{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:07:12Z","timestamp":1700629632584},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":40,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Medicine &amp; Biology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Kallmann syndrome is a genetic disorder characterized by hypogonadotropic hypogonadism and anosmia. We report the case of a 31\u2010year\u2010old woman with Kallmann syndrome who successfully gave birth after intracytoplasmic sperm injection (ICSI) and vitrified\u2013warmed embryo transfer, despite relatively ineffective ovarian stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A 30 year\u2010old woman with primary amenorrhea wished to achieve pregnancy. Diagnostic testing results were consistent with Kallmann syndrome. Follicular stimulation was started with human menopausal gonadotropin (hMG; 150 IU\/day). After 28 days of treatment, 4 follicles were observed (total hMG; 4200 IU), with a dominant follicle diameter of 23 mm. Ovum pick\u2010up was performed and 2 oocytes, one at metaphase II (MII) and one at the germinal vesicle stage, were obtained. Piezo\u2010ICSI was performed on the MII oocyte and an 8\u2010cell stage embryo was cryopreserved on day 3. Subsequently, embryo transfer was performed after endometrial preparation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A gestational sac and embryo heart activity were confirmed by ultrasonographic monitoring, and a healthy male infant weighing 3246 g was delivered by Caesarean section after 41 weeks 3 days of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first report of a healthy delivery after vitrified\u2013warmed embryo transfer for a woman with Kallmann syndrome. Our experience suggests that ICSI and vitrified\u2013warmed embryo transfer are effective for women with Kallmann syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s12522-015-0214-8","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T01:10:54Z","timestamp":1437527454000},"page":"45-49","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful pregnancy by vitrified\u2013warmed embryo transfer for a woman with Kallmann syndrome"],"prefix":"10.1002","volume":"15","author":[{"given":"Misato","family":"Shimoda","sequence":"first","affiliation":[{"name":"Yamashita Ladies\u2019 Clinic  7\u20101\u20108 Isogami\u2010dori, Chuo\u2010ku 651\u20100086 Kobe\u2010shi Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Iwayama","sequence":"additional","affiliation":[{"name":"Yamashita Ladies\u2019 Clinic  7\u20101\u20108 Isogami\u2010dori, 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