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The objective of this study was to investigate the effect of fortifying GSH and PO levels in alcoholic fermentation as a strategy for reduce concentration deoxynivalenol (DON) during the brewing process. The QuEChERS method was validated for quantifying the mycotoxin and estimating reduction. Fermentation was conducted in a reactor containing 20 mL of synthetic wort inoculated\n                    <jats:italic>with Saccharomyces cerevisiae<\/jats:italic>\n                    (0.115\u00a0g). The reduction of DON was evaluated using a 2\n                    <jats:sup>4\u22121<\/jats:sup>\n                    fractional factorial design with the following independent variables: GSH concentration (0\u201350 mg L\n                    <jats:sup>-1<\/jats:sup>\n                    ), PO activity (0\u20130.4 U mL\n                    <jats:sup>-1<\/jats:sup>\n                    ), fortification time (0\u201348\u00a0h), and DON concentration (0.1\u20130.3\u00a0\u00b5g mL\n                    <jats:sup>-1<\/jats:sup>\n                    ). The results of reducing the concentration of DON in experimental planning ranged from 76,2% to non-detection of mycotoxin, significantly, with PO activity as a significant variable. Fortification with GSH and PO was significant in the decrease of DON when it was at a higher level, increasing by 39% compared to the control. Supplementation with GSH and PO demonstrated in this study indicates the effectiveness of DON reduction in the evaluated contamination levels.\n                  <\/jats:p>","DOI":"10.1007\/s12550-026-00674-w","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T01:55:48Z","timestamp":1787536548000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alcoholic beer fermentation: impact of glutathione and peroxidase fortification on deoxynivalenol reduction"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-6067","authenticated-orcid":false,"given":"Danilo Salustiano","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-979X","authenticated-orcid":false,"given":"Larine","family":"Kupski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-090X","authenticated-orcid":false,"given":"Anderson Ferreira","family":"Vilela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-8796","authenticated-orcid":false,"given":"Eliana","family":"Badiale-Furlong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-6217","authenticated-orcid":false,"given":"Jaqueline","family":"Garda-Buffon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"674_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s12550-025-00596-z","volume":"41","author":"F Afacan","year":"2025","unstructured":"Afacan F, Odabas O, Yussuf E, Kabak NH, B (2025) Co-occurrence and risk assessment of ochratoxin A and deoxynivalenol in tortillas. 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