{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:22:42Z","timestamp":1757618562582,"version":"3.44.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s12519-025-00933-3","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T22:11:49Z","timestamp":1751062309000},"page":"766-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the complexities of pediatric Beh\u00e7et\u2019s disease clusters"],"prefix":"10.1007","volume":"21","author":[{"given":"Jun","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-480X","authenticated-orcid":false,"given":"Jian-Long","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"933_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1203\/01.PDR.0000182823.85717.48","volume":"58","author":"JG Schaller","year":"2005","unstructured":"Schaller JG. The history of pediatric rheumatology. Pediatr Res. 2005;58:997\u20131007.","journal-title":"Pediatr Res"},{"key":"933_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/BOR.0000000000001057","volume":"37","author":"M Yildiz","year":"2025","unstructured":"Yildiz M, Koker O, Kasapcopur O. Juvenile Beh\u00e7et syndrome: a contemporary view and differential diagnosis in pediatric practice. Curr Opin Rheumatol. 2025;37:3\u201314.","journal-title":"Curr Opin Rheumatol"},{"key":"933_CR3","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1136\/annrheumdis-2015-208491","volume":"75","author":"I Kon\u00e9-Paut","year":"2016","unstructured":"Kon\u00e9-Paut I, Shahram F, Darce-Bello M, Cantarini L, Cimaz R, Gattorno M, et al. Consensus classification criteria for paediatric Beh\u00e7et\u2019s disease from a prospective observational cohort: pedbd. Ann Rheum Dis. 2016;75:958\u201364.","journal-title":"Ann Rheum Dis"},{"key":"933_CR4","first-page":"1955","volume":"41","author":"J Zou","year":"2023","unstructured":"Zou J. The transcriptional profiling identifies hub genes in immune subsets of patients with Beh\u00e7et\u2019s syndrome. Clin Exp Rheumatol. 2023;41:1955\u201363.","journal-title":"Clin Exp Rheumatol"},{"key":"933_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250181","volume":"53","author":"J Zou","year":"2023","unstructured":"Zou J, Li B, Li D, Bao HF, She CH, Ye JF, et al. Comprehensive analysis of T-cell receptor repertoires reveals antigen-driven T-cell clusters in patients with Beh\u00e7et\u2019s syndrome. Eur J Immunol. 2023;53:e2250181.","journal-title":"Eur J Immunol"},{"key":"933_CR6","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1080\/14397595.2021.1891670","volume":"31","author":"J Zou","year":"2021","unstructured":"Zou J, Luo JF, Shen Y, Guan JL. Distinct clinical characteristics of pediatric Beh\u00e7et\u2019s syndrome: a study from a referral center in China. Mod Rheumatol. 2021;31:1158\u201363.","journal-title":"Mod Rheumatol"},{"key":"933_CR7","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s12519-023-00785-9","volume":"20","author":"D Hu","year":"2024","unstructured":"Hu D, She CH, Bao HF, Zou J, Cai JF, Ye JF, et al. Clinical heterogeneity and five phenotypes identified in pediatric Beh\u00e7et\u2019s syndrome: a cohort study from Shanghai Beh\u00e7et\u2019s syndrome database. World J Pediatr. 2024;20:801\u20138.","journal-title":"World J Pediatr"},{"key":"933_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13075-021-02429-7","volume":"23","author":"J Zou","year":"2021","unstructured":"Zou J, Luo JF, Shen Y, Cai JF, Guan JL. Cluster analysis of phenotypes of patients with Beh\u00e7et\u2019s syndrome: a large cohort study from a referral center in China. Arthritis Res Ther. 2021;23:45.","journal-title":"Arthritis Res Ther"},{"key":"933_CR9","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1007\/s10067-024-06995-4","volume":"43","author":"CH She","year":"2024","unstructured":"She CH, Hu D, Zou J, Bao HF, Shen Y, Cai JF, et al. Clinical phenotypes of adult-onset beh\u00e7et\u2019s syndrome: a comprehensive cross-sectional study in China. Clin Rheumatol. 2024;43:2261\u201371.","journal-title":"Clin Rheumatol"},{"key":"933_CR10","doi-asserted-by":"publisher","first-page":"1759720X2412758","DOI":"10.1177\/1759720X241275822","volume":"16","author":"I Maccora","year":"2024","unstructured":"Maccora I, Orsini SI, Gallizzi R, Montin D, Cattalini M, la Torre F, et al. Uveitis in paediatric beh\u00e7et disease: a large multicentric Italian cohort. Ther Adv Musculoskelet Dis. 2024;16:1759720X241275822.","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"933_CR11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0022-3476(99)70333-1","volume":"135","author":"I Kon\u00e9-Paut","year":"1999","unstructured":"Kon\u00e9-Paut I, Geisler I, Wechsler B, Ozen S, Ozdogan H, Rozenbaum M, et al. Familial aggregation in beh\u00e7et\u2019s disease: high frequency in siblings and parents of pediatric probands. J Pediatr. 1999;135:89\u201393.","journal-title":"J Pediatr"},{"key":"933_CR12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/BOR.0000000000000846","volume":"34","author":"M Takeno","year":"2022","unstructured":"Takeno M. The association of Beh\u00e7et\u2019s syndrome with HLA-B51 as understood in 2021. Curr Opin Rheumatol. 2022;34:4\u20139.","journal-title":"Curr Opin Rheumatol"},{"key":"933_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s11739-020-02369-1","volume":"16","author":"D Poddighe","year":"2021","unstructured":"Poddighe D, Turganbekova A, Mukusheva Z, Abdirakhmanova A, Assylbekova M, Abdrakhmanova S. HLA-B*51 allelic and carrier frequency in Kazakhstan: insights into Beh\u00e7et\u2019s disease prevalence in Central Asia. Intern Emerg Med. 2021;16:325\u201331.","journal-title":"Intern Emerg Med"},{"key":"933_CR14","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/rheumatology\/ker423","volume":"51","author":"M Karaca","year":"2012","unstructured":"Karaca M, Hatemi G, Sut N, Yazici H. The papulopustular lesion\/arthritis cluster of Beh\u00e7et\u2019s syndrome also clusters in families. Rheumatology. 2012;51:1053\u201360.","journal-title":"Rheumatology"},{"key":"933_CR15","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/jgh.16449","volume":"39","author":"JY Chang","year":"2024","unstructured":"Chang JY, Park SJ, Park JJ, Kim TI, Cheon JH, Park J. Impact of age at diagnosis on long-term prognosis in patients with intestinal Beh\u00e7et\u2019s disease. J Gastroenterol Hepatol. 2024;39:519\u201326.","journal-title":"J Gastroenterol Hepatol"},{"key":"933_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.627192","volume":"8","author":"M Yildiz","year":"2021","unstructured":"Yildiz M, Haslak F, Adrovic A, Sahin S, Koker O, Barut K, et al. Pediatric beh\u00e7et\u2019s disease. Front Med (Lausanne). 2021;8:627192.","journal-title":"Front Med (Lausanne)"},{"key":"933_CR17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2147\/TCRM.S232660","volume":"16","author":"G Costagliola","year":"2020","unstructured":"Costagliola G, Cappelli S, Consolini R. Beh\u00e7et\u2019s disease in children: diagnostic and management challenges. Ther Clin Risk Manag. 2020;16:495\u2013507.","journal-title":"Ther Clin Risk Manag"},{"key":"933_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108381","volume":"214","author":"CE Pain","year":"2020","unstructured":"Pain CE. Juvenile-onset beh\u00e7et\u2019s syndrome and mimics. Clin Immunol. 2020;214:108381.","journal-title":"Clin Immunol"},{"key":"933_CR19","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1136\/annrheumdis-2018-213225","volume":"77","author":"G Hatemi","year":"2018","unstructured":"Hatemi G, Christensen R, Bang D, Bodaghi B, Celik AF, Fortune F, et al. 2018 update of the EULAR recommendations for the management of Beh\u00e7et\u2019s syndrome. Ann Rheum Dis. 2018;77:808\u201318.","journal-title":"Ann Rheum Dis"},{"key":"933_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s40272-022-00548-5","volume":"25","author":"T Giani","year":"2023","unstructured":"Giani T, Luppino AF, Ferrara G. Treatment options in pediatric beh\u00e7et\u2019s disease. Paediatr Drugs. 2023;25:165\u201391.","journal-title":"Paediatr Drugs"},{"key":"933_CR21","doi-asserted-by":"publisher","first-page":"1759720X2211240","DOI":"10.1177\/1759720X221124014","volume":"14","author":"J Zou","year":"2022","unstructured":"Zou J, Cai JF, Ye JF, Guan JL. Tofacitinib as an alternative therapy for refractory intestinal Beh\u00e7et\u2019s syndrome. Ther Adv Musculoskelet Dis. 2022;14:1759720X221124014.","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"933_CR22","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1056\/NEJMoa1816594","volume":"381","author":"G Hatemi","year":"2019","unstructured":"Hatemi G, Mahr A, Ishigatsubo Y, Song YW, Takeno M, Kim D, et al. Trial of apremilast for oral ulcers in beh\u00e7et\u2019s syndrome. N Engl J Med. 2019;381:1918\u201328.","journal-title":"N Engl J Med"},{"key":"933_CR23","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s40259-023-00613-6","volume":"37","author":"ED Batu","year":"2023","unstructured":"Batu ED, Sener S, Cam V, AktayAyaz N, Ozen S. Treatment with biologic drugs in pediatric beh\u00e7et\u2019s disease: a comprehensive analysis of the published data. BioDrugs. 2023;37:813\u201328.","journal-title":"BioDrugs"},{"key":"933_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jaut.2015.08.013","volume":"64","author":"M Takeuchi","year":"2015","unstructured":"Takeuchi M, Kastner DL, Remmers EF. The immunogenetics of beh\u00e7et\u2019s disease: a comprehensive review. J Autoimmun. 2015;64:137\u201348.","journal-title":"J Autoimmun"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-025-00933-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-025-00933-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-025-00933-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T23:54:29Z","timestamp":1757202869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-025-00933-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["933"],"URL":"https:\/\/doi.org\/10.1007\/s12519-025-00933-3","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"type":"print","value":"1708-8569"},{"type":"electronic","value":"1867-0687"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"assertion":[{"value":"18 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}