{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:03:08Z","timestamp":1780074188650,"version":"3.54.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Horizontal Research Project of Zhejiang University","award":["2021-KYY-518051-0102"],"award-info":[{"award-number":["2021-KYY-518051-0102"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Pediatr"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12519-026-01030-9","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:15:15Z","timestamp":1775664915000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical efficacy of growth hormone therapy in adolescent short stature during late puberty: a prospective cohort study"],"prefix":"10.1007","volume":"22","author":[{"given":"Ke","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Lan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Feng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun-Hua","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Fang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4273-1341","authenticated-orcid":false,"given":"Chun-Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"1030_CR1","first-page":"206","volume":"72","author":"W Oostdijk","year":"2009","unstructured":"Oostdijk W, Grote FK, de Muinck Keizer-Schrama SM, Wit JM. Diagnostic approach in children with short stature. Horm Res. 2009;72:206\u201317.","journal-title":"Horm Res"},{"key":"1030_CR2","first-page":"29","volume":"91","author":"A Al Shaikh","year":"2020","unstructured":"Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, et al. Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and turner syndrome (TS) in a tertiary care center. Acta Biomed. 2020;91:29\u201340.","journal-title":"Acta Biomed"},{"key":"1030_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta14420","volume":"14","author":"A Takeda","year":"2010","unstructured":"Takeda A, Cooper K, Bird A, Baxter L, Frampton GK, Gospodarevskaya E, et al. Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation. Health Technol Assess. 2010;14:1\u2013209.","journal-title":"Health Technol Assess"},{"key":"1030_CR4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1159\/000499929","volume":"28","author":"N Khawaja","year":"2019","unstructured":"Khawaja N, Owaineh H, Batieha A, Frahid O, El-Khateeb M, Ajlouni KM. The effect of gonadotropin-releasing hormone analogue on final adult height in children with idiopathic short stature. Med Princ Pract. 2019;28:509\u201316.","journal-title":"Med Princ Pract"},{"key":"1030_CR5","first-page":"275","volume":"49","author":"C Wang","year":"2020","unstructured":"Wang C, Liang L. [Reconsideration of the third-generation non-steroidal aromatase inhibitors in pediatrics]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;49:275\u201382.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"1030_CR6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrendo.2018.22","volume":"14","author":"MB Ranke","year":"2018","unstructured":"Ranke MB, Wit JM. Growth hormone - past, present and future. Nat Rev Endocrinol. 2018;14:285\u2013300.","journal-title":"Nat Rev Endocrinol"},{"key":"1030_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1365-2265.2009.03686.x","volume":"72","author":"W H\u00f6gler","year":"2010","unstructured":"H\u00f6gler W, Shaw N. Childhood growth hormone deficiency, bone density, structures and fractures: scrutinizing the evidence. Clin Endocrinol (Oxf). 2010;72:281\u20139.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1030_CR8","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.4103\/2230-8210.145075","volume":"18","author":"A Soliman","year":"2014","unstructured":"Soliman A, De Sanctis V, Elalaily R, Bedair S. Advances in pubertal growth and factors influencing it: Can we increase pubertal growth? Indian J Endocrinol Metab. 2014;18:S53-62.","journal-title":"Indian J Endocrinol Metab"},{"key":"1030_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1514935","volume":"15","author":"HJ Ly","year":"2024","unstructured":"Ly HJ, Ankarberg-Lindgren C, Fors H, Nilsson S, Dahlgren J. Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty. Front Endocrinol (Lausanne). 2024;15:1514935.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1030_CR10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ghir.2015.01.002","volume":"25","author":"A Rothenbuhler","year":"2015","unstructured":"Rothenbuhler A, Ormi\u00e8res B, Kalifa G, Bougn\u00e8res P. A pilot study of growth hormone administration in boys with predicted adult short stature and near-ending growth. Growth Horm IGF Res. 2015;25:96\u2013102.","journal-title":"Growth Horm IGF Res"},{"key":"1030_CR11","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1017\/S1120962300018680","volume":"8","author":"G Iannaccone","year":"1959","unstructured":"Iannaccone G, Greulich WW, Pyle SI, Radiographic atlas of skeletal development of the hand and wrist, 2nd edition: I volume-atlante di 256 pagine. Stanford University Press, Stanford, California, 1959. Acta Genet Med Gemellol. 1959;8:513.","journal-title":"Acta Genet Med Gemellol"},{"key":"1030_CR12","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0022-3476(95)70221-0","volume":"126","author":"A Bar","year":"1995","unstructured":"Bar A, Linder B, Sobel EH, Saenger P, DiMartino-Nardi J. Bayley-Pinneau method of height prediction in girls with central precocious puberty: correlation with adult height. J Pediatr. 1995;126:955\u20138.","journal-title":"J Pediatr"},{"key":"1030_CR13","first-page":"487","volume":"47","author":"H Li","year":"2009","unstructured":"Li H, Ji CY, Zong XN, Zhang YQ. [Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years]. Zhonghua Er Ke Za Zhi. 2009;47:487\u201392.","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"1030_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.4274\/jcrpe.galenos.2024.2024-1-13","volume":"16","author":"PA Lee","year":"2024","unstructured":"Lee PA. Short adult height after rapid-tempo puberty: When is it too late to treat? J Clin Res Pediatr Endocrinol. 2024;16:235\u201342.","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"1030_CR15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jpeds.2004.09.021","volume":"146","author":"RG Rosenfeld","year":"2005","unstructured":"Rosenfeld RG. A tale of two centimeters. J Pediatr. 2005;146:10\u20131.","journal-title":"J Pediatr"},{"key":"1030_CR16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1159\/000520812","volume":"94","author":"DB Allen","year":"2021","unstructured":"Allen DB, Merchant N, Miller BS, Backeljauw PF. Evolution and future of growth plate therapeutics. Horm Res Paediatr. 2021;94:319\u201332.","journal-title":"Horm Res Paediatr"},{"key":"1030_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000530578","volume":"97","author":"D Olwi","year":"2024","unstructured":"Olwi D, Day F, Ong K. Effect of growth hormone therapy on pubertal timing: Systematic review and meta-analysis. Horm Res Paediatr. 2024;97:1\u201310.","journal-title":"Horm Res Paediatr"}],"container-title":["World Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-026-01030-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12519-026-01030-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12519-026-01030-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:15:55Z","timestamp":1780071355000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12519-026-01030-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["1030"],"URL":"https:\/\/doi.org\/10.1007\/s12519-026-01030-9","relation":{},"ISSN":["1708-8569","1867-0687"],"issn-type":[{"value":"1708-8569","type":"print"},{"value":"1867-0687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval was obtained from the Ethics Committee of the First Affiliated Hospital of Zhejiang University School of Medicine (Expedition review No. 642 in 2021). Informed consent to participate in the study has been obtained from participants (or their parent or legal guardian in the case of children under 16).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}