{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:58:21Z","timestamp":1767142701323,"version":"build-2238731810"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,7,19]],"date-time":"2015-07-19T00:00:00Z","timestamp":1437264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Interdiscip Sci Comput Life Sci"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s12539-015-0006-1","type":"journal-article","created":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T02:54:52Z","timestamp":1437188092000},"page":"221-232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Discovery of Potent Antihypertensive Ligands Substituted Imidazolyl Biphenyl Sulfonylureas Analogs as Angiotensin II $$\\hbox {AT}_{1}$$ AT 1 Receptor Antagonists by Molecular Modelling Studies"],"prefix":"10.1007","volume":"7","author":[{"given":"Mukesh C.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,19]]},"reference":[{"key":"6_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI112768","volume":"79","author":"DJ Campbell","year":"1978","unstructured":"Campbell DJ (1978) Circulating and tissue angiotensin systems. J Clin Invest 79:1\u20136","journal-title":"J Clin Invest"},{"key":"6_CR2","first-page":"1631","volume-title":"The heart and cardiovascular system","author":"VJ Dzau","year":"1986","unstructured":"Dzau VJ, Pratt RE (1986) Renin\u2013Angiotensin system: biology, physiology and pharmacology. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE (eds) The heart and cardiovascular system. Raven Press, New York, pp 1631\u20131662"},{"key":"6_CR3","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/00004872-199212007-00002","volume":"10","author":"CI Johnston","year":"1992","unstructured":"Johnston CI, Franz V (1992) Lecture Renin angiotensin system: a dual tissue and hormonal system for cardiovascular control. J Hyperten 10:S13\u2013S26","journal-title":"J Hyperten"},{"key":"6_CR4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.191908","volume":"196","author":"MA Ondetti","year":"1977","unstructured":"Ondetti MA, Rubin A, Cushman DW (1977) Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196:441","journal-title":"Science"},{"key":"6_CR5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2165\/00003495-199040030-00002","volume":"40","author":"D McAreavey","year":"1990","unstructured":"McAreavey D, Robertson JIS (1990) Angiotensin converting enzyme inhibitors and moderate hypertension. Drugs 40:326","journal-title":"Drugs"},{"key":"6_CR6","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1021\/jm9504722","volume":"39","author":"RR Wexler","year":"1996","unstructured":"Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD et al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem 39:625","journal-title":"J Med Chem"},{"key":"6_CR7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/351233a0","volume":"351","author":"TJ Murphy","year":"1991","unstructured":"Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE (1991) Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 351:233\u2013236","journal-title":"Nature"},{"key":"6_CR8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/351230a0","volume":"351","author":"K Sasaki","year":"1991","unstructured":"Sasaki K, Yamano Y, Bardhan S, Iwai N, Murray JJ, Hasegawa M et al (1991) Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature 351:230\u2013233","journal-title":"Nature"},{"key":"6_CR9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF01886795","volume":"14","author":"MP Joseph","year":"1995","unstructured":"Joseph MP, Maigret B, Bonnafous JC, Marie J, Scheraga HA (1995) A computer modeling postulated mechanism for angiotensin II receptor activation. J Prot Chem 14:381\u2013398","journal-title":"J Prot Chem"},{"key":"6_CR10","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/jm00112a031","volume":"34","author":"DJ Carini","year":"1991","unstructured":"Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME et al (1991) Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl) imidazoles as potent, orally active antihypertensives. J Med Chem 34:2525","journal-title":"J Med Chem"},{"key":"6_CR11","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1021\/jm00067a016","volume":"36","author":"K Kubo","year":"1993","unstructured":"Kubo K, Kohara Y, Imamiya E, Sugiura Y, Inada Y, Furukawa Y, Nishikawa K, Naka T (1993) Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids. J Med Chem 36:2182","journal-title":"J Med Chem"},{"key":"6_CR12","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1021\/jm00077a007","volume":"25","author":"UJ Ries","year":"1993","unstructured":"Ries UJ, Mihm G, Narr B, Hasselbach KM, Wittneben H, Entzeroth M, VanMeel JCA, Wienen W, Hauel NH (1993) 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J Med Chem 25:4040","journal-title":"J Med Chem"},{"key":"6_CR13","first-page":"91","volume-title":"Methods and principles in medicinal chemistry","author":"H Kubinyi","year":"1993","unstructured":"Kubinyi H, Mannhold R, Krogsgaard LR, Timmerman HE (1993) Methods and principles in medicinal chemistry, vol 1. VCH, Weinheim, pp 91\u201395"},{"key":"6_CR14","volume-title":"Classical and three-dimensional QSAR in agrochemistry","author":"EL Plummer","year":"1995","unstructured":"Plummer EL (1995) Successful application of the QSAR paradigm in discovery programs. In: Hansch C, Fujita T (eds) Classical and three-dimensional QSAR in agrochemistry. American Chemical Society, Washington"},{"key":"6_CR15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/03602539608994017","volume":"28","author":"H Gao","year":"1996","unstructured":"Gao H, Hansch C (1996) QSAR of p450 oxidation: on the value of comparing kcat and Km with kcat\/Km. Drug Metab Rev 28:513\u2013526","journal-title":"Drug Metab Rev"},{"key":"6_CR16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1023\/A:1016266316100","volume":"12","author":"EJ Lien","year":"1995","unstructured":"Lien EJ, Gao H (1995) QSAR analysis of skin permeability of various drugs in man as compared in vivo and in vitro studies in rodents. Pharm Res 12:583\u2013587","journal-title":"Pharm Res"},{"key":"6_CR17","unstructured":"VLife MDS 3.5, (2008) Molecular design suite. Vlife Sciences Technologies Pvt. Ltd., Pune"},{"issue":"22","key":"6_CR18","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/0960-894X(95)00479-D","volume":"5","author":"P Deprez","year":"1995","unstructured":"Deprez P, Bertrand H, Alain C, Jean-Paul V, Michel F, Jacques G (1995) Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 $$\\alpha$$ \u03b1 -hydroxyacid imidazolyl biphenyl sulfonylureas. Bioorg Med Chem Lett 5(22):2611\u20132616","journal-title":"Bioorg Med Chem Lett"},{"key":"6_CR19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1023\/A:1020869118689","volume":"16","author":"A Golbraikh","year":"2002","unstructured":"Golbraikh A, Tropsha A (2002a) Predictive QSAR modeling based on diversity sampling of experimental datasets for the training and test set selection. J Comput Aided Mol Des 16:357\u2013369","journal-title":"J Comput Aided Mol Des"},{"key":"6_CR20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/(SICI)1096-987X(199604)17:5\/6<553::AID-JCC3>3.0.CO;2-T","volume":"17","author":"TA Halgren","year":"1996","unstructured":"Halgren TA (1996) Merck molecular force field. III. Molecular geometries and vibrational frequencies for MMFF94. J Comput Chem 17:553\u2013586","journal-title":"J Comput Chem"},{"key":"6_CR21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/qsar.200810063","volume":"28","author":"S Ajmani","year":"2009","unstructured":"Ajmani S, Jadhav K, Kulkarni SA (2009) Group-based QSAR (GQSAR): mitigating interpretation challenges in QSAR. QSAR Comb Sci 28:36\u201341","journal-title":"QSAR Comb Sci"},{"key":"6_CR22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1021\/ci0501286","volume":"46","author":"S Ajmani","year":"2006","unstructured":"Ajmani S, Jadhav K, Kulkarni SA (2006) Three-dimensional QSAR using the $$k$$ k -nearest neighbor method and its interpretation. J Chem Inf Model 46:24\u201331","journal-title":"J Chem Inf Model"},{"key":"6_CR23","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcc.540100804","volume":"10","author":"M Clark","year":"1989","unstructured":"Clark M, Cramer RD III, Van ON (1989) Validation of the general purpose tripos 5.2 force field. J Comput Chem 10:982\u20131012","journal-title":"J Comput Chem"},{"key":"6_CR24","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1016\/0040-4020(80)80168-2","volume":"36","author":"J Gasteiger","year":"1980","unstructured":"Gasteiger J, Marsili M (1980) Iterative partial equalization of orbital electronegativity-a rapid access to atomic charges. Tetrahedron 36:3219\u20133228","journal-title":"Tetrahedron"},{"key":"6_CR25","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1021\/ja00226a005","volume":"110","author":"RD Cramer","year":"1988","unstructured":"Cramer RD, Patterson DE, Bunce JD (1988) Comparative molecular field analysis (CoMFA) 1. Effect of shape on binding of steroids to carrier proteins. J Am Chem Soc 110:5959\u20135967","journal-title":"J Am Chem Soc"},{"key":"6_CR26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1093-3263(01)00123-1","volume":"20","author":"A Golbraikh","year":"2002","unstructured":"Golbraikh A, Tropsha A (2002b) Beware of Q2. J Mole Grap Model 20:269\u2013276","journal-title":"J Mole Grap Model"}],"container-title":["Interdisciplinary Sciences: Computational Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0006-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12539-015-0006-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0006-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T19:46:47Z","timestamp":1588708007000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12539-015-0006-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,19]]},"references-count":26,"aliases":["10.1007\/s12539-013-0046-3"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["6"],"URL":"https:\/\/doi.org\/10.1007\/s12539-015-0006-1","relation":{},"ISSN":["1913-2751","1867-1462"],"issn-type":[{"value":"1913-2751","type":"print"},{"value":"1867-1462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,19]]}}}