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We investigated whether platelet-related factors related to treatment efficacy in children suffering from VVS treated with metoprolol.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Metoprolol-treated VVS patients were recruited. The median duration of therapy was three\u00a0months. Patients were followed and divided into two groups, treament-effective group and treatment-ineffective group. Logistic and least absolute shrinkage selection operator regressions were used to examine treatment outcome variables. Receiver-operating characteristic (ROC) curves, precision\u2013recall (PR) curves, calibration plots, and decision curve analyses were used to evaluate the nomogram model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the 72 patients who complete the follow-up, treatment-effective group and treatment-ineffective group included 42 (58.3%) and 30 (41.7%) cases, respectively. The patients in the treatment-effective group exhibited higher mean platelet volume (MPV) [(11.0\u2009\u00b1\u20091.0) fl vs. (9.8\u2009\u00b1\u20091.0) fl, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01] and platelet distribution width [12.7% (12.3%, 14.3%) vs. 11.3% (10.2%, 12.2%), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01]\u00a0than those in the treatment-ineffective group. The sex ratio was significantly different (<jats:italic>P<\/jats:italic>\u2009=\u20090.046). A fit model comprising age [odds ratio (OR)\u2009=\u20090.766, 95% confidence interval (CI)\u2009=\u20090.594\u20130.987] and MPV (OR\u2009=\u20095.613, 95% CI\u2009=\u20092.297\u201313.711) might predict therapeutic efficacy. The area under the curve of the ROC and PR curves was computed to be 0.85 and 0.9, respectively. The <jats:italic>P<\/jats:italic> value of the Hosmer\u2013Lemeshow test was 0.27. The decision curve analysis confirmed that managing children with VVS based on the predictive model led to a net advantage ranging from 0.01 to 0.58. The nomogram is convenient for clinical applications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A novel nomogram based on age and MPV can predict the therapeutic benefits of metoprolol in children with VVS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12519-024-00802-5","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T10:01:46Z","timestamp":1713002506000},"page":"957-965","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Age and mean platelet volume-based nomogram for predicting the therapeutic efficacy of metoprolol in Chinese pediatric patients with vasovagal syncope"],"prefix":"10.1007","volume":"20","author":[{"given":"Xiao-Juan","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Qian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Fang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Bao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"802_CR1","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s12519-023-00693-y","volume":"19","author":"YX Cui","year":"2023","unstructured":"Cui YX, Du JB, Jin HF. 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Author\u00a0Jun-Bao Du is a member of the Editorial Board for <i>World Journal of Pediatrics<\/i>. The paper was handled by the other editor and has undergone a rigorous peer-review process. Author\u00a0Jun-Bao Du was not involved in the journal's review or decisions related to this manuscript. The authors have no conflict of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}