{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T08:11:25Z","timestamp":1751443885758},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T00:00:00Z","timestamp":1438992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Interdiscip Sci Comput Life Sci"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s12539-015-0270-0","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T13:35:31Z","timestamp":1438954531000},"page":"326-333","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In Silico Analysis of Conformational Changes Induced by Normal and Mutation of Macrophage Infectivity Potentiator Catalytic Residues and its Interactions with Rapamycin"],"prefix":"10.1007","volume":"7","author":[{"given":"Ramachandran","family":"Vijayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naidu","family":"Subbarao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natesan","family":"Manoharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,8]]},"reference":[{"key":"270_CR1","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1056\/NEJM197712012972202","volume":"297","author":"JE McDade","year":"1997","unstructured":"McDade JE, Shepard CC, Fraser DW, Tsai TR, Redus MA, Dowdle WR (1997) Legionnaires\u2019 disease. Isolation of the bacterium and demonstration of its role in other respiratory disease. N Engl J Med 297:1197\u20131203","journal-title":"N Engl J Med"},{"key":"270_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1128\/CMR.1.1.60","volume":"1","author":"WC Winn","year":"1988","unstructured":"Winn WC (1988) Legionnaires\u2019 disease: historical perspective. Clin Microbiol Rev 1:60\u201381","journal-title":"Clin Microbiol Rev"},{"key":"270_CR3","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1136\/jcp.33.12.1179","volume":"33","author":"TJ Rowbotham","year":"1980","unstructured":"Rowbotham TJ (1980) Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae. J Clin Pathol 33:1179\u20131183","journal-title":"J Clin Pathol"},{"key":"270_CR4","first-page":"678","volume":"22","author":"TJ Rowbotham","year":"1986","unstructured":"Rowbotham TJ (1986) Current views on the relationship between amoebae, Legionellae and man. Isr J Med Sci 22:678\u2013689","journal-title":"Isr J Med Sci"},{"key":"270_CR5","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1574-6941.1994.tb00253.x","volume":"15","author":"M Steinert","year":"1994","unstructured":"Steinert M, Ott M, Lu\u00f6k PC, Hacker J (1994) Studies on the uptake and intracellular replication of Legionella pneumophila in protozoa and in macrophage-like cells. FEMS Microbiol Ecol 15:299\u2013308","journal-title":"FEMS Microbiol Ecol"},{"key":"270_CR6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF00293641","volume":"30","author":"NP Cianciotto","year":"1995","unstructured":"Cianciotto NP, Stamos JV, Kamp DW (1995) Infectivity of Legionella pneumophila MIP mutant for alveolar epithelial cells. Curr Microbiol 30:247\u2013250","journal-title":"Curr Microbiol"},{"key":"270_CR7","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1128\/IAI.63.12.4576-4583.1995","volume":"63","author":"E Wintermeyer","year":"1995","unstructured":"Wintermeyer E, Ludwig B, Steinert M, Schmidt B, Fischer G, Hacker J (1995) Influence of site specifically altered MIP proteins on intracellular survival of Legionella pneumophila in eucaryotic cells. Infect Immun 63:4576\u20134583","journal-title":"Infect Immun"},{"key":"270_CR8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1021\/jm101156y","volume":"54","author":"C Juli","year":"2011","unstructured":"Juli C, Sippel M, Jager J, Thiele A, Weiwad M, Schweimer K, Rosch P, Steinert M, Sotriffer CA, Holzgrabe U (2011) Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein. J Med Chem 54:277\u2013283","journal-title":"J Med Chem"},{"key":"270_CR9","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/nsb0901-779","volume":"8","author":"A Riboldi-Tunnicliffe","year":"2001","unstructured":"Riboldi-Tunnicliffe A, Konig B, Jessen S, Weiss MS, Rahfeld J, Hacker J, Fischer G, Hilgenfeld R (2001) Crystal structure of MIP, a prolylisomerase from Legionella pneumophila. Nat Struct Biol 8:779\u2013783","journal-title":"Nat Struct Biol"},{"key":"270_CR10","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1111\/j.1365-2958.1992.tb00858.x","volume":"6","author":"G Fischer","year":"1992","unstructured":"Fischer G, Bang H, Ludwig B, Mann K, Hacker J (1992) Mip protein of Legionella pneumophila exhibits peptidyl-prolyl cis\/trans isomerase (PPIase) activity. Mol Microbiol 6:1375\u20131383","journal-title":"Mol Microbiol"},{"key":"270_CR11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nm0202-128","volume":"8","author":"M Guba","year":"2002","unstructured":"Guba M, Breitenbuch VP, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK (2002) Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 8:128\u2013135","journal-title":"Nat Med"},{"key":"270_CR12","doi-asserted-by":"publisher","first-page":"12037","DOI":"10.1073\/pnas.192206699","volume":"99","author":"Q Huai","year":"2002","unstructured":"Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H (2002) Crystal structure of calcineurin\u2013cyclophilin\u2013cyclosporin shows common but distinct recognition of immunophilin\u2013drug complexes. Proc Natl Acad Sci USA 99:12037\u201312042","journal-title":"Proc Natl Acad Sci USA"},{"key":"270_CR13","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/S0006-291X(03)01537-7","volume":"311","author":"H Ke","year":"2003","unstructured":"Ke H, Huai Q (2003) Structures of calcineurin and its complexes with immunophilins\u2013immunosuppressants. Biochem Biophys Res Commun 311:1095\u20131102","journal-title":"Biochem Biophys Res Commun"},{"key":"270_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/0952-7915(94)90085-X","volume":"6","author":"VK Sharma","year":"1994","unstructured":"Sharma VK, Li B, Khanna A, Sehajpal PK, Suthanthiran M (1994) Which way for drug-mediated immunosuppression. Curr Opin Immunol 6:784\u2013790","journal-title":"Curr Opin Immunol"},{"key":"270_CR15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3844\/ajbbsp.2007.216.224","volume":"3","author":"R Vijayan","year":"2007","unstructured":"Vijayan R, Subbarao N, Mallick BN (2007) In silico modeling of $$\\alpha$$ \u03b1 -1A adrenoceptor: interactions of its normal and mutated active sites with noradrenaline as well as its agonist and antagonist. Am J Biochem Biotechnol 3:216\u2013224","journal-title":"Am J Biochem Biotechnol"},{"key":"270_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12539-014-0185-1","volume":"6","author":"A Shanmugam","year":"2014","unstructured":"Shanmugam A, Natarajan J (2014) Combination of site directed mutagenesis and secondary structure analysis predicts the amino acids essential for stability of M. leprae MurE. Interdiscip Sci Comput Life Sci 6:40\u201347","journal-title":"Interdiscip Sci Comput Life Sci"},{"key":"270_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1574-6968.1994.tb06798.x","volume":"118","author":"B Ludwig","year":"1994","unstructured":"Ludwig B, Rahfeld J, Schmidt B, Mann K, Wintermeyer E, Fischer G, Hacker J (1994) Characterization of Mip proteins of Legionella pneumophila. FEMS Microbiol Lett 118:23\u201330","journal-title":"FEMS Microbiol Lett"},{"key":"270_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","volume":"29","author":"MA Mart\u00ed-Renom","year":"2009","unstructured":"Mart\u00ed-Renom MA, Stuart AC, Fiser A, S\u00e1nchez R, Melo F, Sali A (2009) Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct 29:291\u2013325","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"270_CR19","first-page":"7","volume":"7","author":"I Adzhubei","year":"2013","unstructured":"Adzhubei I, Jordan DM, Sunyaev SR (2013) Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet 7:7\u201320","journal-title":"Curr Protoc Hum Genet"},{"key":"270_CR20","doi-asserted-by":"publisher","first-page":"W306","DOI":"10.1093\/nar\/gki375","volume":"33","author":"E Capriotti","year":"2005","unstructured":"Capriotti E, Fariselli P, Casadio R (2005) I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure. Nucl Acids Res 33:W306\u2013W310","journal-title":"Nucl Acids Res"},{"key":"270_CR21","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/prot.20810","volume":"62","author":"J Cheng","year":"2006","unstructured":"Cheng J, Randall A, Baldi P (2006) Prediction of protein stability changes for single-site mutations using support vector machines. Proteins Struct Funct Bioinform 62:1125\u20131132","journal-title":"Proteins Struct Funct Bioinform"},{"key":"270_CR22","unstructured":"The PyMOL molecular graphics system, version 1.5.0.4 Schr\u00f6dinger, LLC"},{"key":"270_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1472-6807-6-19","volume":"6","author":"B Huang","year":"2006","unstructured":"Huang B, Schroeder M (2006) LIGSITE csc: predicting ligand binding sites using the Connolly surface and degree of conservation. BMC Struct Biol 6:19","journal-title":"BMC Struct Biol"},{"key":"270_CR24","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/nar\/gkl282","volume":"34","author":"J Dundas","year":"2006","unstructured":"Dundas J, Ouyang Z, Tseng J, Binkowski A, Turpaz Y, Liang J (2006) CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res 34:116\u2013118","journal-title":"Nucleic Acids Res"},{"key":"270_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NMO Boyle","year":"2011","unstructured":"Boyle NMO, James BM, Morley CA, Vandermeersch T, Hutchison GR (2011) Open Babel: an open chemical toolbox. J Cheminform 3:33","journal-title":"J Cheminform"},{"key":"270_CR26","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"G Jones","year":"1997","unstructured":"Jones G, Willett P, Glen RC, Leach AR, Taylor R (1997) Development and validation of a genetic algorithm for flexible docking. J Mol Biol 267:727\u2013748","journal-title":"J Mol Biol"},{"key":"270_CR27","unstructured":"Accelrys Software Inc. (2013) Discovery studio modeling environment, release 4.0. Accelrys Software Inc., San Diego"}],"container-title":["Interdisciplinary Sciences: Computational Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0270-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12539-015-0270-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0270-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-015-0270-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:17Z","timestamp":1599436817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12539-015-0270-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,8]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["270"],"URL":"https:\/\/doi.org\/10.1007\/s12539-015-0270-0","relation":{},"ISSN":["1913-2751","1867-1462"],"issn-type":[{"value":"1913-2751","type":"print"},{"value":"1867-1462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,8]]},"assertion":[{"value":"29 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}