{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:08:33Z","timestamp":1717970913455},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:00:00Z","timestamp":1312329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To elucidate the etiology of recurrent pregnancy loss in patients with congenital uterine anomalies, an immunohistochemical technique was used to quantitatively evaluate the vascular arrangement of septate uteri with respect to vascular density and morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine specimens obtained from patients who had undergone metroplastic surgery for the treatment of a septate uterus and 10 control specimens from patients who had undergone a hysterectomy because of cervical carcinoma were used in this study. Formalin\u2010fixed paraffin\u2010embedded uterine specimens were then immunostained for CD34, which is specifically expressed in vascular endothelial cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean blood vessel count (mean \u00b1 SD) for the myometrium was 149.7 \u00b1 22.7\/field in the septate uteri and 162.2 \u00b1 36.4\/field in the control uteri; these values were not significantly different. However, the total vessel cross\u2010sectional areas, as evaluated quantitatively using the KS400 image analysis system, were 10350.4 \u00b1 1024.3 \u03bcm<jats:sup>2<\/jats:sup>\/field for the septate uteri and 12002.9 \u00b1 2232.3 \u03bcm<jats:sup>2<\/jats:sup>\/field for the control uteri; these values were significantly different (<jats:italic>p<\/jats:italic> &lt; 0.05). The vessel morphology expressed by vessel irregularity and deformity showed a characteristic change in the septate uterus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant difference in the distribution of the blood vessels existed between the septate and control uteri, presumably impairing blood flow in the myometrium and the adverse pregnancy outcome.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12522-011-0103-8","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T04:37:37Z","timestamp":1312259857000},"page":"277-282","source":"Crossref","is-referenced-by-count":2,"title":["An immunohistochemical study of metroplastic surgical specimens from patients with a septate uterus"],"prefix":"10.1002","volume":"10","author":[{"given":"Tsunehisa","family":"Makino","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Tokai University  Isehara Kanagawa Japan"},{"name":"Tohbu Hospital  1180\u20102 Gumisawa 412\u20100041 Gotemba Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010yi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Tokai University  Isehara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun\u2010ichiro","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine Tokai University  Isehara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University  Isehara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,3]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Abnormalities of the reproductive tract. 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