{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:29:18Z","timestamp":1788838158127,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Interdiscip Sci Comput Life Sci"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s12539-015-0109-8","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T10:47:44Z","timestamp":1439894864000},"page":"132-141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Flavonoids as Multi-target Inhibitors for Proteins Associated with Ebola Virus: In Silico Discovery Using Virtual Screening and Molecular Docking Studies"],"prefix":"10.1007","volume":"8","author":[{"given":"Utkarsh","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritish Kumar","family":"Varadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"109_CR1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1177\/1099800403252603","volume":"4","author":"M Adrian","year":"2003","unstructured":"Adrian M et al (2003) A current review of Ebola virus: pathogenesis, clinical presentation, and diagnostic assessment. Biol Res Nurs 4:268","journal-title":"Biol Res Nurs"},{"key":"109_CR2","doi-asserted-by":"publisher","first-page":"e1000212","DOI":"10.1371\/journal.ppat.1000212","volume":"4","author":"JS Towner","year":"2008","unstructured":"Towner JS et al (2008) Newly discovered ebola virus associated with haemorrhagic fever outbreak in Uganda. PLoS Pathog 4:e1000212","journal-title":"PLoS Pathog"},{"key":"109_CR3","doi-asserted-by":"publisher","first-page":"23186","DOI":"10.1074\/jbc.M112184200","volume":"277","author":"MP Dixon","year":"2002","unstructured":"Dixon MP, Pau RN, Howlett GJ, Dunstan DE, Sawyer WH, Davidson BE (2002) Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association. J Biol Chem 277:23186\u201323192","journal-title":"J Biol Chem"},{"key":"109_CR4","unstructured":"International Commission (1978) Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ 56(2):271\u2013293"},{"key":"109_CR5","first-page":"41830","volume":"278","author":"B Hartlieb","year":"2003","unstructured":"Hartlieb B, Modrof J, M\u00fchlberger E, Klenk HD, Becker S (2003) Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association. J BiolChem 278:41830\u201341836","journal-title":"J BiolChem"},{"key":"109_CR6","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","volume":"377","author":"F Heinz","year":"2011","unstructured":"Heinz F, Geisbert TW (2011) Ebola hemorrhagic fever. Lancet 377:849\u2013862","journal-title":"Lancet"},{"key":"109_CR7","doi-asserted-by":"publisher","first-page":"7260","DOI":"10.1128\/JVI.00051-06","volume":"80","author":"T Hoenen","year":"2011","unstructured":"Hoenen T, Groseth A, Kolesnikova L, Theriault S, Ebihara H, Hartlieb B, Bamberg S, Feldmann H, Stroher U, Becker S (2011) Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association. J Virol 80:7260\u20137264","journal-title":"J Virol"},{"key":"109_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature07082","volume":"454","author":"EO Saphire","year":"2008","unstructured":"Saphire EO, Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR (2008) Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature 454:177\u2013182","journal-title":"Nature"},{"key":"109_CR9","doi-asserted-by":"publisher","first-page":"8532","DOI":"10.1128\/JVI.76.17.8532-8539.2002","volume":"76","author":"M Weik","year":"2002","unstructured":"Weik M, Modrof J, Klenk HD, Becker S, Muhlberger E (2002) Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleo capsid association. J Virol 76:8532\u20138539","journal-title":"J Virol"},{"key":"109_CR10","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1093\/nar\/gkq901","volume":"39","author":"C Hulo","year":"2011","unstructured":"Hulo C, de Castro E, Masson P, Bougueleret L, Bairoch A, Xenarios I, Le Mercier P (2011) ViralZone: a knowledge resource to understand virus diversity. Nucleic Acids Res 39:576\u2013582","journal-title":"Nucleic Acids Res"},{"key":"109_CR11","first-page":"1038","volume":"10","author":"A Nanbo","year":"2013","unstructured":"Nanbo A, Watanabe S, Halfmann P, Kawaoka Y (2013) The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells. Nature 10:1038","journal-title":"Nature"},{"key":"109_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0168-1702(95)00080-1","volume":"39","author":"TW Geisbert","year":"1995","unstructured":"Geisbert TW et al (1995) Differentiation of filoviruses by electron microscopy. Virus Res 39:129","journal-title":"Virus Res"},{"key":"109_CR13","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0969-2126(03)00050-9","volume":"11","author":"FX Gomis R\u00fcth","year":"2003","unstructured":"Gomis R\u00fcth FX (2003) The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties. Structure 11:423","journal-title":"Structure"},{"key":"109_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/jmbi.2000.3822","volume":"300","author":"RW Ruigrok","year":"2000","unstructured":"Ruigrok RW et al (2000) Structural characterization and membrane binding properties of the matrix protein VP40 of Ebola virus. J Mol Biol 300:103","journal-title":"J Mol Biol"},{"issue":"suppl 3","key":"109_CR15","first-page":"884","volume":"204","author":"E Volchkov Victor","year":"2011","unstructured":"Volchkov Victor E et al (2011) Conserved proline-rich region of Ebola virus matrix protein VP40 is essential for plasma membrane targeting and virus-like particle release. J Infect Dis 204(suppl 3):884\u2013891","journal-title":"J Infect Dis"},{"key":"109_CR16","doi-asserted-by":"publisher","first-page":"7945","DOI":"10.1128\/JVI.77.14.7945-7956.2003","volume":"77","author":"CF Basler","year":"2003","unstructured":"Basler CF, Mikulasova A, Martinez-Sobrido L, Paragas J, M\u00fchlberger E, Bray M, Klenk HD, Palese P, Garc\u00eda-Sastre A (2003) The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. J Virol 77:7945\u20137956","journal-title":"J Virol"},{"key":"109_CR17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1099\/vir.0.017343-0","volume":"91","author":"H Jin","year":"2010","unstructured":"Jin H, Yan Z, Prabhakar BS, Feng Z, Ma Y, Verpooten D, Ganesh B, He B (2010) VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide. J Gen Virol 91:352\u2013361","journal-title":"J Gen Virol"},{"key":"109_CR18","doi-asserted-by":"publisher","first-page":"e73","DOI":"10.1371\/journal.ppat.0020073","volume":"2","author":"H Ebihara","year":"2006","unstructured":"Ebihara H, Takada A, Kobasa D et al (2006) Molecular determinants of Ebola virus virulence in mice. PLoS Pathog 2:e73","journal-title":"PLoS Pathog"},{"issue":"s2","key":"109_CR19","doi-asserted-by":"publisher","first-page":"S284","DOI":"10.1086\/520582","volume":"196","author":"Shinji Watanabe","year":"2007","unstructured":"Watanabe S, Noda T, Halfmann P, Jasenosky L, Kawaoka Y (2007) Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genome. J Infect Dis 196","journal-title":"The Journal of Infectious Diseases"},{"key":"109_CR20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.virol.2010.04.002","volume":"403","author":"T Hoenen","year":"2010","unstructured":"Hoenen T, Jung S, Herwig A, Groseth A, Becker S (2010) Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcription. Virology 403:56\u201366","journal-title":"Virology"},{"key":"109_CR21","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S1097-2765(02)00588-9","volume":"10","author":"Y Huang","year":"2002","unstructured":"Huang Y, Xu L, Sun Y, Nabel GJ (2002) The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein. Mol Cell 10:307\u2013316","journal-title":"Mol Cell"},{"key":"109_CR22","doi-asserted-by":"publisher","first-page":"e99","DOI":"10.1371\/journal.ppat.0020099","volume":"2","author":"T Noda","year":"2006","unstructured":"Noda T, Ebihara H, Muramoto Y et al (2006) Assembly and budding of Ebola virus. PLoS Pathog 2:e99","journal-title":"PLoS Pathog"},{"key":"109_CR23","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1128\/JVI.73.3.2333-2342.1999","volume":"73","author":"E M\u00fchlberger","year":"1999","unstructured":"M\u00fchlberger E, Weik M, Volchkov VE, Klenk H-D, Becker S (1999) Comparison of the transcription and replication strategies of Marburg virus and Ebola virus by using artificial replication systems. J Virol 73:2333\u20132342","journal-title":"J Virol"},{"key":"109_CR24","first-page":"308","volume":"10","author":"R Rajamani","year":"2007","unstructured":"Rajamani R, Good AC (2007) Ranking poses in structure-based lead discovery and optimization: current trends in scoring function development. Curr Opin Drug Discov Dev 10:308\u2013315","journal-title":"Curr Opin Drug Discov Dev"},{"key":"109_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nature13777","volume":"514","author":"L Zeitlin","year":"2014","unstructured":"Zeitlin L et al (2014) Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature 514:47\u201353","journal-title":"Nature"},{"key":"109_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nature13027","volume":"508","author":"S Bavari","year":"2014","unstructured":"Bavari S et al (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature 508:402\u2013405","journal-title":"Nature"},{"issue":"2","key":"109_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijantimicag.2011.02.014","volume":"38","author":"TP Cushnie","year":"2011","unstructured":"Cushnie TP, Lamb AJ (2011) Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents 38(2):99\u2013107","journal-title":"Int J Antimicrob Agents"},{"issue":"4","key":"109_CR28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/10408390903584094","volume":"51","author":"R Gonz\u00e1lez","year":"2011","unstructured":"Gonz\u00e1lez R, Ballester I et al (2011) Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr 51(4):331\u2013362","journal-title":"Crit Rev Food Sci Nutr"},{"key":"109_CR29","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.2741\/229","volume":"3","author":"S Nishiumi","year":"2011","unstructured":"Nishiumi S, Miyamoto S et al (2011) Dietary flavonoids as cancer-preventive and therapeutic bio factors. Front Biosci (Sch Ed) 3:1332\u20131362","journal-title":"Front Biosci (Sch Ed)"},{"key":"109_CR30","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1107\/S0907444902003451","volume":"58","author":"HM Berman","year":"2002","unstructured":"Berman HM et al (2002) The protein data bank. Acta Crystallogr D Biol Crystallogr 58:899","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"3","key":"109_CR31","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","volume":"27","author":"GM Sastry","year":"2013","unstructured":"Sastry GM, Adzhigirey M, Day T, Annabhimoju R, Sherman W (2013) Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments. J Comput Aided Mol Des 27(3):221\u2013234","journal-title":"J Comput Aided Mol Des"},{"key":"109_CR32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1021\/ci800324m","volume":"49","author":"T Halgren","year":"2009","unstructured":"Halgren T (2009) Identifying and characterizing binding sites and assessing druggability. J Chem Inf Model 49:377\u2013389","journal-title":"J Chem Inf Model"},{"key":"109_CR33","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1021\/jm030644s","volume":"47","author":"TA Halgren","year":"2004","unstructured":"Halgren TA, Murphy RB, Friesner RA, Beard HS, Frye LL, Pollard WT, Banks JL (2004) Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Med Chem 47:1750\u20131759","journal-title":"J Med Chem"},{"issue":"8","key":"109_CR34","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","volume":"78","author":"DE Shaw","year":"2010","unstructured":"Shaw DE, Lindorff-Larsen K, Piana S, Palmo K, Maragakis P, Klepeis JL, Dror RO (2010) Improved side-chain torsion potentials for the amber ff99SB protein force field. Proteins: Struct Funct Bioinform 78(8):1950\u20131958","journal-title":"Proteins: Struct Funct Bioinform"},{"issue":"3","key":"109_CR35","first-page":"81","volume":"99","author":"VM Mounnissamy","year":"2002","unstructured":"Mounnissamy VM, Kavimani S, Gunasegaran R (2002) Antibacterial activity of gossypetin isolated from hibiscus sabdariffa. Antiseptic 99(3):81\u201382","journal-title":"Antiseptic"},{"key":"109_CR36","doi-asserted-by":"crossref","unstructured":"Todorov D, Hinkov A, Shishkova K, Shishkov S (2014) Antiviral potential of Bulgarian medicinal plants. Phytochem Rev 014-9357-1","DOI":"10.1007\/s11101-014-9357-1"},{"issue":"5","key":"109_CR37","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1515\/HF.2009.095","volume":"63","author":"S Willf\u00f6r","year":"2009","unstructured":"Willf\u00f6r S, Ali M, Karonen M, Reunanen M, Arfan M, Harlamow R (2009) Extractives in bark of different conifer species growing in Pakistan. Holzforschung 63(5):551\u2013558","journal-title":"Holzforschung"},{"issue":"4","key":"109_CR38","first-page":"266","volume":"36","author":"Q Shi","year":"2007","unstructured":"Shi Q, Li C, Huo C, Zhang M (2007) Chemistry of Chinese yew, Taxus chinensis var. mairei. Biochem Syst Ecol 36(4):266\u2013282","journal-title":"Biochem Syst Ecol"},{"issue":"1","key":"109_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/jmv.1890150110","volume":"15","author":"TN Kaul","year":"1985","unstructured":"Kaul TN, Middleton E, Ogra PL (1985) Anti-viral effect of flavonoids on human viruses. J Med Virol 15(1):71\u201379","journal-title":"J Med Virol"}],"updated-by":[{"DOI":"10.1007\/s12539-015-0125-8","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000}}],"container-title":["Interdisciplinary Sciences: Computational Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0109-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12539-015-0109-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0109-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0109-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T08:59:07Z","timestamp":1659085147000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12539-015-0109-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["109"],"URL":"https:\/\/doi.org\/10.1007\/s12539-015-0109-8","relation":{"erratum":[{"id-type":"doi","id":"10.1007\/s12539-015-0125-8","asserted-by":"object"}]},"ISSN":["1913-2751","1867-1462"],"issn-type":[{"value":"1913-2751","type":"print"},{"value":"1867-1462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]},"assertion":[{"value":"18 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"We declare that we have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}