{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:26:53Z","timestamp":1767857213935,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T00:00:00Z","timestamp":1251244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human uterus is unique in that it possesses the tremendous regenerative capacity required for cyclical regeneration and remodeling throughout a woman's reproductive life. Not only must the uterus rapidly enlarge to accommodate the developing fetus, the endometrium must also regenerate with each menstrual cycle. This plasticity of the reproductive system has recently been highlighted. My research group and collaborators showed that functional endometrial tissue could be regenerated from only a small number of singly dispersed human endometrial cells, transplanted beneath the kidney capsule of severely immunodeficient mice. This artificially generated endometrium resembles the natural endometrium, and contains human blood vessels that invade the mouse kidney parenchyma. Additionally, it mimics normal hormone\u2010dependent changes including proliferation, differentiation, and tissue breakdown (menstruation). The regenerative capacity of endometrial cells makes them ideal candidates for tissue reconstitution, angiogenesis, and human\u2013mouse chimeric vessel formation. The smooth muscle cells of the uterus (myometrium) share the plasticity of the endometrium. This is evidenced by their capacity for dramatic, repeatable, pregnancy\u2010induced enlargement. Regeneration and remodeling in the female reproductive tract allude to the existence of endometrial and myometrial stem cell systems. We have recently isolated candidate populations of adult stem cells from both the human endometrium and myometrium. Characterization of these endometrial and myometrial cells, along with the study of the mechanisms controlling their regeneration, will improve the understanding of the physiology and pathophysiology of the female reproductive tract. Furthermore, myometrial and endometrial stem\u2010like cells might also represent a novel source of biological material that could be used for the reconstruction of not only the human uterus but other organs as well.<\/jats:p>","DOI":"10.1007\/s12522-009-0032-y","type":"journal-article","created":{"date-parts":[[2009,8,25]],"date-time":"2009-08-25T01:09:09Z","timestamp":1251162549000},"page":"9-16","source":"Crossref","is-referenced-by-count":9,"title":["Stem\/progenitor cells and the regeneration potentials in the human uterus"],"prefix":"10.1002","volume":"9","author":[{"given":"Tetsuo","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Keio University School of Medicine  35, Shinanomachi, Shinjuku\u2010ku 160\u20108582 Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07040"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1689808"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml045"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/SCCAA.S4269"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K08E\u2010067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod40.3.681"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.024109"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004\u20100021"},{"key":"e_1_2_8_10_1","unstructured":"Strauss III JF Lessey BA: The structure function and evaluation of the female reproductive tract. In: Strauss III JF Barbieri RL editors. Yen and Jaffe's Reproductive Endocrinology. Physiology Pathophysiology and Clinical Management 5th ed. Amsterdam: Elsevier Saunders; 2004. p. 255\u2013305."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.6.1686"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052867"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(04)17403\u20105"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804690"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90240-0"},{"key":"e_1_2_8_16_1","first-page":"337","article-title":"Human uterine endometrium and endometriotic tissue transplanted into nude mice. 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