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D. Janssen: Grants or Contracts: Funding received from Dutch Foundation for Asthma Prevention, Netherlands Respiratory Society (award), ZonMw research grant, and HORIZON-HLTH-2023-DISEASE-03 research grant, all paid to their institution. Payments or Honoraria: Received from Chiesi, Abbott, and AstraZeneca, with payments made to their institution for lectures, presentations, or educational events. Advisory & Safety Boards: Unpaid participation in Better B Steering Committee and Wolfson Palliative Care Research Centre Advisory Board. Dr. Bram van den Borst: Consulting Fees: Received from Sanofi, with payments made to their institution, unrelated to the submitted work. Payments or Honoraria: Received from AstraZeneca, with payments made to their institution, unrelated to the submitted work. Support for Meetings and Travel: Funding received from Chiesi Pharmaceuticals B.V. and AstraZeneca, with payments made to their institution, unrelated to the submitted work. 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