{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:16:14Z","timestamp":1771982174691,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To identify predictive factors for successful expectant management of ectopic pregnancy and to evaluate the prognosis for fertility after expectant management and laparoscopic salpingostomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six cases of expectant management and eighty cases of laparoscopic salpingostomy for tubal ectopic pregnancy were retrospectively analyzed. Subjects were classified in three groups: those who underwent laparoscopic salpingostomy, those treated by expectant management only, and those treated by expectant management but requiring additional treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rates of tubal patency, intrauterine pregnancy and repeated ectopic pregnancy in the laparoscopic salpingostomy group were 75, 40, and 16%. The rates in the expectant management group were not significantly different: 72, 42 and 15%. Finally, the rates in the extra treatment group were 75, 39 and 15%. Success rate of expectant management was 54%. In 93% of cases expectant management was successfully completed when the initial levels of urinal hCG were less than 3000 mIU\/ml and the levels of hCG 48 h later were less than 80% of the initial levels. However, expectant management alone was insufficient and required extra treatment in 90% of cases when the initial levels of hCG were 3000 mIU\/ml and above or when the levels of hCG level 48 h later was 80% of initial levels and above.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Expectant management in combination with salpingostomy is not only minimally invasive but also a useful way to preserve fertility. Initial urine hCG levels and their variation over time can help predict whether expectant management will succeed.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12522-009-0022-0","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T02:46:44Z","timestamp":1246330004000},"page":"119-123","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective analysis of laparoscopic salpingostomy and conservative expectant management of tubal ectopic pregnancy"],"prefix":"10.1002","volume":"8","author":[{"given":"Kunitomo","family":"Takashima","sequence":"first","affiliation":[{"name":"Department of Gynecology Yokohama City University, Medical Center Hospital  4\u201057 Urafune\u2010cho, Minami\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gynecology Yokohama City University, Medical Center Hospital  4\u201057 Urafune\u2010cho, Minami\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Murase","sequence":"additional","affiliation":[{"name":"Department of Gynecology Yokohama City University, Medical Center Hospital  4\u201057 Urafune\u2010cho, Minami\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gynecology Yokohama City University, Medical Center Hospital  4\u201057 Urafune\u2010cho, Minami\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University School of Medicine  3\u20109 Fukuura, Kanazawa\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiki","family":"Hirahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University School of Medicine  3\u20109 Fukuura, Kanazawa\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology Yokohama City University, Medical Center Hospital  4\u201057 Urafune\u2010cho, Minami\u2010ku Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53271-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54539-7"},{"key":"e_1_2_7_4_1","first-page":"70","article-title":"Early ectopic pregnancy","volume":"62","author":"Lund J","year":"1955","journal-title":"J Obstet Gynaecol Br Emp"},{"key":"e_1_2_7_5_1","first-page":"171","article-title":"Spontaneous resolution of ectopic pregnancy","volume":"71","author":"Fernandez H","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.1995.05050297.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57410-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57289-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56638-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1061"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136123"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.236"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(97)00414\u20107"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs12522-009-0022-0","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs12522-009-0022-0","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s12522-009-0022-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T16:51:36Z","timestamp":1699894296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s12522-009-0022-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1007\/s12522-009-0022-0"],"URL":"https:\/\/doi.org\/10.1007\/s12522-009-0022-0","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}