaneous types were identified for pediatric BS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s12519-023-00785-9","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T02:02:06Z","timestamp":1707098526000},"page":"801-808","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical heterogeneity and five phenotypes identified in pediatric Beh\u00e7et\u2019s syndrome: a cohort study from Shanghai Beh\u00e7et\u2019s syndrome database"],"prefix":"10.1007","volume":"20","author":[{"given":"Dan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hui","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Fang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Fei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2011Fen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2011Fen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-480X","authenticated-orcid":false,"given":"Jian-Long","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"785_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1750-1172-7-20","volume":"7","author":"D Saadoun","year":"2012","unstructured":"Saadoun D, Wechsler B. 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