{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:04:56Z","timestamp":1700611496429},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T00:00:00Z","timestamp":1316563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We aimed to compare the efficacy of a gonadotropin\u2010releasing hormone (GnRH) antagonist protocol and a GnRH agonist long protocol used in the first in vitro fertilization\u2013embryo transfer (IVF\u2013ET) cycle in an unspecified population of infertile couples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty and 34 patients were treated with a GnRH agonist long protocol (agonist group) and GnRH antagonist protocol (antagonist group), respectively, in the first treatment cycle. The primary and secondary outcome measures were cumulative live birth rates after fresh and cryopreserved\u2013thawed ETs and incidence of grades II and III ovarian hyperstimulation syndrome (OHSS), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed in clinical pregnancy rates (38.0 vs. 32.4%) and live birth rates (22.0 vs. 23.5%), which included both fresh and cryopreserved\u2013thawed ETs, between the 2 groups. However, the incidence of grade III OHSS was significantly lower with the GnRH antagonist protocol than the GnRH agonist long protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Used in the first IVF\u2013ET cycle in an unspecified population of infertile patients, the GnRH antagonist protocol showed the same clinical outcome as the GnRH agonist long protocol.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12522-011-0109-2","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T11:14:36Z","timestamp":1316517276000},"page":"79-83","source":"Crossref","is-referenced-by-count":1,"title":["Comparison between the gonadotropin\u2010releasing hormone antagonist protocol and the gonadotropin\u2010releasing hormone agonist long protocol for controlled ovarian hyperstimulation in the first in vitro fertilization\u2013embryo transfer cycle in an unspecified population of infertile couples"],"prefix":"10.1002","volume":"11","author":[{"given":"Keiko","family":"Mekaru","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science University of the Ryukyus  207 Uehara, Nishihara 903\u20100215 Naha Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science University of the Ryukyus  207 Uehara, Nishihara 903\u20100215 Naha Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozue","family":"Asato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science University of the Ryukyus  207 Uehara, Nishihara 903\u20100215 Naha Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Masamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science University of the Ryukyus  207 Uehara, Nishihara 903\u20100215 Naha Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Sakumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science University of the Ryukyus  207 Uehara, Nishihara 903\u20100215 Naha Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science University of the Ryukyus  207 Uehara, Nishihara 903\u20100215 Naha Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei086"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.1.83"},{"key":"e_1_2_5_4_1","first-page":"413","article-title":"Ovarian estradiol production in vivo: inhibitory effect of leuprolide acetate","volume":"43","author":"Kowalik A","year":"1998","journal-title":"J Reprod Med"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(99)00524\u20105"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","unstructured":"AI\u2010Inany HG Abou\u2010Setta AM Aboulghar M. Gonadotropin\u2010releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev. 2006;3:CD001750.","DOI":"10.1002\/14651858.CD001750.pub2"},{"key":"e_1_2_5_7_1","unstructured":"Shanbhag S Aucott L Bhattacharya S Hamilton MA McTavish AR. Interventions for \u201cpoor responders\u201d to controlled ovarian hyperstimulation (COH) in in vitro fertilization (IVF). Cochrane Database Syst Rev. 2010;1:CD004379."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep436"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1354"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.025"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.08.050"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den468"}],"container-title":["Reproductive Medicine and Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs12522-011-0109-2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs12522-011-0109-2","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s12522-011-0109-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T17:08:07Z","timestamp":1700586487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s12522-011-0109-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,21]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1007\/s12522-011-0109-2"],"URL":"https:\/\/doi.org\/10.1007\/s12522-011-0109-2","archive":["Portico"],"relation":{},"ISSN":["1445-5781","1447-0578"],"issn-type":[{"value":"1445-5781","type":"print"},{"value":"1447-0578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,21]]}}}