{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:00:02Z","timestamp":1780592402088,"version":"3.54.1"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["Fast track program"],"award-info":[{"award-number":["Fast track program"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anat Sci Int"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12565-020-00550-2","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T18:02:11Z","timestamp":1590948131000},"page":"523-539","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transplantation of human dental pulp stem cells in streptozotocin-induced diabetic rats"],"prefix":"10.1007","volume":"95","author":[{"given":"Ahmed Othman Fathy Othman","family":"El-Kersh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan","family":"El-Akabawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha H.","family":"Al-Serwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"550_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.placenta.2017.04.003","volume":"59","author":"MH Abumaree","year":"2017","unstructured":"Abumaree MH, Abomaray FM, Alshabibi MA, AlAskar AS, Kalionis B (2017) Immunomodulatory properties of human placental mesenchymal stem\/stromal cells. Placenta 59:87\u201395. https:\/\/doi.org\/10.1016\/j.placenta.2017.04.003","journal-title":"Placenta"},{"issue":"4","key":"550_CR2","doi-asserted-by":"publisher","first-page":"e95110","DOI":"10.1371\/journal.pone.0095110","volume":"9","author":"K Aida","year":"2014","unstructured":"Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T (2014) Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of regenerating gene (REG) protein in fulminant type 1 diabetes. PLoS ONE 9(4):e95110. https:\/\/doi.org\/10.1371\/journal.pone.0095110","journal-title":"PLoS ONE"},{"issue":"2","key":"550_CR3","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.bbrc.2018.06.103","volume":"503","author":"K Aida","year":"2018","unstructured":"Aida K, Kobayashi T, Takeshita A, Jimbo E, Nishida Y, Yagihashi S, Hosoi M, Fukui T, Sugawara A, Takasawa S (2018) Crucial role of Reg I from acinar-like cell cluster touching with islets (Atlantis) on mitogenesis of beta cells in EMC virus-induced diabetic mice. Biochem Biophys Res Commun 503(2):963\u2013969. https:\/\/doi.org\/10.1016\/j.bbrc.2018.06.103","journal-title":"Biochem Biophys Res Commun"},{"key":"550_CR4","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/ncb1005","volume":"5","author":"LA Allan","year":"2003","unstructured":"Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 5:647\u2013654","journal-title":"Nat Cell Biol"},{"key":"550_CR5","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s12015-010-9196-4","volume":"7","author":"R Anzalone","year":"2011","unstructured":"Anzalone R, Lo Iacono M, Loria T, Di Stefano A, Giannuzzi P, Farina F, La Rocca G (2011) Wharton\u2019s jelly mesenchymal stem cells as candidates for beta cells regeneration: extending the differentiative and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes. Stem Cell Rev 7:342\u2013363. https:\/\/doi.org\/10.1007\/s12015-010-9196-4","journal-title":"Stem Cell Rev"},{"issue":"8","key":"550_CR6","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/bies.201100015","volume":"33","author":"ME Arntfield","year":"2011","unstructured":"Arntfield ME, van der Kooy D (2011) Beta-cell evolution: how the pancreas borrowed from the brain: the shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relations. Bioassays 33(8):582\u2013587. https:\/\/doi.org\/10.1002\/bies.201100015","journal-title":"Bioassays"},{"key":"550_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","volume":"383","author":"MA Atkinson","year":"2014","unstructured":"Atkinson MA, Eisenbarth GS, Michels AW (2014) Type 1 diabetes. Lancet 383:69\u201382. https:\/\/doi.org\/10.1016\/S0140-6736(13)60591-7","journal-title":"Lancet"},{"issue":"3","key":"550_CR8","doi-asserted-by":"publisher","first-page":"e264","DOI":"10.18295\/squmj.2018.18.03.002","volume":"18","author":"R Berebichez-Fridman","year":"2018","unstructured":"Berebichez-Fridman R, Montero-Olvera PR (2018) Sources and clinical applications of mesenchymal stem cells: state-of-the-art review. Sultan Qaboos Univ Med J 18(3):e264\u2013e277. https:\/\/doi.org\/10.18295\/squmj.2018.18.03.002","journal-title":"Sultan Qaboos Univ Med J"},{"key":"550_CR9","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cmet.2014.02.001","volume":"19","author":"M Brissova","year":"2014","unstructured":"Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A, Poffenberger G, Aramandla R, Levy SE, Powers AC (2014) Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes beta cell regeneration. Cell Metab 19:498\u2013511. https:\/\/doi.org\/10.1016\/j.cmet.2014.02.001","journal-title":"Cell Metab"},{"key":"550_CR10","doi-asserted-by":"publisher","first-page":"e71104","DOI":"10.1371\/journal.pone.0071104","volume":"8","author":"A Bronckaers","year":"2013","unstructured":"Bronckaers A, Hilkens P, Fanton Y, Struys T, Gervois P, Politis C, Martens W, Lambrichts I (2013) Angiogenic properties of human dental pulp stem cells. PLoS ONE 8:e71104. https:\/\/doi.org\/10.1371\/journal.pone.0071104","journal-title":"PLoS ONE"},{"key":"550_CR11","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1002\/term.2914","volume":"13","author":"C Brown","year":"2019","unstructured":"Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind CK, Chaudhry GR (2019) Mesenchymal stem cells: cell therapy and regeneration potential. J Tissue Eng Regen Med. 13:1738\u20131755. https:\/\/doi.org\/10.1002\/term.2914","journal-title":"J Tissue Eng Regen Med."},{"key":"550_CR12","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.2337\/diabetes.52.9.2304","volume":"52","author":"AE Butler","year":"2003","unstructured":"Butler AE, Janson J, Soeller WC, Butler PC (2003) Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes 52:2304\u20132314","journal-title":"Diabetes"},{"issue":"4","key":"550_CR13","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4103\/0976-500X.119726","volume":"4","author":"J Charan","year":"2013","unstructured":"Charan J, Kantharia ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4(4):303\u2013306. https:\/\/doi.org\/10.4103\/0976-500X.119726","journal-title":"J Pharmacol Pharmacother"},{"key":"550_CR14","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.jcyt.2017.07.009","volume":"19","author":"I Datta","year":"2017","unstructured":"Datta I, Bhadri N, Shahani P, Majumdar D, Sowmithra S, Razdan R, Bhonde R (2017) Functional recovery upon human dental pulp stem cell transplantation in a diabetic neuropathy rat model. Cytotherapy 19:1208\u20131224","journal-title":"Cytotherapy"},{"key":"550_CR15","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1016\/j.jcyt.2017.07.009","volume":"37","author":"G Di Gioacchino","year":"2005","unstructured":"Di Gioacchino G, Di Campli C, Zocco MA, Piscaglia AC, Novi M, Santoro M, Santoliquido A, Flore R, Tondi P, Pola P, Gasbarrini G, Gasbarrini A (2005) Transdifferentiation of stem cells in pancreatic cells: state of the art. Transplant Proc 37:2662\u20132663. https:\/\/doi.org\/10.1016\/j.jcyt.2017.07.009","journal-title":"Transplant Proc"},{"key":"550_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nri2925","volume":"11","author":"MY Donath","year":"2011","unstructured":"Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98\u2013107. https:\/\/doi.org\/10.1038\/nri2925","journal-title":"Nat Rev Immunol"},{"key":"550_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nature02520","volume":"429","author":"Y Dor","year":"2004","unstructured":"Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41\u201346","journal-title":"Nature"},{"issue":"Suppl 2","key":"550_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1463-1326.2007.00783.x","volume":"9","author":"L Elghazi","year":"2007","unstructured":"Elghazi L, Rachdi L, Weiss AJ, Cras-Meneur C, Bernal-Mizrachi E (2007) Regulation of beta-cell mass and function by the Akt\/protein kinase B signalling pathway. Diabetes Obes Metab 9(Suppl 2):147\u2013157","journal-title":"Diabetes Obes Metab"},{"key":"550_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4252\/wjsc.v6.i2.163","volume":"6","author":"M Figliuzzi","year":"2014","unstructured":"Figliuzzi M, Bonandrini B, Silvani S, Remuzzi A (2014) Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes. World J Stem Cells 6:163\u2013172. https:\/\/doi.org\/10.4252\/wjsc.v6.i2.163","journal-title":"World J Stem Cells"},{"key":"550_CR20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3727\/096368912X647162","volume":"22","author":"MM Gabr","year":"2013","unstructured":"Gabr MM, Zakaria MM, Refaie AF, Ismail AM, Abou-El-Mahasen MA, Khater SA, El-Halawani SM, Ibrahim RY, Uin GS, Kloc M, Calne RY, Ghoneim MA (2013) Insulin producing-cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant 22:133\u2013145. https:\/\/doi.org\/10.3727\/096368912X647162","journal-title":"Cell Transplant"},{"key":"550_CR21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1634\/stemcells.2007-0484","volume":"26","author":"C Gandia","year":"2008","unstructured":"Gandia C, Arminan A, Garcia-Verdugo JM, Lledo E, Ruiz A, Minana MD, Sanchez-Torrijos J, Paya R, Mirabet V, Carbonell-Uberos F, Llop M, Montero JA, Sepulveda P (2008) Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells 26:638\u2013645","journal-title":"Stem Cells"},{"key":"550_CR22","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1007\/s00125-011-2243-0","volume":"54","author":"RF Gibly","year":"2011","unstructured":"Gibly RF, Graham JG, Luo X, Lowe WL, Hering BJ, Shea LD (2011) Advancing islet transplantation: from engraftment to the immune response. Diabetologia 54:2494\u20132505. https:\/\/doi.org\/10.1007\/s00125-011-2243-0","journal-title":"Diabetologia"},{"key":"550_CR23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4939-3584-0_7","volume":"1416","author":"M Gnecchi","year":"2016","unstructured":"Gnecchi M, Danieli P, Malpasso G, Ciuffreda MC (2016) Paracrine mechanisms of mesenchymal stem cells in tissue repair. Methods Mol Biol 1416:123\u2013146. https:\/\/doi.org\/10.1007\/978-1-4939-3584-0_7","journal-title":"Methods Mol Biol"},{"issue":"5","key":"550_CR24","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1177\/0022034510396879","volume":"90","author":"V Govindasamy","year":"2011","unstructured":"Govindasamy V, Ronald VS, Abdullah AN, Ganesan Nathan KR, Aziz AZAC, Abdullah M, Abu MS, Kasim NH, Bhonde RR (2011) Differentiation of dental pulp stem cells into islet-like aggregates. J Dent Res 90(5):646\u2013652. https:\/\/doi.org\/10.1177\/0022034510396879","journal-title":"J Dent Res"},{"issue":"12","key":"550_CR25","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.3727\/096368912X657972","volume":"22","author":"ET Guimaraes","year":"2013","unstructured":"Guimaraes ET, DaCruz GS, Almeida TF, Souza BS, Kaneto CM, Vasconcelos JF, Santos WL, Santos RR, Villarreal CF, Soares MB (2013) Transplantation of stem cells obtained from murine dental pulp improves pancreatic damage, renal function and painful diabetic neuropathy in diabetic type 1 mouse model. Cell Transplant 22(12):2345\u20132354. https:\/\/doi.org\/10.3727\/096368912X657972","journal-title":"Cell Transplant"},{"issue":"8","key":"550_CR26","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1089\/neu.2008-0733","volume":"26","author":"X Guo","year":"2009","unstructured":"Guo X, Liu L, Zhang M, Bergeron A, Cui Z, Dong JF, Zhang J (2009) Correlation of CD34+ cells with tissue angiogenesis after traumatic brain injury in a rat model. J Neurotrauma 26(8):1337\u20131344. https:\/\/doi.org\/10.1089\/neu.2008-0733","journal-title":"J Neurotrauma"},{"key":"550_CR27","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nbt841","volume":"21","author":"D Hess","year":"2003","unstructured":"Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, Thyssen S, Gray DA, Bhatia M (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 21:763\u2013770","journal-title":"Nat Biotechnol"},{"key":"550_CR28","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.3892\/etm.2016.3544","volume":"12","author":"J Hu","year":"2016","unstructured":"Hu J, Wang Y, Gong H, Yu C, Guo C, Wang F, Yan S, Xu H (2016) Long term effect and safety of Wharton\u2019s jelly-derived mesenchymal stem cells on type 2 diabetes. Exp Ther Med 12:1857\u20131866","journal-title":"Exp Ther Med"},{"key":"550_CR29","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1634\/stemcells.2008-0285","volume":"26","author":"AH Huang","year":"2008","unstructured":"Huang AH, Snyder BR, Cheng PH, Chan AW (2008) Putative dental pulp-derived stem\/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice. Stem Cells 26:2654\u20132663. https:\/\/doi.org\/10.1634\/stemcells.2008-0285","journal-title":"Stem Cells"},{"issue":"23","key":"550_CR30","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1161\/CIRCULATIONAHA.110.955971","volume":"122","author":"XP Huang","year":"2010","unstructured":"Huang XP, Sun Z, Miyagi Y, McDonald Kinkaid H, Zhang L, Weisel RD, Li RK (2010) Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation 122(23):2419\u20132429. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.955971","journal-title":"Circulation"},{"key":"550_CR31","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1096\/fj.04-2078rev","volume":"19","author":"JS Hunt","year":"2005","unstructured":"Hunt JS, Petroff MG, McIntire RH, Ober C (2005) HLA-G and immune tolerance in pregnancy. FASEB J 19:681\u2013693","journal-title":"FASEB J"},{"key":"550_CR32","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1172\/JCI200316502","volume":"111","author":"A Ianus","year":"2003","unstructured":"Ianus A, Holz GG, Theise ND, Hussain MA (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111:843\u2013850","journal-title":"J Clin Invest"},{"key":"550_CR33","doi-asserted-by":"publisher","first-page":"e000128","DOI":"10.1136\/bmjdrc-2015-000128","volume":"3","author":"T Izumoto-Akita","year":"2015","unstructured":"Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y (2015) Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic beta-cell function. BMJ Open Diabetes Res Care 3:e000128. https:\/\/doi.org\/10.1136\/bmjdrc-2015-000128","journal-title":"BMJ Open Diabetes Res Care"},{"key":"550_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1117-6806.127092","volume":"20","author":"R Kabir","year":"2014","unstructured":"Kabir R, Gupta M, Aggarwal A, Sharma D, Sarin A, Kola MZ (2014) Imperative role of dental pulp stem cells in regenerative therapies: a systematic review. Niger J Surg 20:1\u20138","journal-title":"Niger J Surg"},{"key":"550_CR35","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1016\/j.jcyt.2013.05.008","volume":"15","author":"MM Kanafi","year":"2013","unstructured":"Kanafi MM, Rajeshwari YB, Gupta S, Dadheech N, Nair PD, Gupta PK, Bhonde RR (2013) Transplantation of islet-like cell clusters derived from human dental pulp stem cells restores normoglycemia in diabetic mice. Cytotherapy 15:1228\u20131236. https:\/\/doi.org\/10.1016\/j.jcyt.2013.05.008","journal-title":"Cytotherapy"},{"key":"550_CR36","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1155\/2014\/832736","volume":"25","author":"O Karnieli","year":"2007","unstructured":"Karnieli O, Izhar-Prato Y, Bulvik S, Efrat S (2007) Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 25:2837\u20132844. https:\/\/doi.org\/10.1155\/2014\/832736","journal-title":"Stem Cells"},{"key":"550_CR37","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/jdi.12758","volume":"9","author":"TJ Kieffer","year":"2017","unstructured":"Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N (2017) Beta-cell replacement strategies for diabetes. J Diabetes Investig 9:457\u2013463. https:\/\/doi.org\/10.1111\/jdi.12758","journal-title":"J Diabetes Investig"},{"key":"550_CR38","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.3727\/096368912X636803","volume":"21","author":"J Kim","year":"2012","unstructured":"Kim J, Park S, Kang HM, Ahn CW, Kwon HC, Song JH, Lee YJ, Lee KH, Yang H, Baek SY, Yoo SH, Kim SH, Kim H (2012a) Human insulin secreted from insulinogenic xenograft restores normoglycemia in type 1 diabetic mice without immunosuppression. Cell Transplantat 21:2131\u20132147","journal-title":"Cell Transplantat"},{"key":"550_CR39","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3858\/emm.2012.44.1.002","volume":"44","author":"B Kim","year":"2012","unstructured":"Kim B, Yoon BS, Moon JH, Kim J, Jun EK, Lee JH, Kim JS, Baik CS, Kim A, Whang KY, You S (2012b) Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells. Exp Mol Med 44:26\u201335. https:\/\/doi.org\/10.3858\/emm.2012.44.1.002","journal-title":"Exp Mol Med"},{"key":"550_CR40","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1177\/0022034516659642","volume":"95","author":"HJ Kim","year":"2016","unstructured":"Kim HJ, Cho YA, Lee YM, Lee SY, Bae WJ, Kim EC (2016) PIN1 Suppresses the hepatic differentiation of pulp stem cells via Wnt3a. J Dent Res 95:1415\u20131424. https:\/\/doi.org\/10.1177\/0022034516659642","journal-title":"J Dent Res"},{"key":"550_CR41","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.joen.2017.12.007","volume":"44","author":"S Kim","year":"2018","unstructured":"Kim S, Lee S, Jung HS, Kim SY, Shin SJ, Kang MK, Kim E (2018) Evaluation of the biodistribution of human dental pulp stem cells transplanted into mice. J Endod. 44:592\u2013598. https:\/\/doi.org\/10.1016\/j.joen.2017.12.007","journal-title":"J Endod."},{"key":"550_CR42","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1002\/jcb.23250","volume":"112","author":"RH Lee","year":"2011","unstructured":"Lee RH, Oh JY, Choi H, Bazhanov N (2011) Therapeutic factors secreted by mesenchymal stromal cells and tissue repair. J Cell Biochem 112:3073\u20133078. https:\/\/doi.org\/10.1002\/jcb.23250","journal-title":"J Cell Biochem"},{"key":"550_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/odi.12086","volume":"20","author":"Z Li","year":"2014","unstructured":"Li Z, Jiang CM, An S, Cheng Q, Huang YF, Wang YT, Gou YC, Xiao L, Yu WJ, Wang J (2014) Immunomodulatory properties of dental tissue-derived mesenchymal stem cells. Oral Dis 20:25\u201334. https:\/\/doi.org\/10.1111\/odi.12086","journal-title":"Oral Dis"},{"key":"550_CR44","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00441-015-2330-5","volume":"364","author":"L Li","year":"2016","unstructured":"Li L, Li F, Gao F, Yang Y, Liu Y, Guo P, Li Y (2016) Transplantation of mesenchymal stem cells improves type 1 diabetes mellitus. Cell Tissue Res 364:345\u2013355. https:\/\/doi.org\/10.1007\/s00441-015-2330-5","journal-title":"Cell Tissue Res"},{"key":"550_CR45","doi-asserted-by":"publisher","first-page":"2424586","DOI":"10.1155\/2018\/2424586","volume":"2018","author":"X Li","year":"2018","unstructured":"Li X, Meng Q, Zhang L (2018) The fate of allogeneic pancreatic islets following intraportal transplantation: challenges and solutions. J Immunol Res 2018:2424586. https:\/\/doi.org\/10.1155\/2018\/2424586","journal-title":"J Immunol Res"},{"key":"550_CR46","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.mce.2018.01.024","volume":"473","author":"C Liu","year":"2018","unstructured":"Liu C, Zhang W, Peradze N, Lang L, Straetener J, Feilen PJ, Alt M, Jager C, Laubner K, Perakakis N, Seufert J, Path G (2018) Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic beta-cells during cellular stress involves signalling via Akt and ERK1\/2. Mol Cell Endocrinol 473:235\u2013244. https:\/\/doi.org\/10.1016\/j.mce.2018.01.024","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"550_CR47","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.cjca.2019.05.037","volume":"35","author":"TB Marvasti","year":"2019","unstructured":"Marvasti TB, Alibhai FJ, Weisel RD, Li RK (2019) CD34+ stem cells: promising roles in cardiac repair and regeneration. Can J Cardiol 35(10):1311\u20131321. https:\/\/doi.org\/10.1016\/j.cjca.2019.05.037","journal-title":"Can J Cardiol"},{"key":"550_CR48","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.cytogfr","volume":"20","author":"LdS Meirelles","year":"2009","unstructured":"Meirelles LdS, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419\u2013427. https:\/\/doi.org\/10.1016\/j.cytogfr","journal-title":"Cytokine Growth Factor Rev"},{"key":"550_CR49","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.joen.2009.07.024","volume":"35","author":"S Nakamura","year":"2009","unstructured":"Nakamura S, Yamada Y, Katagiri W, Sugito T, Ito K, Ueda M (2009) Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp. J Endod 35:1536\u20131542. https:\/\/doi.org\/10.1016\/j.joen.2009.07.024","journal-title":"J Endod"},{"key":"550_CR50","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/tri.12122","volume":"26","author":"SV Niederhaus","year":"2013","unstructured":"Niederhaus SV, Kaufman DB, Odorico JS (2013) Induction therapy in pancreas transplantation. Transpl Int 26:704\u2013714. https:\/\/doi.org\/10.1111\/tri.12122","journal-title":"Transpl Int"},{"key":"550_CR51","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","volume":"25","author":"DG Phinney","year":"2007","unstructured":"Phinney DG, Prockop DJ (2007) Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair\u2013current views. Stem Cells 25:2896\u20133290","journal-title":"Stem Cells"},{"key":"550_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.metabol.2018.10.005","volume":"90","author":"G Path","year":"2019","unstructured":"Path G, Perakakis N, Mantzoros CS, Seufert J (2019) Stem cells in the treatment of diabetes mellitus-focus on mesenchymal stem cells. Metabolism 90:1\u201315. https:\/\/doi.org\/10.1016\/j.metabol.2018.10.005","journal-title":"Metabolism"},{"key":"550_CR53","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.joen.2016.11.018","volume":"6","author":"A Pisciotta","year":"2015","unstructured":"Pisciotta A, Riccio M, Carnevale G, Lu A, De Biasi S, Gibellini L, La Sala GB, Bruzzesi G, Ferrari A, Huard J, DePol A (2015) Stem cells isolated from human dental pulp and amniotic fluid improve skeletal muscle histopathology in mdx\/SCID mice. Stem Cell Res Ther 6:156. https:\/\/doi.org\/10.1016\/j.joen.2016.11.018","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"550_CR54","doi-asserted-by":"publisher","first-page":"165315","DOI":"10.1016\/j.bbadis.2018.10.033","volume":"1866","author":"P JS","year":"2018","unstructured":"JS P (2018) Mesenchymal stem cells to treat type 1 diabetes. BBA Mol Basis Dis 1866(4):165315. https:\/\/doi.org\/10.1016\/j.bbadis.2018.10.033","journal-title":"BBA Mol Basis Dis"},{"key":"550_CR55","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13287-015-0141-y","volume":"7","author":"A Scuteri","year":"2014","unstructured":"Scuteri A, Donzelli E, Foudah D, Caldara C, Redondo J, D'Amico G, Tredici G, Miloso M (2014) Mesengenic differentiation: comparison of human and rat bone marrow mesenchymal stem cells. Int J Stem Cells 7:127\u2013134. https:\/\/doi.org\/10.1186\/s13287-015-0141-y","journal-title":"Int J Stem Cells"},{"key":"550_CR56","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ccr.2005.09.006","volume":"8","author":"QB She","year":"2005","unstructured":"She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N (2005) The BAD protein integrates survival signaling by EGFR\/MAPK and PI3K\/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 8:287\u2013297","journal-title":"Cancer Cell"},{"key":"550_CR57","doi-asserted-by":"publisher","first-page":"BSR 20182051","DOI":"10.1042\/BSR20182051","volume":"39","author":"SB Shivakumar","year":"2019","unstructured":"Shivakumar SB, Lee HJ, Son YB, Bharti D, Ock SA, Lee SL, Kang YH, Park BW, Rho GJ (2019) In vitro differentiation of single donor derived human dental mesenchymal stem cells into pancreatic beta cell-like cells. Biosci Rep 39:BSR 20182051. https:\/\/doi.org\/10.1042\/BSR20182051","journal-title":"Biosci Rep"},{"key":"550_CR58","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.2337\/db11-1141","volume":"6","author":"Y Si","year":"2012","unstructured":"Si Y, Zhao Y, Hao H, Liu J, Guo Y, Mu Y, Shen J, Cheng Y, Fu X, Han W (2012) Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity. Diabetes 6:1616\u20131625. https:\/\/doi.org\/10.2337\/db11-1141","journal-title":"Diabetes"},{"key":"550_CR59","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.2337\/dc14-2830","volume":"38","author":"JS Skyler","year":"2015","unstructured":"Skyler JS, Fonseca VA, Segal KR, Rosenstock J, Investigators M-D (2015) Allogeneic mesenchymal precursor cells in type 2 diabetes: a randomized, placebo- controlled, dose-escalation safety and tolerability pilot study. Diabetes Care 38:1742\u20131749. https:\/\/doi.org\/10.2337\/dc14-2830","journal-title":"Diabetes Care"},{"key":"550_CR60","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.numecd","volume":"27","author":"V Sordi","year":"2017","unstructured":"Sordi V, Pellegrini S, Krampera M, Marchetti P, Pessina A, Ciardelli G, Fadini G, Pintus C, Pante G, Piemonti L (2017) Stem cells to restore insulin production and cure diabetes. Nutr Metab Cardiovasc Dis 27:583\u2013600. https:\/\/doi.org\/10.1016\/j.numecd","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"550_CR61","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3727\/096368914X683016","volume":"63","author":"J Suchanek","year":"2017","unstructured":"Suchanek J, Nasry SA, Soukup T (2017) The differentiation potential of human natal dental pulp stem cells into insulin-producing cells. Folia Biol (Praha) 63:132\u2013138. https:\/\/doi.org\/10.3727\/096368914X683016","journal-title":"Folia Biol (Praha)"},{"key":"550_CR62","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.devcel.2007.04.011","volume":"12","author":"M Teta","year":"2007","unstructured":"Teta M, Rankin MM, Long SY, Stein GM, Kushner JA (2007) Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12:817\u2013826","journal-title":"Dev Cell"},{"key":"550_CR63","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.3727\/096368914X683016","volume":"24","author":"PJ Tsai","year":"2015","unstructured":"Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF (2015) Undifferentiated Wharton's jelly mesenchymal stem cell transplantation induces insulin-producing cell differentiation and suppres:sion of T-cell-mediated autoimmunity in nonobese diabetic mice. Cell Transplant 24:1555\u20131570","journal-title":"Cell Transplant"},{"issue":"10","key":"550_CR64","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1681\/ASN.2016070775","volume":"28","author":"N Uchida","year":"2017","unstructured":"Uchida N, Kushida Y, Kitada M, Wakao S, Kumagai N, Kuroda Y, Kondo Y, Hirohara Y, Kure S, Chazenbalk G, Dezawa M (2017) Beneficial effects of systemically administered human muse cells in adriamycin. Nephropathy J Am Soc Nephrol 28(10):2946\u20132960. https:\/\/doi.org\/10.1681\/ASN.2016070775","journal-title":"Nephropathy J Am Soc Nephrol"},{"key":"550_CR65","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3727\/096368914X683016","volume":"18","author":"AV Vanikar","year":"2016","unstructured":"Vanikar AV, Trivedi HL, Thakkar UG (2016) Stem cell therapy emerging as the key player in treating type 1 diabetes mellitus. Cytotherapy 18:1077\u20131086. https:\/\/doi.org\/10.3727\/096368914X683016","journal-title":"Cytotherapy"},{"key":"550_CR66","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/ajt.13426","volume":"16","author":"F Vendrame","year":"2016","unstructured":"Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW, Pugliese A (2016) Risk factors for type 1 diabetes recurrence in immunosuppressed recipients of simultaneous pancreas\u2013kidney transplants. Am J Transplant 16:235\u2013245. https:\/\/doi.org\/10.1111\/ajt.13426","journal-title":"Am J Transplant"},{"key":"550_CR67","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/sctm.17-0139","volume":"7","author":"H Wang","year":"2018","unstructured":"Wang H, Strange C, Nietert PJ, Wang J, Turnbull TL, Cloud C, Owczarski S, Shuford B, Duke T, Gilkeson G, Luttrell L, Hermayer K, Fernandes J, Adams DB, Morgan KA (2018a) Autologous mesenchymal stem cell and islet cotransplantation: safety and efficacy. Stem Cells Transl Med 7:11\u201319. https:\/\/doi.org\/10.1002\/sctm.17-0139","journal-title":"Stem Cells Transl Med"},{"key":"550_CR68","doi-asserted-by":"publisher","first-page":"608","DOI":"10.2174\/1574888X13666180720100738","volume":"13","author":"Y Wang","year":"2018","unstructured":"Wang Y, Pan J, Wang D, Liu J (2018b) The use of stem cells in neural regeneration: a review of current opinion. Curr Stem Cell Res Ther 13:608\u2013617","journal-title":"Curr Stem Cell Res Ther"},{"key":"550_CR69","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1172\/JCI66323","volume":"123","author":"X Xiao","year":"2013","unstructured":"Xiao X, Chen Z, Shiota C, Prasadan K, Guo P, El-Gohary Y, Paredes J, Welsh C, Wiersch J, Gittes GK (2013) No evidence for beta cell neogenesis in murine adult pancreas. J Clin Invest 123:2207\u20132217","journal-title":"J Clin Invest"},{"key":"550_CR70","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.diff.2009.01.001","volume":"77","author":"QP Xie","year":"2009","unstructured":"Xie QP, Huang H, Xu B, Dong X, Gao SL, Zhang B, Wu YL (2009) Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation 77:483\u2013491. https:\/\/doi.org\/10.1016\/j.diff.2009.01.001","journal-title":"Differentiation"},{"key":"550_CR71","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.3390\/ijms20051132","volume":"20","author":"Y Yamada","year":"2019","unstructured":"Yamada Y, Nakamura-Yamada S, Kusano K, Baba S (2019) Clinical potential and current progress of dental pulp stem cells for various systemic diseases in regenerative medicine: a concise review. Int J Mol Sci 20:1132. https:\/\/doi.org\/10.3390\/ijms20051132","journal-title":"Int J Mol Sci"},{"key":"550_CR72","doi-asserted-by":"publisher","first-page":"16295","DOI":"10.1038\/srep16295","volume":"5","author":"S Yamaguchi","year":"2015","unstructured":"Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto A (2015) Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion. Sci Rep 5:16295. https:\/\/doi.org\/10.1038\/srep16295","journal-title":"Sci Rep"},{"key":"550_CR73","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1741-7015-11-160","volume":"11","author":"Y Zhao","year":"2013","unstructured":"Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Zhou H, Yin Z, Chen Y, Zhang Y, Wang S, Shen J, Thaker H, Jain S, Li Y, Diao Y, Chen Y, Sun X, Fisk MB, Li H (2013) Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I\/II clinical trial. BMC Med 11:160. https:\/\/doi.org\/10.1186\/1741-7015-11-160","journal-title":"BMC Med"}],"container-title":["Anatomical Science International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12565-020-00550-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12565-020-00550-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12565-020-00550-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T18:42:18Z","timestamp":1722969738000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12565-020-00550-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,31]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["550"],"URL":"https:\/\/doi.org\/10.1007\/s12565-020-00550-2","relation":{},"ISSN":["1447-6959","1447-073X"],"issn-type":[{"value":"1447-6959","type":"print"},{"value":"1447-073X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,31]]},"assertion":[{"value":"9 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}