{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:05:08Z","timestamp":1779951908034,"version":"3.53.1"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","award":["DIP-2022-022"],"award-info":[{"award-number":["DIP-2022-022"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Interdiscip Sci Comput Life Sci"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s12539-025-00792-6","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:39:15Z","timestamp":1765561155000},"page":"534-550","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling Putative Functions of Burkholderia pseudomallei K96243 Hypothetical Proteins Via High-Throughput Characterization of Structural Similarities"],"prefix":"10.1007","volume":"18","author":[{"given":"Syed Abuthakir","family":"Mohamed Husain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Datt","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Firdaus-Raih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Nathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Azlan","family":"Nor Muhammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyan Leong","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"issue":"23","key":"792_CR1","doi-asserted-by":"publisher","first-page":"15475","DOI":"10.3390\/ijerph192315475","volume":"19","author":"K Selvam","year":"2022","unstructured":"Selvam K, Ganapathy T, Najib MA et al (2022) Burden and risk factors of melioidosis in Southeast Asia: a scoping review. Int J Environ Res Public Health 19(23):15475. https:\/\/doi.org\/10.3390\/ijerph192315475","journal-title":"Int J Environ Res Public Health"},{"key":"792_CR2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ijregi.2023.11.014","volume":"10","author":"R Arushothy","year":"2023","unstructured":"Arushothy R, Ali MRM, Zambri HF et al (2023) Assessing the national antibiotic surveillance data to identify burden for melioidosis in Malaysia. IJID Reg 10:94\u201399. https:\/\/doi.org\/10.1016\/j.ijregi.2023.11.014","journal-title":"IJID Reg"},{"issue":"1","key":"792_CR3","doi-asserted-by":"publisher","first-page":"15008","DOI":"10.1038\/nmicrobiol.2015.8","volume":"1","author":"D Limmathurotsakul","year":"2016","unstructured":"Limmathurotsakul D, Golding N, Dance DA et al (2016) Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol 1(1):15008. https:\/\/doi.org\/10.1038\/nmicrobiol.2015.8","journal-title":"Nat Microbiol"},{"issue":"2","key":"792_CR4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1042\/BST20190836","volume":"48","author":"CH Yip","year":"2020","unstructured":"Yip CH, Ghazali AK, Nathan S (2020) Burkholderia pseudomallei pathogenesis and survival in different niches. Biochem Soc Trans 48(2):569\u2013579. https:\/\/doi.org\/10.1042\/BST20190836","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"792_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1128\/CMR.00033-15","volume":"29","author":"E Wagar","year":"2016","unstructured":"Wagar E (2016) Bioterrorism and the role of the clinical microbiology laboratory. Clin Microbiol Rev 29(1):175\u2013189. https:\/\/doi.org\/10.1128\/CMR.00033-15","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"792_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmicom.2024.100008","volume":"1","author":"EM Meumann","year":"2024","unstructured":"Meumann EM, Currie BJ (2024) Approach to melioidosis. CMI Comms 1(1):100008. https:\/\/doi.org\/10.1016\/j.cmicom.2024.100008","journal-title":"CMI Comms"},{"issue":"6","key":"792_CR7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.apjtm.2016.04.003","volume":"9","author":"PV Kingsley","year":"2016","unstructured":"Kingsley PV, Arunkumar G, Tipre M et al (2016) Pitfalls and optimal approaches to diagnose melioidosis. Asian Pac J Trop Med 9(6):515\u2013524. https:\/\/doi.org\/10.1016\/j.apjtm.2016.04.003","journal-title":"Asian Pac J Trop Med"},{"issue":"6","key":"792_CR8","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1016\/j.jinf.2023.03.022","volume":"86","author":"PH Wu","year":"2023","unstructured":"Wu PH, Chen PH, Hsih WH et al (2023) Emergence of meropenem and levofloxacin resistance in Burkholderia pseudomallei in Taiwan. J Infect 86(6):e161\u2013e163. https:\/\/doi.org\/10.1016\/j.jinf.2023.03.022","journal-title":"J Infect"},{"issue":"3","key":"792_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.6026\/97320630012209","volume":"12","author":"K School","year":"2016","unstructured":"School K, Marklevitz J, Schram WK et al (2016) Predictive characterization of hypothetical proteins in Staphylococcus aureus NCTC 8325. Bioinformation 12(3):209\u2013220. https:\/\/doi.org\/10.6026\/97320630012209","journal-title":"Bioinformation"},{"issue":"39","key":"792_CR10","doi-asserted-by":"publisher","first-page":"14240","DOI":"10.1073\/pnas.0403302101","volume":"101","author":"MTG Holden","year":"2004","unstructured":"Holden MTG, Titball RW, Peacock SJ et al (2004) Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A 101(39):14240\u201314245. https:\/\/doi.org\/10.1073\/pnas.0403302101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"792_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.21315\/tlsr2017.28.2.5","volume":"28","author":"OG Luan","year":"2017","unstructured":"Luan OG, Yam H, Samian R et al (2017) Hypothetical protein BPSL3393 of Burkholderia pseudomallei is involved in ethanolamine catabolism. Trop Life Sci Res 28(2):57\u201374. https:\/\/doi.org\/10.21315\/tlsr2017.28.2.5","journal-title":"Trop Life Sci Res"},{"issue":"12","key":"792_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084263","volume":"8","author":"M Shahbaaz","year":"2013","unstructured":"Shahbaaz M, Hassan MI, Ahmad F (2013) Functional annotation of conserved hypothetical proteins from Haemophilus influenzae Rd KW20. PLoS ONE 8(12):e84263. https:\/\/doi.org\/10.1371\/journal.pone.0084263","journal-title":"PLoS ONE"},{"key":"792_CR13","doi-asserted-by":"publisher","first-page":"117793222110111","DOI":"10.1177\/11779322211011140","volume":"15","author":"MF Rabbi","year":"2021","unstructured":"Rabbi MF, Akter SA, Hasan MJ et al (2021) In silico characterization of a hypothetical protein from Shigella dysenteriae ATCC 12039 reveals a pathogenesis-related protein of the type-VI secretion system. Bioinform Biol Insights 15:117793222110111. https:\/\/doi.org\/10.1177\/11779322211011140","journal-title":"Bioinform Biol Insights"},{"issue":"2","key":"792_CR14","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01178-22","volume":"8","author":"M Maranga","year":"2023","unstructured":"Maranga M, Szczerbiak P, Bezshapkin V et al (2023) Comprehensive functional annotation of metagenomes and microbial genomes using a deep learning-based method. mSystems 8(2):e01178\u201322. https:\/\/doi.org\/10.1128\/msystems.01178-22","journal-title":"mSystems"},{"key":"792_CR15","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12859-022-04626-w","volume":"23","author":"MN Kabir","year":"2022","unstructured":"Kabir MN, Wong L (2022) EnsembleFam: towards more accurate protein family prediction in the twilight zone. BMC Bioinformatics 23:90. https:\/\/doi.org\/10.1186\/s12859-022-04626-w","journal-title":"BMC Bioinformatics"},{"key":"792_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13059-023-02942-9","volume":"24","author":"F Ruperti","year":"2023","unstructured":"Ruperti F, Papadopoulos N, Musser JM et al (2023) Cross-phyla protein annotation by structural prediction and alignment. Genome Biol 24:113. https:\/\/doi.org\/10.1186\/s13059-023-02942-9","journal-title":"Genome Biol"},{"key":"792_CR17","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1186\/gb-2010-11-8-r89","volume":"11","author":"BMQ Sim","year":"2010","unstructured":"Sim BMQ, Chantratita N, Ooi WF et al (2010) Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates. Genome Biol 11:R89. https:\/\/doi.org\/10.1186\/gb-2010-11-8-r89","journal-title":"Genome Biol"},{"issue":"23","key":"792_CR18","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1093\/bioinformatics\/btn524","volume":"24","author":"GL Winsor","year":"2008","unstructured":"Winsor GL, Khaira B, Rossum TV et al (2008) The Burkholderia genome database: facilitating flexible queries and comparative analyses. Bioinformatics 24(23):2803\u20132804. https:\/\/doi.org\/10.1093\/bioinformatics\/btn524","journal-title":"Bioinformatics"},{"key":"792_CR19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41597-023-02101-6","volume":"10","author":"P Choudhary","year":"2023","unstructured":"Choudhary P, Anyango S, Berrisford J et al (2023) Unified access to up-to-date residue-level annotations from UniProtKB and other biological databases for PDB data. Sci Data 10:204. https:\/\/doi.org\/10.1038\/s41597-023-02101-6","journal-title":"Sci Data"},{"issue":"2","key":"792_CR20","doi-asserted-by":"publisher","first-page":"W5","DOI":"10.1093\/nar\/gkn201","volume":"36","author":"M Johnson","year":"2008","unstructured":"Johnson M, Zaretskaya I, Raytselis Y et al (2008) Ncbi BLAST: a better web interface. Nucleic Acids Res 36(2):W5\u2013W9. https:\/\/doi.org\/10.1093\/nar\/gkn201","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"792_CR21","doi-asserted-by":"publisher","first-page":"D501","DOI":"10.1093\/nar\/gki025","volume":"33","author":"KD Pruitt","year":"2005","unstructured":"Pruitt KD, Tatusova T, Maglott DR (2005) NCBI reference sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts, and proteins. Nucleic Acids Res 33(1):D501\u2013D504. https:\/\/doi.org\/10.1093\/nar\/gki025","journal-title":"Nucleic Acids Res"},{"key":"792_CR22","doi-asserted-by":"publisher","unstructured":"Wallace JC, Port JA, Smith MN et al (2017) FARME DB: a functional antibiotic resistance element database. Database 2017:baw165. https:\/\/doi.org\/10.1093\/database\/baw165","DOI":"10.1093\/database\/baw165"},{"key":"792_CR23","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper J, Evans R, Pritzel A et al (2021) Highly accurate protein structure prediction with AlphaFold. Nature 596:583\u2013589. https:\/\/doi.org\/10.1038\/s41586-021-03819-2","journal-title":"Nature"},{"issue":"D1","key":"792_CR24","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","volume":"50","author":"M Varadi","year":"2022","unstructured":"Varadi M, Anyango S, Deshpande M et al (2022) AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Res 50(D1):D439\u2013D444. https:\/\/doi.org\/10.1093\/nar\/gkab1061","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"792_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4530","volume":"32","author":"M Holcomb","year":"2023","unstructured":"Holcomb M, Chang Y, Goodsell DS et al (2023) Evaluation of AlphaFold2 structures as docking targets. Protein Sci 32(1):e4530. https:\/\/doi.org\/10.1002\/pro.4530","journal-title":"Protein Sci"},{"key":"792_CR26","doi-asserted-by":"publisher","unstructured":"Baek M, Anishchenko I, Humphreys IR et al (2023) Efficient and accurate prediction of protein structure using RoseTTAFold2. bioRxiv. https:\/\/doi.org\/10.1101\/2023.05.24.542179","DOI":"10.1101\/2023.05.24.542179"},{"key":"792_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41587-023-01773-0","volume":"42","author":"M Van Kempen","year":"2024","unstructured":"Van Kempen M, Kim SS, Tumescheit C et al (2024) Fast and accurate protein structure search with Foldseek. Nat Biotechnol 42:243\u2013246. https:\/\/doi.org\/10.1038\/s41587-023-01773-0","journal-title":"Nat Biotechnol"},{"issue":"7","key":"792_CR28","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/bioinformatics\/btq066","volume":"26","author":"J Xu","year":"2010","unstructured":"Xu J, Zhang Y (2010) How significant is a protein structure similarity with TM-score = 0.5? Bioinformatics 26(7):889\u2013895. https:\/\/doi.org\/10.1093\/bioinformatics\/btq066","journal-title":"Bioinformatics"},{"issue":"D1","key":"792_CR29","doi-asserted-by":"publisher","first-page":"D418","DOI":"10.1093\/nar\/gkac993","volume":"51","author":"T Paysan-Lafosse","year":"2023","unstructured":"Paysan-Lafosse T, Blum M, Chuguransky S et al (2023) InterPro in 2022. Nucleic Acids Res 51(D1):D418\u2013D427. https:\/\/doi.org\/10.1093\/nar\/gkac993","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"792_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","volume":"30","author":"EF Pettersen","year":"2021","unstructured":"Pettersen EF, Goddard TD, Huang CC et al (2021) UCSF chimerax: structure visualization for researchers, educators, and developers. Protein Sci 30(1):70\u201382. https:\/\/doi.org\/10.1002\/pro.3943","journal-title":"Protein Sci"},{"issue":"D1","key":"792_CR31","doi-asserted-by":"publisher","first-page":"D404","DOI":"10.1093\/nar\/gkad630","volume":"52","author":"C Zhang","year":"2023","unstructured":"Zhang C, Zhang X, Freddolino PL, Zhang Y (2023) BioLiP2: an updated structure database for biologically relevant ligand\u2013protein interactions. Nucleic Acids Res 52(D1):D404\u2013D412. https:\/\/doi.org\/10.1093\/nar\/gkad630","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"792_CR32","doi-asserted-by":"publisher","first-page":"D534","DOI":"10.1093\/nar\/gkab988","volume":"50","author":"PDBe-KB consortium","year":"2022","unstructured":"PDBe-KB consortium (2022) PDBe-KB: collaboratively defining the biological context of structural data. Nucleic Acids Res 50(D1):D534\u2013D542. https:\/\/doi.org\/10.1093\/nar\/gkab988","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"792_CR33","doi-asserted-by":"publisher","first-page":"D677","DOI":"10.1093\/nar\/gkaa917","volume":"49","author":"H Luo","year":"2021","unstructured":"Luo H, Lin Y, Liu T et al (2021) DEG 15, an update of the database of essential genes that includes built-in analysis tools. Nucleic Acids Res 49(D1):D677\u2013D686. https:\/\/doi.org\/10.1093\/nar\/gkaa917","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"792_CR34","doi-asserted-by":"publisher","first-page":"D998","DOI":"10.1093\/nar\/gkaa884","volume":"49","author":"S Gurumayum","year":"2021","unstructured":"Gurumayum S, Jiang P, Hao X et al (2021) OGEE v3: online gene essentiality database with increased coverage of organisms and human cell lines. Nucleic Acids Res 49(D1):D998\u2013D1003. https:\/\/doi.org\/10.1093\/nar\/gkaa884","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"792_CR35","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1093\/bib\/bbx085","volume":"20","author":"PD Karp","year":"2019","unstructured":"Karp PD, Billington R, Caspi R et al (2019) The BioCyc collection of microbial genomes and metabolic pathways. Brief Bioinform 20(4):1085\u20131093. https:\/\/doi.org\/10.1093\/bib\/bbx085","journal-title":"Brief Bioinform"},{"key":"792_CR36","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1385\/1-59259-890-0:571","volume-title":"The proteomics protocols handbook","author":"E Gasteiger","year":"2005","unstructured":"Gasteiger E, Hoogland C, Gattiker A et al (2005) Protein identification and analysis tools on the Expasy server. In: Walker JM (ed) The proteomics protocols handbook. Humana Press, Totowa NJ, pp 571\u2013607. https:\/\/doi.org\/10.1385\/1-59259-890-0:571"},{"issue":"5","key":"792_CR37","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S0959-440X(94)90172-4","volume":"4","author":"MW MacArthur","year":"1994","unstructured":"MacArthur MW, Laskowski RA, Thornton JM (1994) Knowledge-based validation of protein structure coordinates derived by X-ray crystallography and NMR spectroscopy. Curr Opin Struct Biol 4(5):731\u2013737. https:\/\/doi.org\/10.1016\/S0959-440X(94)90172-4","journal-title":"Curr Opin Struct Biol"},{"issue":"2","key":"792_CR38","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1107\/s0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski RA, MacArthur MW, Moss DS et al (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26(2):283\u2013291. https:\/\/doi.org\/10.1107\/s0021889892009944","journal-title":"J Appl Crystallogr"},{"issue":"W1","key":"792_CR39","doi-asserted-by":"publisher","first-page":"W384","DOI":"10.1093\/nar\/gkt458","volume":"41","author":"L Heo","year":"2013","unstructured":"Heo L, Park H, Seok C (2013) GalaxyRefine: protein structure refinement driven by side-chain repacking. Nucleic Acids Res 41(W1):W384-388. https:\/\/doi.org\/10.1093\/nar\/gkt458","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"792_CR40","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41557-020-0491-7","volume":"12","author":"A Br\u00e4uer","year":"2020","unstructured":"Br\u00e4uer A, Zhou Q, Grammbitter GLC et al (2020) Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis. Nat Chem 12(8):755\u2013763. https:\/\/doi.org\/10.1038\/s41557-020-0491-7","journal-title":"Nat Chem"},{"issue":"6","key":"792_CR41","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1107\/S0907444913003624","volume":"69","author":"S Fang","year":"2013","unstructured":"Fang S, Li L, Cui B et al (2013) Structural insight into plant programmed cell death mediated by BAG proteins in Arabidopsis thaliana. Acta Crystallogr D Biol Crystallogr 69(6):934\u2013945. https:\/\/doi.org\/10.1107\/S0907444913003624","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"11","key":"792_CR42","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/nsmb850","volume":"11","author":"A Vila-Sanjurjo","year":"2004","unstructured":"Vila-Sanjurjo A, Schuwirth B, Hau CW et al (2004) Structural basis for the control of translation initiation during stress. Nat Struct Mol Biol 11(11):1054\u20131059. https:\/\/doi.org\/10.1038\/nsmb850","journal-title":"Nat Struct Mol Biol"},{"issue":"14","key":"792_CR43","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1039\/D2SC06809E","volume":"14","author":"R Matsumoto","year":"2023","unstructured":"Matsumoto R, Yoshioka S, Yuasa M et al (2023) An artificial metallolyase with pliable 2-His-1-carboxylate facial triad for stereo selective Michael addition. Chem Sci 14(14):3932\u20133937. https:\/\/doi.org\/10.1039\/D2SC06809E","journal-title":"Chem Sci"},{"issue":"3","key":"792_CR44","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cell.2005.11.046","volume":"124","author":"X Chao","year":"2006","unstructured":"Chao X, Muff TJ, Park SY et al (2006) A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation. Cell 124(3):561\u2013571. https:\/\/doi.org\/10.1016\/j.cell.2005.11.046","journal-title":"Cell"},{"issue":"19","key":"792_CR45","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1002\/1873-3468.13534","volume":"593","author":"G Zuo","year":"2019","unstructured":"Zuo G, Chen ZP, Jiang YL et al (2019) Structural insights into repression of the pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP. FEBS Lett 593(19):2730\u20132741. https:\/\/doi.org\/10.1002\/1873-3468.13534","journal-title":"FEBS Lett"},{"key":"792_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.fgb.2020.103506","volume":"148","author":"T Perrot","year":"2021","unstructured":"Perrot T, Schwarts M, Deroy A et al (2021) Diversity of Omega glutathione transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches. Fungal Genet Biol 148:103506. https:\/\/doi.org\/10.1016\/j.fgb.2020.103506","journal-title":"Fungal Genet Biol"},{"issue":"13","key":"792_CR47","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1089\/ars.2012.4739","volume":"18","author":"J Couturier","year":"2013","unstructured":"Couturier J, Prosper P, Winger AM et al (2013) In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima? Antioxid Redox Signal 18(13):1613\u20131622. https:\/\/doi.org\/10.1089\/ars.2012.4739","journal-title":"Antioxid Redox Signal"},{"issue":"16","key":"792_CR48","doi-asserted-by":"publisher","first-page":"8873","DOI":"10.1073\/pnas.96.16.8873","volume":"96","author":"K Komori","year":"1999","unstructured":"Komori K, Sakae S, Shinagawa H et al (1999) A Holliday junction resolvase from Pyrococcus furiosus: functional similarity to Escherichia coli RuvC provides evidence for conserved mechanism of homologous recombination in bacteria, eukarya, and archaea. Proc Natl Acad Sci USA 96(16):8873\u20138878. https:\/\/doi.org\/10.1073\/pnas.96.16.8873","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"792_CR49","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1021\/acs.biochem.1c00774","volume":"61","author":"MJ McBride","year":"2022","unstructured":"McBride MJ, Nair MA, Sil D et al (2022) Substrate-triggered \u03bc-peroxodiiron(III) intermediate in the 4-chloro-l-lysine-fragmenting heme-oxygenase-like diiron oxidase (HDO) BesC substrate dissociation from, and C4 targeting by, the intermediate. Biochemistry 61(8):689\u2013702. https:\/\/doi.org\/10.1021\/acs.biochem.1c00774","journal-title":"Biochemistry"},{"issue":"38","key":"792_CR50","doi-asserted-by":"publisher","first-page":"8398","DOI":"10.1021\/bi100698n","volume":"49","author":"D Parsonage","year":"2010","unstructured":"Parsonage D, Newton GL, Holder RC et al (2010) Characterization of the N-acetyl-\u03b1-D-glucosaminyl L-malate synthase (BshA) and deacetylase (BshB) functions for bacillithiol biosynthesis in Bacillus anthracis. Biochemistry 49(38):8398\u20138414. https:\/\/doi.org\/10.1021\/bi100698n","journal-title":"Biochemistry"},{"issue":"12","key":"792_CR51","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s13238-012-2056-z","volume":"3","author":"W Dong","year":"2012","unstructured":"Dong W, Lu W, McKeehan WL et al (2012) Structural basis of heparan sulfate-specific degradation by heparinase III. Protein Cell 3(12):950\u2013961. https:\/\/doi.org\/10.1007\/s13238-012-2056-z","journal-title":"Protein Cell"},{"key":"792_CR52","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41467-021-27636-3","volume":"13","author":"H Tao","year":"2022","unstructured":"Tao H, Mori T, Chen H et al (2022) Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)\u03b1-ketoglutarate-dependent oxygenase SptF. Nat Commun 13:95. https:\/\/doi.org\/10.1038\/s41467-021-27636-3","journal-title":"Nat Commun"},{"issue":"3","key":"792_CR53","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.bbrc.2009.01.108","volume":"380","author":"YS Hsiao","year":"2009","unstructured":"Hsiao YS, Parker D, Ratner AJ et al (2009) Crystal structures of respiratory pathogen neuraminidases. Biochem Biophys Res Commun 380(3):467\u2013471. https:\/\/doi.org\/10.1016\/j.bbrc.2009.01.108","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"792_CR54","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1002\/prot.24807","volume":"83","author":"EC O\u2019Neill","year":"2015","unstructured":"O\u2019Neill EC, Stevenson CEM, Paterson MJ et al (2015) Crystal structure of a novel two-domain GH 78 family \u03b1-rhamnosidase from Klebsiella oxytoca with rhamnose bound. Proteins 83(9):1742\u20131749. https:\/\/doi.org\/10.1002\/prot.24807","journal-title":"Proteins"},{"issue":"3","key":"792_CR55","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.molcel.2011.07.011","volume":"43","author":"J Zhu","year":"2011","unstructured":"Zhu J, Wen W, Zheng Z et al (2011) LGN\/mInsc and LGN\/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3\/mInsc\/LGN and G\u03b1i\/LGN\/NuMA pathways. Mol Cell 43(3):418\u2013431. https:\/\/doi.org\/10.1016\/j.molcel.2011.07.011","journal-title":"Mol Cell"},{"issue":"26","key":"792_CR56","doi-asserted-by":"publisher","first-page":"18067","DOI":"10.1074\/jbc.M114.573212","volume":"289","author":"KK Touhara","year":"2014","unstructured":"Touhara KK, Nihira T, Kitaoka M et al (2014) Structural basis for reversible phosphorolysis and hydrolysis reactions of 2-O-\u03b1-glucosylglycerol phosphorylase. J Biol Chem 289(26):18067\u201318075. https:\/\/doi.org\/10.1074\/jbc.M114.573212","journal-title":"J Biol Chem"},{"issue":"12","key":"792_CR57","doi-asserted-by":"publisher","first-page":"7164","DOI":"10.1093\/nar\/gkab513","volume":"49","author":"G Garcia-Rodriguez","year":"2021","unstructured":"Garcia-Rodriguez G, Charlier D, Wilmaerts D et al (2021) Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA. Nucleic Acids Res 49(12):7164\u20137178. https:\/\/doi.org\/10.1093\/nar\/gkab513","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"792_CR58","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1016\/j.jmb.2019.04.018","volume":"431","author":"G Ormaza","year":"2019","unstructured":"Ormaza G, Rodriguez JA, Opakua AI et al (2019) The tumor suppressor ING5 is a dimeric, bivalent recognition molecule of the histone H3K4me3 mark. J Mol Biol 431(12):2298\u20132319. https:\/\/doi.org\/10.1016\/j.jmb.2019.04.018","journal-title":"J Mol Biol"},{"issue":"43","key":"792_CR59","doi-asserted-by":"publisher","first-page":"18225","DOI":"10.1073\/pnas.0907635106","volume":"106","author":"J Pandit","year":"2009","unstructured":"Pandit J, Forman MD, Fennell KF et al (2009) Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc Natl Acad Sci USA 106(43):18225\u201318230. https:\/\/doi.org\/10.1073\/pnas.0907635106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"792_CR60","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/prot.21142","volume":"65","author":"KH Chin","year":"2006","unstructured":"Chin KH, Chou CC, Wang AH et al (2006) Crystal structure of XC5357 from Xanthomonas campestris: a putative tetracenomycin polyketide synthesis protein adopting a novel cupin subfamily structure. Proteins 65(4):1046\u20131050. https:\/\/doi.org\/10.1002\/prot.21142","journal-title":"Proteins"},{"issue":"51","key":"792_CR61","doi-asserted-by":"publisher","first-page":"18237","DOI":"10.1073\/pnas.1419701112","volume":"111","author":"Z Rui","year":"2014","unstructured":"Rui Z, Li X, Zhu X et al (2014) Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proc Natl Acad Sci USA 111(51):18237\u201318242. https:\/\/doi.org\/10.1073\/pnas.1419701112","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"792_CR62","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1110\/ps.051501605","volume":"14","author":"X Qiu","year":"2005","unstructured":"Qiu X, Choudhry AE, Janson CA et al (2005) Crystal structure and substrate specificity of the \u03b2-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. Protein Sci 14(8):2087\u20132094. https:\/\/doi.org\/10.1110\/ps.051501605","journal-title":"Protein Sci"},{"issue":"3","key":"792_CR63","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1002\/prot.22020","volume":"71","author":"P Kozbial","year":"2008","unstructured":"Kozbial P, Xu Q, Chiu HJ et al (2008) Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold. Proteins 71(3):1589\u20131596. https:\/\/doi.org\/10.1002\/prot.22020","journal-title":"Proteins"},{"issue":"1","key":"792_CR64","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1128\/JB.05260-11","volume":"194","author":"GH Gauss","year":"2012","unstructured":"Gauss GH, Reott MA, Rocha ER et al (2012) Characterization of the Bacteroides fragilis bfr gene product identifies a bacterial DPS-like protein and suggests evolutionary links in the ferritin superfamily. J Bacteriol 194(1):15\u201327. https:\/\/doi.org\/10.1128\/JB.05260-11","journal-title":"J Bacteriol"},{"issue":"1","key":"792_CR65","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.devcel.2006.11.002","volume":"12","author":"Y Fujita","year":"2007","unstructured":"Fujita Y, Hayashi T, Kiyomitsu T et al (2007) Priming of centromere for CENP-A recruitment by human hMis18\u03b1, hMis18\u03b2, and M18BP1. Dev Cell 12(1):17\u201330. https:\/\/doi.org\/10.1016\/j.devcel.2006.11.002","journal-title":"Dev Cell"},{"issue":"6","key":"792_CR66","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.22541\/au.163768486.60510150\/v1","volume":"90","author":"Y Wen","year":"2022","unstructured":"Wen Y, Li X, Guo W, Wu B (2022) Crystal structures of a new class of pyrimidine\/purine nucleoside phosphorylase (ppnP) revealed a Cupin fold. Proteins 90(6):1233\u20131241. https:\/\/doi.org\/10.22541\/au.163768486.60510150\/v1","journal-title":"Proteins"},{"key":"792_CR67","doi-asserted-by":"publisher","first-page":"7425","DOI":"10.1038\/s41467-023-43285-0","volume":"14","author":"H Li","year":"2023","unstructured":"Li H, Huang JW, Dai L et al (2023) The structural and functional investigation into an unusual nitrile synthase. Nat Commun 14:7425. https:\/\/doi.org\/10.1038\/s41467-023-43285-0","journal-title":"Nat Commun"},{"issue":"1","key":"792_CR68","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/prot.10272","volume":"50","author":"SS Ray","year":"2003","unstructured":"Ray SS, Bonanno JB, Chen H et al (2003) X-ray structure of an M. jannaschii DNA-binding protein: implications for antibiotic resistance in S. aureus. Proteins 50(1):170\u2013173. https:\/\/doi.org\/10.1002\/prot.10272","journal-title":"Proteins"},{"issue":"33","key":"792_CR69","doi-asserted-by":"publisher","first-page":"31074","DOI":"10.1074\/jbc.M101943200","volume":"276","author":"L Mourey","year":"2001","unstructured":"Mourey L, Re SD, Pedelacq JD et al (2001) Crystal structure of the CheA histidine phosphotransfer domain that mediates response regulator phosphorylation in bacterial chemotaxis. J Biol Chem 276(33):31074\u201331082. https:\/\/doi.org\/10.1074\/jbc.M101943200","journal-title":"J Biol Chem"},{"issue":"1","key":"792_CR70","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jmb.2006.01.011","volume":"358","author":"T Nakano","year":"2006","unstructured":"Nakano T, Ikegami T, Suzuki T et al (2006) A new solution structure of ATP synthase subunit c from Thermophilic Bacillus PS3, suggesting a local conformational change for H+-translocation. J Mol Biol 358(1):132\u2013144. https:\/\/doi.org\/10.1016\/j.jmb.2006.01.011","journal-title":"J Mol Biol"},{"issue":"4","key":"792_CR71","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.jmb.2007.12.010","volume":"376","author":"A Ohtaki","year":"2008","unstructured":"Ohtaki A, Kida H, Miyata Y et al (2008) Structure and molecular dynamics simulation of archaeal prefoldin: the molecular mechanism for binding and recognition of nonnative substrate proteins. J Mol Biol 376(4):1130\u20131141. https:\/\/doi.org\/10.1016\/j.jmb.2007.12.010","journal-title":"J Mol Biol"},{"issue":"2","key":"792_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192653","volume":"13","author":"M Engleder","year":"2018","unstructured":"Engleder M, Horvat M, Emmerstorfer-Augustin A et al (2018) Recombinant expression, purification, and biochemical characterization of kievitone hydratase from Nectria haematococca. PLoS ONE 13(2):e0192653. https:\/\/doi.org\/10.1371\/journal.pone.0192653","journal-title":"PLoS ONE"},{"issue":"11","key":"792_CR73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112555","volume":"9","author":"MS Kelker","year":"2014","unstructured":"Kelker MS, Berry C, Evans SL et al (2014) Structural and biophysical characterization of Bacillus thuringiensis insecticidal proteins Cry34Ab1 and Cry35Ab1. PLoS ONE 9(11):e112555. https:\/\/doi.org\/10.1371\/journal.pone.0112555","journal-title":"PLoS ONE"},{"issue":"3","key":"792_CR74","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.jsb.2012.09.005","volume":"180","author":"L Carlier","year":"2012","unstructured":"Carlier L, Haase AS, Zepeda MY et al (2012) The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif. J Struct Biol 180(3):577\u2013584. https:\/\/doi.org\/10.1016\/j.jsb.2012.09.005","journal-title":"J Struct Biol"},{"issue":"3","key":"792_CR75","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41422-022-00620-2","volume":"32","author":"C Dou","year":"2022","unstructured":"Dou C, Long Z, Li S et al (2022) Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. Cell Res 32(3):302\u2013314. https:\/\/doi.org\/10.1038\/s41422-022-00620-2","journal-title":"Cell Res"},{"issue":"12","key":"792_CR76","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1261\/rna.1908309","volume":"15","author":"RJ Grainger","year":"2009","unstructured":"Grainger RJ, Barrass JD, Jacquier A et al (2009) Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300\/SRRM2, suggest a role at the catalytic center of the spliceosome. RNA 15(12):2161\u20132173. https:\/\/doi.org\/10.1261\/rna.1908309","journal-title":"RNA"},{"issue":"13","key":"792_CR77","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1073\/pnas.1403059111","volume":"111","author":"G Song","year":"2014","unstructured":"Song G, Springer TA (2014) Structures of the Toxoplasma gliding motility adhesin. Proc Natl Acad Sci USA 111(13):4862\u20134867. https:\/\/doi.org\/10.1073\/pnas.1403059111","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"792_CR78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048015","volume":"7","author":"G Fibriansah","year":"2012","unstructured":"Fibriansah G, Kovacs AT, Pool TH et al (2012) Crystal structures of two transcriptional regulators from Bacillus cereus define the conserved structural features of a PadR subfamily. PLoS ONE 7(11):e48015. https:\/\/doi.org\/10.1371\/journal.pone.0048015","journal-title":"PLoS ONE"},{"issue":"5","key":"792_CR79","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1128\/jb.173.5.1696-1703.1991","volume":"173","author":"DL Cheo","year":"1991","unstructured":"Cheo DL, Bayles KW, Yasbin RE (1991) Cloning and characterization of DNA damage-inducible promoter regions from Bacillus subtilis. J Bacteriol 173(5):1696\u20131703. https:\/\/doi.org\/10.1128\/jb.173.5.1696-1703.1991","journal-title":"J Bacteriol"},{"issue":"4","key":"792_CR80","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nsb909","volume":"10","author":"S Macedo","year":"2003","unstructured":"Macedo S, Romao CV, Mitchell E et al (2003) The nature of the di-iron site in the bacterioferritin from Desulfovibrio desulfuricans. Nat Struct Mol Biol 10(4):285\u2013290. https:\/\/doi.org\/10.1038\/nsb909","journal-title":"Nat Struct Mol Biol"},{"issue":"10","key":"792_CR81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013402","volume":"5","author":"A Graebsch","year":"2010","unstructured":"Graebsch A, Roche S, Kostrewa D et al (2010) Of bits and bugs\u2014on the use of bioinformatics and a bacterial crystal structure to solve a eukaryotic repeat-protein structure. PLoS ONE 5(10):e13402. https:\/\/doi.org\/10.1371\/journal.pone.0013402","journal-title":"PLoS ONE"},{"issue":"2","key":"792_CR82","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.gene.2015.11.037","volume":"577","author":"S Werten","year":"2016","unstructured":"Werten S, Kohler C, Bayer NJ et al (2016) Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4. Gene 577(2):140\u2013147. https:\/\/doi.org\/10.1016\/j.gene.2015.11.037","journal-title":"Gene"},{"issue":"37","key":"792_CR83","doi-asserted-by":"publisher","first-page":"14510","DOI":"10.1021\/jacs.9b06093","volume":"141","author":"B Zhang","year":"2019","unstructured":"Zhang B, Rajakovich LJ, Cura DV et al (2019) Substrate-triggered formation of a peroxo-Fe2\u207a(III\/III) intermediate during fatty acid decarboxylation by UndA. J Am Chem Soc 141(37):14510\u201314514. https:\/\/doi.org\/10.1021\/jacs.9b06093","journal-title":"J Am Chem Soc"},{"key":"792_CR84","doi-asserted-by":"publisher","first-page":"1264801","DOI":"10.3389\/fmicb.2023.1264801","volume":"14","author":"CA Dupont","year":"2023","unstructured":"Dupont CA, Bourigault Y, Osmond T et al (2023) Pseudomonas fluorescens MFE01 uses 1-undecene as an aerial communication molecule. Front Microbiol 14:1264801. https:\/\/doi.org\/10.3389\/fmicb.2023.1264801","journal-title":"Front Microbiol"},{"issue":"6536","key":"792_CR85","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax9050","volume":"371","author":"S Breinlinger","year":"2021","unstructured":"Breinlinger S, Phillips TJ, Haram BN et al (2021) Hunting the eagle killer: a cyanobacterial neurotoxin causes vacuolar myelinopathy. Science 371(6536):eaax9050. https:\/\/doi.org\/10.1126\/science.aax9050","journal-title":"Science"},{"issue":"2","key":"792_CR86","doi-asserted-by":"publisher","first-page":"304","DOI":"10.7164\/antibiotics.39.304","volume":"39","author":"M Sanada","year":"1986","unstructured":"Sanada M, Miyand T, Iwadare S (1986) \u03b2-Ethynylserine, an antimetabolite of L-threonine, from Streptomyces cattleya. J Antibiot (Tokyo) 39(2):304\u2013305. https:\/\/doi.org\/10.7164\/antibiotics.39.304","journal-title":"J Antibiot (Tokyo)"},{"issue":"2","key":"792_CR87","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.22207\/JPAM.16.2.44","volume":"16","author":"CM Koshy","year":"2022","unstructured":"Koshy CM, Asirvatham D, Majumdar R et al (2022) In silico structural and functional characterization of a hypothetical protein from Stenotrophomonas maltophilia SRM01. J Pure Appl Microbiol 16(2):1167\u20131178. https:\/\/doi.org\/10.22207\/JPAM.16.2.44","journal-title":"J Pure Appl Microbiol"},{"key":"792_CR88","doi-asserted-by":"publisher","first-page":"7665","DOI":"10.1007\/s10462-022-10350-x","volume":"56","author":"MMM Mufassirin","year":"2023","unstructured":"Mufassirin MMM, Newton MAH, Sattar A (2023) Artificial intelligence for template-free protein structure prediction: a comprehensive review. Artif Intell Rev 56:7665\u20137732. https:\/\/doi.org\/10.1007\/s10462-022-10350-x","journal-title":"Artif Intell Rev"},{"key":"792_CR89","doi-asserted-by":"publisher","unstructured":"Stormo GD (2009) An introduction to sequence similarity (\"homology\") searching. In: Baxevanis AD, Petsko GA, Stein LD, Stormo GD (eds) Current protocols in bioinformatics. Wiley, Hoboken, Chapter 3, Unit 3.1, pp 3.1.1\u20133.1.7. https:\/\/doi.org\/10.1002\/0471250953.bi0301s27","DOI":"10.1002\/0471250953.bi0301s27"},{"issue":"3","key":"792_CR90","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/prot.22458","volume":"77","author":"K Illerg\u00e5rd","year":"2009","unstructured":"Illerg\u00e5rd K, Ardell DH, Elofsson A (2009) Structure is three to ten times more conserved than sequence: a study of structural response in protein cores. Proteins 77(3):499\u2013508. https:\/\/doi.org\/10.1002\/prot.22458","journal-title":"Proteins"},{"issue":"9","key":"792_CR91","doi-asserted-by":"publisher","DOI":"10.3390\/life12091430","volume":"12","author":"A Bhardwaj","year":"2022","unstructured":"Bhardwaj A, Kishore S, Pandey DK (2022) Artificial intelligence in biological sciences. Life 12(9):1430. https:\/\/doi.org\/10.3390\/life12091430","journal-title":"Life"},{"key":"792_CR92","doi-asserted-by":"publisher","first-page":"1162697","DOI":"10.3389\/fpara.2023.1162697","volume":"2","author":"V Muthye","year":"2023","unstructured":"Muthye V, Wasmuth JD (2023) Proteome-wide comparison of tertiary protein structures reveals molecular mimicry in Plasmodium-human interactions. Front Parasitol 2:1162697. https:\/\/doi.org\/10.3389\/fpara.2023.1162697","journal-title":"Front Parasitol"},{"key":"792_CR93","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jip.2016.07.013","volume":"142","author":"JM Jez","year":"2017","unstructured":"Jez JM (2017) Revisiting protein structure, function, and evolution in the genomic era. J Invertebr Pathol 142:11\u201315. https:\/\/doi.org\/10.1016\/j.jip.2016.07.013","journal-title":"J Invertebr Pathol"},{"issue":"1","key":"792_CR94","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00926-13","volume":"5","author":"MG Moule","year":"2014","unstructured":"Moule MG, Hemsley CM, Seet Q et al (2014) Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. MBio 5(1):e00926\u201313. https:\/\/doi.org\/10.1128\/mBio.00926-13","journal-title":"MBio"},{"issue":"2","key":"792_CR95","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.chom.2011.07.004","volume":"10","author":"TE Kehl-Fie","year":"2011","unstructured":"Kehl-Fie TE, Chitayat S, Hood MI et al (2011) Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe 10(2):158\u2013164. https:\/\/doi.org\/10.1016\/j.chom.2011.07.004","journal-title":"Cell Host Microbe"},{"key":"792_CR96","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1007\/s11030-022-10584-5","volume":"27","author":"SS Hassan","year":"2023","unstructured":"Hassan SS, Shams R, Camps I et al (2023) Subtractive sequence analysis aided druggable targets mining in Burkholderia cepacia complex and finding inhibitors through bioinformatics approach. Mol Divers 27:2823\u20132847. https:\/\/doi.org\/10.1007\/s11030-022-10584-5","journal-title":"Mol Divers"}],"container-title":["Interdisciplinary Sciences: Computational Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-025-00792-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12539-025-00792-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12539-025-00792-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:33:02Z","timestamp":1779949982000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12539-025-00792-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":96,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["792"],"URL":"https:\/\/doi.org\/10.1007\/s12539-025-00792-6","relation":{},"ISSN":["1913-2751","1867-1462"],"issn-type":[{"value":"1913-2751","type":"print"},{"value":"1867-1462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"15 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"During the preparation of this manuscript the author used the AI tool ChatGPT to refine the language. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"AI Used for Writing Manuscript"}}]}}