{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:03:46Z","timestamp":1793563426963,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008751","name":"Bundesinstitut f\u00fcr Risikobewertung","doi-asserted-by":"publisher","award":["51-006 and 1322-623"],"award-info":[{"award-number":["51-006 and 1322-623"]}],"id":[{"id":"10.13039\/501100008751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mycotoxin Res"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s12550-018-0339-9","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T19:32:19Z","timestamp":1544815939000},"page":"157-168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["In vitro characterization of hepatic toxicity of Alternaria toxins"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6153-0035","authenticated-orcid":false,"given":"Stefanie","family":"Hessel-Pras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Kieshauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giana","family":"Roenn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Luckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Braeuning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Lampen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"339_CR1","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.bbadis.2010.12.018","volume":"1812","author":"MM Aagaard","year":"2011","unstructured":"Aagaard MM, Siersbaek R, Mandrup S (2011) Molecular basis for gene-specific transactivation by nuclear receptors. Biochim Biophys Acta 1812:824\u2013835. https:\/\/doi.org\/10.1016\/j.bbadis.2010.12.018","journal-title":"Biochim Biophys Acta"},{"key":"339_CR2","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1021\/jf00089a029","volume":"37","author":"Y An","year":"1989","unstructured":"An Y, Zhao T, Miao J, Liu G, Zheng Y, Xu Y, Van Etten RL (1989) Isolation, identification, and mutagenicity of alternariol monomethyl ether. J Agric Food Chem 37:1341\u20131343. https:\/\/doi.org\/10.1021\/jf00089a029","journal-title":"J Agric Food Chem"},{"key":"339_CR3","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1177\/1087057114541147","volume":"19","author":"M Ando","year":"2014","unstructured":"Ando M, Yoshikawa K, Iwase Y, Ishiura S (2014) Usefulness of monitoring gamma-H2AX and cell cycle arrest in HepG2 cells for estimating genotoxicity using a high-content analysis system. J Biomol Screen 19:1246\u20131254. https:\/\/doi.org\/10.1177\/1087057114541147","journal-title":"J Biomol Screen"},{"key":"339_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1124\/dmd.105.006759","volume":"34","author":"C Aninat","year":"2006","unstructured":"Aninat C, Piton A, Glaise D, le Charpentier T, Langou\u00ebt S, Morel F, Guguen-Guillouzo C, Guillouzo A (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75\u201383","journal-title":"Drug Metab Dispos"},{"key":"339_CR5","first-page":"4347","volume":"63","author":"JP Ban\u00e1th","year":"2003","unstructured":"Ban\u00e1th JP, Olive PL (2003) Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Res 63:4347\u20134350","journal-title":"Cancer Res"},{"key":"339_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/B978-0-12-374126-4.00008-5","volume-title":"Mycotoxins in fruits and vegetables","author":"R Barkai-Golan","year":"2008","unstructured":"Barkai-Golan R (2008) Chapter 8 - Alternaria mycotoxins. In: Mycotoxins in fruits and vegetables. Academic Press, San Diego, pp 185\u2013203. https:\/\/doi.org\/10.1016\/B978-0-12-374126-4.00008-5"},{"key":"339_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s12550-009-0022-2","volume":"25","author":"B Burkhardt","year":"2009","unstructured":"Burkhardt B, Pfeiffer E, Metzler M (2009) Absorption and metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in Caco-2 cells in vitro. Mycotoxin Res 25:149\u2013157. https:\/\/doi.org\/10.1007\/s12550-009-0022-2","journal-title":"Mycotoxin Res"},{"key":"339_CR8","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/mnfr.201000487","volume":"55","author":"B Burkhardt","year":"2011","unstructured":"Burkhardt B, Wittenauer J, Pfeiffer E, Schauer UM, Metzler M (2011) Oxidative metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in precision-cut rat liver slices in vitro. Mol Nutr Food Res 55:1079\u20131086. https:\/\/doi.org\/10.1002\/mnfr.201000487","journal-title":"Mol Nutr Food Res"},{"key":"339_CR9","doi-asserted-by":"publisher","unstructured":"Cuperus FJ, Claudel T, Gautherot J, Halilbasic E, Trauner M (2014) The role of canalicular ABC transporters in cholestasis. Drug Metab Dispos: Biol Fate Chem 42:546\u2013560. https:\/\/doi.org\/10.1124\/dmd.113.056358","DOI":"10.1124\/dmd.113.056358"},{"key":"339_CR10","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1432-1033.1997.00150.x","volume":"250","author":"M Delaforge","year":"1997","unstructured":"Delaforge M et al (1997) Metabolism of tentoxin by hepatic cytochrome P-450 3A isozymes. Eur J Biochem 250:150\u2013157. https:\/\/doi.org\/10.1111\/j.1432-1033.1997.00150.x","journal-title":"Eur J Biochem"},{"key":"339_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.foodchem.2017.12.013","volume":"248","author":"L Dellafiora","year":"2018","unstructured":"Dellafiora L, Warth B, Schmidt V, Del Favero G, Mikula H, Frohlich J, Marko D (2018) An integrated in silico\/in vitro approach to assess the xenoestrogenic potential of Alternaria mycotoxins and metabolites. Food Chem 248:253\u2013261. https:\/\/doi.org\/10.1016\/j.foodchem.2017.12.013","journal-title":"Food Chem"},{"key":"339_CR12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2903\/j.efsa.2011.2407","volume":"9","author":"EFSA","year":"2011","unstructured":"EFSA (2011) Alternaria toxins in feed and food. EFSA J 9:97. https:\/\/doi.org\/10.2903\/j.efsa.2011.2407","journal-title":"EFSA J"},{"key":"339_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2903\/j.efsa.2016.4654","volume":"14","author":"EFSA","year":"2016","unstructured":"EFSA (2016) Dietary exposure to Alternaria toxins. EFSA J 14:32. https:\/\/doi.org\/10.2903\/j.efsa.2016.4654","journal-title":"EFSA J"},{"key":"339_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1155\/2017\/1569748","volume":"2017","author":"L Escriv\u00e1","year":"2017","unstructured":"Escriv\u00e1 L, Oueslati S, Font G, Manyes L (2017) Alternaria mycotoxins in food and feed: an overview. J Food Qual 2017:20\u201320. https:\/\/doi.org\/10.1155\/2017\/1569748","journal-title":"J Food Qual"},{"key":"339_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/mnfr.200700379","volume":"53","author":"M Fehr","year":"2009","unstructured":"Fehr M, Pahlke G, Fritz J, Christensen MO, Boege F, Altem\u00f6ller M, Podlech J, Marko D (2009) Alternariol acts as a topoisomerase poison, preferentially affecting the IIalpha isoform. Mol Nutr Food Res 53:441\u2013451. https:\/\/doi.org\/10.1002\/mnfr.200700379","journal-title":"Mol Nutr Food Res"},{"key":"339_CR16","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.fct.2016.01.011","volume":"89","author":"C Fern\u00e1ndez-Blanco","year":"2016","unstructured":"Fern\u00e1ndez-Blanco C, Font G, Ruiz M-J (2016) Role of quercetin on Caco-2 cells against cytotoxic effects of alternariol and alternariol monomethyl ether. Food Chem Toxicol 89:60\u201366. https:\/\/doi.org\/10.1016\/j.fct.2016.01.011","journal-title":"Food Chem Toxicol"},{"key":"339_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.fct.2015.11.022","volume":"88","author":"C Fernandez-Blanco","year":"2016","unstructured":"Fernandez-Blanco C, Juan-Garcia A, Juan C, Font G, Ruiz MJ (2016) Alternariol induce toxicity via cell death and mitochondrial damage on Caco-2 cells. Food Chem Toxicol 88:32\u201339. https:\/\/doi.org\/10.1016\/j.fct.2015.11.022","journal-title":"Food Chem Toxicol"},{"key":"339_CR18","doi-asserted-by":"publisher","first-page":"8560","DOI":"10.1021\/acs.jafc.5b02828","volume":"63","author":"S Fraeyman","year":"2015","unstructured":"Fraeyman S, Devreese M, Broekaert N, de Mil T, Antonissen G, de Baere S, de Backer P, Rychlik M, Croubels S (2015) Quantitative determination of tenuazonic acid in pig and broiler chicken plasma by LC-MS\/MS and its comparative toxicokinetics. J Agric Food Chem 63:8560\u20138567. https:\/\/doi.org\/10.1021\/acs.jafc.5b02828","journal-title":"J Agric Food Chem"},{"key":"339_CR19","doi-asserted-by":"publisher","unstructured":"Fraeyman S, Croubels S, Devreese M, Antonissen G (2017) Emerging fusarium and Alternaria mycotoxins: occurrence, Toxicity and Toxicokinetics. Toxins 9:228\u2013257. https:\/\/doi.org\/10.3390\/toxins9070228","DOI":"10.3390\/toxins9070228"},{"key":"339_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.taap.2013.05.002","volume":"271","author":"C Frizzell","year":"2013","unstructured":"Frizzell C, Ndossi D, Kalayou S, Eriksen GS, Verhaegen S, S\u00f8rlie M, Elliott CT, Ropstad E, Connolly L (2013) An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol 271:64\u201371. https:\/\/doi.org\/10.1016\/j.taap.2013.05.002","journal-title":"Toxicol Appl Pharmacol"},{"key":"339_CR21","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1055\/s-0033-1358520","volume":"33","author":"C Fuchs","year":"2013","unstructured":"Fuchs C, Claudel T, Trauner M (2013) Bile acid-mediated control of liver triglycerides. Semin Liver Dis 33:330\u2013342. https:\/\/doi.org\/10.1055\/s-0033-1358520","journal-title":"Semin Liver Dis"},{"key":"339_CR22","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/hy1101.099499","volume":"38","author":"ER Garcia-Tevijano","year":"2001","unstructured":"Garcia-Tevijano ER et al (2001) Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis. Hypertension (Dallas, TX: 1979) 38:1217\u20131221","journal-title":"Hypertension (Dallas, TX: 1979)"},{"key":"339_CR23","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1007\/s00204-013-1078-5","volume":"87","author":"P Godoy","year":"2013","unstructured":"Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, B\u00f6ttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CEP, G\u00f3mez-Lech\u00f3n MJ, Groothuis GMM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, H\u00e4ussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzh\u00fctter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EHK, Stieger B, St\u00f6ber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 87:1315\u20131530. https:\/\/doi.org\/10.1007\/s00204-013-1078-5","journal-title":"Arch Toxicol"},{"key":"339_CR24","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1128\/AEM.46.6.1420-1422.1983","volume":"46","author":"GF Griffin","year":"1983","unstructured":"Griffin GF, Chu FS (1983) Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay. Appl Environ Microbiol 46:1420\u20131422","journal-title":"Appl Environ Microbiol"},{"key":"339_CR25","doi-asserted-by":"publisher","unstructured":"Grover S, Lawrence CB (2017) The Alternaria alternata mycotoxin alternariol suppresses lipopolysaccharide-induced inflammation Int J Mol Sci 18. doi: https:\/\/doi.org\/10.3390\/ijms18071577","DOI":"10.3390\/ijms18071577"},{"key":"339_CR26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jhep.2012.08.002","volume":"58","author":"E Halilbasic","year":"2013","unstructured":"Halilbasic E, Claudel T, Trauner M (2013) Bile acid transporters and regulatory nuclear receptors in the liver and beyond. J Hepatol 58:155\u2013168. https:\/\/doi.org\/10.1016\/j.jhep.2012.08.002","journal-title":"J Hepatol"},{"key":"339_CR27","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.tiv.2016.04.016","volume":"34","author":"A Juan-Garc\u00eda","year":"2016","unstructured":"Juan-Garc\u00eda A, Juan C, Manyes L, Ruiz M-J (2016) Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: toxic effects and evaluation of degradation products. Toxicol in Vitro 34:264\u2013273. https:\/\/doi.org\/10.1016\/j.tiv.2016.04.016","journal-title":"Toxicol in Vitro"},{"key":"339_CR28","doi-asserted-by":"publisher","unstructured":"Kanebratt KP, Andersson TB (2008) Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab Dispos: Biol Fate Chem 36:1444\u20131452. https:\/\/doi.org\/10.1124\/dmd.107.020016","DOI":"10.1124\/dmd.107.020016"},{"key":"339_CR29","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1128\/jb.175.14.4427-4435.1993","volume":"175","author":"N Kimura","year":"1993","unstructured":"Kimura N, Tsuge T (1993) Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata. J Bacteriol 175:4427\u20134435","journal-title":"J Bacteriol"},{"key":"339_CR30","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1007\/s00204-015-1591-9","volume":"90","author":"F Kolrep","year":"2016","unstructured":"Kolrep F, Hessel S, These A, Ehlers A, Rein K, Lampen A (2016) Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases. Arch Toxicol 90:2025\u20132036. https:\/\/doi.org\/10.1007\/s00204-015-1591-9","journal-title":"Arch Toxicol"},{"key":"339_CR31","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.tiv.2017.04.009","volume":"42","author":"F Kolrep","year":"2017","unstructured":"Kolrep F, Rein K, Lampen A, Hessel-Pras S (2017) Metabolism of okadaic acid by NADPH-dependent enzymes present in human or rat liver S9 fractions results in different toxic effects. Toxicol in Vitro 42:161\u2013170. https:\/\/doi.org\/10.1016\/j.tiv.2017.04.009","journal-title":"Toxicol in Vitro"},{"key":"339_CR32","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1006\/rwgn.2001.1295","volume-title":"Encyclopedia of genetics","author":"E Kutter","year":"2001","unstructured":"Kutter E (2001) Topoisomerases A2 - Brenner, Sydney. In: Miller JH (ed) Encyclopedia of genetics. Academic Press, New York, p 1970. https:\/\/doi.org\/10.1006\/rwgn.2001.1295"},{"key":"339_CR33","doi-asserted-by":"publisher","first-page":"371","DOI":"10.5941\/MYCO.2015.43.3.371","volume":"43","author":"HB Lee","year":"2015","unstructured":"Lee HB, Patriarca A, Magan N (2015) Erratum: Alternaria in food: ecophysiology, mycotoxin production and toxicology. Mycobiology 43:371\u2013371. https:\/\/doi.org\/10.5941\/MYCO.2015.43.3.371","journal-title":"Mycobiology"},{"key":"339_CR34","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.fct.2005.08.013","volume":"44","author":"L Lehmann","year":"2006","unstructured":"Lehmann L, Wagner J, Metzler M (2006) Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. Food Chem Toxicol 44:398\u2013408. https:\/\/doi.org\/10.1016\/j.fct.2005.08.013","journal-title":"Food Chem Toxicol"},{"key":"339_CR35","first-page":"394","volume":"105","author":"GT Liu","year":"1992","unstructured":"Liu GT, Qian YZ, Zhang P, Dong WH, Qi YM, Guo HT (1992) Etiological role of Alternaria alternata in human esophageal cancer. Chin Med J 105:394\u2013400","journal-title":"Chin Med J"},{"key":"339_CR36","doi-asserted-by":"publisher","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif) 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","DOI":"10.1006\/meth.2001.1262"},{"key":"339_CR37","doi-asserted-by":"publisher","first-page":"5891","DOI":"10.3390\/molecules18055891","volume":"18","author":"J Lou","year":"2013","unstructured":"Lou J, Fu L, Peng Y, Zhou L (2013) Metabolites from Alternaria fungi and their bioactivities. Molecules 18:5891\u20135935. https:\/\/doi.org\/10.3390\/molecules18055891","journal-title":"Molecules"},{"key":"339_CR38","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1053\/j.gastro.2005.08.052","volume":"130","author":"RP Oude Elferink","year":"2006","unstructured":"Oude Elferink RP, Paulusma CC, Groen AK (2006) Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology 130:908\u2013925. https:\/\/doi.org\/10.1053\/j.gastro.2005.08.052","journal-title":"Gastroenterology"},{"key":"339_CR39","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/bioinformatics\/19.2.295","volume":"19","author":"P Pavlidis","year":"2003","unstructured":"Pavlidis P, Noble WS (2003) Matrix2png: a utility for visualizing matrix data. Bioinformatics 19:295\u2013296. https:\/\/doi.org\/10.1093\/bioinformatics\/19.2.295","journal-title":"Bioinformatics"},{"key":"339_CR40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/BF02951512","volume":"23","author":"E Pfeiffer","year":"2007","unstructured":"Pfeiffer E, Eschbach S, Metzler M (2007) Alternaria toxins: DNA strand-breaking activity in mammalian cellsin vitro. Mycotoxin Res 23:152\u2013157. https:\/\/doi.org\/10.1007\/bf02951512","journal-title":"Mycotoxin Res"},{"key":"339_CR41","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/BF03032337","volume":"24","author":"E Pfeiffer","year":"2008","unstructured":"Pfeiffer E, Burkhardt B, Altemoller M, Podlech J, Metzler M (2008) Activities of human recombinant cytochrome P450 isoforms and human hepatic microsomes for the hydroxylation ofAlternaria toxins. Mycotoxin Res 24:117\u2013123. https:\/\/doi.org\/10.1007\/bf03032337","journal-title":"Mycotoxin Res"},{"key":"339_CR42","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12550-008-0001-z","volume":"25","author":"E Pfeiffer","year":"2009","unstructured":"Pfeiffer E, Schmit C, Burkhardt B, Altem\u00f6ller M, Podlech J, Metzler M (2009) Glucuronidation of the mycotoxins alternariol and alternariol-9-methyl ether in vitro: chemical structures of glucuronides and activities of human UDP-glucuronosyltransferase isoforms. Mycotoxin Res 25:3\u201310. https:\/\/doi.org\/10.1007\/s12550-008-0001-z","journal-title":"Mycotoxin Res"},{"key":"339_CR43","doi-asserted-by":"publisher","first-page":"9390","DOI":"10.1074\/jbc.275.13.9390","volume":"275","author":"EP Rogakou","year":"2000","unstructured":"Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM (2000) Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 275:9390\u20139395","journal-title":"J Biol Chem"},{"key":"339_CR44","first-page":"365","volume":"132","author":"S Rozen","year":"2000","unstructured":"Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132:365\u2013386","journal-title":"Methods Mol Biol"},{"key":"339_CR45","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.mrgentox.2006.02.008","volume":"606","author":"TJ Schrader","year":"2006","unstructured":"Schrader TJ, Cherry W, Soper K, Langlois I (2006) Further examination of the effects of nitrosylation on Alternaria alternata mycotoxin mutagenicity in vitro. Mutat Res 606:61\u201371. https:\/\/doi.org\/10.1016\/j.mrgentox.2006.02.008","journal-title":"Mutat Res"},{"key":"339_CR46","doi-asserted-by":"crossref","unstructured":"Schuchardt S, Ziemann C, Hansen T (2014) Combined toxicokinetic and in vivo genotoxicity study on Alternaria toxins. EFSA Supporting Publications EN-679:130","DOI":"10.2903\/sp.efsa.2014.EN-679"},{"key":"339_CR47","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1021\/bi00905a039","volume":"2","author":"HT Shigeura","year":"1963","unstructured":"Shigeura HT, Gordon CN (1963) The biological activity of Tenuazonic acid. Biochemistry 2:1132\u20131137. https:\/\/doi.org\/10.1021\/bi00905a039","journal-title":"Biochemistry"},{"key":"339_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mrfmmm.2012.09.001","volume":"738-739","author":"A Solhaug","year":"2012","unstructured":"Solhaug A, Vines LL, Ivanova L, Spilsberg B, Holme JA, Pestka J, Collins A, Eriksen GS (2012) Mechanisms involved in alternariol-induced cell cycle arrest. Mutat Res 738-739:1\u201311. https:\/\/doi.org\/10.1016\/j.mrfmmm.2012.09.001","journal-title":"Mutat Res"},{"key":"339_CR49","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/bcpt.12635","volume":"119","author":"A Solhaug","year":"2016","unstructured":"Solhaug A, Eriksen GS, Holme JA (2016) Mechanisms of action and toxicity of the mycotoxin Alternariol: a review. Basic Clin Pharmacol Toxicol 119:533\u2013539. https:\/\/doi.org\/10.1111\/bcpt.12635","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"339_CR50","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s00204-016-1801-0","volume":"91","author":"C Tiessen","year":"2017","unstructured":"Tiessen C, Ellmer D, Mikula H, Pahlke G, Warth B, Gehrke H, Zimmermann K, Heiss E, Fr\u00f6hlich J, Marko D (2017) Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells. Arch Toxicol 91:1213\u20131226. https:\/\/doi.org\/10.1007\/s00204-016-1801-0","journal-title":"Arch Toxicol"},{"key":"339_CR51","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s00204-016-1795-7","volume":"91","author":"K Vejdovszky","year":"2017","unstructured":"Vejdovszky K, Hahn K, Braun D, Warth B, Marko D (2017) Synergistic estrogenic effects of fusarium and Alternaria mycotoxins in vitro. Arch Toxicol 91:1447\u20131460. https:\/\/doi.org\/10.1007\/s00204-016-1795-7","journal-title":"Arch Toxicol"},{"key":"339_CR52","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jhep.2009.05.012","volume":"51","author":"M Wagner","year":"2009","unstructured":"Wagner M, Zollner G, Trauner M (2009) New molecular insights into the mechanisms of cholestasis. J Hepatol 51:565\u2013580. https:\/\/doi.org\/10.1016\/j.jhep.2009.05.012","journal-title":"J Hepatol"},{"key":"339_CR53","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s12282-018-0873-5","volume":"25","author":"L Wen","year":"2018","unstructured":"Wen L, Liu L, Wen L, Yu T, Wei F (2018) Artesunate promotes G2\/M cell cycle arrest in MCF7 breast cancer cells through ATM activation. Breast Cancer 25:681\u2013686. https:\/\/doi.org\/10.1007\/s12282-018-0873-5","journal-title":"Breast Cancer"},{"key":"339_CR54","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1080\/01926230152499980","volume":"29","author":"H Yekeler","year":"2001","unstructured":"Yekeler H, Bitmis K, Ozcelik N, Doymaz MZ, Calta M (2001) Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy. Toxicol Pathol 29:492\u2013497. https:\/\/doi.org\/10.1080\/01926230152499980","journal-title":"Toxicol Pathol"},{"key":"339_CR55","unstructured":"Zhen YZ et al. (1991) Mutagenicity of Alternaria alternata and penicillium cyclopium isolated from grains in an area of high incidence of oesophageal cancer-Linxian, China. IARC Sci Publ:253\u2013257"}],"container-title":["Mycotoxin Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12550-018-0339-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12550-018-0339-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12550-018-0339-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T20:52:46Z","timestamp":1605646366000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12550-018-0339-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["339"],"URL":"https:\/\/doi.org\/10.1007\/s12550-018-0339-9","relation":{},"ISSN":["0178-7888","1867-1632"],"issn-type":[{"value":"0178-7888","type":"print"},{"value":"1867-1632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,14]]},"assertion":[{"value":"21 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Experiments with animals for preparing rat S9 fraction were performed according to European laws and with consent of the responsible authority of the state of Berlin (Regional Office for Health and Social Affairs Berlin\u2014LAGeSo), numbers H0256\/02 (treatment of animals) and T0258\/02 (killing of animals and removal of organs).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}